H. Brightbill

发表

TAZ is required for lung alveolar epithelial cell differentiation after injury.

J. Egen, Min Xu, A. Dey, 2019, JCI insight.

Quilizumab is an Afucosylated Humanized Anti-M1 Prime Therapeutic Antibody

M. Balázs, Lawren C. Wu, Y. Meng, 2014 .

The effects of c-Abl mutation on developing B cell differentiation and survival.

M. Schlissel, H. Brightbill, Mark Schlissel, 2009, International immunology.

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.

Jianwen A. Feng, Y. Ran, A. Zarrin, 2019, Journal of medicinal chemistry.

Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation

M. Balázs, Lawren C. Wu, Zhonghua Lin, 2015, The Journal of Immunology.

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses

Lawren C. Wu, Hongbo Hu, Shao-Cong Sun, 2016, Scientific Reports.

Host-tumor interaction in ovarian cancer. Spontaneous release of tumor necrosis factor and interleukin-1 inhibitors by purified cell populations from human ovarian carcinoma in vitro.

R. Burger, P. Disaia, M. V. van Eden, 1994, Gynecologic oncology.

NF-κB inducing kinase maintains T cell metabolic fitness in antitumor immunity

Jie Yang, Jing Wang, Shao-Cong Sun, 2020, Nature Immunology.

The toll of innate immunity on microbial pathogens.

P. Godowski, H. Brightbill, R. Modlin, 1999, The New England journal of medicine.

Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells

I. Mellman, Lawren C. Wu, L. Delamarre, 2015, Proceedings of the National Academy of Sciences.

BMP1 is not required for lung fibrosis in mice

W. Sandoval, P. Caplazi, M. Roose-Girma, 2021, Scientific Reports.

A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis.

Jason A. Vander Heiden, P. Wolters, S. Marsters, 2022, Cell metabolism.

A Role for CD40-CD40 Ligand Interactions in the Generation of Type 1 Cytokine Responses in Human Leprosy1

H. Brightbill, R. Modlin, K. Schlienger, 2000, The Journal of Immunology.

IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models

N. Ghilardi, H. Brightbill, Sean Flanagan, 2022, PloS one.

IgE+ memory B cells and plasma cells generated through a germinal-center pathway

J. Egen, Lawren C. Wu, D. Yan, 2012, Nature Immunology.

Responses in Human Leprosy in the Generation of Type 1 Cytokine A Role for CD 40-CD 40 Ligand Interactions

H. Brightbill, R. Modlin, K. Schlienger, 2000 .

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.

Hoai An Le Thi, Jun Liang, Y. Ran, 2019, ACS medicinal chemistry letters.

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).

Adam R. Johnson, Jianwen A. Feng, Brandon J. Bravo, 2017, Journal of medicinal chemistry.

Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses1

S. Akira, W. Cunliffe, O. Takeuchi, 2002, The Journal of Immunology.

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.

B. Bloom, S. Smale, S. Plevy, 1999, Science.

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

Shao-Cong Sun, Y. Cong, H. Brightbill, 2018, Nature Immunology.

A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production

K. Ansel, P. Woodruff, J. Fahy, 2014, Nature Immunology.

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

A. Zarrin, S. Warming, J. Hackney, 2020, Science Signaling.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

Toll‐like receptors: molecular mechanisms of the mammalian immune response

H. Brightbill, R L Modlin, R. Modlin, 2000, Immunology.

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

Z. Modrušan, Alexander R. Abbas, D. Seshasayee, 2021, Science Translational Medicine.

22 Activation of innate immune receptors by bacterial products

H. Brightbill, R. Modlin, 2002 .

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.

Min Xu, Charles Eigenbrot, Meijuan Zhou, 2010, The Journal of clinical investigation.

A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages1

S. Smale, S. Plevy, H. Brightbill, 2000, The Journal of Immunology.

IL-10 Promoter in Macrophages Lipopolysaccharide-Mediated Induction of A Prominent Role for Sp 1 During

S. Smale, S. Plevy, H. Brightbill, 2000 .

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Jianwen A. Feng, P. McEwan, Lawren C. Wu, 2018, Journal of medicinal chemistry.

Filling a nick in NIK: extending the half-life of a NIK inhibitor through structure-based drug design.

Matthew L Landry, P. McEwan, Adam Johnson, 2023, Bioorganic & medicinal chemistry letters.

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

Shao-Cong Sun, Y. Cong, H. Brightbill, 2018, Nature Immunology.

Targeted alveolar regeneration with Frizzled-specific agonists

Ahmad N. Nabhan, S. Seshagiri, Z. Modrušan, 2023, Cell.

Direct detection of IgE-switched B cells in an IgE-GFP reporter mouse reveals a germinal center pathway for the generation of IgE memory B cells and plasma cells (109.3)

J. Egen, D. Yan, Wyne P. Lee, 2012, Journal of Immunology.

LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung

P. Caplazi, M. Roose-Girma, E. N’Diaye, 2023, Science advances.

Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway

J. Egen, D. Yan, Wyne P. Lee, 2013, Nature Immunology.

Targeted alveolar regeneration with Frizzled-specific agonists

Ahmad N. Nabhan, S. Seshagiri, Z. Modrušan, 2023, Cell.

A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis.

P. Wolters, S. Marsters, A. Feldstein, 2022, Cell metabolism.

Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells

I. Mellman, L. Delamarre, A. Katakam, 2015, Proceedings of the National Academy of Sciences.

Reply to "On the differentiation of mouse IgE+ cells"

J. Egen, D. Yan, Wyne P. Lee, 2012, Nature Immunology.