C. Pietrzik

S. Weggen, C. Behl, C. Pietrzik, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains

W. Annaert, D. Schmidt-Arras, O. Janssen, 2016, Biological chemistry.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.

W. Annaert, D. Schmidt-Arras, O. Janssen, 2016, Biological chemistry.

Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of beta-amyloid precursor-like proteins.

V. Herzog, C. Pietrzik, P. Lemansky, 1996, Endocrinology.

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis

W. Annaert, A. Roebroek, S. Weggen, 2009, Cellular and Molecular Life Sciences.

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

Mahmoud A. Bassal, R. Lüllmann-Rauch, P. Saftig, 2020, Autophagy.

From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells.

C. Y. Chen, V. Herzog, C. Pietrzik, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The physiological functions of the β-amyloid precursor protein APP

U. Müller, T. Deller, C. Pietrzik, 2012, Experimental Brain Research.

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

S. Weggen, M. Jucker, K. Baumann, 2007, The Journal of biological chemistry.

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

A. Roebroek, S. Weggen, S. Reuss, 2011, Neurobiology of Aging.

The physiological functions of the β-amyloid precursor protein APP

U. Müller, T. Deller, C. Pietrzik, 2012, Experimental Brain Research.

Brain endothelial LRP1 maintains blood–brain barrier integrity

C. Pietrzik, Magdalena Kurtyka, Steffen Storck, 2021, Fluids and barriers of the CNS.

The role of lipoprotein receptors on the physiological function of APP

C. Pietrzik, Timo Wagner, 2012, Experimental Brain Research.

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

C. Pietrzik, C. Becker-Pauly, Fred Armbrust, 2019, Cellular and Molecular Life Sciences.

Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes.

C. Behl, C. Pietrzik, T. Skutella, 2005, Neuroscience.

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

S. Weggen, T. Golde, E. Koo, 2006, Journal of neurochemistry.

Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain*

S. Weggen, T. Golde, E. Koo, 2003, Journal of Biological Chemistry.

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Rong Wang, Pritam Das, Jason L. Eriksen, 2001, Nature.

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

Isabella Ogorek, S. Weggen, M. Hubálek, 2017, Biochemistry.

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

C. Pietrzik, C. Becker-Pauly, 2017, Front. Mol. Neurosci..

LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries.

Liam Cassidy, Andreas Tholey, A. Tholey, 2014, Journal of proteome research.

Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

P. S. St George-Hyslop, B. de Strooper, M. Heneka, 2008, The Journal of Neuroscience.

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

C. Hock, P. Saftig, L. Kulic, 2023, Scientific Reports.

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

C. Haass, D. Thal, F. Leuven, 2011, Journal of Neural Transmission.

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.

T. Bayer, R. Vandenbroucke, S. Weggen, 2015, The Journal of clinical investigation.

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

O. Wirths, S. Weggen, M. Glatzel, 2022, Cellular and Molecular Life Sciences.

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

S. Weggen, J. Walter, M. Glatzel, 2016, Molecular Neurodegeneration.

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species*

G. Multhaup, S. Weggen, M. Causevic, 2012, The Journal of Biological Chemistry.

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

J. Wiltfang, O. Wirths, Isabella Ogorek, 2018, Acta Neuropathologica.

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.

S. Weggen, W. Mueller‐Klieser, C. Pietrzik, 2016, Experimental cell research.

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

M. Gütschow, A. Tholey, T. Koudelka, 2015, The Biochemical journal.

The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

M. Korte, D. Wolfer, J. Herms, 2007, The Journal of Neuroscience.

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

M. Korte, D. Wolfer, J. Herms, 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

R. Katzman., C. Kawas, J. Troncoso, 2000, The Journal of clinical investigation.

Glycogen synthase kinase 3β links neuroprotection by 17β-estradiol to key Alzheimer processes

C. Behl, C. Pietrzik, T. Skutella, 2005, Neuroscience.

Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein*

Christian Haass, C. Haass, S. Lichtenthaler, 2006, Journal of Biological Chemistry.

The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases.

C. Pietrzik, C. Becker-Pauly, Fred Armbrust, 2021, Biochimica et biophysica acta. Molecular cell research.

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State

S. Kins, C. Dowds, C. Pietrzik, 2017, Front. Mol. Neurosci..

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA

T. Willnow, C. Tischer, E. Koo, 2017, Cellular and Molecular Life Sciences.

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

G. Multhaup, S. Weggen, S. Kins, 2011, Cellular and Molecular Life Sciences.

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo*

C. Overall, O. Schilling, S. Weggen, 2011, The Journal of Biological Chemistry.

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.

Mark R. Wilson, A. Stracke, I. Björkhem, 2018, Biochimica et biophysica acta. Molecular and cell biology of lipids.

The Blood brain-barrier and its role in Alzheimer’s disease

C. Pietrzik, Steffen E. Storck, 2018, Neuroforum.

The LepR-mediated leptin transport across brain barriers controls food reward

H. Lehnert, M. Schwaninger, H. Oster, 2017, Molecular metabolism.

Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease

C. Pietrzik, Steffen E. Storck, 2017, Pharmaceutical Research.

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

A. Roebroek, L. Pradier, C. Pietrzik, 2019, Molecular Neurobiology.

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid &bgr;-Protein in Perivascular Astrocytes

D. Thal, J. Walter, C. Pietrzik, 2008, Journal of neuropathology and experimental neurology.

Endothelial LRP 1 transports amyloid-β 1 – 42 across the blood-brain barrier

T. Bayer, R. Vandenbroucke, S. Weggen, 2015 .

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

C. Pietrzik, C. Becker-Pauly, Fred Armbrust, 2019, Cellular and Molecular Life Sciences.

The cytoplasmic domain of the LDL receptor‐related protein regulates multiple steps in APP processing

Sascha Weggen, S. Weggen, E. Koo, 2002, The EMBO journal.

The Amyloidogenic Pathway of Amyloid Precursor Protein (APP) Is Independent of Its Cleavage by Caspases*

S. Chandra, E. Koo, C. Pietrzik, 2001, The Journal of Biological Chemistry.

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

T. Brüning, O. Langer, C. Pietrzik, 2017, Acta neuropathologica communications.

Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application

C. Behl, C. Pietrzik, Claus Pietrzik, 2005, International journal of experimental pathology.

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein

J. Wiltfang, S. Weggen, J. Maler, 2008, Neurodegenerative Diseases.

FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein

Sascha Weggen, Edward H. Koo, S. Weggen, 2004, The Journal of Neuroscience.

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

S. Weggen, B. Bulic, Andreas Rennhack, 2012, PloS one.

The Blood-Brain Barrier in Alzheimer's Disease.

A. Hartz, C. Pietrzik, Steffen E. Storck, 2021, Handbook of experimental pharmacology.

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

A. Roebroek, S. Weggen, C. Pietrzik, 2013, Molecular Neurodegeneration.

Flurbiprofen-loaded Nanoparticles Can Cross a Primary Porcine In vitroBlood-brain Barrier Model to Reduce Amyloid-ÃÂ²42 Burden

K. Langer, Sylvia Wagner, C. Pietrzik, 2016 .

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity*

S. Weggen, T. Golde, E. Koo, 2003, Journal of Biological Chemistry.

Low‐density lipoprotein receptor‐related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation

A. Faissner, F. Edenhofer, C. Pietrzik, 2016, Glia.

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

S. Weggen, C. Pietrzik, C. Becker-Pauly, 2022, Cellular and Molecular Life Sciences.

The Alzheimer’s disease associated bacterial protease RgpB from P. gingivalis activates the alternative β-secretase meprin β thereby increasing Aβ generation

C. Pietrzik, C. Becker-Pauly, Cynthia Colmorgen, 2019, bioRxiv.

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

C. Pietrzik, Alexander D Mazura, Alexander D. Mazura, 2023, Pharmaceutics.

Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

Gisbert Schneider, Karlheinz Baumann, Volker Hähnke, 2012, ACS chemical biology.

Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood–brain barrier model

S. Ropele, R. Schmidt, S. Weggen, 2013, Alzheimer's Research & Therapy.

Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier

L. Stitz, S. Weggen, C. Korth, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing

E. Zeggini, H. Fuchs, N. W. Rayner, 2022, Human molecular genetics.

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

S. Weggen, A. Hartz, C. Pietrzik, 2018, Brain, Behavior, and Immunity.

Identification of novel-type γ-secretase modulators by text-based virtual screening

G. Schneider, Volker Hähnke, S. Weggen, 2012 .

Meprin β: A novel regulator of blood–brain barrier integrity

C. Pietrzik, C. Becker-Pauly, Franka Scharfenberg, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD‐associated genes

P. Rosenstiel, R. Häsler, J. Potempa, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

S. Kins, C. Pietrzik, K. Wild, 2017, Front. Mol. Neurosci..

The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation of N-Methyl-D-aspartate Receptors*

H. Luhmann, A. Roebroek, S. Weggen, 2008, Journal of Biological Chemistry.

Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice

M. Uhr, C. Hiemke, C. Pietrzik, 2010, Neuropharmacology.

Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures

D. Manahan‐Vaughan, M. Mark, S. Herlitze, 2020, Glia.

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

G. Multhaup, S. Weggen, S. Kins, 2011, Cellular and Molecular Life Sciences.

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

A. Chalaris, S. Rose-John, C. Overall, 2012, Cellular and Molecular Life Sciences.

Functional Role of the Low-Density Lipoprotein Receptor-Related Protein in Alzheimer’s Disease

C. Pietrzik, S. Jaeger, E. Waldron, 2006, Neurodegenerative Diseases.

The role of lipoprotein receptors on the physiological function of APP

C. Pietrzik, Timo Wagner, 2011, Experimental Brain Research.

Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid β Protein Production via the β-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling*

D. Kang, E. Koo, C. Pietrzik, 2005, Journal of Biological Chemistry.

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

C. Pietrzik, C. Becker-Pauly, Friederike Zunke, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1

J. Lopez-Rios, A. Roebroek, Isabella Ogorek, 2023, The Journal of biological chemistry.

Antibody‐mediated inhibition of tissue‐type plasminogen activator binding to the low‐density lipoprotein receptor‐related protein 1 as a potential beneficial modulator for stroke therapy

S. Weggen, C. Pietrzik, Alexander D Mazura, 2023, Journal of Cellular Biochemistry.

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

C. Pietrzik, C. Becker-Pauly, 2016, EBioMedicine.

Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease

G. Multhaup, M. Hull, M. Heneka, 2011 .

Degradome of soluble ADAM10 and ADAM17 metalloproteases

D. Schmidt-Arras, S. Rose-John, A. Tholey, 2019, Cellular and Molecular Life Sciences.

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA

T. Willnow, C. Tischer, E. Koo, 2017, Cellular and Molecular Life Sciences.

Endothelial LRP 1 transports amyloid-β 1 – 42 across the blood-brain barrier

T. Bayer, R. Vandenbroucke, S. Weggen, 2015 .

Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

Young-Bum Kim, Y. Jo, Hu Huang, 2013, Nature Communications.

A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes

C. Pietrzik, C. Becker-Pauly, H. Altmeppen, 2024, Cellular and molecular life sciences : CMLS.

LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries.

A. Tholey, T. Koudelka, C. Pietrzik, 2014, Journal of proteome research.

Correction: Corrigendum: Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

Y. Jo, Hu Huang, Bonghee Lee, 2013, Nature Communications.

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.

Mark R. Wilson, A. Stracke, I. Björkhem, 2018, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

Isabella Ogorek, S. Weggen, M. Hubálek, 2018, Bioorganic & medicinal chemistry letters.