A. Glukhova

发表

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

Zhan Chen, H. Mosberg, J. Tesmer, 2014, Langmuir : the ACS journal of surfaces and colloids.

Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20).

N. Gusev, O. Bukach, A. Glukhova, 2009, Biochimica et biophysica acta.

Differential GLP-1R binding and activation by peptide and non-peptide agonists

David E. Gloriam, C. Langmead, P. Sexton, 2020, bioRxiv.

Regulation of G protein-coupled receptor kinases by phospholipids.

J. Tesmer, A. Glukhova, K. Homan, 2012, Current medicinal chemistry.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

P. Sexton, A. Christopoulos, A. Tobin, 2023, eLife.

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Arthur Christopoulos, Wolfgang Baumeister, Radostin Danev, 2018, Nature.

Structural insights into G-protein-coupled receptor allostery

Arthur Christopoulos, Patrick M. Sexton, Alisa Glukhova, 2018, Nature.

Rules of Engagement: GPCRs and G Proteins.

P. Sexton, A. Christopoulos, R. Sunahara, 2018, ACS pharmacology & translational science.

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

D. Purcell, K. Subbarao, A. Wheatley, 2022, iScience.

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Arthur Christopoulos, Patrick M. Sexton, Alisa Glukhova, 2017, Cell.

Membrane Orientation and Binding Determinants of G Protein-Coupled Receptor Kinase 5 as Assessed by Combined Vibrational Spectroscopic Studies

Pei Yang, J. Tesmer, A. Glukhova, 2013, PloS one.

Structural insights into G-protein-coupled receptor allostery

P. Sexton, A. Christopoulos, A. Glukhova, 2018, Nature.

Novel Irreversible Agonists Acting at the A1 Adenosine Receptor.

A. T. Nguyen, P. White, P. Sexton, 2016, Journal of medicinal chemistry.

Structure and dynamics of the active Gs-coupled human secretin receptor

P. Sexton, A. Christopoulos, C. Reynolds, 2020, Nature Communications.

Automatic local resolution-based sharpening of cryo-EM maps

José María Carazo, Roberto Melero, Roberto Marabini, 2018, bioRxiv.

Phase-plate cryo-EM structure of a class B GPCR-G protein complex

Arthur Christopoulos, Wolfgang Baumeister, Georgios Skiniotis, 2017, Nature.

Recent advances in the determination of G protein-coupled receptor structures.

P. Sexton, A. Christopoulos, Yi-Lynn Liang, 2018, Current opinion in structural biology.

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

A. T. Nguyen, P. White, P. Sexton, 2021, Nature.

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase

A. Abe, J. Shayman, A. Glukhova, 2015, Nature Communications.

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

M. Davenport, S. Kent, K. Subbarao, 2021, Cell Reports.

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Nichollas E. Scott, D. Purcell, M. Davenport, 2021, Proceedings of the National Academy of Sciences.

The Molecular Control of Calcitonin Receptor Signaling.

Arthur Christopoulos, Ming-Wei Wang, Erney Ramírez-Aportela, 2019, ACS pharmacology & translational science.

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.

Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, 2018, ACS pharmacology & translational science.

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

A. Jadhav, A. Remaley, K. Manthei, 2018, bioRxiv.

A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

K. Manthei, C. Larkin, J. Shayman, 2017, The Journal of Biological Chemistry.

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

C. Langmead, P. Sexton, A. Christopoulos, 2020, Molecular cell.

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Robert M. Williams, W. Koch, D. Sherman, 2019, Proceedings of the National Academy of Sciences.

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor*♦

J. Cheung, W. Koch, J. Tesmer, 2015, The Journal of Biological Chemistry.

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

K. Gregory, P. Sexton, A. Christopoulos, 2021, bioRxiv.

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

K. Gregory, P. Sexton, A. Christopoulos, 2022, Nature Communications.

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

Activation mechanism of PINK1

K. Rogers, Michael J. Mlodzianoski, D. Komander, 2021, Nature.

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

W. Baumeister, A. T. Nguyen, Joanne Baltos, 2018, Nature.

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

T. Holman, H. Venugopal, M. Tran, 2023, bioRxiv.

The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.

L. May, Liudi Zhang, A. Glukhova, 2023, Current opinion in structural biology.

Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain*♦

Min Su, Alisa Glukhova, Min Su, 2014, The Journal of Biological Chemistry.

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

P. Sexton, A. Christopoulos, R. Danev, 2023, Nature communications.

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding.

S. Sligar, G. Schertler, V. Gurevich, 2013, Cellular signalling.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

P. Sexton, A. Christopoulos, C. Lindsley, 2022, bioRxiv.

Structural insights into the human P2X1 receptor and ligand interactions

A. Glukhova, D. Thal, J. Mobbs, 2024, bioRxiv.

Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes

T. Holman, M. Holinstat, A. Glukhova, 2023, International journal of molecular sciences.