Julia Lohman

发表

Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.

K. Rex, K. Shah, Douglas Hoffman, 2008, Journal of medicinal chemistry.

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.

K. Rex, K. Shah, S. Bellon, 2009, Bioorganic & medicinal chemistry letters.

Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.

A. Malikzay, M. C. Tuma, A. Kiselyov, 2006, Bioorganic & medicinal chemistry letters.

Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.

M. Mcgrath, Rohan V Mendonca, J. Janc, 2006, Bioorganic & medicinal chemistry letters.

Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors

D. Whittington, Yi Chen, K. Miner, 2012 .

Discovery and structure-activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers.

L. Qiu, A. Estevez, P. Sabbatini, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

J. Palmer, R. Rydzewski, Rohan V Mendonca, 2006, Bioorganic & medicinal chemistry letters.

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors.

D. Whittington, Yi Chen, K. Miner, 2012, Journal of medicinal chemistry.

Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.

K. Rex, A. Coxon, D. Whittington, 2016, Journal of medicinal chemistry.

Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.

K. Rex, D. Whittington, S. Bellon, 2015, Journal of medicinal chemistry.

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.

K. Rex, K. Shah, S. Bellon, 2009, Bioorganic & medicinal chemistry letters.