C. Fridrich

Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.

K. Rex, K. Shah, Douglas Hoffman, 2008, Journal of medicinal chemistry.

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Sarah L. Williams, W. Sellers, F. Lombardo, 2016, Journal of medicinal chemistry.

Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor

C. Fridrich, J. Bian, F. Gao, 2020 .

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Sarah L. Williams, W. Sellers, Z. Deng, 2020, Journal of medicinal chemistry.

Structure-based design and pre-clinical characterization of selective and orally bioavailable Factor XIa inhibitors: Demonstrating the power of an integrated S1 protease family approach.

V. Hornak, E. Altmann, A. D'arcy, 2020, Journal of medicinal chemistry.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

D. Curtis, M. Hild, Yiping Shen, 2018, Journal of medicinal chemistry.

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ping Zhu, Gang Liu, Peter Fekkes, 2016, Nature.

Palladium Catalyzed C−O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers

Malte S. Mikus, C. Fridrich, J. Larrow, 2020 .