D. Chan

发表

Over‐expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis

K. Yao, H. Ngan, D. Chan, 2008, The Journal of pathology.

Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer

Dakang Xu, Liyun Shi, D. Chan, 2017, Oncotarget.

Preparation and imaging of nuclear spreads from cells of the zebrafish embryo

T. Yager, D. Chan, Thomas D. Yager, 1998, Chromosoma.

Differential Functions of Growth Factor Receptor–Bound Protein 7 (GRB7) and Its Variant GRB7v in Ovarian Carcinogenesis

D. Chan, V. W. Liu, H. Ngan, 2010, Clinical Cancer Research.

Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1

M. K. Siu, A. Cheung, D. Chan, 2019, Oncoimmunology.

DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.

Wei Zheng, Weiqun Peng, Yan Kai, 2018, Cancer letters.

A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer

M. K. Siu, H. Ngan, D. Chan, 2021, Biomolecules.

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

B. Williams, Dakang Xu, Liyun Shi, 2018, Oncoimmunology.

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

B. Williams, Dakang Xu, Liyun Shi, 2017, Journal of Translational Medicine.

Genetic and epigenetic inactivation of T‐cadherin in human hepatocellular carcinoma cells

I. Ng, Joyce M F Lee, D. Chan, 2008, International journal of cancer.

Knock‐down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells

Irene Oi-Lin Ng, D. Chan, 2006, The Journal of pathology.

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling

H. Ngan, Dakang Xu, B. Tsang, 2016, Oncogene.

Orchestrated Action of AMPK Activation and Combined VEGF/PD-1 Blockade with Lipid Metabolic Tunning as Multi-Target Therapeutics against Ovarian Cancers

M. K. Siu, D. Chan, H. Ngan, 2022, International journal of molecular sciences.

The Potential Molecular Therapeutic Approach in Targeting Ovarian Clear Cell Carcinoma

D. Chan, H. Ngan, 2012 .

Title Increased expression of PITX 2 transcription factor contributes toovarian cancer progression

A. Cheung, D. Chan, V. W. Liu, 2012 .

FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c

K. Yao, D. Chan, V. W. Liu, 2013, Front. Oncol..

Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

Noel Southall, P. Shinn, Wei Zheng, 2018, Oncogene.

Inhibition of Cervical Cancer Cell Growth through Activation of Upstream Kinases of AMP-Activated Protein Kinase

H. Ngan, D. Chan, V. W. Liu, 2009, Tumor Biology.

SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells

D. Chan, H. Ngan, Y. Chan, 2021, Theranostics.

GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade

H. Ngan, Dakang Xu, D. Chan, 2018, Theranostics.

Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells

H. Ngan, D. Chan, K. Chan, 2012, PloS one.

Title Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells

H. Ngan, D. Chan, K. Chan, 2012 .

Novel Nuclear Partnering Role of EPS8 With FOXM1 in Regulating Cell Proliferation

K. Yao, D. Chan, W. Leung, 2019, Front. Oncol..

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis.

Dakang Xu, Jinbiao Zhan, T. Ng, 2020, Pharmacological research.

Title Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer

Thomas H. Leung, D. Chan, H. Ngan, 2013 .

Down-regulation of Sox7 is associated with aberrant activation of Wnt/β-catenin signaling in endometrial cancer

Thomas H. Leung, D. Chan, H. Ngan, 2012, Oncotarget.

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

M. K. Siu, D. Chan, H. Ngan, 2022, International journal of molecular sciences.

The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression

D. Chan, H. Ngan, Karen K. L. Chan, 2021, International journal of molecular sciences.

Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants.

M. Waye, H. Ngan, T. Ng, 2017, Current medicinal chemistry.

Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer

K. Yao, D. Chan, P. Chiu, 2014, Molecular Cancer.

Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications

D. Chan, P. Chiu, H. Ngan, 2012, BMC Cancer.

miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer

Weiqun Peng, Yan Kai, A. Tzatsos, 2018, Oncogene.

Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis

M. K. Siu, S. Tsui, Dakang Xu, 2023, Molecular Cancer.

CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer

Dakang Xu, Xiaobao Yang, D. Chan, 2021, Frontiers in Immunology.

Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer

M. K. Siu, H. Ngan, A. Cheung, 2020, British Journal of Cancer.

Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.

I. Ng, Y. Ching, D. Chan, 2006, Gastroenterology.

Overexpression of PLXDC2 in Stromal Cell-Associated M2 Macrophages Is Related to EMT and the Progression of Gastric Cancer

Dakang Xu, Jingsong Xu, D. Chan, 2021, Frontiers in Cell and Developmental Biology.

The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells

H. Ngan, S. Wong, D. Chan, 2013, British Journal of Cancer.

Discovery and characterization of potent And‐1 inhibitors for cancer treatment

Ruili Huang, M. Xia, Wei Zheng, 2021, Clinical and translational medicine.

ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer

Wei Zheng, A. Cheung, Wei Sun, 2019, Clinical Cancer Research.

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

K. Yao, H. Ngan, D. Chan, 2009, British Journal of Cancer.

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells.

T. Furukawa, K. Yao, D. Chan, 2008, Carcinogenesis.

Loss of MKP3 is associated with cisplatin-resistance and tumorigenicity of ovarian cancer

D. Chan, V. W. Liu, H. Ngan, 2007 .

Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

D. Chan, H. Ngan, M. Yung, 2016, Acta biochimica et biophysica Sinica.

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade

F. Ross, D. Hardie, Jinbiao Zhan, 2015, Integrative cancer therapies.

Title Bitter melon ( Momordica charantia ) extract functions as a natural AMPK activator and synergistically enhances cisplatin cytotoxicity in ovarian cancer cells

F. Ross, D. Hardie, Jinbiao Zhan, 2016 .

AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

H. Ngan, A. Cheung, D. Chan, 2013, PloS one.

Title Reduced expression of AMPK-β 1 during tumor progressionenhances the oncogenic capacity of advanced ovarian cancer

K. Yao, D. Chan, P. Chiu, 2014 .

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling

H. Ngan, K. Yao, Lei Shi, 2014, Oncotarget.

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells

K. Yao, D. Chan, V. W. Liu, 2011, PloS one.

Title Elevated TAK 1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κ B signaling

Thomas, K. Yao, Lei Shi, 2014 .

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade

H. Ngan, K. Yao, D. Chan, 2013, BMC Cancer.

Mechanisms of Chemoresistance in Human Ovarian Cancer at a Glance

D. Chan, H. Ngan, M. Liu, 2012 .

Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors

Nicole J. Lambert, R. Srivas, Y. Chae, 2019, Molecular Cancer Therapeutics.

Identification of Carboxypeptidase of Glutamate Like-B as a Candidate Suppressor in Cell Growth and Metastasis in Human Hepatocellular Carcinoma

I. Ng, Jianren Gu, D. Wan, 2006, Clinical Cancer Research.

Title Aberrant activation of ERK / FOXM 1 signaling cascade triggersthe cell migration / invasion in ovarian cancer cells

D. Chan, V. W. Liu, H. Ngan, 2011 .

Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells

K. Yao, D. Chan, H. Ngan, 2011, The Journal of pathology.

Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer

M. K. Siu, Y. Song, R. Bast, 2021, Cancers.

MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis

Kai-Fai Lee, D. Chan, H. Ngan, 2017, Molecular Cancer.

1338PEGFR mutation detection in plasma cell-free DNA correlates with clinical outcomes in non-small cell lung cancer

T. Chin, D. Chan, C. Toh, 2017 .

Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer

D. Chan, H. Ngan, M. Siu, 2013, Oncotarget.

Title Epigenetic silencing of microRNA-199 b-5 p is associated with acquired chemoresistance via activation of JAG 1-Notch 1 signaling in ovarian cancer

D. Chan, H. Ngan, M. Siu, 2014 .

p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer

B. Tsang, R. Parks, D. Patten, 2019, Molecular carcinogenesis.

CD71+ Population Enriched by HPV-E6 Protein Promotes Cancer Aggressiveness and Radioresistance in Cervical Cancer Cells

M. K. Siu, H. Ngan, A. Cheung, 2019, Molecular Cancer Research.

Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers

D. Chan, H. Ngan, K. Chan, 2021, Clinical Epigenetics.

Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer

M. K. Siu, H. Ngan, A. Cheung, 2020, British Journal of Cancer.

SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance

Wei Zheng, A. Cheung, Huadong Pei, 2021, Cell Death & Disease.

Increased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression

A. Cheung, D. Chan, V. W. Liu, 2012, PloS one.

Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways

Siew-Fei Ngu, Dakang Xu, Huijuan Yang, 2018, Theranostics.

Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis

Xueyu Wang, D. Chan, H. Ngan, 2021, Cancers.

PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer

A. Cheung, D. Chan, H. Ngan, 2022, Frontiers in Oncology.

Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulators in ovarian cancer.

M. K. Siu, H. Ngan, D. Chan, 2014, The Journal of endocrinology.

Infiltration of T cells promotes the metastasis of ovarian cancer cells via the modulation of metastasis-related genes and PD-L1 expression

M. K. Siu, H. Ngan, A. Cheung, 2020, Cancer Immunology, Immunotherapy.

Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells

Dakang Xu, D. Chan, H. Ngan, 2019, Communications Biology.

Title MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF 12 / Sp 1 / survivin axis

Kai-Fai Lee, D. Chan, H. Ngan, 2017 .

ERBB2 mutation: A promising target in non-squamous cervical cancer.

H. Ngan, Gong Yang, Xiaoyan Zhou, 2018, Gynecologic oncology.

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment

D. Chan, H. Ngan, K. Chan, 2021, Cancers.

Epigenetic Alteration of the Metallothionein 1E Gene in Human Endometrial Carcinomas

H. Ngan, A. Cheung, D. Chan, 2009, Tumor Biology.

Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness

M. K. Siu, H. Ngan, A. Cheung, 2018, The Journal of pathology.