H. Yoshino

发表

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.

A general method for acylation of indoles at the 3-position with acyl chlorides in the presence of dialkylaluminum chloride.

T. Owa, K. Kitoh, H. Yoshino, 2000, Organic letters.

A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties.

K. Soda, H. Yoshino, H. Misono, 1980, The Journal of biological chemistry.

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.

T. Owa, T. Nagasu, N. Koyanagi, 2000, Bioorganic & medicinal chemistry letters.

Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions.

H. Yoshino, H. Shiba, H. Kawaguchi, 1997, Journal of endodontics.

Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2002, Molecular cancer therapeutics.

Isolation and properties of lysine-producing mutants with feedback-resistant aspartokinase derived from a Brevibacterium flavum strain with citrate synthase- and pyruvate kinase-defects and feedback-resistant phosphoenolpyruvate carboxylase

S. Sugimoto, I. Shiio, H. Yoshino, 1990 .

Mechanism and kinetics of secretion degradation in aqueous solutions.

H. Yoshino, Y. Miyake, T. Tsuda, 1990, Journal of pharmaceutical sciences.

Purification and Properties of a New Enzyme, Glutathione Oxidase from Penicillium sp. K-6-5

H. Yoshino, H. Kusakabe, A. Kuninaka, 1982 .

Expression of endothelins and their receptors in cells from human periodontal tissues.

D. Fujioka, H. Yoshino, H. Shiba, 2003, Journal of periodontal research.

Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo.

T. Fujita, H. Yoshino, H. Shiba, 2002, Cytokine.

Brain-derived neurotrophic factor enhances periodontal tissue regeneration.

H. Yoshino, H. Shiba, H. Kurihara, 2005, Tissue engineering.

Neurotrophins in cultured cells from periodontal tissues.

H. Yoshino, H. Shiba, H. Kurihara, 2003, Journal of periodontology.

Immobilization of Nuclease P_1 on Inorganic Supports by Titanium Complex Method : Studies on Immobilized Enzyme (III)

H. Yoshino, K. Rokugawa, A. Kuninaka, 1980 .

Creutzfeldt–Jakob disease associated with cadaveric dura mater grafts in Japan

T. Sato, H. Yanagawa, H. Yoshino, 2000, Neurology.

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.

T. Nagasu, T. Taguchi, Y. Funahashi, 1994, Cancer research.

Mode of Action of Nuclease P1 on Nucleic Acids and Its Specificity for Synthetic Phosphodiesters

H. Yoshino, A. Kuninaka, M. Fujimoto, 1974 .

Substrate Specificity of Nuclease P1

H. Yoshino, A. Kuninaka, M. Fujimoto, 1974 .

Isolation and Properties of Threonine-producing Mutants with both Dihydrodipicolinate Synthase Defect and Feedback-resistant Homoserine Dehydrogenase from Brevibacterium flavum

S. Sugimoto, I. Shiio, H. Yoshino, 1990 .

Analgesia produced by E-2078, a systemically active dynorphin analog, in mice.

H. Yoshino, T. Nakazawa, S. Tachibana, 1990, The Journal of pharmacology and experimental therapeutics.

Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.

H. Yoshino, T. Nakazawa, Y. Tsuchiya, 1990, Journal of medicinal chemistry.

Collagen formation at the tooth-cell interface: comparative ultrastructural study on the effect of partial demineralization of cementum with dentin.

G. Satoh, H. Yoshino, H. Okamoto, 1995, Journal of periodontology.

A novel carbazole topoisomerase II poison, ER‐37328: potent tumoricidal activity against human solid tumors in vitro and in vivo

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2003, Cancer science.

A sensitive radioimmunoassay for adenosine in biological samples.

M. Ui, H. Yoshino, A. Kuninaka, 1982, Analytical biochemistry.

Purification and Properties of a New Enzyme, L-Glutamate Oxidase, from Streptomyces sp. X-119-6 Grown on Wheat Bran

H. Yoshino, Hitoshi Kusakabe, Yuichiro Midorikawa, 1983 .

Distribution of Extracellular Oxygen Related Enzymes in Molds

H. Yoshino, H. Kusakabe, A. Kuninaka, 1983 .

Occurrence of a new enzyme, L-glutamate oxidase in a wheat bran culture extract of Streptomyces sp. X-119-6.

H. Yoshino, H. Kusakabe, A. Kuninaka, 1983 .

Effect of L-Lysine α-Oxidase on Growth of Mouse Leukemic Cells

K. Soda, H. Yoshino, H. Kusakabe, 1980 .

Extracellular Production of l-Lysine α-Oxidase in Wheat Bran Culture of a Strain of Trichoderma viride

K. Soda, H. Yoshino, H. Kusakabe, 1979 .

New Attachment to Periodontally Diseased Root Surfaces Treated with Hydrochloric Acid

H. Yoshino, H. Kurihara, H. Kawaguchi, 1996 .

Novel sulfonamides as potential, systemically active antitumor agents.

T. Nagasu, Y. Kotake, J. Niijima, 1992, Journal of medicinal chemistry.

Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.

T. Owa, T. Nagasu, N. Koyanagi, 1999, Journal of medicinal chemistry.

Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils

H. Yoshino, A. Kuninaka, H. Machida, 1981, Antimicrobial Agents and Chemotherapy.

In Vitro Antiherpesviral Activity of 5-Alkyl Derivatives of 1-β-d-Arabinofuranosyluracil

M. Saneyoshi, H. Yoshino, A. Kuninaka, 1979, Antimicrobial Agents and Chemotherapy.

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.

T. Owa, T. Nagasu, N. Koyanagi, 2002, Bioorganic & medicinal chemistry letters.

Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis.

T. Owa, T. Nagasu, K. Yoshimatsu, 2002, Molecular cancer therapeutics.

E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.

T. Owa, T. Nagasu, T. Watanabe, 2001, European journal of cancer.

Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin.

A. Yamaguchi, N. Koyanagi, K. Kitoh, 1997, Cancer research.

Antitumor Activity and Pharmacology of 1‐β‐D‐Arabinofuranosylcytosine‐5′‐stearylphosphate: An Orally Active Derivative of 1‐β‐D‐Arabinofuranosylcytosine

K. Saitoh, M. Saneyoshi, H. Yoshino, 1989, Japanese journal of cancer research : Gann.

Molecular Rotational Potentials in Solid Halogenated Benzenes: C6Cl6, sym-C6Cl3F3, and C6F6

N. Nakamura, H. Yoshino, 1990 .

Synthetic nucleosides and nucleotides. XVI. Synthesis and biological evaluations of a series of 1-beta-D-arabinofuranosylcytosine 5'-alkyl or arylphosphates.

M. Saneyoshi, H. Yoshino, K. Kodama, 1980, Chemical & pharmaceutical bulletin.

Structure of Malonogalactan, an Acidic Polysaccharide of Penicillium citrinzum

H. Yoshino, A. Kuninaka, M. Fujimoto, 1974 .

Promoting Effect of Pentamethylbenzene on the Deprotection of O-Benzyltyrosine and Nε-Benzyloxycarbonyllysine with Trifluoroacetic Acid

M. Tsujii, I. Saito, H. Yoshino, 1987 .

Incidence rate of Creutzfeldt-Jakob disease in Japan.

T. Sato, H. Yanagawa, H. Yoshino, 1998, International journal of epidemiology.

Clinical and Light Microscopic Findings on Process of Experimental Periodontitis in Beagle Dogs

H. Yoshino, H. Kawaguchi, T. Ogawa, 1994 .

Relationship between the molecular size of poly I-poly C and its biological activity.

H. Yoshino, A. Kuninaka, H. Machida, 1976, Japanese Journal of Microbiology.

Interferon production and resistance to viral infection induced by poly I-poly C in chick embryo cells. II. Lack of enhancement by DEAE-dextran.

H. Yoshino, A. Kuninaka, H. Machida, 1974, Japanese journal of microbiology.

Interferon Production and Resistance to Viral Infection Induced by Poly I· Poly C in Chick Embryo Cells. II. Lack of Enhancement by DEAE-Dextran

H. Yoshino, A. Kuninaka, H. Machida, 1975 .

Susceptibility of Influenza Viruses to Interferon and to Poly (I) · Poly (C) Determined by the Plaque Reduction Method

H. Yoshino, A. Kuninaka, H. Machida, 1980, Microbiology and immunology.

Effect of Nucleosides on Interferon Production and Development of Antiviral State Induced by Poly I·Poly C

H. Yoshino, A. Kuninaka, H. Machida, 1979, Microbiology and immunology.

Synthesis of Polynucleotides by Microorganisms

H. Yoshino, A. Kuninaka, Yoshiki Katoh, 1973 .

Interferon Production in Human Diploid Cell Strains Derived from Embryonic Lungs

H. Yoshino, A. Kuninaka, H. Machida, 1980, Microbiology and immunology.

Relationship of Tm and S Value of Double-stranded Polynucleotides Prepared from Various Sizes of Single-stranded Homopolynucleotides

H. Yoshino, A. Kuninaka, Yoshiki Katoh, 1975 .

Polynucleotide Phosphorylase from Acromobacter sp. KR 170-4

H. Yoshino, K. Rokugawa, A. Kuninaka, 1975 .

Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus

H. Yoshino, A. Kuninaka, H. Machida, 1982, Antimicrobial Agents and Chemotherapy.

Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil

H. Yoshino, A. Kuninaka, H. Machida, 1980, Antimicrobial Agents and Chemotherapy.

Synthesis and antiherpesviral activity of 5-C-substituted uracil nucleosides.

H. Yoshino, S. Shibuya, H. Machida, 1980, Nucleic acids symposium series.

Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice

M. Saneyoshi, H. Yoshino, A. Kuninaka, 1980, Antimicrobial Agents and Chemotherapy.

Direct Synthesis of 2, 5'-Anhydro Pyrimidine Nucleosides

H. Yoshino, A. Kuninaka, S. Shibuya, 1974 .

Conversion of Hypoxanthine Derivatives to Succinyl Adenine Derivatives by Bacillus subtilis

H. Yoshino, A. Kuninaka, Y. Midorikawa, 1972 .

Effects of Salt Concentration and pH on the Absorption Spectra of Polynucleotides with Various S-Values

H. Yoshino, A. Kuninaka, Yoshiki Katoh, 1975 .

SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. XVI. SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF 1-β-D-ARABINOFURANOSYLCYTOSINE 5′-ALKYL OR ARYLPHOSPHATES

M. Saneyoshi, H. Yoshino, K. Kodama, 1981 .

Purification of a Nuclease from Penicillium citrinum

H. Yoshino, A. Kuninaka, M. Fujimoto, 1974 .

Comparison of the in vitro and in vivo anti-herpes activities of 1-beta-D-arabinofuranosylthymine and its 5'-monophosphate.

H. Yoshino, A. Kuninaka, H. Machida, 1982, Antiviral research.

Structure of Malonogalactan: Carbon-13 Nuclear Magnetic Resonance Spectra of Malonogalactan

H. Yoshino, H. Sugiyama, A. Kuninaka, 1974 .

DIRECT SYNTHESIS OF 2,5′‐ANHYDRO PYRIMIDINE NUCLEOSIDES

H. Yoshino, A. Kuninaka, S. Shibuya, 1974 .

A practically sensitive radioimmunoassay for cyclic CMP by 2'-O-acetylation.

H. Yoshino, A. Kuninaka, T. Sato, 1982, Analytical biochemistry.

Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons

K. Fukunaga, H. Yoshino, An Cheng, 2022, Redox biology.

Isolation of 2'-deoxycoformycin and cordycepin from wheat bran culture of Aspergillus nidulans Y 176-2.

H. Yoshino, H. Kusakabe, K. Kodama, 1979 .

12-Lipoxygenase product as an inhibitor of the action of chemoattractant peptide fMet-Leu-Phe in rat neutrophils.

H. Okamoto, K. Morita, T. Dohi, 1993, General pharmacology.

2-Keto-L-gulonic Acid Fermentation:Part I. Paper Chromatographic Characterization of Metabolic Products from Sorbitol and L-Sorbose by Various Bacteria

H. Yoshino, T. Kanzaki, M. Isono, 1968 .

Interferon Induction and Therapy of Brain Tumors in Rats by Poly(ICLC)

K. Takakura, H. Yoshino, A. Kuninaka, 1982, Microbiology and immunology.

Identification of secretin diastereoisomers produced during synthesis.

H. Yoshino, Y. Miyake, T. Tsuda, 1989, Journal of pharmaceutical sciences.

Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents.

T. Owa, T. Nagasu, K. Yoshimatsu, 2001, Current medicinal chemistry.

Cellular localization and properties of glutaminase in Aspergillus oryzae.

H. Yoshino, Takeshi Furuya, K. Uchida, 1985 .

Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils.

K. Morita, T. Dohi, H. Yoshino, 2000, Prostaglandins & other lipid mediators.

Photoluminescence in Copolymers of Poly(p-phenylene vinylene) and Poly(2,5-dimethoxy-p-phenylene vinylene)

S. Morita, H. Yoshino, M. Onoda, 1993 .

Studies on 5′-Phosphodiesterases in Microorganisms: Part II. Properties and Application of Penicillium citrinum 5′-Phosphodiesterase

H. Yoshino, A. Kuninaka, K. Sakaguchi, 1961 .

Plasma cyclic nucleotides in spontaneously hypertensive rats: hyperresponse to acute hot stress.

M. Ui, H. Yoshino, A. Kuninaka, 1984, Japanese journal of pharmacology.

Stimulation by carrageenan of arachidonate 12-lipoxygenase activity in dog gingival tissue.

H. Okamoto, T. Dohi, H. Yoshino, 1991, Archives of oral biology.

Inhibition of Growth of L5178Y Leukemia Cells by a Fungal Folate-deaminating Enzyme

H. Yoshino, H. Kusakabe, K. Kodama, 1974 .

Fermentative Production of Hypoxanthine Derivatives

H. Yoshino, A. Kuninaka, K. Uchida, 1961 .

Interferon production and resistance to viral infection induced by poly I-poly C in chick embryo cells. I. Effect of growth medium.

H. Yoshino, A. Kuninaka, H. Machida, 1974, Japanese journal of microbiology.

The Role of Zinc Atoms in Nuclease P1

H. Yoshino, K. Rokugawa, A. Kuninaka, 1980 .

Secondary Structure of Nuclease P1

H. Yoshino, A. Kuninaka, M. Fujimoto, 1975 .

Some Physical and Chemical Properties of Nuclease P1

H. Yoshino, A. Kuninaka, M. Fujimoto, 1975 .

Identity of Phosphodiesterase and Phosphomonoesterase Activities with Nuclease P1 (a Nuclease from Penicillium citrinum)

H. Yoshino, A. Kuninaka, M. Fujimoto, 1974 .

Synthesis and biological activity of [MeTyr1,MeArg7,D-Leu8]-dynorphin A(1-9)-NHEt and [D-Cys2-Cys5,MeArg7,D-Leu8]-dynorphin A(1-9)-NH2.

H. Yoshino, T. Nakazawa, Y. Tsuchiya, 1990, Chemical & pharmaceutical bulletin.

Antitumor Activity of Cell Walls of Microorganisms

H. Yoshino, K. Kodama, S. Sasaki, 1985 .

Effect of 12-hydroxyeicosatetraenoic acid on cytosolic calcium in human neutrophils.

H. Okamoto, K. Morita, T. Dohi, 1994, Journal of lipid mediators and cell signalling.

Urinary excretion of cyclic nucleotides and principal electrolytes in healthy humans of different ages.

H. Yoshino, A. Kuninaka, T. Sato, 1981, Clinica chimica acta; international journal of clinical chemistry.

Sensitive radioimmunoassay for cytarabine and uracil arabinoside in plasma.

H. Yoshino, K. Kodama, A. Kuninaka, 1984, Cancer treatment reports.

2-Keto-L-gulonic Acid Fermentation

H. Yoshino, T. Kanzaki, M. Isono, 1968 .

Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.

T. Nagasu, Jun-ichi Kamata, Toshimi Okada, 2004, Chemical & pharmaceutical bulletin.

Cases of Sprague-Dawley Rats Which Did Not Respond to an ‘Alarm Substance’ in the Forced Swimming Test

H. Yoshino, T. Tachibana, Akie Yoko, 1996, Psychological reports.