R. Brito

发表

The low-affinity Ca2(+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction.

P. Rosevear, J. Putkey, H. Sweeney, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Calcium plays distinctive structural roles in the N- and C-terminal domains of cardiac troponin C.

P. Rosevear, J. Putkey, R. Brito, 1993, The Journal of biological chemistry.

A Relational Learning Approach to Structure-Activity Relationships in Drug Design Toxicity Studies

Carlos J. V. Simões, V. S. Costa, Rui Camacho, 2011 .

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants*

Rui M. M. Brito, Alexandre Quintas, Daniela C. Vaz, 2001, The Journal of Biological Chemistry.

Towards Data Warehousing and Mining of Protein Unfolding Simulation Data

Werner Dubitzky, Daniel Berrar, Frederic T. Stahl, 2005, Journal of Clinical Monitoring and Computing.

Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase

Bruno L. Victor, A. Velázquez‐Campoy, J. Sancho, 2022, International journal of molecular sciences.

The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection

I. Moreira, Rita Melo, A. J. Preto, 2020, International journal of molecular sciences.

Structure and Aggregation Mechanisms in Amyloids

R. Brito, Zaida L. Almeida, Zaida L Almeida, 2020, Prime Archives in Molecular Sciences.

Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system.

L. Domingues, P. Madureira, C. Gonçalves, 2010, International journal of pharmaceutics.

Corema album spp: Edible wild crowberries with a high content in minerals and organic acids.

P. Cruz, Daniela C. Vaz, M. J. Moreno, 2020, Food chemistry.

Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

B. Correia, Daniela C. Vaz, R. Brito, 2020, Molecules.

Amyloid Disassembly: What Can We Learn from Chaperones?

R. Brito, Zaida L. Almeida, Zaida L Almeida, 2022, Biomedicines.

Effect of ethyleneoxide groups of anionic surfactants on lipase activity

M. J. Moreno, M. Sebastião, B. Medronho, 2016, Biotechnology progress.

Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo(1,2-c)thiazoles and 2-vinyl-1H-pyrroles

P. Cruz, R. Brito, M. Soares, 2008 .

Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin.

V. Shnyrov, G. Zhadan, J. M. Sanchez-Ruiz, 2000, Biophysical chemistry.

Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA.

P. Cruz, R. Brito, C. Serpa, 2016, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Edible flowers of Helichrysum italicum: Composition, nutritive value, and bioactivities.

P. Cruz, Daniela C. Vaz, M. J. Moreno, 2022, Food research international.

Development of sugar based biodegradable nanoencapsulators: Understanding the role of the alcohol injection method on the preparation of aqueous dispersions of sorbitan ester vesicles

P. Cruz, E. Feitosa, R. Brito, 2019, Journal of Molecular Liquids.

A Serpin Released by an Entomopathogen Impairs Clot Formation in Insect Defense System

R. Montiel, Youjin Hao, N. Simões, 2013, PloS one.

The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

S. Macedo-Ribeiro, C. Montecucco, A. do Vale, 2013, PLoS pathogens.

Conformation study of HA(306-318) antigenic peptide of the haemagglutinin influenza virus protein.

C. Geraldes, A. Alix, J. Lancelin, 2006, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

In situ ultra-fast heat deposition does not perturb the structure of serum albumin

R. Brito, C. Serpa, Catarina S. H. Jesus, 2016, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4

C. Dobson, Daniela C. Vaz, W. Sebald, 2006, Protein science : a publication of the Protein Society.

Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding.

P. Rosevear, J. Putkey, R. Brito, 1992, Biochemistry.

Assignment and calcium dependence of methionyl epsilon C and epsilon H resonances in cardiac troponin C.

P. Rosevear, J. Putkey, R. Brito, 1994, Biochemistry.

Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II.

M. James, P. Rosevear, J. Putkey, 1991, Biochemistry.

Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus

R. Parkhouse, R. Brito, E. Henriques, 2010, Protein science : a publication of the Protein Society.

The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders

Carlos J. V. Simões, João P. Luís, R. Brito, 2022, International journal of molecular sciences.

An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpretation and Prediction: The Use of Molecular Interaction Fields to Detect HIV-1 Protease Binding-Site Dissimilarities

Rui M. M. Brito, Carlos J. V. Simões, Nuno G. Alves, 2020, Frontiers in Chemistry.

FH8 – a small EF‐hand protein from Fasciola hepatica

A. Almeida, F. Pinto, R. Brito, 2010, The FEBS journal.

The V30M Amyloidogenic Mutation Decreases the Rate of Refolding Kinetics of the Tetrameric Protein Transthyretin

Daniela C. Vaz, M. Saraiva, R. Brito, 2012 .

A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition.

Carlos J. V. Simões, M. Saraiva, R. Brito, 2016, European journal of medicinal chemistry.

Cell Spotting: educational and motivational outcomes of cell biology citizen science project in the classroom

Francisco Brasileiro, Nazareno Andrade, Cândida G. Silva, 2016 .

Comparative Study of Classification Algorithms Using Molecular Descriptors in Toxicological DataBases

Nuno A. Fonseca, Rui Camacho, Vítor Santos Costa, 2009, BSB.

Conformation of NADP+ bound to a type II dihydrofolate reductase.

P. Rosevear, F. Rudolph, R. Brito, 1991, Biochemistry.

A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation

Daniela C. Vaz, R. Brito, Catarina S. H. Jesus, 2016, International journal of molecular sciences.

A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model.

P. Cruz, R. Brito, Catarina S. H. Jesus, 2015, Physical chemistry chemical physics : PCCP.

Functional and conformational changes in the aspartic protease cardosin A induced by TFE.

P. Cruz, A. Cooper, A. Esteves, 2012, International journal of biological macromolecules.

VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells.

M. Grãos, M. H. Gil, L. Ferreira, 2012, Biomacromolecules.

The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

R. Brito, A. Quintas, M. Saraiva, 1997, FEBS letters.

One Peptide Reveals the Two Faces of α-Helix Unfolding-Folding Dynamics.

P. Cruz, L. Arnaut, R. Brito, 2018, The journal of physical chemistry. B.

The Saposin-like Domain of the Plant Aspartic Proteinase Precursor Is a Potent Inducer of Vesicle Leakage*

M. C. D. de Lima, C. Egas, C. Faro, 2000, The Journal of Biological Chemistry.

Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I.

P. Rosevear, V. Gaponenko, R. Solaro, 1999, Biochemistry.

On Mining Protein Unfolding Simulation Data with Inductive Logic Programming

Rui Camacho, Cândida G. Silva, Rui M. M. Brito, 2008, IWPACBB.

Protein folding and unfolding simulations: a new challenge for data mining.

Werner Dubitzky, Rui M M Brito, J Rui Rodrigues, 2004, Omics : a journal of integrative biology.

In Search of Predictive Models for Inhibitors of 5-alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data

Joana Sousa, Cândida G. Silva, Rui M. M. Brito, 2014, IWBBIO.

Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption

P. Cruz, P. Veríssimo, R. Brito, 2021, International journal of molecular sciences.

The low-affinity Ca2(+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction.

P. Rosevear, J. Putkey, H. Sweeney, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel

R. Carvalho, J. Morais-Cabral, R. Brito, 2012, PloS one.

Biophysical characterization of laforin-carbohydrate interaction.

P. Baaske, C. Geraldes, A. Ciulli, 2016, The Biochemical journal.

The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

M. Saraiva, R. Brito, A. Quintas, 1999, The Journal of Biological Chemistry.

Conformational Dynamics of the Soluble and Membrane-Bound Forms of Interleukin-1 Receptor Type-1: Insights into Linker Flexibility and Domain Orientation

Carlos J. V. Simões, João P. Luís, R. Brito, 2022, International journal of molecular sciences.

Poly(9‐undecyl‐9‐methyl‐fluorene) and poly(9‐pentadecyl‐9‐methyl‐fluorene): Synthesis, solution structure, and effect of side chain asymmetry on aggregation behavior

P. Cruz, U. Scherf, M. Forster, 2019, Journal of Polymer Science Part B: Polymer Physics.

DIBMA nanodiscs keep α-synuclein folded.

D. Otzen, P. Cruz, Daniela C. Vaz, 2020, Biochimica et biophysica acta. Biomembranes.

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

D. Laurents, E. Buratti, F. Baralle, 2014, Archives of biochemistry and biophysics.

Predicting hydrophobic solvation by molecular simulation: 1. Testing united‐atom alkane models

Cândida G. Silva, Rui M. M. Brito, Carlos J. V. Simões, 2017, J. Comput. Chem..

Amyloid Formation by Transthyretin: From Protein Stability to Protein Aggregation

Rui M. M. Brito, M. Saraiva, R. Brito, 2003 .

Toward the Discovery of Functional Transthyretin Amyloid Inhibitors: Application of Virtual Screening Methods

Rui M. M. Brito, Carlos J. V. Simões, Richard M. Jackson, 2010, J. Chem. Inf. Model..

Spatial Clustering of Molecular Dynamics Trajectories in Protein Unfolding Simulations

Paulo J. Azevedo, Cândida G. Silva, Rui M. M. Brito, 2009, CIBB.

Detection of Hydrophobic Clusters in Molecular Dynamics Protein Unfolding Simulations Using Association Rules

Paulo J. Azevedo, J. Rodrigues, Cândida G. Silva, 2005, ISBMDA.

Using Data Mining Techniques to Probe the Role of Hydrophobic Residues in Protein Folding and Unfolding Simulations

Cândida G. Silva, P. Ferreira, P. Azevedo, 2010 .

Enhancing Scoring Performance of Docking-Based Virtual Screening Through Machine Learning

Cândida G. Silva, Carlos J. V. Simões, R. Brito, 2016 .

P-found: The Protein Folding and Unfolding Simulation Repository

Werner Dubitzky, Daniel P. Berrar, Martin T. Swain, 2006, 2006 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology.

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

D. Laurents, E. Buratti, F. Baralle, 2014, Archives of biochemistry and biophysics.

A Closer Look on Protein Unfolding Simulations through Hierarchical Clustering

Paulo J. Azevedo, Cândida G. Silva, Rui M. M. Brito, 2007, 2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology.