P. Hopcroft

发表

Flexible fitting of PROTAC concentration-response curves with changepoint Gaussian Processes

Avid M. Afzal, S. Lazic, M. Guerriero, 2020, bioRxiv.

AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors

M. Garnett, S. Barry, B. Davies, 2022, Oncogene.

Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.

S. Emery, C. Forder, D. Buttar, 2008, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.

J. Debreczeni, A. Turnbull, S. Degorce, 2015, Journal of medicinal chemistry.

Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC).

J. Breed, M. Anderton, Lyman J. L. Feron, 2019, Journal of medicinal chemistry.

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.

J. Debreczeni, Lyman J. L. Feron, Michael Tonge, 2017, Journal of medicinal chemistry.

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.

Karen Roberts, Michael James, Philip Hopcroft, 2015, Journal of medicinal chemistry.

AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

M. Garnett, O. Delpuech, Paul D. Smith, 2020, Molecular Cancer Therapeutics.

Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.

E. Hennessy, Nichola L. Davies, A. Doherty, 2021, Journal of medicinal chemistry.

Batch mode active learning for mitotic phenotypes using conformal prediction

Claus Bendtsen, Adam M Corrigan, Philip Hopcroft, 2020, COPA.

Development of a Medium-Throughput Targeted LCMS Assay to Detect Endogenous Cellular Levels of Malonyl-CoA to Screen Fatty Acid Synthase Inhibitors

David I. Fisher, P. Hopcroft, 2016, Journal of biomolecular screening.