A. O'Brien

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Early Health Technology Assessment during Nonalcoholic Steatohepatitis Drug Development: A Two-Round, Cross-Country, Multicriteria Decision Analysis

A. Canbay, M. Thursz, P. Kanavos, 2020, Medical decision making : an international journal of the Society for Medical Decision Making.

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.

N. Freemantle, D. Gilroy, A. O'Brien, 2021, The New England journal of medicine.

Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway

Amit A. Patel, D. Gilroy, Roel P. H. De Maeyer, 2021, JHEP reports : innovation in hepatology.

PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial

A. Douiri, V. Patel, D. Shawcross, 2019, BMJ Open.

Administration of Albumin Solution Increases Serum Levels of Albumin in Patients With Chronic Liver Failure in a Single-Arm Feasibility Trial

D. Gilroy, J. O’Beirne, A. O'Brien, 2017, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Antimicrobial resistance in liver disease: better diagnostics are needed.

A. O'Brien, L. Shallcross, 2017, The Lancet Gastroenterology and Hepatology.

The pore‐forming subunit of the KATP channel is an important molecular target for LPS‐induced vascular hyporeactivity in vitro

M. Singer, A. O'Brien, L. Clapp, 2005, British journal of pharmacology.

Lipid mediators in immune dysfunction after severe inflammation

D. Gilroy, A. O'Brien, J. Fullerton, 2014, Trends in immunology.

BK Large Conductance Ca2+-Activated K+ Channel-Deficient Mice are not Resistant to Hypotension and Display Reduced Survival Benefit Following Polymicrobial Sepsis

M. Singer, P. Zolfaghari, N. Davies, 2011, Shock.

Targeted Albumin Infusions Do Not Improve Systemic Inflammation or Cardiovascular Function in Decompensated Cirrhosis

N. Freemantle, A. O'Brien, N. Becares, 2022, Clinical and translational gastroenterology.

Long-term albumin treatment in patients with cirrhosis and ascites.

P. Caraceni, P. Ginès, A. O'Brien, 2022, Journal of hepatology.

Con: The Unclear Benefit of Albumin

A. O'Brien, 2019, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Immune Regulatory Mediators in Plasma from Patients With Acute Decompensation Are Associated With 3-Month Mortality

A. O'Brien, N. Becares, S. Skene, 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

MACHT - Outpatient albumin infusions do not prevent complications of cirrhosis in patients on the liver transplant waiting list.

P. Kamath, J. Trotter, A. O'Brien, 2018, Journal of hepatology.

Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

S. Atkinson, M. Thursz, G. Foster, 2016, Gut.

Assessing hepatitis C spontaneous clearance and understanding associated factors—A systematic review and meta‐analysis

A. Hayward, A. O'Brien, L. Shallcross, 2018, Journal of viral hepatitis.

Rapid diagnosis of Wilson disease in acute liver failure: No more waiting for the ceruloplasmin level?

Roger Williams, A. O'Brien, 2008, Hepatology.

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

K. Massey, D. Gilroy, A. Nicolaou, 2014, Nature Medicine.

Monocyte and Neutrophil Isolation, Migration, and Phagocytosis Assays

Amit A. Patel, S. Yona, I. Avraham-Davidi, 2018, Current protocols in immunology.

The potential danger of empiric antimicrobial therapy for nosocomial SBP

V. Gant, A. O'Brien, L. China, 2016, Hepatology.

ASEPTIC: primary antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis—study protocol for an interventional randomised controlled trial

N. Freemantle, P. Richardson, J. Dillon, 2022, Trials.

ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for an interventional randomised controlled trial

D. Gilroy, A. O'Brien, N. Becares, 2018, BMJ Open.

Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease

D. Gilroy, A. O'Brien, S. Skene, 2017, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide

M. Singer, F. Coluzzi, A. O'Brien, 2005, The Lancet.

Temporal variation in endotoxin‐induced vascular hyporeactivity in a rat mesenteric artery organ culture model

M. Singer, A. O'Brien, A. Wilson, 2001, British journal of pharmacology.

Use of non-selective B-blockers is safe in hospitalised decompensated cirrhosis patients and exerts a potential anti-inflammatory effect: Data from the ATTIRE trial

N. Freemantle, A. O'Brien, S. Ryder, 2022, EClinicalMedicine.

Campylobacter pyloridis-associated primary gastritis in children.

P. Sherman, E. Cutz, A. O'Brien, 1987, Pediatrics.

VARIABLE EFFECTS OF INHIBITING iNOS AND CLOSING THE VASCULAR ATP-SENSITIVE POTASSIUM CHANNEL (VIA ITS PORE-FORMING AND SULFONYLUREA RECEPTOR SUBUNITS) IN ENDOTOXIC SHOCK

M. Singer, A. O'Brien, L. Clapp, 2009, Shock.

Pathways mediating resolution of inflammation: when enough is too much

D. Gilroy, A. O'Brien, J. Fullerton, 2013, The Journal of pathology.

Effectiveness of pneumococcal and influenza vaccines to prevent serious health complications in adults with chronic liver disease: a protocol for a systematic review

C. Parisinos, A. Hayward, A. O'Brien, 2018, BMJ Open.

Renal tubular proteinuria in patients with irritable bowel syndrome

A. Muller, A. O'Brien, E. Lamb, 2003, European journal of gastroenterology & hepatology.

An investigation of the mechanisms underlying hypotension and vascular hyporeactivity in septic shock.

A. O'Brien, 2006 .

Guidelines on the management of ascites in cirrhosis

P. Hayes, K. Moore, G. Aithal, 2020, Gut.

Albumin in decompensated cirrhosis: new concepts and perspectives

R. Moreau, R. Jalan, J. Trebicka, 2020, Gut.

Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

K. Massey, D. Gilroy, A. Nicolaou, 2015, Liver international : official journal of the International Association for the Study of the Liver.

Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19

D. Gilroy, Roel P. H. De Maeyer, A. Akbar, 2020, Pharmacology & Therapeutics.

Terlipressin for norepinephrine-resistant septic shock

M. Singer, A. O'Brien, L. Clapp, 2002, The Lancet.

In vivo and in vitro differences in responses to catecholamines and vasopressin in rat models of LPS

M. Singer, A. O'Brien, L. Clapp, 2002 .

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

M. Garabedian, E. Treuter, M. Gage, 2019, Cell reports.

Impaired LXR a Phosphory lation Attenuates Progression of Fatty Liver Disease Graphical Abstract Highlights

M. Garabedian, E. Treuter, M. Gage, 2019 .

Nutrition in end-stage liver disease: principles and practice.

Roger Williams, A. O'Brien, 2008, Gastroenterology.

Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5

G. Foster, S. Bhattacharya, A. O'Brien, 2016, Annals of surgery.

Vasopressin in Septic Shock – A Step Forward or Just Another Vasopressor?

A. O'Brien, 2006 .

Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

C. Parisinos, A. Hayward, A. O'Brien, 2019, BMJ Open.

Effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in adults with cirrhosis: a protocol for a systematic review

C. Parisinos, A. O'Brien, J. Ryan, 2019, BMJ Open.

Development and validation of a prediction model to estimate the risk of liver cirrhosis in primary care patients with abnormal liver blood test results: protocol for an electronic health record study in Clinical Practice Research Datalink

K. Direk, C. Parisinos, A. Hayward, 2019, Diagnostic and Prognostic Research.

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis

R. Goldin, S. Nourshargh, H. Heath, 2013, Proceedings of the National Academy of Sciences.

A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation

D. Gilroy, A. O'Brien, R. Day, 2016, PloS one.

Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients

M. Singer, D. Harrison, A. O'Brien, 2012, Intensive Care Medicine.

Evaluating the Role of Antibiotics in Patients Admitted to Hospital With Decompensated Cirrhosis: Lessons From the ATTIRE Trial

N. Freemantle, A. O'Brien, S. Ryder, 2022, The American journal of gastroenterology.

In search of a roadmap towards improving care of patients with cirrhosis and ascites, could a platform trial design transform clinical research?

A. O'Brien, 2022, Hepatobiliary surgery and nutrition.

Investigating potential confounding by indication when considering the association between proton pump inhibitor use, infection, hepatic encephalopathy and mortality in hospitalised decompensated cirrhosis: a post-hoc analysis of the ATTIRE trial.

N. Freemantle, A. O'Brien, S. Ryder, 2023, EClinicalMedicine.

Targeted Albumin Therapy Does Not Improve Short-Term Outcome in Hyponatremic Patients Hospitalized With Complications of Cirrhosis: Data From the ATTIRE Trial

N. Freemantle, A. O'Brien, S. Ryder, 2021, The American journal of gastroenterology.

The use of glypressin in norepinephrine-resistant septic shock

M. Singer, A. O'Brien, L. Clapp, 2001 .

Con: The Unclear Benefit of Albumin

A. O'Brien, 2019, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Use of albumin infusion for cirrhosis-related complications: An international position statement

F. Tacke, R. Teschke, R. Jalan, 2023, JHEP reports : innovation in hepatology.

Prevalence of frailty in patients with non-cirrhotic non-alcoholic fatty liver disease

A. O'Brien, 2022, BMJ open gastroenterology.

Parenclitic Network Mapping Identifies Response to Targeted Albumin Therapy in Patients Hospitalized With Decompensated Cirrhosis

K. Moore, A. O'Brien, A. Mani, 2023, Clinical and translational gastroenterology.

Diagnosis and management of ascites and hepatorenal syndrome (acute kidney injury) in cirrhosis

A. O'Brien, 2019, Medicine.

Guidelines on the management of ascites in cirrhosis

P. Hayes, K. Moore, G. Aithal, 2006, Gut.

Antimicrobial prophylaxis in decompensated cirrhosis: friend or foe?

A. O'Brien, D. Crocombe, 2023, Hepatology communications.