P. C. Hopkins

发表

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

L. Mucke, E. Masliah, K. Scearce-Levie, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy.

J. Whisstock, S. Bottomley, P. C. Hopkins, 2001, Biophysical journal.

Role of the P2 residue in determining the specificity of serpins.

P. C. Hopkins, B. L. Le Bonniec, S. Stone, 1996, Biochemistry.

Inhibitory Mechanism of Serpins MOBILITY OF THE C-TERMINAL REGION OF THE REACTIVE-SITE LOOP*

M. Wardell, P. C. Hopkins, S. Stone, 1997, The Journal of Biological Chemistry.

Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

J. Whisstock, A. Lesk, R. Carrell, 1997, Protein science : a publication of the Protein Society.

The Contribution of Arginine Residues within the P6–P1 Region of α1-Antitrypsin to Its Reaction with Furin*

R. Leduc, J. Denault, P. Lavigne, 2001, The Journal of Biological Chemistry.

Development of a Novel Recombinant Serpin with Potential Antithrombotic Properties (*)

R. Carrell, D. Crowther, D. Crowther, 1995, The Journal of Biological Chemistry.

Effects of mutations in the hinge region of serpins.

R. Carrell, P. C. Hopkins, S. Stone, 1993, Biochemistry.

Inhibitory mechanism of serpins

M. Wardell, P. C. Hopkins, S. Stone, 1997 .

Serpin‐like properties of α1‐antitrypsin Portland towards furin convertase

R. Leduc, J. Denault, P. C. Hopkins, 1998 .

Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase.

R. Leduc, J. Denault, P. C. Hopkins, 1998, FEBS letters.

Alpha 1-antitrypsin polymerisation can occur by both loop A and C sheet mechanisms.

J. Whisstock, S. Bottomley, P. C. Hopkins, 1998, Biochemical and biophysical research communications.

TMCC2 Associates with Alzheimer’s Disease Pathology in the Human Brain

C. Troakes, G. Tear, A. King, 2021, bioRxiv.

Structural basis of tankyrase activation by polymerization

F. Beuron, E. Morris, A. Desfosses, 2022, Nature.

Evolution of Serpin Specificity: Cooperative Interactions in the Reactive-Site Loop Sequence of Antithrombin Specifically Restrict the Inhibition of Activated Protein C

R. Pike, P. C. Hopkins, S. Stone, 2000, Journal of Molecular Evolution.

Evidence for differential effects of apoE3 and apoE4 on HDL metabolism Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200172-JLR200

R. E. Pitas, Yadong Huang, P. C. Hopkins, 2002, Journal of Lipid Research.

Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein

P. C. Hopkins, 2013, PloS one.

Serpins. A mechanistic class of their own.

J. Whisstock, S. Bottomley, P. C. Hopkins, 1997, Advances in experimental medicine and biology.

The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β.

S. Lovestone, R. Sáinz-Fuertes, P. C. Hopkins, 2011, Journal of Alzheimer's disease : JAD.

The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase.

P. C. Hopkins, S. Stone, S R Stone, 1995, Biochemistry.