A. Gruzman

发表

Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model

G. Cestra, S. Ebbinghaus, Michal Afri, 2021, Pharmacological Reports.

A New Oxopiperazin‐Based Peptidomimetic Molecule Inhibits Prostatic Acid Phosphatase Secretion and Induces Prostate Cancer Cell Apoptosis

D. Vertommen, M. Shubely, Sharon Ruthstein, 2016 .

Activators of AMPK: not just for type II diabetes.

A. Gruzman, Tamar Getter, I. Zaks, 2014, Future medicinal chemistry.

Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

Lukas Hofmann, A. Gruzman, G. Cohen, 2020, International journal of molecular sciences.

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.

H. Senderowitz, M. B. Major, D. Offen, 2018, ChemPlusChem.

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells

J. Eckel, B. Staels, A. Gruzman, 2010, Diabetes.

Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKα-independent manner

R. Reich, A. Gruzman, G. Cohen, 2006, Diabetologia.

The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes

A. Gruzman, G. Cohen, S. Sasson, 2007, Archives of physiology and biochemistry.

Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives

G. Maulucci, M. De Spirito, A. Gruzman, 2021, International journal of molecular sciences.

Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis

V. Lingappa, S. McAllister, Ming-Fong Lin, 2021, Bioscience reports.

Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis.

V. Lingappa, S. McAllister, Ming-Fong Lin, 2021, Bioscience reports.

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction*

V. De Pinto, V. Shoshan-Barmatz, D. Ben-Hail, 2016, The Journal of Biological Chemistry.

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2

E. Melamed, D. Offen, N. Regev, 2015, PloS one.

Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.

A. Klip, E. Cerasi, A. Gruzman, 2017, Biochimica et biophysica acta. Biomembranes.

A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

S. Petri, H. Senderowitz, M. Shubely, 2015, ChemMedChem.

4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.

A. Gruzman, Dana Barnea, S. Sasson, 2004, Biochemical pharmacology.

Delayed autoregulation of glucose transport in vascular endothelial cells

G. Weisinger, N. Kaiser, J. Eckel, 2005, Diabetologia.

Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.

Kamesh R. Ayasolla, J. Chill, A. Gruzman, 2013, Journal of medicinal chemistry.

A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.

N. Kaiser, R. Reich, A. Gruzman, 2002, The Biochemical journal.

Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage

H. Senderowitz, A. Gruzman, G. Cohen, 2019, Skin Pharmacology and Physiology.

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

A. Dinkova-Kostova, Lukas Hofmann, A. Gruzman, 2022, Free radical biology & medicine.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

H. Senderowitz, Aviv Meir, Sharon Ruthstein, 2018, MedChemComm.

One‐pot three‐component preparation of novel selenium‐containing spiroketals

H. Gottlieb, M. Sprecher, I. Goldberg, 2013 .

Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin.

E. Lewis, A. Gruzman, Yotam Lior, 2021, European journal of medicinal chemistry.

4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice

S. Ebbinghaus, Leenor Alfahel, A. Israelson, 2022, International journal of molecular sciences.

Peptide-based development of PKA activators

H. Senderowitz, Sharon Ruthstein, M. Arad, 2018 .

Gene silencing by siRNA nanoparticles synthesized via sonochemical method

Ulyana Shimanovich, A. Gedanken, A. Gomes, 2014 .

Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation

A. Gruzman, O. Viskind, B. Daniel, 2013, Amyotrophic lateral sclerosis & frontotemporal degeneration.

The lipophilic 4-phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins.

G. Cestra, E. Giorda, A. Setini, 2019, Chemistry.

Direct production of glucose from glycogen under microwave irradiation

N. Perkas, A. Gedanken, I. Pulidindi, 2012 .

Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model.

H. Senderowitz, Michal Afri, M. Weitman, 2018, Journal of medicinal chemistry.

Antiproliferative Effect of Novel Aminoacridine-based Compounds.

A. Gruzman, G. Gellerman, B. Redko, 2015, Medicinal chemistry (Shariqah (United Arab Emirates)).

Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice

E. Cerasi, A. Hoffman, E. Mishani, 2012, Journal of cellular and molecular medicine.

Synthesis and characterization of new and potent α-lipoic acid derivatives

J. Katzhendler, A. Gruzman, S. Sasson, 2004 .

Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator

T. Espevik, A. Skjesol, H. Husebye, 2021, Molecular Diversity.

SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex

Aviv Meir, A. Gruzman, Ohad Fleker, 2015, JBIC Journal of Biological Inorganic Chemistry.

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist.

K. Palczewski, Michal Afri, A. Gruzman, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner.

T. Tennenbaum, A. Gruzman, S. Sasson, 2007, Biochemical pharmacology.

Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives

Lukas Hofmann, A. Gruzman, G. Cohen, 2021, Pharmacological Reports.

Novel inhibitors of leukocyte transendothelial migration.

H. Senderowitz, N. Khazanov, B. Imhof, 2019, Bioorganic chemistry.

Design and synthesis of novel protein kinase R (PKR) inhibitors

K. Rosenblum, M. Niv, T. Yarnitzky, 2016, Molecular Diversity.

Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Hanoch Senderowitz, Erol Cerasi, Neta Uritsky, 2013, Journal of medicinal chemistry.

Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases.

K. Palczewski, Jianye Zhang, A. Gruzman, 2020, Bioorganic & medicinal chemistry letters.

Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Michal Afri, A. Gruzman, Katerina Chumin, 2020 .

Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics

Aviv Meir, A. Gruzman, Lada Gevorkyan‐Airapetov, 2019, bioRxiv.

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

H. Senderowitz, N. Khazanov, H. Eldar-Finkelman, 2020, International journal of molecular sciences.

A versatile water-soluble chelating and radical scavenging platform.

R. Lavi, D. Yufit, A. Gruzman, 2016, Chemical communications.

Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor.

M. Ligumsky, S. Yedgar, A. Gruzman, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.

E. Cerasi, A. Hoffman, A. Gruzman, 2008, Journal of medicinal chemistry.

Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.

A. Gruzman, S. Sasson, Gali Babai, 2009, The review of diabetic studies : RDS.

Activation of PPARδ: from computer modelling to biological effects

H. Senderowitz, A. Livne, A. Gruzman, 2015, British journal of pharmacology.

Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules

A. Gedanken, T. Knowles, A. Cavaco‐Paulo, 2014 .

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis

R. Bowser, Robert G. Miller, V. Lingappa, 2007, Proceedings of the National Academy of Sciences.

A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK

M. Shubely, E. Cerasi, Yosef Avrahami, 2017, Pharmaceutical Research.

SH-29 and SK-119 Attenuates Air-Pollution Induced Damage by Activating Nrf2 in HaCaT Cells

Lukas Hofmann, A. Gruzman, E. Silberstein, 2021, International journal of environmental research and public health.

Glucose Transport Regulators

A. Gruzman, S. Sasson, E. Alpert, 2005 .

Carbonic Anhydrase I Is Recognized by an SOD1 Antibody upon Biotinylation of Human Spinal Cord Extracts

R. Bowser, V. Lingappa, A. Gruzman, 2010, International journal of molecular sciences.

Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

H. Senderowitz, L. Israel, J. Lellouche, 2017, ACS applied materials & interfaces.

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

E. Cerasi, J. Eckel, A. Gruzman, 2014, Chemical communications.

Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.

J. Contreras, A. Gruzman, S. Sasson, 2023, Bioorganic & medicinal chemistry.

Hydrogel nanoparticles covered by neuroligin-2-derived peptide-protected β cells under oxidative stress and increase their proliferation

G. Byk, A. Gruzman, M. Kolitz-Domb, 2018, Journal of Nanoparticle Research.

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose

A. Klip, E. Cerasi, A. Gruzman, 2017, Data in brief.

Erratum to: Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations by Gruzman et al., Rev Diabet Stud 2009, 6(1):13-36.

A. Gruzman, S. Sasson, Gali Babai, 2009 .

Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cδ-dependent manner

T. Tennenbaum, A. Gruzman, S. Sasson, 2007 .

Development and characterisation of SMURF2-targeting modifiers

M. Shubely, A. Gruzman, M. Shokhen, 2021, Journal of enzyme inhibition and medicinal chemistry.

Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.

D. Häussinger, J. Eckel, J. Eckel, 2001, The Biochemical journal.

Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells.

M. Linial, P. Lazarovici, E. Bloch-Shilderman, 2002, The Journal of pharmacology and experimental therapeutics.

Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.

K. Palczewski, Jianye Zhang, P. Kiser, 2021, Journal of medicinal chemistry.

Activators of AMPK: not just for type II diabetes.

A. Gruzman, Tamar Getter, I. Zaks, 2014, Future medicinal chemistry.

Activation of PPARδ: from computer modelling to biological effects

H. Senderowitz, A. Livne, A. Gruzman, 2015, British journal of pharmacology.

Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel

S. Ebbinghaus, A. Israelson, S. Ribeiro, 2023, Biological chemistry.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

H. Senderowitz, Aviv Meir, J. Lellouche, 2018, MedChemComm.

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.

H. Senderowitz, D. Offen, Zhengyu Jiang, 2018, ChemPlusChem.

Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

H. Senderowitz, E. Cerasi, J. Eckel, 2013, Journal of medicinal chemistry.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions

H. Senderowitz, Aviv Meir, J. Lellouche, 2019 .