L. Klickstein

发表

OC-035 Elastography for the diagnosis of severity of fibrosis in chronic liver disease: a diagnostic test accuracy meta-analysis

S. Lewitzky, Joanne M. Meyer, J. Singer, 2010, Gut.

Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis

Meilan K. Han, F. Martinez, M. Karsdal, 2012, Biomarker insights.

Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

Meilan K. Han, F. Martinez, M. Karsdal, 2012, BMC Pulmonary Medicine.

Matrix metalloproteinase‐9‐mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

M. Karsdal, C. Christiansen, B. Vainer, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule*

I. Ghiran, L. Klickstein, A. Nicholson-Weller, 2003, Journal of Biological Chemistry.

Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes

D. Fearon, L. Klickstein, J. Weis, 1986, The Journal of experimental medicine.

Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.

D. Speicher, E. Lally, I. Kieba, 2007, Cellular microbiology.

Aggregatibacter actinomycetemcomitans leukotoxin requires β‐sheets 1 and 2 of the human CD11a β‐propeller for cytotoxicity

D. Speicher, E. Lally, I. Kieba, 2007, Cellular microbiology.

Antibody CR1‐2B11 recognizes a non‐polymorphic epitope of human CR1 (CD35)

I. Ghiran, L. Klickstein, A. Nicholson-Weller, 2007, Clinical and experimental immunology.

Rituximab for steroid-refractory chronic graft-versus-host disease.

J. Ritz, D. Miklos, D. Bienfang, 2006, Blood.

Dissection of the temporal artery in a patient with giant cell arteritis.

L. Klickstein, E. Weiss, C. Kunst, 2001, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans.

K. Seuwen, L. Klickstein, M. Kneissel, 2011, Bone.

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women.

K. Seuwen, J. Mason, J. Loeffler, 2014, Bone.

C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion.

L. Klickstein, A. Nicholson-Weller, S. Tas, 1999, Journal of immunology.

Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

L. Klickstein, A. Nicholson-Weller, R. Jack, 1997, Immunity.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers

B. Laffitte, Lu Gan, S. Neelakantham, 2019, Clinical pharmacology in drug development.

Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains.

C. Weber, L. Klickstein, K. Weber, 1999, Molecular biology of the cell.

Localization of the Binding Site on Intercellular Adhesion Molecule-3 (ICAM-3) for Lymphocyte Function-associated Antigen 1 (LFA-1)*

T. Springer, A. D. de Fougerolles, L. Klickstein, 1996, The Journal of Biological Chemistry.

C1q-binding proteins and C1q receptors.

L. Klickstein, A. Nicholson-Weller, A. Nicholson‐Weller, 1999, Current opinion in immunology.

Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1

T. Springer, A. D. de Fougerolles, A. D. Fougerolles, 1993, The Journal of experimental medicine.

Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele

D. Fearon, E. Bonaccio, L. Klickstein, 1989, The Journal of experimental medicine.

STRUCTURE OF THE HUMAN CRl GENE Molecular Basis of the Structural and Quantitative Polymorphisms and Identification of a New CRl-like Allele

James G. Wilson, D. Fearon, E. Bonaccio, 1989 .

Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

D. Fearon, J. Smith, L. Klickstein, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Ligation of Linkers or Adapters to Double‐Stranded cDNA

R. Neve, L. Klickstein, 1991, Current protocols in molecular biology.

Farnesoid X receptor agonist tropifexor attenuates cholestasis in a randomised trial in patients with primary biliary cholangitis

K. Kowdley, H. Wedemeyer, G. Hirschfield, 2022, JHEP reports : innovation in hepatology.

gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation

M. Lacouture, K. Austen, J. Cumplido, 2001, Nature Immunology.

Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin

J. Jensenius, I. Ghiran, L. Klickstein, 2000, The Journal of experimental medicine.

Production of a Subtracted cDNA Library

L. Klickstein, 2001, Current protocols in molecular biology.

Production of a Subtracted cDNA Library

L. Klickstein, 1988, Current protocols in molecular biology.

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

Stephen M. Canham, John A. Tallarico, J. Tallarico, 2021, Cell chemical biology.

Expression and function of C1q receptors and C1q binding proteins at the cell surface.

I. Ghiran, L. Klickstein, A. Nicholson-Weller, 2002, Immunobiology.

Intercellular adhesion molecule 1 and beta2 integrins in C1q-stimulated superoxide production by human neutrophils: an example of a general regulatory mechanism governing acute inflammation.

L. Klickstein, A. Nicholson-Weller, S. Tas, 2000, Arthritis and rheumatism.

Mapping of the C3b-binding site of CR1 and construction of a (CR1)2- F(ab')2 chimeric complement inhibitor

D. Fearon, J. Ahearn, K. Kalli, 1991, The Journal of experimental medicine.

CD35 (Complement Receptor Type 1, CR1)

L. Klickstein, A. Nicholson-Weller, A. Nicholson‐Weller, 2002 .

A role for lipid rafts in C1q-triggered O2- generation by human neutrophils.

I. Ghiran, L. Klickstein, A. Nicholson-Weller, 2004, Molecular immunology.

Production of a Complete cDNA Library

L. Klickstein, 1992, Current protocols in molecular biology.

Production of a Complete cDNA Library

L. Klickstein, 1988, Current protocols in molecular biology.

A transgenic mouse model for studying the clearance of blood‐borne pathogens via human complement receptor 1 (CR1)

S. Jones, R. Finberg, S. Pincus, 2005, Clinical and experimental immunology.

Urinary Monocyte Chemoattractant Protein-1 in Patients With Alport Syndrome

Xin Liu, L. Jennings, L. Klickstein, 2022, Kidney international reports.

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

M. Egerman, D. Glass, T. Shavlakadze, 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

A Comparison of Type I Collagen, Fibronectin, and Vitronectin in Supporting Adhesion of Mechanically Strained Osteoblasts

M. Lacouture, L. Klickstein, J. Schaffer, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Characterization of two novel LPS‐binding sites in leukocyte integrin βA domain

J. Luk, S. Fan, R. Cheng, 2007 .

Characterization of two novel LPS-binding sites in leukocyte integrin betaA domain.

J. Luk, S. Fan, R. Cheng, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CRISPR/Cas9 Gene-Edited Hematopoietic Stem Cell Therapy for Sickle Cell Disease

Jennifer L. Snead, M. Curran, C. Mickanin, 2017 .

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis

D. Fearon, J. Smith, L. Klickstein, 1988, The Journal of experimental medicine.

Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

D. Fearon, J. Smith, L. Klickstein, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Human C3b/C4b Receptor (Cr1): Isolation, Protein Sequence Analysis, and Cloning of a Partial cDNA from Human Tonsil

D. Fearon, L. Klickstein, J. Weis, 1987 .

Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials

L. Klickstein, J. Mannick, D. Quinn, 2021, The Lancet Healthy Longevity.

TORC1 inhibition enhances immune function and reduces infections in the elderly

M. Beibel, D. Glass, T. Shavlakadze, 2018, Science Translational Medicine.

mTOR inhibition improves immune function in the elderly

J. Praestgaard, J. Kovarik, H. Maecker, 2014, Science Translational Medicine.

LMX1B mutations cause hereditary FSGS without extrarenal involvement.

J. Szustakowski, B. Linghu, E. Oakeley, 2013, Journal of the American Society of Nephrology : JASN.

Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes

D. Fearon, R. Carter, J. Ahearn, 1993, The Journal of experimental medicine.

RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

B. Lim, L. Klickstein, L. Cherry, 2004, Nature Immunology.

A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth1

L. Klickstein, K. Weber, L. Cherry, 2001, The Journal of Immunology.

Associated with Increased Cell Growth Inhibits LFA-1-Mediated Cell Adhesion Is A Dominant Jurkat T Cell Mutation That

L. Klickstein, K. Weber, L. Cherry, 2001 .

Chemokine‐induced monocyte transmigration requires cdc42‐mediated cytoskeletal changes

C. Weber, P. Weber, L. Klickstein, 1998, European journal of immunology.

Dual role of H-Ras in regulation of lymphocyte function antigen-1 activity by stromal cell-derived factor-1alpha: implications for leukocyte transmigration.

A. Zernecke, C. Weber, A. Schröder, 2001, Molecular biology of the cell.

AdhesionAdditively Support Erythrocyte C1q and C4b Bind Simultaneously to CR1

Anne Nicholson-Weller, Sander W. Tas, Lloyd B. Klickstein, 2013 .

C5a‐stimulated human neutrophils use a subset of β2 integrins to support the adhesion‐dependent phase of superoxide production

L. Klickstein, A. Nicholson-Weller, S. Tyagi, 2000, Journal of leukocyte biology.

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2

D. Fearon, R. Carter, J. Ahearn, 1989, The Journal of experimental medicine.

Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins

D. Fearon, J. Smith, L. Klickstein, 1987, The Journal of experimental medicine.

Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1

D. Fearon, J. Smith, M. Carroll, 1988, The Journal of experimental medicine.

Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype

D. Fearon, E. Bonaccio, L. Klickstein, 1986, The Journal of experimental medicine.

Manifestations of Inflammatory Arthritis Are Critically Dependent on LFA-11

C. Ballantyne, M. Brenner, David M. Lee, 2005, The Journal of Immunology.

Rituxan for steroid-refractory chronic GVHD

J. Ritz, D. Miklos, D. Bienfang, 2005 .

Rituximab Therapy for Steroid-Refractory Chronic GVHD: Safety and Efficacy Analysis.

J. Ritz, D. Miklos, D. Bienfang, 2004 .

Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are interdependent for cell surface expression.

T. Springer, L. Klickstein, M. York, 1997, Journal of immunology.

A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.

C. Morton, G. Bruns, D. Fearon, 1987, Journal of immunology.

Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family.

D. Fearon, L. Klickstein, J. Weis, 1987, Journal of immunology.

The C3b/C4b receptor (CR1, CD35) on erythrocytes: methods for study of the polymorphisms.

J. Atkinson, V. Subramanian, L. Klickstein, 1999, Molecular immunology.

Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

P. McNamara, W. Dietrich, J. Walker, 2019, Hepatology communications.

Early assessment of safety and efficacy of tropifexor, a potent non bile-acid FXR agonist, in patients with primary biliary cholangitis: An interim analysis of an ongoing phase 2 study

H. Wedemeyer, G. Hirschfield, C. Schramm, 2018 .

Sialylation of ICAM-2 on Platelets Impairs Adhesion of Leukocytes via LFA-1 and DC-SIGN

R. Alon, L. Klickstein, K. Weber, 2004, Inflammation.

TORC1 inhibition as an immunotherapy to reduce infections in the elderly

M. Beibel, D. Glass, T. Shavlakadze, 2017, bioRxiv.

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

M. Karsdal, C. Christiansen, E. Dam, 2009, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.

M. Lacouture, K. Austen, J. Cumplido, 2001, Nature immunology.

Critically Dependent on LFA-1 Manifestations of Inflammatory Arthritis Are

C. Ballantyne, M. Brenner, David M. Lee, 2005 .

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

C. Shapleigh, E. Goetzl, L. Klickstein, 1980, The Journal of clinical investigation.

Developing a Molecular Therapeutic for Hearing Loss

D. Brough, H. Staecker, L. Klickstein, 2016 .

The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation.

M. Shimaoka, T. Springer, T. Xiao, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin

J. Jensenius, I. Ghiran, L. Klickstein, 2000, The Journal of experimental medicine.

Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1.

I. Ghiran, L. Klickstein, G. Weaver, 2008, Blood.

A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants

R. Woessner, L. Klickstein, W. Prince, 2022, Clinical pharmacology in drug development.