D. Calderwood

发表

Integrin signalling at a glance

David S. Harburger, D. Calderwood, 2009, Journal of Cell Science.

Regulation of integrin-mediated adhesions.

David A Calderwood, D. Calderwood, Daniel V Iwamoto, 2015, Current opinion in cell biology.

Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain*

David A. Calderwood, B. Yaspan, B. Yan, 2001, The Journal of Biological Chemistry.

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain.

B. Yaspan, B. Yan, M. Ginsberg, 2001, The Journal of biological chemistry.

Coarse-Grained Simulation of Full-Length Integrin Activation.

G. Voth, M. Schwartz, D. Calderwood, 2019, Biophysical journal.

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

Emmanuel Delamarche, David A Calderwood, Andrés J. García, 2012, Journal of Cell Science.

The Phosphotyrosine Binding-like Domain of Talin Activates Integrins*

David A. Calderwood, Robert C. Liddington, B. Yan, 2002, The Journal of Biological Chemistry.

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

S. Ishibe, L. Holzman, Daniel M Balkin, 2014, The Journal of clinical investigation.

Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling*

David A. Calderwood, D. Calderwood, S. Shattil, 2000, The Journal of Biological Chemistry.

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

R. Liddington, J. M. de Pereda, M. Ginsberg, 2003, Science.

Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

N. Watanabe, V. Boussiotis, C. Lim, 2006, Current Biology.

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

Eunice E. Cho, B. Turk, H. Lou, 2020, bioRxiv.

Integrin α2 I-domain is a binding site for collagens

M. Humphries, D. Calderwood, D. Tuckwell, 1995 .

Talin and signaling through integrins.

David S. Harburger, D. Calderwood, M. Bouaouina, 2012, Methods in molecular biology.

Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.

I. Campbell, T. Ulmer, M. Ginsberg, 2003, Biochemistry.

Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration

David A. Calderwood, Anna Huttenlocher, Martin A. Schwartz, 2001, Nature Cell Biology.

Integrin cytoskeletal interactions.

David S. Harburger, D. Calderwood, Y. Lad, 2007, Methods in enzymology.

Competition for Talin Results in Trans-dominant Inhibition of Integrin Activation*

P. De Camilli, G. Di Paolo, M. Ginsberg, 2004, Journal of Biological Chemistry.

Functional differences between kindlin-1 and kindlin-2 in keratinocytes

G. Rothschild, Srikala Raghavan, D. Calderwood, 2012, Journal of Cell Science.

A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

S. Spanò, D. Calderwood, M. Baldassarre, 2021, Frontiers in Cellular and Infection Microbiology.

A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

S. Spanò, D. Calderwood, M. Baldassarre, 2020, bioRxiv.

Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6

B. Turk, T. Boggon, H. Lou, 2013, PloS one.

Cerebral cavernous malformation proteins at a glance

T. Boggon, D. Calderwood, O. Fisher, 2014, Journal of Cell Science.

Integrin activation

D. Calderwood, 2004, Journal of Cell Science.

JCB_201407129 1..15

T. Boggon, Xiaofeng Li, D. Calderwood, 2015 .

Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport*

M. Ginsberg, J. Satriano, D. Calderwood, 2001, The Journal of Biological Chemistry.

PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape

T. Boggon, Elizabeth M. Morse, B. Ha, 2016, Journal of Cell Science.

Novel ecto-tagged integrins reveal their trafficking in live cells

D. Toomre, E. Kromann, D. Calderwood, 2017, Nature Communications.

New Insights into the Conformational Activation of Full-Length Integrin

Aleksander E. P. Durumeric, G. Voth, M. Schwartz, 2017, bioRxiv.

Correction for Zhou et al., Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

Joseph, B. Turk, Xiarong Shi, 2021, Proceedings of the National Academy of Sciences.

Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

P. Kanchanawong, D. Calderwood, 2022, Nature Reviews Molecular Cell Biology.

Zasp regulates integrin activation

Elizabeth M. Morse, F. Schöck, G. Tanentzapf, 2012, Journal of Cell Science.

Talin forges the links between integrins and actin

M. Ginsberg, D. Calderwood, 2003, Nature Cell Biology.

Nuclear Localization of Integrin Cytoplasmic Associated Protein-1 Influences β1 Integrin Activation and Recruits Krev/ Interaction Trapped-1 to the Nucleus

D. Calderwood, B. Simon, K. Draheim, 2016 .

Kindlin Binds Migfilin Tandem LIM Domains and Regulates Migfilin Focal Adhesion Localization and Recruitment Dynamics*

M. Parsons, Srikala Raghavan, David S. Harburger, 2013, The Journal of Biological Chemistry.

Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

T. Boggon, Weizhi Liu, Rong Zhang, 2013, Molecular cell.

COMMENTARY Integrin cytoplasmic domain-binding proteins

M. Ginsberg, D. Calderwood, Shouchun Liu, 2000 .

Integrin alpha 2 I-domain is a binding site for collagens.

M. Humphries, D. Calderwood, D. Tuckwell, 1995, Journal of cell science.

Cell Adhesion: A FERM Grasp of the Tail Sorts Out Integrins

D. Calderwood, Nina N. Brahme, 2012, Current Biology.

FAK promotes recruitment of talin to nascent adhesions to control cell motility

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2012, The Journal of Cell Biology.

FAK promotes recruitment of talin to nascent adhesions to control cell motility

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2012, The Journal of cell biology.

The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences

D. Calderwood, Xiaowen Sun, Valerie L. Su, 2019, The Journal of Biological Chemistry.

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin*

M. Humphries, D. Calderwood, D. Tuckwell, 1997, The Journal of Biological Chemistry.

Molecular characterisation of integrin-procollagen C-propeptide interactions.

M. Humphries, M. Takigawa, D. Calderwood, 1997, European journal of biochemistry.

Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)

T. Boggon, Elizabeth M. Morse, B. Ha, 2022, Communications Biology.

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells

B. Turk, Dianqing Wu, Wenwen Tang, 2022, bioRxiv.

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

N. Watanabe, V. Boussiotis, C. Lim, 2006, Current biology : CB.

Integrins in the ovary.

P. Monget, D. Monniaux, S. Fabre, 2006, Seminars in reproductive medicine.

Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion

D. Toomre, D. Calderwood, F. Rivera-Molina, 2022, The Journal of cell biology.

Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase*

A. Koleske, M. Parsons, David S. Harburger, 2015, The Journal of Biological Chemistry.

Direct Interactions with Integrin β 1 Modulate Arg Kinase Activity ! ! 1 Direct Interactions with the Integrin β 1 Cytoplasmic Tail Activate the Abl 2 / Arg Kinase

A. Koleske, M. Parsons, David S. Harburger, 2015 .

Talins and kindlins: partners in integrin-mediated adhesion

I. Campbell, D. Critchley, D. Calderwood, 2013, Nature Reviews Molecular Cell Biology.

Structural determinants of integrin recognition by talin.

R. Liddington, I. Campbell, J. M. de Pereda, 2003, Molecular cell.

Chapter 22: Structural and signaling functions of integrins.

D. Calderwood, Yasmin A. Kadry, 2020, Biochimica et biophysica acta. Biomembranes.

Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling

David A Calderwood, R. Liddington, B. Margolis, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Signalling through cerebral cavernous malformation protein networks

D. Calderwood, Valerie L. Su, 2020, Open Biology.

The Kindler Syndrome Protein Is Regulated by Transforming Growth Factor-β and Involved in Integrin-mediated Adhesion*

M. Beckerle, S. Kloeker, David A Jones, 2004, Journal of Biological Chemistry.

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.

E. Formstecher, J. Camonis, J. Ramos, 2001, Developmental cell.

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.

K. Eliceiri, V. Weaver, P. Keely, 2009, Molecular biology of the cell.

Forces and Bond Dynamics in Cell Adhesion

David A Calderwood, E. Evans, D. Calderwood, 2007, Science.

Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function*

W. Sessa, M. Schwartz, M. Simons, 2014, The Journal of Biological Chemistry.

Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation

D. Calderwood, B. Simon, K. Draheim, 2020, The Journal of Biological Chemistry.

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects*

David S. Harburger, D. Calderwood, M. Bouaouina, 2009, Journal of Biological Chemistry.

Talin controls integrin activation.

D. Calderwood, 2004, Biochemical Society transactions.

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

James B. Munro, P. Uchil, J. Bewersdorf, 2014, Journal of Cell Science.

The structural basis of integrin-linked kinase–PINCH interactions

T. Boggon, Rong Zhang, D. Calderwood, 2008, Proceedings of the National Academy of Sciences.

CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation

T. Boggon, Xiaofeng Li, D. Calderwood, 2015, The Journal of cell biology.

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.

T. Boggon, D. Calderwood, A. L. Stiegler, 2009, Journal of structural biology.

Integrin Cytoplasmic Tail Interactions

David A. Calderwood, Elizabeth M. Morse, D. Calderwood, 2014, Biochemistry.

Integrin cytoplasmic domain-binding proteins.

M. Ginsberg, D. Calderwood, S. Liu, 2000, Journal of cell science.

Purification and SAXS Analysis of the Integrin Linked Kinase, PINCH, Parvin (IPP) Heterotrimeric Complex

J. Luft, T. Boggon, E. Snell, 2013, PloS one.

The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation

D. Calderwood, M. Heuzé, A. Métais, 2009, Cell Death and Differentiation.

ASB2 targets filamins A and B to proteasomal degradation.

D. Calderwood, M. Heuzé, M. Baldassarre, 2008, Blood.

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*

R. Hynes, D. Rees, M. Ginsberg, 1999, The Journal of Biological Chemistry.

Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A*

M. Glogauer, I. Maridonneau-Parini, D. Calderwood, 2012, The Journal of Biological Chemistry.

Class- and Splice Variant-specific Association of CD98 with Integrin β Cytoplasmic Domains*

M. Ginsberg, D. Calderwood, R. Zent, 2000, The Journal of Biological Chemistry.

The molecular basis of filamin binding to integrins and competition with talin.

I. Campbell, J. Ylänne, K. Wegener, 2006, Molecular cell.

The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering

G. Tanentzapf, B. Goult, D. Calderwood, 2014, PLoS genetics.

A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation*

B. Goult, N. Bate, D. Critchley, 2012, The Journal of Biological Chemistry.

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain*

Craig N. Lumb, R. Owens, L. Bird, 2012, The Journal of Biological Chemistry.

Structural basis of the filamin A actin-binding domain interaction with F-actin

C. Sindelar, D. Calderwood, M. Baldassarre, 2018, Nature Structural & Molecular Biology.

Filamins in mechanosensing and signaling.

J. Ylänne, D. Calderwood, Z. Razinia, 2012, Annual review of biophysics.

The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain

D. Calderwood, M. Baldassarre, I. Lamsoul, 2011, Journal of Cell Science.

Filamins Regulate Cell Spreading and Initiation of Cell Migration

D. Calderwood, M. Baldassarre, I. Lamsoul, 2009, PloS one.

The role of FilGAP-filamin A interactions in mechanoprotection.

C. McCulloch, D. Calderwood, Y. Ohta, 2009, Molecular biology of the cell.

The N-terminal SH2 Domains of Syk and ZAP-70 Mediate Phosphotyrosine-independent Binding to Integrin β Cytoplasmic Domains*

David A. Calderwood, M. Ginsberg, D. Calderwood, 2002, The Journal of Biological Chemistry.

Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus*

D. Calderwood, B. Simon, K. Draheim, 2017, The Journal of Biological Chemistry.

Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

B. Turk, T. Boggon, H. Lou, 2022, Nature Communications.

Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

B. Turk, T. Boggon, H. Lou, 2022, Nature communications.

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding

Olli T Pentikäinen, Yatish Lad, Tiila Kiema, 2007, The EMBO journal.

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

B. Turk, J. Schlessinger, Xiarong Shi, 2020, Proceedings of the National Academy of Sciences.

Structural Basis for Paxillin Binding and Focal Adhesion Targeting of β-Parvin*

T. Boggon, N. Chayen, Xiaofeng Li, 2012, The Journal of Biological Chemistry.

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

T. Boggon, Srikala Raghavan, D. Calderwood, 2014, Journal of Cell Science.

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

I. Campbell, G. Roberts, Nicholas J Anthis, 2009, Journal of molecular biology.

ICAP 1 influences integrin activation and KRIT 1 localization 1 Nuclear Localization of Integrin Cytoplasmic Associated Protein-1 Influences β 1 Integrin A ctivation and Recruits Krev Interaction Trapped-1 to the Nucleus

D. Calderwood, B. Simon, K. Draheim, 2016 .

Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

T. Boggon, Weizhi Liu, Xiaofeng Li, 2012, The Journal of Biological Chemistry.

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

P. R. Elliott, G. Roberts, B. Goult, 2010, The EMBO journal.

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms

B. Turk, J. Schlessinger, Peng Yue, 2016, Proceedings of the National Academy of Sciences.

Novel ecto-tagged integrins reveal their trafficking in live cells

D. Toomre, E. Kromann, D. Calderwood, 2017, Nature Communications.

JAM-L–mediated leukocyte adhesion to endothelial cells is regulated in cis by α4β1 integrin activation

P. Couraud, S. Bourdoulous, D. Calderwood, 2008, The Journal of cell biology.

The N-terminal Domains of Talin Cooperate with the Phosphotyrosine Binding-like Domain to Activate β1 and β3 Integrins*

D. Calderwood, Y. Lad, M. Bouaouina, 2008, Journal of Biological Chemistry.

Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading

D. Calderwood, B. Simon, Clotilde Huet-Calderwood, 2018, Journal of Cell Science.

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells

D. Calderwood, R. Buccione, M. Baldassarre, 2012, Journal of Cell Science.

Setdb1-loss induces type-I interferons and immune clearance of melanoma

B. Turk, A. Iwasaki, S. Kaech, 2023, bioRxiv.

Differences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding

D. Calderwood, Clotilde Huet-Calderwood, Yasmin A. Kadry, 2020, The Journal of Biological Chemistry.

Integrin signalling at a glance

David S. Harburger, D. Calderwood, 2009, Journal of Cell Science.

Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells*

Thibault Houles, D. Calderwood, M. Baldassarre, 2011, The Journal of Biological Chemistry.

ASB2α, an E3 Ubiquitin Ligase Specificity Subunit, Regulates Cell Spreading and Triggers Proteasomal Degradation of Filamins by Targeting the Filamin Calponin Homology 1 Domain*

D. Calderwood, M. Baldassarre, G. Cantelli, 2013, The Journal of Biological Chemistry.

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails*

I. Campbell, J. Ylänne, S. Ruskamo, 2008, Journal of Biological Chemistry.

Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis

P. De Camilli, W. Sessa, Yunzhou Dong, 2014, Development.

Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis

P. De Camilli, W. Sessa, Yunzhou Dong, 2014, Journal of Cell Science.

The Rap1-RIAM pathway prefers β2 integrins.

D. Calderwood, 2015, Blood.

Comment on Su et al , page 2695 , and Klapproth et al , page 2704 The Rap 1-RIAM pathway prefers b 2 integrins

David A. Calderwood, D. Calderwood, 2015 .

Structural basis of the filamin A actin-binding domain interaction with F-actin

C. Sindelar, D. Calderwood, M. Baldassarre, 2018, Nature Structural & Molecular Biology.

Filamin A mediates isotropic distribution of applied force across the actin network

T. Svitkina, M. Schwartz, D. Calderwood, 2019, The Journal of cell biology.

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.

T. Boggon, D. Calderwood, A. L. Stiegler, 2009, Journal of structural biology.

ASB2 targets filamins A and B to proteasomal degradation.

D. Calderwood, M. Baldassarre, P. Lutz, 2008, Blood.

Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis

P. De Camilli, W. Sessa, Yunzhou Dong, 2014, Development.

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells

D. Calderwood, R. Buccione, M. Baldassarre, 2012, Journal of Cell Science.