J. Arron

发表

TAZ is required for lung alveolar epithelial cell differentiation after injury.

J. Egen, Min Xu, A. Dey, 2019, JCI insight.

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

N. Thomson, E. Bleecker, M. Castro, 2013, European Respiratory Journal.

Lebrikizumab treatment in adults with asthma.

Nicola A Hanania, Zheng Su, Sofia Mosesova, 2011, The New England journal of medicine.

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

Barmak Modrek, Prescott G Woodruff, Joseph R Arron, 2009, American journal of respiratory and critical care medicine.

Single cell reconstruction of human basal cell diversity in normal and IPF lung

C. Yao, J. McQualter, B. Stripp, 2020, bioRxiv.

The role of periostin in tissue remodeling across health and disease

R. Markwald, K. Izuhara, A. Kudo, 2013, Cellular and Molecular Life Sciences.

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.

B. Hargadon, Alexander R. Abbas, Lawren C. Wu, 2012, The Journal of allergy and clinical immunology.

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.

T. Curtis, P. Bradding, M. Ennis, 2014, The Journal of allergy and clinical immunology.

Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study.

W. Busse, S. Mosesova, S. Wenzel, 2013, American journal of respiratory and critical care medicine.

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells.

Z. Modrušan, Alexander R. Abbas, R. Soriano, 2015, The Journal of allergy and clinical immunology.

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma

P. Bradding, S. McQuaid, L. Mcgarvey, 2011, Thorax.

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β

T. Wynn, M. Bilodeau, R. Gieseck, 2017, Science Translational Medicine.

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

I. Pavord, A. Woodcock, P. Howarth, 2020, The Lancet. Respiratory medicine.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

I. Pavord, A. Woodcock, Dirk E. Smith, 2015, Thorax.

Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab.

J. Matthews, C. Holweg, J. Arron, 2017, The Journal of allergy and clinical immunology.

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development

R. Gangnon, J. Gern, R. Lemanske, 2017, The Journal of allergy and clinical immunology.

Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma

I. Pavord, P. Howarth, F. Symon, 2022, Allergy.

Seasonal variability of lung function and Asthma Quality of Life Questionnaire Scores in adults with uncontrolled asthma

J. Matthews, C. Holweg, J. Arron, 2019, BMJ Open Respiratory Research.

ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma—implications for COVID-19

P. Howarth, S. Wenzel, P. Bradding, 2020, Journal of Allergy and Clinical Immunology.

IFN‐stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma

J. Derisi, D. Erle, P. Woodruff, 2017, American journal of respiratory and critical care medicine.

Galectin-8 is upregulated in keratinocyte by IL-17A and promotes proliferation by regulating mitosis in psoriasis.

Fu-Tong Liu, Huan-Yuan Chen, J. Arron, 2020, The Journal of investigative dermatology.

Lebrikizumab, An Anti-IL-13 Monoclonal Antibody, Reduces Severe Asthma Exacerbations Over 32 Weeks In Adults With Inadequately Controlled Asthma

S. Mosesova, M. Eisner, N. Hanania, 2012, ATS 2012.

Efficacy of an anti-IL13 monoclonal antibody, lebrikizumab, in adults with inadequately controlled asthma is enhanced in those with high periostin levels

S. Mosesova, Zheng Su, P. Korenblat, 2011 .

Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation

I. Pavord, S. Fowler, C. Brightling, 2022, Allergy.

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.

Z. Modrušan, Alexander R. Abbas, H. Clark, 2011, The American journal of pathology.

Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs

C. Yao, J. McQualter, B. Stripp, 2020 .

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.

S. Mosesova, Lawren C. Wu, Q. Hamid, 2011, The Journal of allergy and clinical immunology.

Molecular Th2 Phenotypes of Asthma: New Biomarker or NO? Authors' reply

P. Woodruff, J. Fahy, J. Arron, 2010 .

Peripheral Biomarkers of an IL-13 Induced Bronchial Epithelial Gene Signature in Asthma

B. Modrek, Alexander R. Abbas, P. Woodruff, 2009 .

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge

N. Jarjour, J. Matthews, J. Arron, 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Lebrikizumab Treatment Reduces Serum Periostin Levels In Asthma Patients With Elevated Baseline Levels Of Periostin

S. Mosesova, J. Matthews, J. Arron, 2012, ATS 2012.

Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma Asthma Stratification

I. Pavord, S. Walker, R. Djukanović, 2022 .

Airway epithelial miRNA expression is altered in asthma.

M. Love, K. Ansel, M. Solon, 2012, American journal of respiratory and critical care medicine.

Biomarkers in systemic sclerosis: mechanistic insights into pathogenesis and treatment

J. Arron, 2021, Current opinion in rheumatology.

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids.

S. Mosesova, P. Korenblat, J. Matthews, 2013, The Journal of allergy and clinical immunology.

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

Z. Modrušan, D. Seshasayee, D. Hsu, 2012, The Journal of allergy and clinical immunology.

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

J. Egen, B. Hargadon, Alexander R. Abbas, 2015, Science Translational Medicine.

Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator.

Sharon D. Solomon, P. Campochiaro, H. Ying, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

B. Yaspan, J. Hackney, Lawren C. Wu, 2019, Cell.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

J. DeVoss, A. Zarrin, Lawren C. Wu, 2015, Science Signaling.

A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production

K. Ansel, P. Woodruff, J. Fahy, 2014, Nature Immunology.

Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma

Z. Modrušan, Alexander R. Abbas, D. Yan, 2022, Science Translational Medicine.

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

Z. Modrušan, Alexander R. Abbas, D. Seshasayee, 2021, Science Translational Medicine.

Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis

B. Yaspan, J. Hackney, Jianping Yin, 2022, Science Translational Medicine.

The airway microbiome in patients with severe asthma: Associations with disease features and severity.

Joseph R Arron, H. Boushey, S. Lynch, 2015, The Journal of allergy and clinical immunology.

Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic Airways

Barmak Modrek, Prescott G Woodruff, Joseph R Arron, 2011, The Journal of Immunology.

The role of periostin in tissue remodeling across health and disease

R. Markwald, K. Izuhara, A. Kudo, 2013, Cellular and Molecular Life Sciences.

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.

S. Mosesova, Lawren C. Wu, Q. Hamid, 2011, The Journal of allergy and clinical immunology.

A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk

Matthew J. Brauer, M. McCarthy, B. Yaspan, 2022, Scientific Reports.

Title A qPCR-based metric of Th 2 airway inflammation in asthma Permalink

P. Woodruff, O. Solberg, J. Fahy, 2013 .

Interleukin-13 in Asthma and Other Eosinophilic Disorders

C. Holweg, J. Arron, Kit Wong, 2017, Front. Med..

Depletion of major pathogenic cells in asthma by targeting CRTh2.

I. Hötzel, J. Payandeh, D. Yan, 2016, JCI insight.

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics

C. Laprise, Q. Hamid, J. Arron, 2017, Front. Immunol..

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

I. Pavord, A. Woodcock, P. Howarth, 2018, Trials.

Roles of Periostin in Respiratory Disorders.

K. Izuhara, H. Matsumoto, B. Moore, 2016, American journal of respiratory and critical care medicine.

Monitoring ocular drug therapy by analysis of aqueous samples.

P. Campochiaro, Q. Nguyen, Roman G. Rubio, 2009, Ophthalmology.

Biomarkers in the clinical development of asthma therapies.

J. Arron, D. Choy, Tracy Staton, 2016, Biomarkers in medicine.

Molecular Heterogeneity, Biomarker Discovery, and Targeted Therapy in Asthma

J. Arron, Jeffrey M Harris, 2014 .

Redefining approaches to asthma: developing targeted biologic therapies.

J. Matthews, J. Arron, H. Scheerens, 2013, Advances in pharmacology.

IL-13 is a therapeutic target in radiation lung injury

D. Citrin, T. Wynn, E. Chung, 2016, Scientific Reports.

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma

J. Johnston, P. Bradding, A. Kissenpfennig, 2016, European Respiratory Journal.

Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma.

Christopher R. Cabanski, R. Maciuca, S. Mosesova, 2016, The Journal of allergy and clinical immunology.

A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma

B. Hargadon, Alexander R. Abbas, Lawren C. Wu, 2017, The Journal of Immunology.

Universal Principled Review: A Community-Driven Method to Improve Peer Review

Greg Barton, Matt Williams, Sebastian Amigorena, 2019, Cell.

A randomized, placebo‐controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER)

E. Israel, M. Solon, G. Gauvreau, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma

I. Pavord, A. Woodcock, P. Howarth, 2021, European Respiratory Journal.

A qPCR-based metric of Th2 airway inflammation in asthma

P. Woodruff, O. Solberg, J. Fahy, 2013, Clinical and Translational Allergy.

Beyond type 2 cytokines in asthma - new insights from old clinical trials

J. Arron, D. Choy, 2020, Expert opinion on therapeutic targets.

Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma.

J. Matthews, J. Arron, D. Choy, 2013, Annals of the American Thoracic Society.

Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung.

C. Yao, J. McQualter, B. Stripp, 2020, American journal of respiratory and critical care medicine.

Interleukin‐18 Has Antipermeablity and Antiangiogenic Activities in the Eye: Reciprocal Suppression With VEGF

P. Campochiaro, J. Arron, T. Iwase, 2014, Journal of cellular physiology.