K. Madauss

发表

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

I. McLay, Shawn P. Williams, I. Uings, 2009, Proceedings of the National Academy of Sciences.

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

M. Lambert, I. McLay, Shawn P. Williams, 2004, Journal of medicinal chemistry.

Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP).

R. A. Reid, M. Hanlon, A. Hassell, 2008, Bioorganic & medicinal chemistry letters.

Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes

Lionel Urán Landaburu, Fernán Agüero, Joel Karpiak, 2017, Scientific Reports.

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.

I. McLay, Shawn P. Williams, I. Uings, 2008, Bioorganic & medicinal chemistry letters.

Generation and Characterization of Human Steroidogenic Factor 1 LBD Crystals with and without Bound Cofactor Peptide

Shawn P. Williams, G. Waitt, K. Madauss, 2004, Endocrine research.

Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

G. Drewes, S. O. Siri, V. Gottifredi, 2022, bioRxiv.

NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia

A. Hidalgo-Miranda, J. Mejía-Aranguré, D. A. Duarte-Rodríguez, 2022, Frontiers in Oncology.

Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.

C. Duraiswami, N. Laping, Shawn P. Williams, 2009, Bioorganic & medicinal chemistry letters.

The evolution of progesterone receptor ligands

Shawn P. Williams, E. Stewart, K. Madauss, 2007, Medicinal research reviews.

2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.

C. Duraiswami, Yonghui Wang, T. Graybill, 2009, Bioorganic & medicinal chemistry letters.

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists.

Shawn P. Williams, S. Thompson, E. Stewart, 2005, Bioorganic & medicinal chemistry letters.

FXR agonist activity of conformationally constrained analogs of GW 4064.

Shawn P. Williams, D. Parks, K. Madauss, 2009, Bioorganic & medicinal chemistry letters.

Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.

G. Drewes, V. Gottifredi, G. Soria, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

G. Drewes, V. Gottifredi, M. Federico, 2019, Clinical Cancer Research.

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

M. C. Llorens, V. Gottifredi, S. Mansilla, 2019, Oncogene.

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.

R. A. Reid, M. Head, E. Baloglu, 2013, Nature chemical biology.

Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1

T. Willson, R. Fletterick, R. Guy, 2005, Cell.

Aberrant O-glycosylation modulates aggressiveness in neuroblastoma

D. Alonso, F. Lubieniecki, V. Segatori, 2018, Oncotarget.

A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor*[boxs]

Timothy M Willson, Shawn P Williams, Kenneth H Pearce, 2005, Journal of Biological Chemistry.

Crystallization of protein–ligand complexes

Lisa M. Shewchuk, L. Shewchuk, W. Rocque, 2006, Acta crystallographica. Section D, Biological crystallography.

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.

Shawn P Williams, N. Laping, Shawn P. Williams, 2007, Molecular endocrinology.

Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

K. Madauss, K. Hance, F. Goldbaum, 2020, Journal for immunotherapy of cancer.

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2011, Bioorganic & medicinal chemistry letters.

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2009, Bioorganic & medicinal chemistry letters.

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.

Shawn P. Williams, S. Short, T. Consler, 2009, Acta crystallographica. Section D, Biological crystallography.

Structure of neurolysin reveals a deep channel that limits substrate access

D. Rodgers, W. Tolbert, K. Madauss, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Improving the developability profile of pyrrolidine progesterone receptor partial agonists.

C. Duraiswami, N. Laping, Shawn P. Williams, 2010, Bioorganic & medicinal chemistry letters.

Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.

G. B. Wisely, Shawn P. Williams, D. Parks, 2011, Bioorganic & medicinal chemistry letters.

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2008, Bioorganic & medicinal chemistry letters.