K. Frydenvang

T. Liljefors, C. Larsen, K. Frydenvang, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Structure − Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist ( 2 S , 3 R ) ‐ 3-( 3-Carboxyphenyl ) pyrrolidine-2-carboxylic Acid

J. Kastrup, L. Bunch, D. Pickering, 2015 .

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidin

J. Kastrup, L. Bunch, D. Bowie, 2017, Journal of medicinal chemistry.

L‐Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand‐binding domain

J. Kastrup, M. Gajhede, C. Krintel, 2014, The FEBS journal.

Structural and Pharmacological Characterization of Phenylalanine‐Based AMPA Receptor Antagonists at Kainate Receptors

J. Kastrup, D. Pickering, K. Frydenvang, 2012, ChemMedChem.

Kainate induces various domain closures in AMPA and kainate receptors

J. Kastrup, M. Gajhede, K. Frydenvang, 2012, Neurochemistry International.

A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure.

Elena Frola, J. Kastrup, Z. Serafimoska, 2011, Journal of medicinal chemistry.

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

Irina S. Moreira, Harel Weinstein, S. Brøgger Christensen, 2010, Organic & biomolecular chemistry.

Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications.

T. O. Larsen, M. Munro, D. Overy, 2005, Mycological research.

Ionotropic Glutamate Receptors (iGluRs): Overview of iGluR2 ligand binding domain in complex with agonists and antagonists

Z. Serafimoska, L. Šuturkova, K. Frydenvang, 2011 .

epi-Neoxaline, a chemotaxonomic marker for Penicillium tulipae

T. O. Larsen, D. Overy, K. Frydenvang, 2006 .

Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C–H insertion

J. Kehler, K. Frydenvang, M. Begtrup, 2010 .

Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell.

T. Liljefors, C. Larsen, C. Cornett, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.

J. Kastrup, M. Gajhede, T. Gefflaut, 2012, Journal of structural biology.

Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.

J. Kastrup, M. Gajhede, L. Bunch, 2011, Journal of structural biology.

Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

Hans Bräuner-Osborne, P. Wellendorph, B. Frølund, 2008, Journal of medicinal chemistry.

Solid Forms of Amlodipine Besylate: Physicochemical, Structural, and Thermodynamic Characterization

J. Rantanen, A. Bond, A. Müllertz, 2010 .

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

O. Mirza, D. Geerke, F. Jørgensen, 2019, PloS one.

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2003, The Journal of organic chemistry.

The ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions.

J. Kastrup, Simone Brogi, S. Gemma, 2020, ACS chemical neuroscience.

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

J. Kastrup, D. Bowie, K. Frydenvang, 2019, Neuron.

Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.

J. Kastrup, T. S. Thorsen, A. Pinto, 2017, ACS chemical neuroscience.

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

L. Danober, P. Lestage, J. Kastrup, 2016, ACS Chemical Neuroscience.

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain.

J. Kastrup, M. Gajhede, C. Krintel, 2013, Acta crystallographica. Section D, Biological crystallography.

New Analogues of Epiboxidine Incorporating the 4,5‐Dihydroisoxazole Nucleus: Synthesis, Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors, and Molecular Modeling Investigations

Giovanni Grazioso, Clelia Dallanoce, Cecilia Gotti, 2009, Chemistry & biodiversity.

Some transformations of tacrolimus, an immunosuppressive drug.

P. G. Nielsen, S. Hansen, J. Jaroszewski, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Bioorganic & medicinal chemistry.

Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues.

J. Kastrup, R. Clausen, D. Pickering, 2016, Journal of medicinal chemistry.

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

L. Olsen, J. Kastrup, K. Frydenvang, 2015, Neuroscience.

A perdeuterated cryoprotectant for neutron studies and a demonstration of its use for neutron powder diffraction on l-(−)-ephedrine hemihydrate

F. Krebs, M. Jørgensen, K. Frydenvang, 2001 .

Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

A. Kristensen, R. Clausen, D. Pickering, 2014, Neurochemical Research.

Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.

M. Sehested, S. Nielsen, P. B. Jensen, 2010, Journal of medicinal chemistry.

Plant analysis by butterflies: occurrence of cyclopentenylglycines in Passifloraceae, Flacourtiaceae, and Turneraceae and discovery of the novel nonproteinogenic amino acid 2-(3'-cyclopentenyl)glycine in Rinorea.

J. Jaroszewski, L. B. Jørgensen, K. Frydenvang, 2002, Journal of natural products.

Structural characterisation and dehydration behaviour of siramesine hydrochloride.

J. Rantanen, F. Tian, L. Hovgaard, 2009, Journal of pharmaceutical sciences.

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.

L. Olsen, J. Kastrup, C. Krintel, 2016, Journal of medicinal chemistry.

Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

A. Kristensen, R. Clausen, D. Pickering, 2014, Neurochemical Research.

Molecular Recognition of Two 2,4‐syn‐Functionalized (S)‐Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain

J. Kastrup, M. Gajhede, T. Gefflaut, 2014, ChemMedChem.

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.

P. Krogsgaard‐Larsen, K. Frydenvang, U. Madsen, 2001, Chirality.

Stereospecific GABAB Receptor Antagonism

U. Kristiansen, P. Krogsgaard‐Larsen, B. Frølund, 1996 .

Structures of two ribonucleotide reductase inhibitors: 1-hydroxy-1-methylurea and 1-hydroxy-3-methylurea

K. Frydenvang, I. K. Larsen, B. B. Nielsen, 1993 .

A tetrazolyl-substituted subtype-selective AMPA receptor agonist.

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2007, Journal of medicinal chemistry.

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine*

R. Sakai, P. Naur, J. Kastrup, 2009, Journal of Biological Chemistry.

Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Chirality.

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.

P. Krogsgaard‐Larsen, B. Bang-Andersen, K. Frydenvang, 2000, Chirality.

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.

J. Kastrup, B. Pirotte, S. Laulumaa, 2018, ACS medicinal chemistry letters.

Structural Features of ATPA and Thio-ATPA—Potent and Selective GluR5 Receptor Agonists. Crystal Structure Determinations and Quantum Chemical Calculations

Jeremy R. Greenwood, J. Greenwood, K. Frydenvang, 2002 .

Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by X-ray crystallography and ab initio calculations

T. Liljefors, P. Krogsgaard‐Larsen, J. Jaroszewski, 1997 .

N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

P. Krogsgaard‐Larsen, K. Frydenvang, U. Madsen, 1996, Journal of medicinal chemistry.

Structure of Cytochrome P450 BM3 M11 mutant in complex with DTT at resolution 2.16A

O. Mirza, D. Geerke, F. Jørgensen, 2019 .

UV-guided screening of benzodiazepine producing species in Penicillium.

J. Frisvad, K. Frydenvang, Frydenvang, 2000, Biochemical systematics and ecology.

Molecular Recognition of Two 2,4‐syn‐Functionalized (S)‐Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain

J. Kastrup, M. Gajhede, T. Gefflaut, 2014, ChemMedChem.

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.

J. Kastrup, M. Gajhede, T. Gefflaut, 2012, Journal of structural biology.

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2010, Journal of medicinal chemistry.

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

L. Danober, J. Kastrup, D. Pickering, 2023, bioRxiv.

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

J. Kastrup, D. Bowie, K. Frydenvang, 2019, Neuron.

Small molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: Development of screening assays and insight into GluK3 structure

P. Biggin, J. Kastrup, M. Gajhede, 2023, bioRxiv.

The positive allosteric modulator BPAM344 and L‐glutamate introduce an active‐like structure of the ligand‐binding domain of GluK2

J. Kastrup, D. Pickering, K. Frydenvang, 2024, FEBS letters.

Discovery and Structure–Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists

K. Frydenvang, G. Smits, Emil M Ro Rsted, 2024, Journal of medicinal chemistry.

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538

J. Kastrup, D. Pickering, K. Frydenvang, 2023, bioRxiv.

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation.

Ming Chen, L. Zhai, S. Christensen, 2016, European journal of medicinal chemistry.