Haifeng Tang

发表

Selective small-molecule inhibition of an RNA structural element

John J. Cummings, T. Roemer, T. Fischmann, 2015, Nature.

Understanding the inhibitory mechanism of tea polyphenols against tyrosinase using fluorescence spectroscopy, cyclic voltammetry, oximetry, and molecular simulations

Yunqi Li, Haijuan Li, Qingrong Huang, 2018, RSC advances.

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter’s Syndrome Type II Phenotype

J. Metzger, G. Kaczorowski, B. Priest, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Total synthesis of ingenol.

T. Maruyama, Haifeng Tang, J. L. Wood, 2004, Journal of the American Chemical Society.

Ligands for palladium-catalyzed cross-couplings of alkyl halides: use of an alkyldiaminophosphane expands the scope of the Stille reaction.

G. C. Fu, Haifeng Tang, Karsten Menzel, 2003, Angewandte Chemie.

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

S. Xu, B. Priest, P. Morissette, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.

K. Samuel, Haifeng Tang, B. Pio, 2021, Journal of medicinal chemistry.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.

Margaret S. Wu, Michael E. Lassman, J. Berger, 2010, Bioorganic & medicinal chemistry letters.

The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.

J. Metzger, K. Maloney, E. Joshi, 2017, Bioorganic & medicinal chemistry letters.

Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis

A. Swensen, K. Hoagland, G. Kaczorowski, 2014, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Small-Angle X-ray Scattering Study of Protein Complexes with Tea Polyphenols.

Yunqi Li, Jie Xiao, Qingrong Huang, 2017, Journal of agricultural and food chemistry.

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

D. Wyss, A. Therien, T. Fischmann, 2022, Journal of Medicinal Chemistry.

Construction of explicit models to correlate the structure and the inhibitory activity of aldose reductase: Flavonoids and sulfonyl‐pyridazinones as inhibitors

Lunyang Liu, Fengchao Cui, Kecheng Yang, 2017, Chemical biology & drug design.

Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.

A. Swensen, G. Kaczorowski, B. Priest, 2013, Bioorganic & medicinal chemistry letters.

The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.

L. Kiss, G. Kaczorowski, B. Priest, 2012, Assay and drug development technologies.

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

T. Roemer, T. Fischmann, J. Howe, 2016, RNA biology.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis

A. Swensen, K. Hoagland, G. Kaczorowski, 2014, The Journal of Pharmacology and Experimental Therapeutics.