K. Kitoh

发表

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.

A general method for acylation of indoles at the 3-position with acyl chlorides in the presence of dialkylaluminum chloride.

T. Owa, K. Kitoh, H. Yoshino, 2000, Organic letters.

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.

T. Owa, T. Nagasu, N. Koyanagi, 2000, Bioorganic & medicinal chemistry letters.

Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2002, Molecular cancer therapeutics.

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.

T. Nagasu, T. Taguchi, Y. Funahashi, 1994, Cancer research.

A novel carbazole topoisomerase II poison, ER‐37328: potent tumoricidal activity against human solid tumors in vitro and in vivo

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2003, Cancer science.

E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system

T. Nagasu, K. Kitoh, N. Watanabe, 1987, Antimicrobial Agents and Chemotherapy.

In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin

S. Mitsuhashi, K. Kitoh, M. Inoue, 1982, Antimicrobial Agents and Chemotherapy.

Prophylactic activity of dihydro-heptaprenol, a synthetic polyprenol derivative, against Sendai virus infection in mice

J. Iida, I. Azuma, K. Tsukidate, 1990 .

Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.

T. Owa, T. Nagasu, N. Koyanagi, 1999, Journal of medicinal chemistry.

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.

T. Owa, T. Nagasu, N. Koyanagi, 2002, Bioorganic & medicinal chemistry letters.

E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.

T. Owa, T. Nagasu, T. Watanabe, 2001, European journal of cancer.

Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin.

A. Yamaguchi, N. Koyanagi, K. Kitoh, 1997, Cancer research.

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.

Y. Funahashi, K. Kitoh, N. Tsukahara, 1997, The Journal of antibiotics.

In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity

K. Kitoh, N. Watanabe, K. Katsu, 1988, Antimicrobial Agents and Chemotherapy.

Enhancement of resistance to Escherichia coli infection in mice by dihydroheptaprenol, a synthetic polyprenol derivative

K. Kitoh, Y. Fukazawa, M. Kimura, 1987, Infection and immunity.

Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.

N. Tamai, Y. Kotake, N. Koyanagi, 1994, Journal of medicinal chemistry.

Rapid development of hepatic metastasis with high incidence following orthotopic transplantation of murine colon 38 carcinoma as intact tissue in syngeneic C57BL/6 mice

Y. Funahashi, N. Koyanagi, K. Kitoh, 1999, Journal of surgical oncology.

Novel sulfonamides as potential, systemically active antitumor agents.

T. Nagasu, Y. Kotake, J. Niijima, 1992, Journal of medicinal chemistry.

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.

E7010 a novel sulfonamide antitumor agent iii mechanism of action and cell kill kinetics

K. Kitoh, K. Yoshimatsu, M. Asada, 1992 .

Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor.

Y. Funahashi, K. Kitoh, K. Yoshimatsu, 1999, Oncology research.