Y. Kotake

发表

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.

Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor

D. Ito, K. Sawada, K. Miyazaki, 2011, International journal of molecular medicine.

Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2002, Molecular cancer therapeutics.

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

Y. Mizui, Y. Kotake, M. Hamaguchi, 2011, The FEBS journal.

E7107, a new 7-urethane derivative of pladienolide D: Discovery of a novel antitumor agent

Y. Mizui, Y. Kotake, J. Niijima, 2004 .

A novel carbazole topoisomerase II poison, ER‐37328: potent tumoricidal activity against human solid tumors in vitro and in vivo

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2003, Cancer science.

Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61

Zhihong Chen, W. Gerwick, Y. Kotake, 2016, Molecular Cancer Therapeutics.

Total synthesis of the potent antitumor macrolides pladienolide B and D.

Y. Mizui, Y. Kotake, J. Niijima, 2007, Angewandte Chemie.

Novel sulfonamides as potential, systemically active antitumor agents.

T. Nagasu, Y. Kotake, J. Niijima, 1992, Journal of medicinal chemistry.

A NOVEL CYCLAM APPENDE WITH 3-HYDROXYPYRIDINE. AN AMBIDENT DONOR LIGAND COMPRISING A PYRIDYL N AND A PYRIDINOLATE O- DONOR

T. Koike, E. Kimura, Y. Kotake, 1990 .

Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.

D. Ito, K. Miyazaki, K. Okamoto, 2014, Bioorganic & medicinal chemistry.

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

K. Agarwala, Z. Dezső, Qunli Xu, 2015, Cancer biology & therapy.

Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate.

Y. Kotake, K. Yoshimatsu, T. Okauchi, 1995, Chemical & pharmaceutical bulletin.

Novel 6‐5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2, 4‐Diamino‐6,7‐dihydro‐5H‐cyclopenta(d)pyrimidine Antifolate.

Y. Kotake, K. Yoshimatsu, T. Okauchi, 1995 .

Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.

N. Tamai, Y. Kotake, N. Koyanagi, 1994, Journal of medicinal chemistry.

Chemical Approaches to a Novel Antitumor Natural Product Pladienolide

Y. Kotake, 2009 .

Stereochemistry of Pladienolide B

Taisuke Uehara, Y. Kotake, J. Niijima, 2007, The Journal of Antibiotics.

Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.

Y. Kotake, J. McGuire, C. Russell, 1994, Cancer research.

Splicing factor SF3b as a target of the antitumor natural product pladienolide

T. Owa, Y. Ishihama, Y. Mimori-Kiyosue, 2007, Nature Chemical Biology.

Identification of a novel ALDH1A3‐selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity‐based drug target discovery

Y. Kotake, H. Kamiyama, Yosuke Kaburagi, 2022, Chemical biology & drug design.

Selective degradation of splicing factor CAPERα by anticancer sulfonamides.

T. Owa, Taku Yoshida, Taisuke Uehara, 2017, Nature chemical biology.

2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.

T. Inoue, Y. Kotake, J. Niijima, 2001, Journal of medicinal chemistry.

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.