R. Jankov

发表

Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.

A. Tanswell, Jun Li, Azhar Masood, 2015, American journal of physiology. Lung cellular and molecular physiology.

Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD.

A. Tanswell, R. Auten, E. Benner, 2017, American journal of physiology. Lung cellular and molecular physiology.

Preview : Published ahead of advance online publication Controversies in the identification and management of acute pulmonary hypertension in preterm neonates

P. McNamara, Amish Jain, R. Jankov, 2017 .

Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs).

A. Tanswell, M. Tsai, S. Tsai, 2002, American Journal of Respiratory Cell and Molecular Biology.

Multiplexed single-cell transcriptomic analysis of normal and impaired lung development in the mouse

B. Vanderhyden, B. Thébaud, M. Heikinheimo, 2019, bioRxiv.

Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling.

Amish Jain, Crystal Kantores, R. Jankov, 2016, American journal of physiology. Lung cellular and molecular physiology.

Effect of inhaled oxygen concentration on 129Xe chemical shift of red blood cells in rat lungs

A. Kassner, G. Santyr, B. Zanette, 2021, Magnetic resonance in medicine.

Multicentre prospective observational study exploring the predictive value of functional echocardiographic indices for early identification of preterm neonates at risk of developing chronic pulmonary hypertension secondary to chronic neonatal lung disease

P. McNamara, L. Mertens, A. El-Khuffash, 2021, BMJ Open.

8-Isoprostane-induced endothelin-1 production by infant rat pulmonary artery smooth muscle cells is mediated by Rho-kinase.

A. Tanswell, R. Belcastro, Crystal Kantores, 2006, Free radical biology & medicine.

Neutrophil elastase-induced elastin degradation mediates macrophage 1 influx and lung injury in 60 % O 2-exposed neonatal rats 2 3 [ L-00298-2014-R 1 ]

A. Tanswell, Jun Li, Azhar Masood, 2015 .

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60 % O 2-exposed neonatal rats

A. Tanswell, Jun Li, Azhar Masood, 2015 .

Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile rats.

P. McNamara, K. Connelly, Amish Jain, 2014, Free radical biology & medicine.

Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle.

R. Belcastro, Crystal Kantores, R. Jankov, 2013, Free radical biology & medicine.

Antioxidants as Therapy in the Newborn: Some Words of Caution

A. Tanswell, R. Jankov, A. Negus, 2001, Pediatric Research.

Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α.

P. McNamara, A. Tanswell, A. Sewing, 2012, American journal of physiology. Lung cellular and molecular physiology.

Pulmonary Hypertension in Chronic Neonatal Lung Disease: Mechanisms and Targets

A. Tanswell, R. Jankov, 2018 .

Sodium nitrite augments lung S-nitrosylation and reverses chronic hypoxic pulmonary hypertension in juvenile rats.

Amish Jain, Crystal Kantores, R. Jankov, 2018, American journal of physiology. Lung cellular and molecular physiology.

Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat.

A. Tanswell, R. Jankov, J. Belik, 2004, Free radical biology & medicine.

Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats.

P. McNamara, A. Tanswell, Crystal Kantores, 2010, Free radical biology & medicine.

Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.

P. McNamara, K. Connelly, Amish Jain, 2014, American journal of respiratory cell and molecular biology.

A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores.

P. McNamara, F. Dallaire, K. Connelly, 2014, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury.

Amish Jain, Crystal Kantores, R. Jankov, 2016, American journal of physiology. Lung cellular and molecular physiology.

Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

P. McNamara, B. Kavanagh, Crystal Kantores, 2010, American journal of physiology. Heart and circulatory physiology.

Characterization of a New Monocrotaline Rat Model to Study Chronic Neonatal Pulmonary Hypertension.

B. Thébaud, S. Zhong, R. Jankov, 2021, American journal of respiratory cell and molecular biology.

Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide.

P. McNamara, B. Kavanagh, Crystal Kantores, 2008, American journal of physiology. Lung cellular and molecular physiology.

Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats.

Crystal Kantores, R. Jankov, J. Belik, 2008, American journal of physiology. Lung cellular and molecular physiology.

ment of pulmonary hypertension and vascular remodeling in newborn rats chronically exposed from birth to moderate normobaric hypoxia

P. McNamara, B. Kavanagh, Crystal Kantores, 2006 .

Inhibition of apoptosis by 60% oxygen: a novel pathway contributing to lung injury in neonatal rats.

A. Tanswell, Jun Li, Azhar Masood, 2011, American journal of physiology. Lung cellular and molecular physiology.

A peroxynitrite decomposition catalyst prevents 60% O2-mediated rat chronic neonatal lung injury.

A. Tanswell, Jun Li, Azhar Masood, 2010, Free radical biology & medicine.

Endothelin-1 and O2-Mediated Pulmonary Hypertension in Neonatal Rats: A Role for Products of Lipid Peroxidation

A. Tanswell, H. Frndova, S. Lye, 2000, Pediatric Research.

Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation.

P. McNamara, M. Letarte, Crystal Kantores, 2013, American journal of respiratory cell and molecular biology.

Chronic O2 exposure enhances vascular and airway smooth muscle contraction in the newborn but not adult rat.

A. Tanswell, R. Jankov, J. Belik, 2003, Journal of applied physiology.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Arginase inhibition prevents bleomycin-induced pulmonary hypertension , vascular remodeling , and collagen deposition in neonatal rat lungs

P. McNamara, H. Grasemann, Crystal Kantores, 2015 .

Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.

J. Mancini, P. Hardy, X. Hou, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Long-term follow-up of cardiorespiratory outcomes in children born extremely preterm: Recommendations from a Canadian consensus workshop.

K. Adamo, B. Thébaud, A. Nuyt, 2017, Paediatrics & child health.

Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats.

P. McNamara, P. Backx, Crystal Kantores, 2010, Free radical biology & medicine.

Chronic O2 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostane.

A. Tanswell, M. Yi, R. Jankov, 2004, Journal of applied physiology.

altered smooth muscle response to isoprostane decreased pulmonary arterial nitric oxide release and exposure in the newborn rat results in

Jullie W Pan, A. Tanswell, S. Wedgwood, 2015 .

Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats.

P. McNamara, B. Kavanagh, Amish Jain, 2012, American journal of physiology. Heart and circulatory physiology.

Changes in Expression of Platelet-Derived Growth Factor and Its Receptors in the Lungs of Newborn Rats Exposed to Air or 60% O2

A. Tanswell, M. Post, S. Lye, 2000, Pediatric Research.

adult rat smooth muscle contraction in the newborn but not exposure enhances vascular and airway

Jullie W Pan, A. Tanswell, Richard J Martin, 2015 .

Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium.

A. Tanswell, M. Yi, R. Jankov, 2003, Journal of applied physiology.

Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism.

A. Tanswell, S. Lye, R. Belcastro, 2002, American journal of respiratory and critical care medicine.

Growth factors, postnatal lung growth and bronchopulmonary dysplasia.

R. Jankov, A. Keith Tanswell, 2004, Paediatric respiratory reviews.

Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.

A. Tanswell, M. Post, R. Auten, 2004, American journal of respiratory and critical care medicine.

Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat.

H. Grasemann, Crystal Kantores, R. Jankov, 2009, American journal of physiology. Lung cellular and molecular physiology.

Lgl1 Is Suppressed in Oxygen Toxicity Animal Models of Bronchopulmonary Dysplasia and Normalizes During Recovery in Air

A. Tanswell, R. Jankov, N. Sweezey, 2006, Pediatric Research.

Endothelin-1 Inhibits Apoptosis of Pulmonary Arterial Smooth Muscle in the Neonatal Rat

A. Tanswell, M. Yi, R. Belcastro, 2006, Pediatric Research.

Bronchial epithelium-associated pulmonary arterial muscle relaxation in the rat is absent in the fetus and suppressed by postnatal hypoxia.

A. Tanswell, R. Jankov, J. Belik, 2005, American journal of physiology. Lung cellular and molecular physiology.

Vascular Remodeling Protects against Ventilator-induced Lung Injury in the In Vivo Rat

C. Ackerley, P. McNamara, M. Post, 2008, Anesthesiology.

Bronchopulmonary dysplasia: one disease or two?

A. Tanswell, R. Jankov, 2003, American journal of respiratory and critical care medicine.

Cardiac Function and Ventricular Interactions in Persistent Pulmonary Hypertension of the Newborn.

P. McNamara, L. Mertens, A. El-Khuffash, 2020, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury.

C. McKerlie, J. Laffey, A. Tanswell, 2003, American journal of respiratory and critical care medicine.

Cyclooxygenase‐2 inhibition partially protects against 60% O2‐mediated lung injury in neonatal rats

A. Tanswell, Jun Li, Azhar Masood, 2014, Pediatric pulmonology.

A Critical Role for the IL-1 Receptor in Lung Injury Induced in Neonatal Rats by 60% O2

A. Tanswell, Jun Li, Azhar Masood, 2009, Pediatric Research.

Gadolinium Chloride Inhibits Pulmonary Macrophage Influx and Prevents O2-Induced Pulmonary Hypertension in the Neonatal Rat

A. Tanswell, M. Post, H. Frndova, 2001, Pediatric Research.

mTOR‐Notch3 signaling mediates pulmonary hypertension in hypoxia‐exposed neonatal rats independent of changes in autophagy

M. Post, B. Yeganeh, Amish Jain, 2017, Pediatric pulmonology.

Effects of Rho-Kinase Inhibition on Pulmonary Hypertension, Lung Growth, and Structure in Neonatal Rats Chronically Exposed to Hypoxia

P. McNamara, A. Tanswell, R. Belcastro, 2010, Pediatric Research.

hypertension unresponsive to nitric oxide Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary

P. McNamara, A. Tanswell, R. Belcastro, 2008 .

A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling.

A. Tanswell, M. Post, R. Belcastro, 2005, American journal of physiology. Lung cellular and molecular physiology.

A role for platelet-derived growth factor -receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling

A. Tanswell, M. Post, R. Belcastro, 2005 .

A role for platelet-derived growth factor (cid:1) -receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling

A. Tanswell, M. Post, R. Belcastro, 2005 .

Cardiopulmonary Adaptation During First Day of Life in Human Neonates

P. McNamara, B. Kavanagh, L. Mertens, 2018, The Journal of pediatrics.

pulmonary vascular tone in the newborn rat A bronchial epithelium-derived factor reduces

Jullie W Pan, A. Tanswell, P. Vanhoutte, 2015 .

Vascular Tone in the Newborn Rat a Bronchial Epithelium-derived Factor Reduces Pulmonary

A. Tanswell, R. Jankov, J. Belik, 2003 .

Lipid hydroperoxide formation regulates postnatal rat lung cell apoptosis and alveologenesis.

Jun Li, Azhar Masood, R. Belcastro, 2013, Free radical biology & medicine.

Sex-dependent changes in the pulmonary vasoconstriction potential of newborn rats following short-term oxygen exposure

M. Enomoto, M. Vento, R. Jankov, 2012, Pediatric Research.

The IGF-I/IGF-R1 pathway regulates postnatal lung growth and is a nonspecific regulator of alveologenesis in the neonatal rat.

A. Tanswell, Jun Li, Azhar Masood, 2013, American journal of physiology. Lung cellular and molecular physiology.

Impact of Stewardship on Inhaled Nitric Oxide Utilization in a Neonatal ICU.

R. Jankov, K. More, A. Elmekkawi, 2016, Hospital pediatrics.

Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse.

A. Tanswell, R. Jankov, Xiaoping Luo, 2002, The Journal of pharmacology and experimental therapeutics.

Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage

B. Vanderhyden, B. Thébaud, M. Heikinheimo, 2021, Nature Communications.

All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2

V. Natarajan, D. Arbach, R. Jankov, 2015, PloS one.

arterial wall tension are not endothelium dependent on pulmonary 2 Effects of changes in pH and CO

H. Ghofrani, N. Weissmann, F. Grimminger, 2015 .

Hypercapnia and the neonate

R. Jankov, A. K. Tanswell, 2008, Acta paediatrica.

Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat.

P. McNamara, B. Kavanagh, Crystal Kantores, 2006, American journal of physiology. Lung cellular and molecular physiology.

Care of the critically ill neonate with hypoxemic respiratory failure and acute pulmonary hypertension: framework for practice based on consensus opinion of neonatal hemodynamics working group

P. McNamara, Y. Elsayed, J. Ting, 2022, Journal of Perinatology.

Chemical shift of 129Xe dissolved in red blood cells: Application to a rat model of bronchopulmonary dysplasia

A. Kassner, G. Santyr, B. Zanette, 2019, Magnetic resonance in medicine.

Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats.

P. McNamara, A. Tanswell, B. Kavanagh, 2009, American journal of physiology. Lung cellular and molecular physiology.

Hepatocyte growth factor is required for alveologenesis in the neonatal rat.

A. Tanswell, M. Yi, R. Belcastro, 2005, American journal of respiratory and critical care medicine.

Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen.

A. Tanswell, H. Frndova, S. Lye, 2003, American journal of respiratory and critical care medicine.

Macrophages as a major source of oxygen radicals in the hyperoxic newborn rat lung.

A. Tanswell, B. Robinson, R. Jankov, 2003, Free radical biology & medicine.

Left Ventricular Function in Healthy Term Neonates During the Transitional Period

P. McNamara, K. Connelly, L. Mertens, 2017, The Journal of pediatrics.

A Stewardship Program to Optimize the Use of Inhaled Nitric Oxide in Pediatric Critical Care

P. Laussen, R. Jankov, Christina Sperling, 2018, Quality management in health care.

A Critical Role for Fibroblast Growth Factor-7 during Early Alveolar Formation in the Neonatal Rat

A. Tanswell, Azhar Masood, M. Yi, 2008, Pediatric Research.

Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension

J. Fish, M. Al-Omran, S. Verma, 2017, Molecular and Cellular Biochemistry.

Variation in the Management of Persistent Pulmonary Hypertension of the Newborn: A Survey of Physicians in Canada, Australia, and New Zealand

P. McNamara, M. Kluckow, R. Jankov, 2012, American Journal of Perinatology.

Hypocapnia attenuates mesenteric ischemia-reperfusion injury in a rat model

A. Tanswell, B. Kavanagh, G. Hare, 2005, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators.

P. McNamara, Amish Jain, M. Enomoto, 2014, American Journal of Physiology - Lung cellular and Molecular Physiology.

Coinfusion of dextrose‐containing fluids and red blood cells does not adversely affect in vitro red blood cell quality

J. Acker, J. Callum, A. Keir, 2014, Transfusion.

Is it safe to co‐infuse dextrose‐containing fluids with red blood cells?

J. Callum, A. Keir, R. Jankov, 2013, Journal of paediatrics and child health.

Oxygen-mediated parenchymal and vascular lung injury

A. Tanswell, R. Jankov, N. Qin, 2002 .

Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension

Laura E. Mantella, M. Al-Omran, Crystal Kantores, 2017, Molecular and Cellular Biochemistry.

Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

P. McNamara, B. Kavanagh, Crystal Kantores, 2010, American journal of physiology. Heart and circulatory physiology.

Oh NO! Loss of PHD2 leads to “radical” changes in the lung vasculature

R. Jankov, D. Stewart, M. Ormiston, 2022, European Respiratory Journal.

Fractal Dimension Does Not Correlate As Well With Models of Neonatal Chronic Lung Injury as It Does With Placental Distal Villous Hypoplasia

A. Chan, D. Grynspan, R. Jankov, 2019, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.