S. D. Young

发表

Inhibition of human immunodeficiency virus integrase by bis-catechols

D. Hazuda, E. Emini, R. Lafemina, 1995, Antimicrobial agents and chemotherapy.

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

W. M. Sanders, T. Tucker, M. Goldman, 1994, Journal of Medicinal Chemistry.

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

P. Anderson, W. Schleif, E. Emini, 1995, Antimicrobial agents and chemotherapy.

Pharmacological profile of a new potent and specific α2-adrenoceptor antagonist, L-657,743

V. J. Lotti, J. Huff, J. Vacca, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Steven V. Fox, John D. Schreier, J. Renger, 2014, Bioorganic & medicinal chemistry letters.

A potent and orally active HIV-1 integrase inhibitor.

Wei Xu, D. Hazuda, Michael D. Miller, 2007, Bioorganic & medicinal chemistry letters.

Metabolism of synthetic inositol trisphosphate analogs.

J. Huff, J. Vacca, M. Polokoff, 1988, The Journal of biological chemistry.

Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Steven V. Fox, John D. Schreier, S. Doran, 2012, ChemMedChem.

Chapter 18. Recent advances in the chemotherapy of HIV

S. D. Young, 2003 .

Synthesis and Biological Evaluation of [11C]MK-912 as an α2-Adrenergic Receptor Radioligand for PET Studies

D. Bylund, R. Pleus, J. Sunderland, 1998 .

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Linghang Zhuang, D. Hazuda, W. Schleif, 2003, Journal of medicinal chemistry.

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

H. M. Langford, D. Hazuda, W. Schleif, 2000, Journal of medicinal chemistry.

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

D. Hazuda, Jiunn H. Lin, W. Schleif, 2005, Bioorganic & medicinal chemistry letters.

Chapter 21 – The Mutilated Wrist

M. Moneim, S. D. Young, E. Mikola, 2005 .

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

A. Dilella, T. Mcdonald, D. Reiss, 2011, ACS chemical neuroscience.

ACYCLIC STEREOSELECTION. 6. A REAGENT FOR ACHIEVING HIGH 1,2-DIASTEREOSELECTION IN THE ALDOL CONVERSION OF CHIRAL ALDEHYDES INTO 3-HYDROXY-2-METHYLCARBOXYLIC ACIDS

J. E. Sohn, M. Pirrung, S. D. Young, 1979 .

Facile Conversion of Hantzsch Type 4-Ary1-2,6-dimethyl-1,4-dihydropyridine-3,5-carboxylates into 4-Aryl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylates

S. D. Young, 1984 .

Acyclic stereoselection. 12. Double stereodifferentiation with mutual kinetic resolution. A superior class of reagents for control of Cram's rule stereoselection in synthesis of erythro-.alpha.-alkyl-.beta.-hydroxy carboxylic acids from chiral aldehydes

M. Pirrung, J. Lampe, S. D. Young, 1981 .

Acyclic stereoselection. 25. Stereoselective synthesis of the C-1 to C-7 moiety of erythronolide A

S. D. Young, R. Pilli, C. Heathcock, 1985 .

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.

John D. Schreier, S. Doran, G. McGaughey, 2010, Journal of medicinal chemistry.

Acyclic stereoselection. 9. Stereochemistry of the addition of lithium enolates to .alpha.-alkoxy aldehydes

M. Pirrung, D. VanDerveer, S. D. Young, 1980 .

Hantzsch 1,2,3,4-tetrahydropyridines related to calcium antagonists. Two synthetic approaches.

S. D. Young, D. Claremon, 1985 .

Facile Conversion of Hantzsch Type 4-Ary1-2,6-dimethyl-1,4-dihydropyridine-3,5-carboxylates into 4-Aryl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylates

S. D. Young, 1984 .

Discovery of 5′′‐Chloro‐N‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia

Steven V. Fox, John D. Schreier, J. Renger, 2014, ChemMedChem.

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.

P. Darke, A. Deana, S. Graham, 1992, Journal of medicinal chemistry.

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

W. M. Sanders, P. Darke, I. Sigal, 1991, Journal of medicinal chemistry.

Non-nucleoside inhibitors of HIV-1 reverse transcriptase

Steven D. Young, S. D. Young, 1993 .

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

D. Hazuda, J. Shiver, W. Schleif, 2004, Science.

Raltegravir: the first HIV‐1 integrase strand transfer inhibitor in the HIV armamentarium

D. Hazuda, R. Leavitt, H. Teppler, 2011, Annals of the New York Academy of Sciences.

Inhibitors of human immunodeficiency virus integration

Steven D. Young, D. Hazuda, S. D. Young, 2003 .

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

D. Hazuda, W. Schleif, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase

W. Schleif, J. Huff, J. O'brien, 1995 .

Thumb carpometacarpal arthrosis

S. D. Young, E. Mikola, 2004 .

Thumb Amputations from Team Roping

K. Firoozbakhsh, M. Moneim, S. D. Young, 2003, The American journal of sports medicine.

2‐Methyl‐2‐(Trimethylsiloxy)Pentan‐3‐one

S. D. Young, C. Heathcock, C. T. Buse, 2003 .

[3H]L-657, 743 (MK-912): A new, high affinity, selective radioligand for brain α2-adrenoceptors

J. Huff, S. D. Young, D. Pettibone, 1989 .

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).

J. Renger, P. Coleman, S. Garson, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity studies and antiviral properties of hydroxyethylene transition state inhibitors of HIV-1 protease

P. Anderson, P. Darke, W. Schleif, 1992 .

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2006, Bioorganic & medicinal chemistry letters.

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of HIV-1 integrase by small molecules: the potential for a new class of AIDS chemotherapeutics.

S. D. Young, S D Young, 2001, Current opinion in drug discovery & development.

Synthesis of a Series of 4-(Arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.

W. M. Sanders, P. Anderson, W. Schleif, 1994 .

Non-peptide glycoprotein IIb/IIIa inhibitors. 9. Centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function

R. Gould, G. Hartman, S. D. Young, 1996 .