A. Minchinton

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Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.

P. Hoodless, A. Karsan, J. Parker, 2019, Cell reports.

Drug penetration in solid tumours

I. Tannock, A. Minchinton, Ian F. Tannock, 2006, Nature Reviews Cancer.

A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation.

A. Karsan, J. Parker, C. Eaves, 2015, Microvascular research.

Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism.

A. Karsan, M. Fuller, Linda Chang, 2014, Cancer research.

Direct Assessment of Drug Penetration into Tissue Using a Novel Application of Three-Dimensional Cell Culture

A. Minchinton, A. Kyle, L. Huxham, 2004, Cancer Research.

Simultaneous pO2 and HbO2 measurement to determine absolute HbO2 concentration for in vivo near infrared spectroscopy

Andrew J. Macnab, Roy E. Gagnon, Faith A. Gagnon, 2003 .

Abstract A10: Combined blockade of VEGF and Ang2 promotes dramatic tumor necrosis and growth inhibition of colorectal cancer xenografts.

G. Thurston, A. Lalani, A. Minchinton, 2011 .

Targeting the Tumour Vasculature: Exploitation of Low Oxygenation and Sensitivity to NOS Inhibition by Treatment with a Hypoxic Cytotoxin

A. Minchinton, A. Kyle, J. Baker, 2013, PloS one.

Computerized histographic oxygen tension measurements of murine tumors.

J. Brown, D. Terris, A. Minchinton, 1992, Advances in experimental medicine and biology.

Multi-modal magnetic resonance imaging and histology of vascular function in xenografts using macromolecular contrast agent hyperbranched polyglycerol (HPG-GdF).

U. Häfeli, K. Saatchi, S. Reinsberg, 2016, Contrast media & molecular imaging.

SHIP represses the generation of alternatively activated macrophages.

A. Mui, G. Krystal, Victor W H Ho, 2005, Immunity.

Tissue Penetration and Activity of Camptothecins in Solid Tumor Xenografts

S. Reinsberg, A. Minchinton, A. Kyle, 2014, Molecular Cancer Therapeutics.

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

P. Sorensen, Yuzhuo Wang, S. McKinney, 2015, Cancer cell.

Carbogen Breathing after Irradiation Enhances the Effectiveness of Tirapazamine in SiHa Tumors but not SCCVII Tumors in Mice

A. Minchinton, A. Kyle, Danika A Tonn, 2002, Radiation research.

Effect of breathing carbogen on the oxygen tension of murine and human tumours measured using an Eppendorf pO2 histograph.

C. Aquino-Parsons, A. Minchinton, K. H. Fryer, 1999, Advances in experimental medicine and biology.

Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro.

D. Shrieve, J. Denekamp, A. Minchinton, 1984, Radiation research.

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition

S. Leung, H. Horlings, K. Gelmon, 2016, Oncotarget.

Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake.

B. Wouters, D. Acheson, L. Skarsgard, 1995, British Journal of Cancer.

In vivo Evaluation of Mucoadhesive Nanoparticulate Docetaxel for Intravesical Treatment of Non–Muscle-Invasive Bladder Cancer

M. Gleave, R. Liggins, D. Brooks, 2011, Clinical Cancer Research.

Tissue uptake of docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols and their effects on the morphology of the bladder urothelium.

M. Gleave, L. Fazli, R. Liggins, 2012, Biomaterials.

Irinophore C, a Novel Nanoformulation of Irinotecan, Alters Tumor Vascular Function and Enhances the Distribution of 5-Fluorouracil and Doxorubicin

M. Bally, A. Yung, P. Kozlowski, 2008, Clinical Cancer Research.

Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation

I. B. Borel Rinkes, O. Kranenburg, A. Minchinton, 2012, The British journal of surgery.

Loss of the Notch effector RBPJ promotes tumorigenesis

M. Robinson, W. Lam, M. Marra, 2014, The Journal of experimental medicine.

Multilayers of cells growing on a permeable support. An in vitro tumour model.

K. Clow, A. Minchinton, K. H. Fryer, 1997, Acta oncologica.

Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion.

J. Brown, H. Stone, A. Minchinton, 1992, International journal of radiation oncology, biology, physics.

The Prognostic Impact of CD163-Positive Macrophages in Follicular Lymphoma: A Study from the BC Cancer Agency and the Lymphoma Study Association

R. Gascoyne, D. Scott, G. Salles, 2015, Clinical Cancer Research.

Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.

Helen E. Burston, A. Minchinton, A. Kyle, 2003, Cancer research.

Evidence for intermittent radiobiological hypoxia in experimental tumour systems.

M. Trotter, D. Chaplin, A. Minchinton, 1989, Biomedica biochimica acta.

Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342.

D. Chaplin, A. Minchinton, R. Durand, 1990, British Journal of Cancer.

Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models.

B. S. Sørensen, J. Overgaard, J. Alsner, 2014, Anticancer research.

Clinical experience with nitroimidazoles as radiosensitizers.

S. Dische, M. Stratford, A. Minchinton, 1982, International journal of radiation oncology, biology, physics.

Notch-Dependent Regulation of the Ischemic Vasodilatory Response—Brief Report

A. Karsan, I. Laher, Alex C Y Chang, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro.

G. Hahn, A. Koong, A. Giaccia, 1992, International journal of radiation oncology, biology, physics.

Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration

M. Gold, C. Roskelley, M. Gold, 2011, PloS one.

The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.

S. Dische, M. Stratford, P. Riley, 1981, British Journal of Cancer.

Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo.

J. Brown, M. Lemmon, A. Minchinton, 1992, International journal of radiation oncology, biology, physics.

A serial study of the concentration of misonidazole in human tumors correlated with histologic structure.

T. Rich, S. Dische, M. Stratford, 1981, International journal of radiation oncology, biology, physics.

A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice.

M. Stratford, A. Minchinton, 1986, International journal of radiation oncology, biology, physics.

In vivo assessment of basic 2-nitroimidazole radiosensitizers.

M. Williams, J. Denekamp, M. Stratford, 1982, British Journal of Cancer.

The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.

S. Dische, M. Stratford, A. Minchinton, 1984, International journal of radiation oncology, biology, physics.

Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation.

A. Minchinton, A. Kyle, M. Gandolfo, 2016, Advances in experimental medicine and biology.

Carbogen inhalation in cervical cancer: assessment of oxygenation change.

C. Aquino-Parsons, A. Minchinton, P. Lim, 1999, Gynecologic oncology.

Differential toxicity of methylglyoxal‐bis[guanylhydrazone]

M. Stratford, A. Minchinton, D. L. Dewey, 1983, The Journal of pathology.

Spatial characterization of glutathione depletion in the KHT sarcoma using flow cytometry.

D. Chaplin, A. Minchinton, 1991, International journal of radiation biology.

Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.

J. Brown, A. Minchinton, J. Brown, 1992, British Journal of Cancer.

Effect of glutathione depletion on radiosensitivity in vivo

J. Soranson, J. Denekamp, K. Smith, 1984 .

In vivo testing of a 2-nitroimidazole radiosensitizer (Ro 03-8799) using repeated administration.

M. Williams, J. Denekamp, M. Stratford, 1982, International Journal of Radiation Oncology, Biology, Physics.

Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo.

F. Stewart, J. Denekamp, M. Stratford, 1982, British Journal of Cancer.

Improving the effectiveness of the bioreductive antitumor agent SR 4233 by induced hypoxia.

J. Brown, A. Minchinton, J. Brown, 1992, Advances in experimental medicine and biology.

Radiosensitization of a mouse tumour by Ro 03-8799: acute and protracted administration.

J. Fowler, J. Denekamp, M. Stratford, 1983, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233.

A. Giaccia, J. Brown, A. Minchinton, 1992, International journal of radiation oncology, biology, physics.

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

S. Leung, A. Oloumi, B. Clarke, 2011, Cancer research.

Exploring vascular dysfunction caused by tirapazamine.

A. Minchinton, A. Kyle, J. Baker, 2008, Microvascular research.

Reduction of nitroimidazoles in model chemical and biological systems.

E. Clarke, M. Stratford, P. Wardman, 1982, International journal of radiation oncology, biology, physics.

A drug for improved radiosensitization in radiotherapy.

J. Fowler, S. Dische, M. Stratford, 1980, British Journal of Cancer.

Pharmacokinetic Studies on Some Novel (2-Nitro-1-Imidazolyl) Propanolamine Radiosensitizers

F. Stewart, M. Stratford, A. Minchinton, 1982 .

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.

B. Nelson, M. Bally, G. Krystal, 2011, Cancer research.

Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase.

M. Marra, P. Hoodless, A. Karsan, 2011, Developmental cell.

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

S. C. Chafe, A. Bashashati, S. Shah, 2019, Cancer Immunology Research.

The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity

K. Gelmon, M. Bally, D. Masin, 2011, BMC Cancer.

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.

Alastair H Kyle, Gavin Thurston, G. Yancopoulos, 2013, Cancer research.

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)

D. Huntsman, S. Dedhar, M. Bally, 2008, Molecular Cancer Therapeutics.

Glutathione depletion in tissues after administration of buthionine sulphoximine.

D. Shrieve, J. Soranson, K. Smith, 1984, International journal of radiation oncology, biology, physics.

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth

C. Scudamore, D. Owen, A. Buczkowski, 2016, Angiogenesis.

Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma

C. Scudamore, D. Owen, A. Buczkowski, 2010, British Journal of Cancer.

Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model

M. Bally, A. Minchinton, A. Kyle, 2021, International journal of molecular sciences.

Targeting quiescent tumor cells via oxygen and IGF-I supplementation.

Alastair H Kyle, A. Minchinton, Andrew I Minchinton, 2012, Cancer research.

Vascularization predicts overall survival and risk of transformation in follicular lymphoma

R. Gascoyne, J. Connors, P. Farinha, 2010, Haematologica.

Decreased levels of hypoxic cells in gefitinib treated ER+ HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with rapamycin

K. Gelmon, M. Bally, M. Verreault, 2007, Breast Cancer Research and Treatment.

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

Alastair H Kyle, A. Minchinton, Andrew I Minchinton, 2008, Clinical Cancer Research.

Limited Tissue Penetration of Taxanes: A Mechanism for Resistance in Solid Tumors

Alastair H Kyle, A. Minchinton, Andrew I Minchinton, 2007, Clinical Cancer Research.

A report on misonidazole in randomized trial in locally advanced head and neck cancer.

M. Stratford, A. Minchinton, R. Sealy, 1982, International journal of radiation oncology, biology, physics.

Drug Penetration and Therapeutic Resistance

A. Minchinton, A. Kyle, 2010 .

The Impact of Complement Activation on Tumor Oxygenation During Photodynamic Therapy †

Mladen Korbelik, Ivana Cecic, M. Korbelik, 2007, Photochemistry and photobiology.

The hypoxic cytotoxin SR 4233 increases the effectiveness of radioimmunotherapy in mice with human non-Hodgkin's lymphoma xenografts.

M. Goris, E. Waller, S. Knox, 1994, International journal of radiation oncology, biology, physics.

Selective radiosensitization of hypoxic cells using BCCA621C: a novel hypoxia activated prodrug targeting DNA-dependent protein kinase

A. Minchinton, A. Kyle, G. Winters, 2013 .

The relative biological effectiveness of the modulated proton beam at TRIUMF.

K. Nemoto, A. Minchinton, G. Lam, 1998, Radiation medicine.

Desmethylmisonidazole (Ro 05-9963): clinical pharmacokinetics after multiple oral administration.

S. Dische, M. Stratford, A. Minchinton, 1982, International journal of radiation oncology, biology, physics.

Computerized histographic characterization of changes in tissue pO2 induced by erythropoietin.

D. Terris, A. Minchinton, 1994, Advances in experimental medicine and biology.

DEVELOPMENT OF A HYPOXIA ACTIVATED PRODRUG FOR THE SELECTIVE INHIBITION OF DNA-DEPENDENT PROTEIN KINASE by JORDAN DARICE CRAN

A. Minchinton, 2013 .

HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.

K. Gelmon, M. Bally, Yanping Hu, 2004, Molecular cancer research : MCR.

Cancer Therapy : Preclinical In vivo Evaluation of Mucoadhesive Nanoparticulate Docetaxel for Intravesical Treatment of Non – Muscle-Invasive Bladder Cancer

M. Gleave, R. Liggins, D. Brooks, 2011 .

Oxygen tension in primary gynaecological tumours: the influence of carbon dioxide concentration.

C. Aquino-Parsons, A. Minchinton, A. Green, 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Radiobiological effects of altering dose rate in filter-free photon beams

B Gill, V. Moiseenko, B. Gill, 2013, Physics in medicine and biology.

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors

B. Oronsky, J. Scicinski, P. Cabrales, 2016, Clinical Epigenetics.

Abstract 4371: RRx-001 modulates intratumor blood flow in SCCVII and U87 tumors

B. Oronsky, S. Knox, J. Scicinski, 2012 .

Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment

U. Häfeli, K. Saatchi, S. Reinsberg, 2018, Clinical & Experimental Metastasis.

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

A. Karsan, M. Noseda, D. Dumont, 2012, Proceedings of the National Academy of Sciences.

Microregional Effects of Gemcitabine in HCT-116 Xenografts

A. Minchinton, A. Kyle, J. Baker, 2004, Cancer Research.

Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model

A. Minchinton, A. Kyle, 1999, Cancer Chemotherapy and Pharmacology.

A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799.

S. Dische, M. Stratford, P. Wardman, 1986, The British journal of radiology.

Enhancement of misonidazole radiosensitization by buthionine sulphoximine.

J. Soranson, J. Denekamp, K. Smith, 1984, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.

S. Dische, M. Stratford, A. Minchinton, 1986, International journal of radiation oncology, biology, physics.

Measurements of glutathione and other thiols in cells and tissues: a simplified procedure based on the HPLC separation of monobromobimane derivatives of thiols.

A. Minchinton, 1984, International journal of radiation oncology, biology, physics.

Fast and sensitive dynamic oxygen‐enhanced MRI with a cycling gas challenge and independent component analysis

A. Yung, P. Kozlowski, S. Reinsberg, 2018, Magnetic resonance in medicine.

Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment

U. Häfeli, K. Saatchi, S. Reinsberg, 2018, Clinical & Experimental Metastasis.

Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts.

A. Minchinton, A. Kyle, J. Baker, 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

The effect of deep inspiration breath-hold on tumour oxygenation.

C. Ries, C. Aquino-Parsons, A. Minchinton, 2003, Clinical oncology (Royal College of Radiologists (Great Britain)).

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors

P. Cabrales, B. Oronsky, J. Scicinski, 2016, Clinical Epigenetics.

Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy.

C. T. Chan, Carmel T. Chan, A. Minchinton, 1999, Biophysical journal.

Pharmacokinetic studies using multiple administration of RO 03-8799, a 2-nitroimidazole radiosensitizer.

M. Williams, N. J. McNally, M. Stratford, 1982, International journal of radiation oncology, biology, physics.

The effect of thalidomide on experimental tumors and metastases

M. Hayes, K. Clow, A. Minchinton, 1996, Anti-cancer drugs.

Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay.

K. Lam, A. Minchinton, A. Kyle, 2006, Microvascular research.

Detecting vascular-targeting effects of the hypoxic cytotoxin tirapazamine in tumor xenografts using magnetic resonance imaging.

L. Bains, S. Reinsberg, A. Minchinton, 2009, International journal of radiation oncology, biology, physics.

Dosimetry with a clinical linac adapted to FLASH electron beams

S. Szpala, K. Kohli, A. Minchinton, 2021, Journal of applied clinical medical physics.

DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost

A. Minchinton, A. Kyle, J. Baker, 2023, Scientific reports.

The Prognostic Impact of CD163-Positive Macrophages in Follicular Lymphoma: A Study from the BC Cancer Agency and the Lymphoma Study Association

R. Gascoyne, D. Scott, G. Salles, 2015, Clinical Cancer Research.

The Prognostic Impact of Cd163-positive Macrophages in Follicular Lymphoma: a Study from the Bc Cancer Agency and the Lymphoma Study Association. Kridel Et Al Follicular Lymphoma-associated Macrophages Kridel Et Al Follicular Lymphoma-associated Macrophages

R. Gascoyne, L. Sehn, J. Connors, 2022 .

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

A. Karsan, M. Noseda, D. Dumont, 2012, Proceedings of the National Academy of Sciences.

Vascularization predicts overall survival and risk of transformation in follicular lymphoma

R. Gascoyne, J. Connors, P. Farinha, 2010, Haematologica.

DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors.

A. Minchinton, A. Kyle, J. Baker, 2024, DNA repair.