B. Shan

发表

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

N. Grishin, H. Hobbs, Liqing Yu, 2000, Science.

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

N. Walker, Hiroshi Yamamoto, Zhulun Wang, 2008, Bioorganic & medicinal chemistry.

Role of LXRs in control of lipogenesis.

D. Mangelsdorf, J. Repa, K. Lustig, 2000, Genes & development.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Jean-Marc A. Lobaccaro, Joseph L. Goldstein, I. Shimomura, 2000 .

Discovery and optimization of a novel series of liver X receptor-α agonists

J. Medina, B. Shan, Bei Shan, 2006 .

The search for proteins involved in transport of cholesterol and related sterols

I. Kema, F. Kuipers, V. Bloks, 2004 .

Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

I. Kema, F. Kuipers, V. Bloks, 2004, Gastroenterology.

Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice

F. Kuipers, L. Agellon, M. Schwarz, 2003, Journal of Biological Chemistry.

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Sean P. Brown, S. Wong, B. Shan, 2012, PloS one.

circulation of bile salts in health and disease

F. Kuipers, L. Agellon, M. Schwarz, 2017 .

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

P. Emmerson, P. Mitchell, R. Gimeno, 2017, Nature Medicine.

Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.

Masahiro Tanaka, Kexue Li, Masahiro Suzuki, 2014, Journal of medicinal chemistry.

The Hypocholesterolemic Agent LY295427 Reverses Suppression of Sterol Regulatory Element-binding Protein Processing Mediated by Oxysterols*

D. Russell, B. Shan, B. A. Janowski, 2001, The Journal of Biological Chemistry.

Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.

Masahiro Tanaka, Kexue Li, B. Shan, 2010, Bioorganic & medicinal chemistry letters.

The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol.

N. Walker, S. Thibault, D. E. Piper, 2007, Structure.

Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists.

P. Coward, J. Medina, B. Shan, 2014, Bioorganic & medicinal chemistry letters.

Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

Li Yang, Li Yang, W. Yeh, 2015, PloS one.

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.

P. Baeuerle, V. Baichwal, J. Jaén, 1998, Bioorganic & medicinal chemistry letters.

Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells.

J. Jaén, J. Medina, B. Shan, 1999, Bioorganic & medicinal chemistry letters.

Glutathione S-transferase metabolism of the antineoplastic pentafluorophenylsulfonamide in tissue culture and mice.

J. Medina, B. Shan, H. Beckmann, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis.

D. Russell, M. Schwarz, Manfred Schneider, 2002, Developmental cell.

Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors.

J. Jaén, J. Medina, B. Shan, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

I. Shimomura, D. Mangelsdorf, J. Repa, 2000, Genes & development.

Identification of a nuclear receptor for bile acids.

M. Makishima, D. Mangelsdorf, J. Repa, 1999, Science.

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.

D. Mangelsdorf, J. Repa, J. Dietschy, 2000, Science.

Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists.

P. Coward, J. Medina, B. Shan, 2014, Bioorganic & medicinal chemistry letters.

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo*

P. Coward, N. Walker, Zhulun Wang, 2009, Journal of Biological Chemistry.

FXR, a bile acid receptor and biological sensor.

B. Shan, H. Tu, B Shan, 2000, Trends in cardiovascular medicine.

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Yan Wang, M. Retter, N. Walker, 2009, Proceedings of the National Academy of Sciences.

Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors.

Yun Ling, M. Lizarzaburu, J. Medina, 2011, Bioorganic & medicinal chemistry letters.

Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.

P. Coward, J. Medina, J. Eksterowicz, 2013, Bioorganic & medicinal chemistry letters.

Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using hydrodynamic intravascular injection

Li Yang, P. Kassner, Yan Gong, 2014, Expert opinion on therapeutic targets.

Discovery and optimization of a novel series of liver X receptor-alpha agonists.

J. Medina, B. Shan, Julio C Medina, 2006, Bioorganic & medicinal chemistry letters.