J. Harlan

发表

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

H. Ochs, P. Beatty, K. Stanness, 1986, Journal of immunology.

Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.

M. Ferguson, A. Chait, C. Benjamin, 1993, The Journal of clinical investigation.

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.

G. Starkebaum, J. Harlan, 1986, The Journal of clinical investigation.

Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.

T. Carlos, J. Harlan, A. Dobrina, 1991, The Journal of clinical investigation.

Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process.

T. Kuijpers, T. Kavanagh, J. Calafat, 1994, Journal of immunology.

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.

P. Tarr, R. Tizard, T. Pohlman, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Leukocyte-endothelial adhesion molecules.

T. Carlos, J. Harlan, J M Harlan, 1994, Blood.

Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.

H. Ochs, E. Wayner, T. Carlos, 1990, The Journal of clinical investigation.

Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues.

G. Haines, A. Koch, S. Leibovich, 1991, Laboratory investigation; a journal of technical methods and pathology.

Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIbIIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), αvβ3 Integrin, and GPIbα

J. Harlan, B. Schwartz, T. Bombeli, 1998, The Journal of experimental medicine.

Role of neutrophils in ischemia-reperfusion-induced microvascular injury.

M. Grisham, D. Granger, J. Harlan, 1987, The American journal of physiology.

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin

M. Ginsberg, J. Harlan, R. Faull, 1993, The Journal of cell biology.

Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

J. Gamble, M. Vadas, C. Begley, 1986, The Journal of clinical investigation.

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.

A. Karsan, K. Kaushansky, J. Harlan, 1996, Blood.

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo.

L. Lindbom, P. Beatty, J. Harlan, 1987, Blood.

Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18-and VLA-4-dependent mechanisms and stimulate smooth muscle migration.

F. Lang, D. Kling, J. Harlan, 1995, Circulation research.

Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis.

T. Pohlman, J. Harlan, John M. Harlan, 1989, Cellular immunology.

Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia.

D. Stirewalt, F. Appelbaum, C. Willman, 2009, Blood.

Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock.

J. Harlan, N. Vedder, B. Fouty, 1989, Surgery.

Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.

E. Chi, J. Harlan, N. Vedder, 1990, Proceedings of the National Academy of Sciences of the United States of America.

A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits.

E. Chi, J. Harlan, N. Vedder, 1988, The Journal of clinical investigation.

The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials.

J. Harlan, N. Vedder, A. Iwata, 2002, Blood.

Leukocyte adhesion deficiency (LAD) II: a new adhesion defect due to absence of sialyl Lewis X, the ligand for selectins.

R. Gershoni-baruch, J. Paulson, Amos Etzioni, 1993, Immunodeficiency.

Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect 1

I. Weissman, M. Tasch, J. Harlan, 2003, The Journal of Immunology.

Short communication: adhesion pathways utilized by HIV-infected lymphocytes.

L. Schnapp, J. Harlan, B. Schwartz, 2012, AIDS research and human retroviruses.

Cyclin-Dependent Kinase Inhibitors Block Leukocyte Adhesion and Migration1

H. Kiyokawa, E. Raines, L. Schnapp, 2008, The Journal of Immunology.

Atrial Fibrillation and Stroke: More Concepts and Controversies

S. Juvela, K. Becker, J. Harlan, 2001 .

Does Antibody to the a 4 Integrin Inhibit the Function of Lymphocytes and Monocytes

S. Juvela, K. Becker, J. Harlan, 2001 .

homolog A 1 Perturbation of B-cell development in mice overexpressing the Bcl-2

Chien-Ying Liu, D. Willerford, J. Harlan, 2002 .

The role of protein kinase C in the induction of VCAM‐1 expression on human umbilical vein endothelial cells

K. Kaushansky, T. Pohlman, J. Harlan, 1993, FEBS letters.

Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2.

H. Ochs, J. Paulson, R. Bayer, 1995, The Journal of clinical investigation.

Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.

E. Raines, W. Liles, Xiaodong Zhu, 2011, The American journal of pathology.

Selectins: A family of adhesion receptors

I. Weissman, A. Varki, T. Springer, 1991, Cell.

HEMOSTASIS , THROMBOSIS , AND VASCULAR BIOLOGY Endothelial Cells Undergoing Apoptosis Become Proadhesive for Nonactivated Platelets

J. Harlan, B. Schwartz, T. Bombeli, 1999 .

Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils.

H. Ochs, C. June, P. Beatty, 1986, Blood.

Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1.

C. Benjamin, E. Wayner, T. Carlos, 1991, Blood.

Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1

C. Benjamin, E. Wayner, T. Carlos, 1991 .

Multiple Receptors on Human Monocytes Are Involved in Adhesion to Cultured Human Endothelial Cells

R. Ross, T. Carlos, J. Harlan, 1990, Journal of leukocyte biology.

Anticoagulants and Thrombolytic Agents in Cardiovascular Disease 'ombosis: Its Role Prevention in rdiovascuIar 3,nts Part

L. Harker, J. Harlan, A. Thompson, 2005 .

Apoptotic vascular endothelial cells become procoagulant.

A. Karsan, J. Tait, J. Harlan, 1997, Blood.

Metalloproteinase-mediated Shedding of Integrin β2 Promotes Macrophage Efflux from Inflammatory Sites*

E. Raines, J. Heinecke, Wei Yan, 2011, The Journal of Biological Chemistry.

a-Thrombin Induces Release of Platelet-derived Growth Factor-like Molecule ( s ) by Cultured Human Endothelial Cells

R. Ross, J. Harlan, P. J. Thompson, 2003 .

Participation of Leukocytes in the Development of Experimentally Induced Arteriosclerotic Lesions — Morphological and Functional Aspects

D. Kling, J. Harlan, H. Heinle, 1991 .

Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

J. Adamson, V. Broudy, K. Kaushansky, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.

J. Adamson, V. Broudy, K. Kaushansky, 1988, Journal of immunology.

Tumor necrosis factor-alpha exhibits greater proinflammatory activity than lymphotoxin in vitro.

C. Desch, B. Aggarwal, J. Harlan, 1990, Blood.

Extracellular BCL2 Proteins Are Danger-Associated Molecular Patterns That Reduce Tissue Damage in Murine Models of Ischemia-Reperfusion Injury

Xiaodong Zhu, J. Harlan, B. Schwartz, 2010, PloS one.

FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharide.

J. Harlan, D. Bannerman, R. Winn, 2004, The American journal of pathology.

The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β

J. Harlan, D. Bannerman, J. Kelly, 2002 .

Interleukin‐4 induces endothelial vascular cell adhesion molecule‐1 (VCAM‐1) by an NF‐κb‐independent mechanism

K. Kaushansky, J. Harlan, J. McCarty, 1995, FEBS letters.

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA- dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components

T. Carlos, J. Harlan, N. Kovach, 1992, The Journal of cell biology.

molecule-1 and vascular cell adhesion molecule-1 cultured human endothelial cells : endothelial-leukocyte adhesion Human monocytes bind to two cytokine-induced adhesive ligands on

E. Wayner, T. Carlos, J. Harlan, 2022 .

Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88‐dependent, caspase‐independent pathway

W. Altemeier, W. Liles, Xiaodong Zhu, 2007, Journal of leukocyte biology.

The Role of Neutrophil Membrane Proteins in Neutrophil Emigration1

T. Pohlman, J. Harlan, B. Schwartz, 1987 .

Neutrophil-mediated vascular injury.

J. Harlan, 2009, Acta medica Scandinavica. Supplementum.

Consequences of Leukocyte-Vessel Wall Interactions in Inflammatory and Immune Reactions

J. Harlan, 1987, Seminars in thrombosis and hemostasis.

CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits.

H. Coxson, J. Harlan, C. Doerschuk, 1990, Journal of immunology.

Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria.

K. Kain, F. Lovegrove, W. Liles, 2008, The American journal of tropical medicine and hygiene.

Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture.

L. Harker, J. Harlan, M. Joseph, 1982, Blood.

Blockade of Leukocyte Adhesion in in Vivo Models of Inflammation

J. Harlan, R. Winn, L. Flaherty, 1994 .

Integrin-dependent Leukocyte Adhesion Involves Geranylgeranylated Protein(s)*

S. Sebti, A. Hamilton, J. Harlan, 1999, The Journal of Biological Chemistry.

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration

F. Gaeta, T. Kuijpers, M. Elices, 1993, The Journal of experimental medicine.

Shiga-like Toxin Inhibition of FLICE-like Inhibitory Protein Expression Sensitizes Endothelial Cells to Bacterial Lipopolysaccharide-induced Apoptosis*

J. Harlan, D. Bannerman, R. Winn, 2002, The Journal of Biological Chemistry.

Mechanisms and consequences of phagocyte adhesion to endothelium.

H. Repo, J. Harlan, H. Repo, 1999, Annals of medicine.

Adhesion : its role in inflammatory disease

J. Harlan, David Liu, 1992 .

Monocyte-endothelial interactions: insights and questions.

T. Kuijpers, J. Harlan, 1993, The Journal of laboratory and clinical medicine.

Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells

Xianwu Li, C. Rhodes, J. Harlan, 2003, Infection and Immunity.

Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection.

C. Alpers, C. Benjamin, K. Hudkins, 1993, The American journal of pathology.

A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells.

A. Karsan, J. Harlan, B. Schwartz, 1999, Journal of immunology.

Allograft Rejection

G. Daughters, C. Alpers, C. Benjamin, 2005 .

Streptococcus pneumoniae-stimulated macrophages induce neutrophils to emigrate by a CD18-independent mechanism of adherence.

J. Harlan, W. Mileski, C. Rice, 1990, Circulatory shock.

Leukocyte Adhesion and Migration Cyclin-Dependent Kinase Inhibitors Block

H. Kiyokawa, E. Raines, L. Schnapp, 2008 .

The role of leukocyte emigration and IL-8 on the development of lipopolysaccharide-induced lung injury in rabbits.

S. Sharar, T. Martin, O. Kajikawa, 1998, Journal of immunology.

Antibody against neutrophil adhesion improves reperfusion and limits alveolar infiltrate following unilateral pulmonary artery occlusion.

M. Bishop, J. Harlan, T. Kowalski, 1992, The Journal of surgical research.

Blockade of CD49d ( (cid:97) 4 Integrin) on Intrapulmonary but Not Circulating Leukocytes Inhibits Airway Inﬂammation and Hyperresponsiveness in a Mouse Model of Asthma

E. Chi, W. Henderson, S. Chu, 1997 .

Divergence of Bacterial Lipopolysaccharide Pro-apoptotic Signaling Downstream of IRAK-1*

J. Harlan, D. Bannerman, R. Winn, 2002, The Journal of Biological Chemistry.

The CD40-inducible Bcl-2 family member A1 protects B cells from antigen receptor-mediated apoptosis.

E. Clark, J. Harlan, A. Craxton, 2000, Cellular immunology.

Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-beta/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells.

J. Adamson, V. Broudy, J. Harlan, 1987, Journal of immunology.

The platelet glycoprotein IIb/IIIa-like protein in human endothelial cells promotes adhesion but not initial attachment to extracellular matrix

S. Schwartz, R. Heimark, J. Harlan, 1987, The Journal of cell biology.

Pentoxifylline inhibits integrin-mediated adherence of interleukin-2- activated human peripheral blood lymphocytes to human umbilical vein endothelial cells, matrix components, and cultured tumor cells.

J. Thompson, T. Yednock, J. Harlan, 1994, Blood.

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

K. Titani, E. Davie, J. Harlan, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Cytokine-induced adhesion molecule expression on human umbilical vein endothelial cells is not regulated by cyclic adenosine monophosphate accumulation.

J. Harlan, T. Deisher, I. García, 1993, Life sciences.

Selective inhibition of thromboxane synthesis during experimental endotoxemia in the goat: effects on pulmonary haemodynamics and lung lymph flow.

J. Harlan, J. Hildebrandt, L. Harker, 1983, British journal of clinical pharmacology.

Leukocyte-Mediated Endothelial Injury

J. Harlan, 1998 .

NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide.

A. Karsan, M. Kay, J. Harlan, 1999, The Journal of biological chemistry.

Endothelial and leukocyte adhesion molecules in inflammation and disease.

S. Sharar, J. Harlan, N. Vedder, 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

A monoclonal antibody-defined membrane antigen complex is required for neutrophil-neutrophil aggregation.

H. Ochs, P. Beatty, J. Harlan, 1985, Blood.

Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.

L. Harker, J. Harlan, B. Schwartz, 1984, The Journal of clinical investigation.

Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo

C. Raetz, R. Munford, J. Harlan, 1990, The Journal of experimental medicine.

Cytoskeletal changes as an early event in hydrogen peroxide-induced cell injury: a study in A549 cells.

G. Raghu, A. Gown, G. Striker, 1986, British journal of experimental pathology.

Concepts of Thrombogenesis and Its Prevention ombosis: Its Role Prevention in diovascular )nts Part

L. Harker, A. Thompson, J. Harlan, 2005 .

Tumor necrosis factors α and β differ in their capacities to generate interleukin 1 release from human endothelial cells

R. Locksley, B. Aggarwal, H. Shepard, 1987 .

The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta.

J. Harlan, D. Bannerman, J. Kelly, 2002, The Journal of clinical investigation.

C1‐Inhibitor Reduces the Ischaemia–Reperfusion Injury of Skeletal Muscles in Mice after Aortic Cross‐Clamping

T. Mollnes, T. Mollnes, J. Harlan, 2002, Scandinavian journal of immunology.

Effect trans in Septic Mice by a Over-Expression of Bcl-2 Provides Protection

M. Tasch, J. Harlan, E. Lagasse, 2003 .

Role of Cdk4 in lymphocyte function and allergen response

Xiaopei Huang, L. Schnapp, J. Harlan, 2010, Cell cycle.

ABSENCE OF MONOCLONAL-ANTIBODY-DEFINED PROTEIN COMPLEX IN BOY WITH ABNORMAL LEUCOCYTE FUNCTION

P. Beatty, T. Price, H. Rosen, 1984, The Lancet.

Administration of Antiadhesion Molecules: A Feasible Approach?

S. Sharar, J. Harlan, W. Mileski, 1993 .

Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

J. Harlan, K. Callahan, K. S. Callahan, 1984, The Journal of clinical investigation.

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences

M. Ginsberg, J. Harlan, R. Faull, 1994, The Journal of experimental medicine.

Regulation of β1-Integrin Function in Cultured Human Vascular Smooth Muscle Cells

A. Clowes, T. Yednock, J. Harlan, 1996 .

Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

K. C. Jordan, Xiaodong Zhu, J. Harlan, 2011, PloS one.

Production of human tumor necrosis factor from whole blood ex vivo.

J. Harlan, N. Kovach, C. E. Desch, 1989, Lymphokine research.

Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mo1).

J. Harlan, B. Schwartz, John M. Harlan, 1989, Biochemical and biophysical research communications.

Neutrophil Membrane Sulfhydryl Groups Are Involved in Stimulated Neutrophil Adherence to Endothelium

J. Harlan, B. Schwartz, 1989, Journal of leukocyte biology.

Deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro

R. Munford, T. Pohlman, J. Harlan, 1987, The Journal of experimental medicine.

Tumor necrosis factor type a stimulates human endothelial cells to produce granulocyte / macrophage colony-stimulating factor

J. Adamson, V. Broudy, K. Kaushansky, 2022 .

Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates.

T. Pohlman, J. Harlan, N. Vedder, 1990, Surgery.

Rabbits Lipopolysaccharide-Induced Lung Injury in on the Development of The Role of Leukocyte Emigration and IL-8

S. Sharar, T. Martin, O. Kajikawa, 1998 .

Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.

J. Harlan, J. Hildebrandt, C. Carrico, 1986, The Journal of surgical research.

Platelet-derived growth factor does not stimulate prostacyclin synthesis by cultured endothelial cells.

A. Schorer, J. Harlan, K. Callahan, 1986, Blood.

Cross-linking of sialophorin (CD43) induces neutrophil aggregation in a CD18-dependent and a CD18-independent way.

T. Kuijpers, J. Harlan, B. Schwartz, 1992, Journal of immunology.

Synergistic mobilization of hemopoietic progenitor cells using concurrent β1 and β2 integrin blockade or β2-deficient mice

L. Scott, T. Papayannopoulou, B. Nakamoto, 2001 .

The role of neutrophil membrane glycoprotein 150 (Gp-150) in neutrophil-mediated endothelial cell injury in vitro.

H. Ochs, P. Beatty, J. Harlan, 1985, Journal of immunology.

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

E. Chi, W. Henderson, S. Chu, 1997, The Journal of clinical investigation.

Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro.

A. Clowes, T. Yednock, E. Mattsson, 1996, The American journal of pathology.

Sensitivity to endotoxin in rabbits is increased after hemorrhagic shock.

J. Harlan, W. Mileski, C. Rice, 1992, Journal of applied physiology.

Mechanisms and consequences of leukocyte-endothelial interaction.

J. Harlan, N. Vedder, C. Rice, 1991, The Western journal of medicine.

Human monocyte adherence to cultured vascular endothelium: monoclonal antibody-defined mechanisms.

H. Ochs, P. Beatty, J. Harlan, 1985, Journal of immunology.

Short Report: Failure of Two Distinct Anti-apoptotic Approaches to Reduce Mortality in Experimental Cerebral Malaria

K. Kain, F. Lovegrove, W. Liles, 2008 .

A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits.

S. Sharar, C. Murry, J. Harlan, 1991, Surgery.

Role of leukocyte CD11/CD18 complex in endotoxic and septic shock in rabbits.

J. Harlan, C. Rice, R. Winn, 1992, Journal of applied physiology.

Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation.

S. Sharar, H. Repo, J. Harlan, 1997, Journal of immunology.

Synergistic mobilization of hemopoietic progenitor cells using concurrent b 1 and b 2 integrin blockade or b 2-deﬁcient mice

L. Scott, T. Papayannopoulou, B. Nakamoto, 2001 .

FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling

K. C. Jordan, J. Harlan, J. Tupper, 2011, Cell Communication and Signaling.

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

J. Harlan, N. Vedder, 1988, The Journal of clinical investigation.

Leukocyte-endothelial interactions.

J. Harlan, 1985, Blood.

The adhesion cascade and anti-adhesion therapy: an overview

S. Sharar, J. Harlan, R. Winn, 2004, Springer Seminars in Immunopathology.

Stimulation of neutrophils by tumor necrosis factor.

J. Gamble, M. Vadas, S. Klebanoff, 1986, Journal of immunology.

The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro.

H. Ochs, P. Beatty, T. Price, 1985, Blood.

Dimethylthiourea prevents hydrogen peroxide and neutrophil mediated damage to lung endothelial cells in vitro and disappears in the process.

S. Linas, J. Repine, J. Harlan, 1989, Free radical biology & medicine.

Lung permeability and hemodynamics during endotoxemia: effect of aprotinin.

R. Maunder, J. Harlan, J. Gleisner, 1986, Journal of Surgical Research.

The Role of Leukocyte and Endothelial Adhesion Molecules in Ischemia – Reperfusion Injury

J. Harlan, R. Winn, R. Thiagarajan, 1997, Thrombosis and Haemostasis.

Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma.

K. Y. Yeung, M. Peters, E. Raines, 2004, Molecular cancer research : MCR.

Membrane Proteins Involved in Phagocyte Adherence to Endothelium

T. Carlos, J. Harlan, 1990, Immunological reviews.

Reduction of Burn Injury by Inhibiting CD18‐Mediated Leukocyte Adherence in Rabbits

J. May, L. Bucky, H. Ehrlich, 1994, Plastic and reconstructive surgery.

Severe neutropenia in infectious mononucleosis.

W. Hammond, J. Harlan, S. E. Steinberg, 1979, The Western journal of medicine.

Anti-adhesion therapy.

J. Harlan, C J Cornejo, R K Winn, 1997, Advances in pharmacology.

Adaptive responses of the endothelium to stress.

T. Pohlman, J. Harlan, 2000, The Journal of surgical research.

Outcome after hemorrhagic shock in trauma patients.

M. Copass, S. Heckbert, R. Maier, 1998, The Journal of trauma.

Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells.

K. Kaushansky, J. Harlan, T. Deisher, 1993, Cell adhesion and communication.

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

J. Gamble, M. Vadas, J. Harlan, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Of man and mouse: leukocyte and endothelial adhesion molecule deficiencies.

A Etzioni, Amos Etzioni, J. Harlan, 1999, Blood.

Introduction: anti-adhesion therapy in sickle cell disease.

J. Harlan, John M. Harlan, 2000, Blood.

Endothelial Cell Death Induced by Tumor Necrosis Factor-α Is Inhibited by the Bcl-2 Family Member, A1*

A. Karsan, J. Harlan, E. Yee, 1996, The Journal of Biological Chemistry.

Proinflammatory Role of Leukocyte Adhesion Molecules

J. Harlan, N. Vedder, R. Winn, 1993 .

Targeting leukocyte integrins in human diseases

J. Harlan, K. Yonekawa, 2005, Journal of leukocyte biology.

Lipopolysaccharide Mediates Endothelial Apoptosis by a FADD-dependent Pathway*

A. Karsan, P. Chaudhary, J. Harlan, 1998, The Journal of Biological Chemistry.

A Constitutive Cytoprotective Pathway Protects Endothelial Cells from Lipopolysaccharide-induced Apoptosis*

C. F. Bennett, W. Ricketts, J. Harlan, 2001, The Journal of Biological Chemistry.

Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.

R. Locksley, J. Harlan, D. Hickstein, 1987, Journal of immunology.

Shiga toxin induces decreased expression of the anti-apoptotic protein Mcl-1 concomitant with the onset of endothelial apoptosis.

J. Harlan, D. Bannerman, R. Winn, 2003, Microbial pathogenesis.

GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells

J. Harlan, John T. Li, E. Taylor, 2007, Biochemical pharmacology.

Effector functions of endothelium in inflammatory and immunologic reactions.

J. Harlan, W. Wallis, 1986, Pathology and immunopathology research.

Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.

J. Adamson, V. Broudy, K. Kaushansky, 1987, Journal of immunology.

Mechanisms of Hypoxia-induced Endothelial Cell Death

A. Karsan, A. Stempien-Otero, J. Harlan, 1999, The Journal of Biological Chemistry.

Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms.

A. Karsan, R. Craig, G. Poirier, 1997, The American journal of pathology.

Inhibition of leukocyte extravasation with a monoclonal antibody to CD18 during formation of experimental intimal thickening in rabbit carotid arteries.

D. Kling, J. Harlan, J. Fingerle, 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells.

A. Karsan, Xiao-long Hu, J. Harlan, 1998, Blood.

A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils.

A. Karsan, J. Harlan, E. Yee, 1998, Biochemical and biophysical research communications.

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils.

E. Chi, W. Liles, A. Takemasa, 2003, Blood.

Cytoplasmic Domain of E-selectin Contains a Non-tyrosine Endocytosis Signal*

J. Harlan, C. Cornejo, R. Winn, 1997, The Journal of Biological Chemistry.

miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

J. Fish, K. Kain, A. Conroy, 2017, Molecular medicine.

A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits.

J. Paulson, J. Harlan, R. Winn, 1994, The American journal of physiology.

The GTPase Rap1 Regulates Phorbol 12-Myristate 13-Acetate-stimulated but Not Ligand-induced β1Integrin-dependent Leukocyte Adhesion*

J. Harlan, B. Schwartz, R. Winn, 2002, The Journal of Biological Chemistry.

Leukocyte—Endothelial Cell Interactions in Ischemia‐Reperfusion Injury

S. Sharar, J. Harlan, N. Vedder, 1997, Annals of the New York Academy of Sciences.

In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes.

H. Ochs, U. V. von Andrian, J. Paulson, 1993, The Journal of clinical investigation.

Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines.

V. Broudy, T. Yednock, N. Lin, 1995, Blood.

Apoptotic vascular endothelial cells become procoagulant

A. Karsan, J. Tait, J. Harlan, 1997 .

A Broad-Spectrum Caspase Inhibitor Attenuates Allergic Airway Inflammation in Murine Asthma Model1

E. Chi, W. Henderson, J. Harlan, 2003, The Journal of Immunology.

Haematological malignancies in sub-Saharan Africa: east Africa as an example for improving care.

S. Turner, M. Ferraresso, H. Ddungu, 2021, The Lancet. Haematology.

TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.

J. Harlan, D. Bannerman, R. Winn, 2002, Biochemical and biophysical research communications.

CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

D. Egan, R. Judge, L. Benatuil, 2019, BMC Molecular and Cell Biology.

NF-κB Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-α but Not to Interleukin-1β or Lipopolysaccharide*

A. Karsan, M. Kay, Xianwu Li, 1999, The Journal of Biological Chemistry.

Endothelial activation and dysfunction in sepsis

J. Harlan, 2010 .

Leukocyte-endothelial interactions: Clinical trials of anti-adhesion therapy

J. Harlan, R. Winn, 2002, Critical care medicine.

Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells*

Xianwu Li, S. Sebti, A. Hamilton, 2002, The Journal of Biological Chemistry.

Promises and limitations of targeting adhesion molecules for therapy

J. Harlan, K. Yonekawa, 2007 .

Requirement for RhoA Kinase Activation in Leukocyte De-Adhesion1

J. Harlan, B. Schwartz, R. Winn, 2002, The Journal of Immunology.

Leukocyte De-Adhesion Requirement for RhoA Kinase Activation in

J. Harlan, B. Schwartz, R. Winn, 2002 .

Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors

Francesco Saverio Tedesco, E. Ferrero, J. Harlan, 1998, The Journal of cell biology.

Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium.

A Etzioni, A. Karsan, H. Ochs, 1998, The Journal of clinical investigation.

Molecular Basis and Pathologic Consequences of Neutrophil Adherence to Endothelium

S. Sharar, Amos Etzioni, J. Harlan, 1995 .

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

L. Lindbom, J. Harlan, K. Arfors, 1987 .

Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits.

S. Sharar, T. Tedder, J. Harlan, 1996, The American journal of physiology.

CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro.

H. Ochs, P. Beatty, T. Carlos, 1989, Immunology.

Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear.

S. Sharar, B. Schleiffenbaum, T. Tedder, 1994, Blood.

overall survival for patients with acute myeloid leukemia Very late antigen-4 function of myeloblasts correlates with improved

D. Stirewalt, K. Kopecky, T. Papayannopoulou, 2013 .

Effect of intravenous catalase on the pulmonary vascular response to endotoxemia in goats.

R. Maunder, J. Harlan, J. Hildebrandt, 1988, Journal of applied physiology.

Trafficking of Th1 cells to lung: a role for selectins and a P-selectin glycoprotein-1-independent ligand.

D. Bullard, D. Madtes, A. Dixon, 2004, American journal of respiratory cell and molecular biology.

Lung lymph flow after bone marrow injection into goats was reduced by indomethacin.

R. Maunder, J. Harlan, R. Winn, 1987, Journal of applied physiology.

Antilipopolysaccharide factor from horseshoe crab, Tachypleus tridentatus, inhibits lipopolysaccharide activation of cultured human endothelial cells

J. Harlan, P. O’Hara, C. E. Desch, 1989, Infection and immunity.

Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats.

E. Chi, R. Maunder, J. Harlan, 1987, Journal of applied physiology.

Neutrophils contribute to hepatic ischemia‐ reperfusion injury by a CD18‐independent mechanism

H. D. Liggitt, J. Harlan, C. Rice, 1993, Journal of leukocyte biology.

Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration.

J. Harlan, 1993, Clinical immunology and immunopathology.

Lipopolysaccharide-induced NF-κB activation in human endothelial cells involves degradation of IκBα but not IκBβ

A. Karsan, J. Harlan, E. Yee, 1998 .

CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus

S. Sharar, J. Harlan, C. Ramamoorthy, 1997, Journal of leukocyte biology.

Whom to treat? Factors associated with chemotherapy recommendations and outcomes among patients with NHL at the Uganda Cancer Institute

J. Orem, J. Harlan, W. Phipps, 2018, PloS one.

Leukocyte and endothelial adhesion molecules in ischaemia/reperfusion injuries.

S. Sharar, J. Harlan, N. Vedder, 1995, Ciba Foundation symposium.

Ischemia reperfusion injury in the rabbit ear is reduced by both immediate and delayed CD18 leukocyte adherence blockade.

S. Sharar, J. Harlan, R. Winn, 1994, Journal of immunology.

Sialyl Lewis(x) oligosaccharide reduces ischemia-reperfusion injury in the rabbit ear.

S. Sharar, J. Harlan, M. L. Phillips, 1995, Journal of immunology.

Role of protein synthesis and CD11/CD18 adhesion complex in neutrophil emigration into the lung.

J. Harlan, N. Kovach, C. Doerschuk, 1993, Experimental lung research.

NF-k B Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-a but Not to Interleukin-1 b or Lipopolysaccharide *

A. Karsan, M. Kay, Xianwu Li, 1999 .

Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear.

D. Liggitt, J. Paulson, J. Harlan, 1993, The Journal of clinical investigation.

Leukocyte-endothelial interactions and organ injury

S. Sharar, J. Harlan, R. Winn, 1994 .

Harlan’s Dissent: Citizenship, Education, and the Color-Conscious Constitution

J. Harlan, Harlan’s Dissent, 2020 .

Fibroblast and endothelial apoptosis in systemic sclerosis

K. Elkon, J. Jun, M. Kuechle, 2003, Current opinion in rheumatology.

Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats.

R Winn, J. Relton, K. Becker, 2001, Stroke.

Antibody to the α4 Integrin Decreases Infarct Size in Transient Focal Cerebral Ischemia in Rats

J. Relton, K. Becker, J. Harlan, 2001 .

Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis.

J. Harlan, W. Mileski, C. Rice, 1991, Surgery.

Mechanisms and Consequences of Leukocyte Adhesion

S. Sharar, J. Harlan, W. Mileski, 1993 .

Monoclonal antibodies to leukocyte and endothelial adhesion molecules attenuate ischemia-reperfusion injury.

S. Sharar, J. Harlan, N. Vedder, 1993, Behring Institute Mitteilungen.

The role of adhesion molecules in reperfusion injury.

J. Harlan, N. Vedder, L. Langdale, 1993, Agents and actions. Supplements.

Association Between HIV Infection and Cancer Stage at Presentation at the Uganda Cancer Institute

J. Orem, J. Harlan, W. Phipps, 2017, Journal of global oncology.

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

J. Harlan, R K Winn, J M Harlan, 1993, The Journal of clinical investigation.

Neutrophil Adhesion Molecule Expression Is Comparable in Perinatal Rabbits and Humans

S. Sharar, J. Harlan, C. Ramamoorthy, 1997, Anesthesiology.

Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen.

S. Nourshargh, T. Williams, P. Jose, 1989, Journal of immunology.

Amos Etzioni, J. Harlan, C. Doerschuk, 2000, Advances in experimental medicine and biology.

Measurement of plasma fibronectin in patients who develop the adult respiratory distress syndrome.

P. Pepe, R. Maunder, L. Hudson, 1984, The Journal of laboratory and clinical medicine.

Bronchial brush biopsy in Hodgkin's disease.

N. Gross, J. Harlan, J. Fennessy, 1974, Chest.

Endotoxin-induced interactions of inflammatory cells with the lungs

S. Sharar, J. Harlan, R. Winn, 1994 .

Blocking of up-regulated ICAM-1 does not prevent macrophage infiltration during Wallerian degeneration of peripheral nerve

M. Kliot, S. Sharar, A. Avellino, 2004, Experimental Neurology.

A glycolipid precursor of bacterial lipopolysaccharide (lipid X) lacks activity against endothelial cells in vitro and is not toxic in vivo.

R. Maier, T. Pohlman, J. Harlan, 1988, The Journal of surgical research.

The Role of β2-Leukocyte Integrins In Vivo

S. Sharar, J. Harlan, N. Vedder, 1993 .

Neutrophil-mediated vascular injury in shock and multiple organ failure.

J. Harlan, N. Vedder, C. Rice, 1989, Progress in clinical and biological research.

Leukocyte adhesion deficiency (LAD) II.

J. Paulson, Amos Etzioni, J. Harlan, 1995, Ciba Foundation symposium.

Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury.

G. Striker, L. Harker, J. Harlan, 1980, Thrombosis research.

Modulation of endothelial cell apoptosis: mechanisms and pathophysiological roles.

A. Karsan, J. Harlan, J. Harlan, 1996, Journal of atherosclerosis and thrombosis.

Leukocyte-endothelial interactions and organ injury: the role of adhesion molecules.

S. Sharar, J. Harlan, R. Winn, 1994, New horizons.

In vivo neutrophil and lymphocyte function studies in a patient with leukocyte adhesion deficiency type II.

A Etzioni, H. Ochs, R. Gershoni-baruch, 1994, Blood.

P-selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits.

S. Sharar, J. Paulson, J. Harlan, 1993, Journal of immunology.

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

G. Striker, L. Harker, J. Harlan, 1981, The Journal of clinical investigation.

L-selectin (CD62L) blockade does not impair peritoneal neutrophil emigration or subcutaneous host defense to bacteria in rabbits.

S. Sharar, T. Tedder, N. Chapman, 1996, Journal of immunology.

Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.

R. Locksley, B. Aggarwal, H. Shepard, 1987, Journal of immunology.

Membrane glycoproteins of neutrophils and related diseases.

G. Ricevuti, A. Mazzone, J. Harlan, 1988, Haematologica.

Leukocyte?Endothelial Cell Interactions in Ischemia-Reperfusion Injury

S. Sharar, J. Harlan, N. Vedder, 1997 .

PILOT PHASE 2 CLINICAL TRIAL OF A HUMANIZED CD11/CD18 MONOCLONAL ANTIBODY IN HEMORRHAGIC SHOCK: 659

M. Copass, S. Heckbert, R. Maier, 1997 .

A monoclonal antibody that blocks neutrophil adherence improves survival from hemorrhagic shock in rabbits

J. Harlan, N. Vedder, C. Rice, 1987 .

Mechanisms of Neutrophil Emigration

J. Harlan, C. Doerschuk, R. Winn, 1990 .

Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1.

D. Willerford, J. Harlan, P. Chuang, 2002, Blood.

The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials.

J. Harlan, N. Vedder, A. Iwata, 2002, Blood.

Expression of vascular cell adhesion molecule-1 in kidney allograft rejection.

C. Alpers, C. Benjamin, K. Hudkins, 1993, Kidney international.

Inhibition of leukocyte adherence and aggregation for treatment of severe cold injury in rabbits.

J. Harlan, W. Mileski, C. Rice, 1993, Journal of applied physiology.