M. Wani

发表

7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents.

D. V. Von Hoff, B. Vladu, J. Woynarowski, 2000, Molecular pharmacology.

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Geoffrey A. Cordell, Norman R. Farnsworth, G. Cordell, 1995, Nature Medicine.

Camptothecin and taxol: from discovery to clinic.

M. Wani, M. Wall, Monroe E. Wall, 1996, Journal of ethnopharmacology.

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts.

L. Liu, B. Giovanella, M. Wani, 1989, Science.

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.

A. McPhail, M. Wani, M. Wall, 1971, Journal of the American Chemical Society.

Lipid bilayer partitioning and stability of camptothecin drugs.

T. Burke, M. Wani, M. Wall, 1993, Biochemistry.

Camptothecin analogues with enhanced antitumor activity at acidic pH

M. Dewhirst, O. Colvin, M. P. Gamcsik, 2000, Cancer Chemotherapy and Pharmacology.

Oberlies “ Sorbicillinoid Analogs with Cytotoxic and Selective Anti-Aspergillus Activities from Scytalidium album

M. Grever, H. Raja, T. El-Elimat, 2019 .

Sorbicillinoid Analogues with Cytotoxic and Selective Anti-Aspergillus Activities from Scytalidium album

M. Grever, H. Raja, T. El-Elimat, 2014, The Journal of Antibiotics.

MECHANISTIC AND EXPLORATORY PHOTOCHEMISTRY. XII. CHARACTERIZATION OF THE REACTIVITY OF THE BETA-CARBON IN THE TRIPLET EXCITED STATE OF ALPHA,BETA-UNSATURATED KETONES.

H. Morrison, M. Wani, H. Zimmerman, 1965, Journal of the American Chemical Society.

Plant antitumor agents, 19. Novel triterpenes from Maprounea africana.

M. Wani, M. Wall, H. Taylor, 1983, Journal of natural products.

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

C. Pearce, N. Oberlies, D. Kroll, 2011, Journal of natural products.

Novel strategies for the discovery of plant-derived anticancer agents

G. Cordell, J. Pezzuto, C. Fairchild, 1994 .

Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts.

D. V. Von Hoff, G. Mangold, P. Potter, 1999, Cancer research.

Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.

D. Kroll, P. Burke, P. Senter, 2009, Bioconjugate chemistry.

Bioactive prenylated flavonoids from the stem bark ofartocarpus kemando

G. Cordell, J. Pezzuto, A. Kinghorn, 2003, Archives of pharmacal research.

Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles

C. Pearce, N. Oberlies, D. Kroll, 2010, The Journal of Antibiotics.

Camptothecin and Analogues. Synthesis, Biological in vitro and in vivo Activities, and Clinical Possibilities

M. Wani, M. Wall, 1994 .

Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin.

M. Wani, M. Wall, A. W. Nicholas, 1987, Journal of medicinal chemistry.

Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.

Y. Pommier, O. Colvin, G. Kohlhagen, 2001, Molecular cancer therapeutics.

Camptothecin analogs in malignant gliomas: comparative analysis and characterization.

H. Brem, B. Tyler, M. Wani, 2003, Journal of neurosurgery.

Chapter One - Taxol

M. Wani, M. Wall, 1995 .

Plant antitumor agents, 26. Isolation, structure, and antitumor activity of alkaloids from Anopterus glandulosus.

M. Wani, M. Wall, H. Taylor, 1987, Journal of natural products.

Nature as a remarkable chemist: a personal story of the discovery and development of Taxol

S. Horwitz, M. Wani, 2014, Anti-cancer drugs.

Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

C. Day, H. Raja, T. El-Elimat, 2013, Journal of natural products.

Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022)

S. Matthew, C. Pearce, N. Oberlies, 2011, The Journal of Antibiotics.

Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.

Brandie M. Ehrmann, C. Pearce, N. Oberlies, 2011, Tetrahedron letters.

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

C. Pearce, N. Oberlies, D. Kroll, 2011, Tetrahedron letters.

Discovery to Clinic a

M. Wani, M. Wall, 1996 .

Apoptotic Anticancer Effect

G. Cordell, G. Tan, J. Pezzuto, 2009 .

Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.

G. Cordell, G. Tan, J. Pezzuto, 2005, Anticancer Research.

Camptothecin and taxol – from nature to bench to bedside

M. Wani, 2015 .

Selective Drug Resistant Human Osteosarcoma Cell Lines

M. Edin, M. Wani, M. Wall, 2001, Clinical orthopaedics and related research.

Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin.

K. Kohn, Y. Pommier, G. Manikumar, 1990, Journal of medicinal chemistry.

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations.

G. Manikumar, M. Wani, M. Wall, 1987, Journal of medicinal chemistry.

Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.

Mark W Grinstaff, Nicholas H Oberlies, M. Grinstaff, 2006, Cancer research.

Plant antitumor agents. II. Structure of two new alkaloids from Camptotheca acuminata

M. Wani, M. Wall, 1969 .

Discovery of anticancer agents of diverse natural origin

A. Kinghorn, D. Jarjoura, S. Emanuel, 2009, Pure and applied chemistry. Chimie pure et appliquee.

Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.

R. Agarwal, N. Oberlies, D. Kroll, 2007, Planta medica.

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues.

M. Wani, M. Wall, J. Lindley, 1980, Journal of medicinal chemistry.

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

A. McPhail, M. Wani, M. Wall, 1966 .

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Nam-Cheol Kim, M. Wani, M. Wall, 2003, Organic & biomolecular chemistry.

Specific Receptor Site and a Relation to Antitumor Activity Derivatives on Mammalian Topoisomerase I : Evidence for a Structure-Activity Study of the Actions of Camptothecin Updated

K. Kohn, Y. Pommier, C. Jaxel, 2006 .

Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.

D. V. Von Hoff, D. Bearss, G. Manikumar, 2004, Bioorganic & medicinal chemistry letters.

Hydrophilic Camptothecin Analogs That Form Extremely Stable Cleavable Complexes with DNA and Topoisomerase I

D. V. Von Hoff, D. Bearss, G. Manikumar, 2004, Cancer Research.

Chapter 13 History and Future Prospects of Camptothecin and Taxol

M. Wani, M. Wall, 1998 .

Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations.

A. Bodley, T. Shapiro, M. Wani, 1995, Biochemical pharmacology.

Synthesis of position-specific tritium-labeled 20(S)-camptothecin, 9-amino-20(S)-camptothecin, and 10,11-methylenedioxy-20(S)-camptothecin

M. Wani, M. Wall, A. W. Nicholas, 1993 .

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

L. Liu, Y. Hsiang, G. Manikumar, 1989, Cancer research.

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

K. Kohn, Y. Pommier, C. Jaxel, 1989, Cancer research.

PLANT ANTITUMOR AGENTS. 18. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CAMPTOTHECIN N ANALOGS

M. Wani, M. Wall, J. Lindley, 1980 .

Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator

Dongho Lee, N. Oberlies, J. Falkinham, 2003, Antimicrobial Agents and Chemotherapy.

Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).

A. McPhail, G. Manikumar, M. Wani, 1989, Journal of natural products.

Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids

N. Oberlies, Nam-Cheol Kim, M. Wani, 2004, Public Health Nutrition.

Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.

M. Wani, M. Wall, 1995, Cancer research.

Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception.

Y. Gu, P. Fail, M. Wani, 1995, Journal of Medicinal Chemistry.

Plant antitumour agents: colubrinol acetate and colubrinol, antileukaemic ansa macrolides from Colubrina texensis

M. Wani, M. Wall, H. Taylor, 1973 .

New bioactive aromatic compounds from Vismia guianensis.

A. Kinghorn, H. Navarro, N. Farnsworth, 2000, Phytochemistry.

Cytotoxic constituents from the roots of Tovomita brevistaminea.

A. Kinghorn, H. Navarro, N. Farnsworth, 1999, Phytochemistry.

New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii.

H. Navarro, N. Farnsworth, M. Wani, 1998, Journal of natural products.

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.

G. Tan, J. Pezzuto, A. Kinghorn, 2001, Journal of natural products.

Plant antitumor agents. IX. The total synthesis of dl-camptothecin.

M. Wani, M. Wall, S. Levine, 1972, Journal of the American Chemical Society.

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Nam-Cheol Kim, M. Wani, M. Wall, 2003, Organic & biomolecular chemistry.

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Dongho Lee, Nicholas H Oberlies, Joseph O Falkinham, 2004, Journal of natural products.

A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

A. Kinghorn, Dongho Lee, N. Oberlies, 2005, Organic letters.

Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.

L. Moore, J. Besterman, A. Truesdale, 1993, Journal of medicinal chemistry.

The Total Synthesis and Anti-Fertility Activity of 6-Silasteroids:

M. Wani, C. G. Pitt, C. Pitt, 1974 .

Palladium/hydrogen catalyzed alcoholysis of benzylsilanes

M. Wani, A. Friedman, C. G. Pitt, 1976 .

Reactions of Ethylenethiourea with a- and -Halo Acids and Derivatives

M. Wani, E. Campaigne, 1964 .

Plant antimutagens, 6. Intricatin and intricatinol, new antimutagenic homoisoflavonoids from Hoffmanosseggia intricata.

G. Manikumar, M. Wani, M. Wall, 1989, Journal of Natural Products.

Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.

H. Raja, C. Pearce, N. Oberlies, 2015, Tetrahedron.

Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.

H. Raja, T. El-Elimat, C. Pearce, 2015, European journal of organic chemistry.

Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues.

M. Wani, M. Wall, M E Wall, 1986, Journal of medicinal chemistry.

Antineoplastic agents from plants.

M. Wani, M. Wall, 1977, Annual review of pharmacology and toxicology.

Antimutagenic agents from natural products of terrestrial and marine origin.

M. Wani, M. Wall, 1993, Basic life sciences.

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species.

H. Raja, T. El-Elimat, C. Pearce, 2013, Tetrahedron letters.

Peptaibols, tetramic acid derivatives, isocoumarins, and sesquiterpenes from a Bionectria sp. (MSX 47401).

H. Raja, C. Pearce, N. Oberlies, 2013, Journal of natural products.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

C. Pearce, N. Oberlies, M. Figueroa, 2012, The Journal of Antibiotics.

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.

S. Matthew, C. Pearce, N. Oberlies, 2011, Journal of natural products.

Two new aromatic constitutents from the rootwood of Aeschynomene mimosifolia.

N. Farnsworth, M. Wani, M. Wall, 1996, Journal of natural products.

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemia and antitumor agent from

M. Wani, M. C. Wani, H. E. A. Taylor, 1971 .

Plant antitumor agents, 24. Rapid 9-KB assay.

M. Wani, M. Wall, H. Taylor, 1987, Journal of Natural Products.

Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons

T. El-Elimat, N. Oberlies, D. Kroll, 2006, Natural product research.

A New Colchicinoid from Colchicum tauri, an Unexplored Meadow Saffron Native to Jordan

N. Oberlies, A. Alkofahi, A. Qandil, 2006 .

Synthesis, crystal and molecular structure of a 1,11-etheno-steroid: 3-methyoxy-1,11-ethenoestra-1,3,5(10),9(11)-tetraen-17-one.

A. McPhail, M. Wani, C. Pitt, 1977, Journal of the Chemical Society. Perkin transactions 1.

Synthesis and crystal and molecular structure of a 1,11-methano-steroid, 3-methoxy-1′β-methyl-1,11α-methano-9β-estra-1,3,5(10)-trien-17β-ol

A. McPhail, M. Wani, Richard W. Miller, 1976 .

Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera.

D. M. Brown, J. Pezzuto, A. Kinghorn, 1995, Journal of natural products.

Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal.

D. M. Brown, G. Cordell, J. Pezzuto, 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla.

M. Wani, M. Wall, H. Taylor, 1987, Journal of natural products.

Plant antimutagenic agents, 1. General bioassay and isolation procedures.

M. Wani, M. Wall, H. Taylor, 1988, Journal of natural products.

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient

M. Dewhirst, M. Wahl, G. Manikumar, 2005, Cancer Chemotherapy and Pharmacology.

Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.

A. Kinghorn, C. Fairchild, N. Oberlies, 2002, Journal of natural products.

Plant antimutagenic agents, 2. Flavonoids.

G. Manikumar, M. Wani, M. Wall, 1988, Journal of natural products.

Plant antimutagenic agents, 3. Coumarins.

G. Manikumar, M. Wani, M. Wall, 1988, Journal of Natural Products.

Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

J. Heitman, M. Del Poeta, J. Perfect, 1999, Antimicrobial Agents and Chemotherapy.

Isolation and structural elucidation of pentacyclic triterpenoids from Maprounea africana.

S. K. Chaudhuri, D. M. Brown, S. K. Lee, 1995, Journal of natural products.

Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase.

J. Pezzuto, H. Fong, M. Wani, 1994, Journal of natural products.

Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Jeanine M. Davis, N. Oberlies, M. Andrews, 2007, Journal of agricultural and food chemistry.

Bioactive constituents of the stem bark of Mitrephora glabra.

A. Kinghorn, Dongho Lee, N. Oberlies, 2009, Journal of natural products.

Plant antimutagenic agents, 5. Isolation and structure of two new isoflavones, fremontin and fremontone from Psorothamnus fremontii.

G. Manikumar, M. Wani, M. Wall, 1989, Journal of natural products.

Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities

Brandie M. Ehrmann, C. Pearce, N. Oberlies, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Triggered Drug Delivery Systems

M. Wani, Z. Gu, C. G. Pitt, 1985 .

Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex

Y. Pommier, O. Colvin, G. Kohlhagen, 2005, Cancer Chemotherapy and Pharmacology.

Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage.

J. Holden, G. Manikumar, M. Wani, 1999, Archives of biochemistry and biophysics.

Discovery of Anticancer Agents of Diverse Natural Origin.

Xiaoli Zhang, Nicholas H Oberlies, Brent R Stockwell, 2016, Anticancer research.

Synthesis, antifertility activity, and protein binding affinity of 7(8 leads to 11 alpha)abeo steroids.

G. Kimmel, M. Wani, C. G. Pitt, 1977, Journal of medicinal chemistry.

Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.

A. Kinghorn, C. Fairchild, H. Navarro, 2002, Journal of natural products.

Novel bioactive phenanthrene derivatives from Domohinea perrieri

G. Cordell, J. Pezzuto, A. Kinghorn, 1997 .

BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors

W. Waud, G. Manikumar, M. Wani, 2011, Cancer Chemotherapy and Pharmacology.

New biphenyl compounds with DNA strand-scission activity from Clusia paralicola.

H. Navarro, N. Farnsworth, M. Wani, 1999, Journal of natural products.

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

M. Del Rio, C. Gongora, Fengzhi Li, 2015, Molecular Cancer.

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.

C. Yu, L. Liu, M. Wani, 1991, Cancer research.

Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization

P. Marathe, C. Fairchild, T. Monticello, 2006, Cancer Chemotherapy and Pharmacology.

The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH

M. Dewhirst, H. Friedman, R. Hoffman, 2003, Cancer Chemotherapy and Pharmacology.

Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11 beta-aryl steroids.

P. Fail, M. Wani, C. Cook, 1994, Human reproduction.

Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.

K. Kohn, Y. Pommier, G. Kohlhagen, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Esters and lactones of phenolic amino carboxylic acids: prodrugs for iron chelation.

M. Wani, C. G. Pitt, H. Rosenkrantz, 1986, Journal of medicinal chemistry.

Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.

K. Kohn, Y. Pommier, M. Valenti, 1997, Molecular pharmacology.

Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

A. Kinghorn, D. Jarjoura, D. Lantvit, 2012, Methods in molecular biology.

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

R. Agarwal, N. Oberlies, D. Kroll, 2005, Cancer research.

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

R. Agarwal, N. Oberlies, D. Kroll, 2010, Planta medica.

Large-scale Isolation of Flavonolignans from Silybum marianum ( Milk Thistle ) Extract Affords New Minor Constituents and Preliminary Structure-Activity Relationships

N. Oberlies, D. Kroll, Rajesh, 2010 .

Enhanced bioactivity of silybin B methylation products.

R. Agarwal, S. Polyak, N. Oberlies, 2013, Bioorganic & medicinal chemistry.

Paclitaxel: From Discovery to Clinic

M. Wani, M. Wall, 1994 .

PHOTOCHEMISTRY OF 2-ALKYLAMINOPHENOXAZ -3-ONES. II.

M. Wani, S. Levine, 1965 .

Letter: Antitumor agents. XIII. Isolation and absolute configuration of carminomycin I from Streptosporangium sp.

A. McPhail, M. Wani, M. Wall, 1975, Journal of the American Chemical Society.

Reversal of activity profile in analogs of the antiprogestin RU 486: effect of a 16 alpha-substituent on progestational (agonist) activity.

P. Fail, M. Wani, C. Cook, 1993, Life sciences.

Novel A-ring modified camptothecins as topoisomerase I inhibitors

D. Sternbach, J. Besterman, M. Peel, 1995 .

Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.

D. Cohen, O. Colvin, G. Manikumar, 1999, Leukemia research.

, against Fungal and Cancer Cells Camptothecin and Nitidine Derivatives Comparison of In Vitro Activities of

J. Heitman, M. Del Poeta, J. Perfect, 1999 .

Comparative molecular field analysis and molecular modeling studies of 20-(S)- camptothecin analogs as inhibitors of DNA topoisomerase I and anticancer/antitumor agents

Peter C. Fox, Sean W. Carrigan, S W Carrigan, 1997, J. Comput. Aided Mol. Des..

Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity.

M. Wani, M. Wall, M E Wall, 1986, Journal of medicinal chemistry.

Plant antitumor agents. IV. An approach toward the synthesis of camptothecin.

M. Wani, M. Wall, S. Levine, 1969, The Journal of organic chemistry.

Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity.

D. V. Von Hoff, D. Bearss, G. Manikumar, 2004, Current medicinal chemistry. Anti-cancer agents.

SYNTHESIS OF 11β,13β- AND 13β,16β-PROPANO STEROIDS: PROBES OF HORMONAL ACTIVITY

M. Wani, C. Cook, C. G. Pitt, 1980 .

Synthesis of 11 beta,13 beta- and 13 beta,16 beta-propano steroids: probes of hormonal activity.

M. Wani, C. Cook, C. G. Pitt, 1979, Journal of medicinal chemistry.

The preparation of tritium and deuterium-labelled camptothecin

M. Wani, M. Wall, P. Ronman, 1981 .

Novel A-Ring Modified Camptothecins as Topoisomerase I Inhibitors.

D. Sternbach, J. Besterman, M. Peel, 1996 .

Indoles in edible members of the Cruciferae.

M. Wani, M. Wall, H. Taylor, 1988, Journal of Natural Products.

A reinvestigation of Maprounea triterpenes.

M. Boyd, J. Beutler, M. Currens, 1995, Journal of natural products.

Identity of maprounic acid with aleuritolic acid. Revision of the structure of maprounic acid: X-ray crystal structure of p-bromobenzyl acetylmaprounate.

A. McPhail, M. Wani, M. Wall, 1989, Journal of natural products.

Triterpenes from the combined leaf and stem of Lithospermum caroliniense.

C. Beecher, M. Wani, M. Wall, 1996, Phytochemistry.

New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.

Nicholas H Oberlies, Feras Q Alali, Khaled Tawaha, 2005, Journal of natural products.

Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography.

R W Handy, N. Oberlies, M. Wani, 2001, Journal of natural products.

Isolation and chemical characterization of antitumor agents from plants.

M. Wani, M. Wall, H. Taylor, 1976, Cancer treatment reports.

16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.

D. Edwards, M. Imhof, G. Pollio, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Flavonoids. 8. Synthesis and antifertility and estrogen receptor binding activities of coumarins and delta3-isoflavenes.

G. Kimmel, M. Wani, C. Cook, 1975, Journal of medicinal chemistry.

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

M. Del Rio, C. Gongora, Fengzhi Li, 2015, Molecular Cancer.

Camptothecin. Discovery to clinic.

M. Wani, M. Wall, 1996, Annals of the New York Academy of Sciences.

Two isoflavones from the bark of Petalostemon purpureus.

S. K. Chaudhuri, C. Beecher, M. Wani, 1996, Phytochemistry.

Plant antitumour agents-XV: Isolation and x-ray crystal structure of a new antileukaemic quassinoid undulatone from Hannoa undulata

A. McPhail, M. Wani, M. Wall, 1979 .

Plant antitumor agents. 17. Structural requirements for antineoplastic activity in quassinoids.

M. Wani, M. Wall, 1978, Journal of medicinal chemistry.

Bioactive constituents of the roots of Licania intrapetiolaris.

N. Oberlies, H. Navarro, N. Farnsworth, 2001, Journal of natural products.

Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora.

M. Wani, M. Wall, H. Taylor, 1978, Lloydia.

Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.

J. Pezzuto, A. Kinghorn, N. Farnsworth, 2009, Journal of natural products.

Plant antimutagenic agents, 4. Isolation and structure elucidation of maesol, an inactive constituent of Maesa spp.

G. Manikumar, M. Wani, M. Wall, 1988, Journal of Natural Products.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

C. Pearce, N. Oberlies, M. Figueroa, 2012, The Journal of Antibiotics.

Sorbicillinoid Analogues with Cytotoxic and Selective Anti-Aspergillus Activities from Scytalidium album

M. Grever, H. Raja, T. El-Elimat, 2014, The Journal of Antibiotics.

Pharmacodynamics/pharmacokinetics of intragastric camptothecin analogs in a human-cancer xenograft model

B. Giovanella, M. Wani, M. Wall, 1995 .

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