P. Villa

发表

Identification of Nonpeptide Oxytocin Receptor Ligands by Receptor‐Ligand Fingerprint Similarity Search

D. Rognan, Nathanael Weill, C. Valencia, 2011, Molecular informatics.

Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study

C. Bernard, C. Duval, B. Marie, 2020, Biomolecules.

Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study

C. Bernard, C. Duval, B. Marie, 2020, Biomolecules.

Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Lars Kaderali, Ralf Bartenschlager, Patrick Pessaux, 2015, Nature Biotechnology.

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.

D. Rognan, Muriel Hachet-Haas, J. Galzi, 2018, Journal of medicinal chemistry.

Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging.

Y. Mély, L. Richert, A. Klymchenko, 2015, Journal of the American Chemical Society.

Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation

X. Pivot, O. Collange, Z. Huang, 2021, Journal of Controlled Release.

A Time‐Resolved FRET Cell‐Based Binding Assay for the Apelin Receptor

T. Roux, E. Trinquet, C. Llorens-Cortes, 2017, ChemMedChem.

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

J. Galzi, N. Frossard, J. Haiech, 2015, Scientific Reports.

Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging.

Y. Mély, A. Klymchenko, D. Bonnet, 2015, Chemical communications.

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

E. Kellenberger, D. Rognan, J. Haiech, 2010, Bioorganic & medicinal chemistry.

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein.

Jacques Haiech, Alain Van Dorsselaer, Yves Mély, 2009, Biochimie.

Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

Jacques Haiech, Samir Mameri, Maria Zeniou, 2015, PloS one.

Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands.

C. Wermuth, J. Haiech, C. Pigault, 2006, Biochimica et biophysica acta.

Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model

L. Reber, N. Frossard, M. Stern, 2020, Transplantation.

Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians.

E. Bourreau, D. Stien, M. Kaiser, 2016, Journal of ethnopharmacology.

Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds.

P. Gressens, M. Spedding, A. Markham, 2002, European journal of pharmacology.

Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor.

A. Klymchenko, D. Bonnet, P. Villa, 2020, ACS chemical biology.

Therapeutic benefit of ciliary neurotrophic factor in progressive motor neuronopathy depends on the route of delivery

B. Pettmann, H. Schmalbruch, A. Kahn, 1999, Annals of neurology.

Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

D. Rognan, F. Bihel, J. Bourguignon, 2021, Molecules.

The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.

P. Gressens, M. Spedding, L. Hársing, 2005, European journal of pharmacology.

Engineering Novel 3D Models to Recreate High‐Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment

B. Lhermitte, A. Klymchenko, M. Dontenwill, 2022, Advanced healthcare materials.

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

M. Dehouck, J. Goossens, F. Gosselet, 2020, Biomolecules.

Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.

M. Barrot, F. Bihel, J. Bourguignon, 2018, European journal of medicinal chemistry.

Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae).

D. Stien, V. Eparvier, P. Villa, 2015, Journal of ethnopharmacology.

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.

B. Mouillac, T. Durroux, D. Bonnet, 2018, Journal of medicinal chemistry.

Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.

J. Bourguignon, N. Romeiro, M. Martins, 2012, Journal of medicinal chemistry.

Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices.

M. Ginouves, G. Prévot, E. Bourreau, 2022, Journal of ethnopharmacology.

Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury

M. Barrot, J. Bourguignon, S. Hugel, 2021, Neuropharmacology.

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.

P. Villa, P. Wagner, X. Iturrioz, 2022, Bioconjugate chemistry.

WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3− cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling

E. Réal, M. Junier, F. Bihel, 2018, Oncotarget.

Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity

B. Lhermitte, Chris Jones, I. Namer, 2019, Cancers.

Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

M. Junier, S. Kahn, E. El-Habr, 2019 .

Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen

M. Koenig, P. Rustin, J. Haiech, 2009, BMC neurology.

A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains.

P. Tsvetkov, A. Makarov, J. Haiech, 2013, Biochimica et biophysica acta.

Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking.

D. Rognan, P. Villa, M. Hibert, 2022, Journal of medicinal chemistry.

SynAggreg: A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds.

Y. Nominé, F. Klein, Y. Trottier, 2018, Journal of molecular biology.

Red Fluorescent Turn‐On Ligands for Imaging and Quantifying G Protein‐Coupled Receptors in Living Cells

Y. Mély, B. Mouillac, A. Klymchenko, 2014, Chembiochem : a European journal of chemical biology.