A. Harstrick

发表

Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor.

J. Baselga, F. Rojo, O. Dirsch, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

126 Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidilate synthase inhibitor tomudex (D1694)

Y. Rustum, S. Seeber, N. Schleucher, 1995 .

Schedule-dependent antagonism of paclitaxel and cisplatin in human gastric and ovarian carcinoma cell lines in vitro.

U. Vanhoefer, S. Seeber, N. Schleucher, 1995, European journal of cancer.

Activity- and schedule-dependent interactions of paclitaxel, etoposide and hydroperoxy-ifosfamide in cisplatin-sensitive and -refractory human ovarian carcinoma cell lines.

U. Vanhoefer, S. Seeber, N. Schleucher, 1996, British Journal of Cancer.

Phase I study of a weekly schedule of irinotecan, high-dose leucovorin, and infusional fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer.

C. Köhne, U. Vanhoefer, Y. Rustum, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Raltitrexed (Tomudex) in combination with 5-fluorouracil for the treatment of patients with advanced colorectal cancer: preliminary results from phase I clinical trials.

G. Schwartz, A. Harstrick, M. González Barón, 1999, European journal of cancer.

Chemotherapy for germ cell tumors relapsing after high-dose chemotherapy and stem cell support: a retrospective multicenter study of the Austrian Study Group on Urologic Oncology.

C. Bokemeyer, H. Greinix, F. Stoiber, 1997, Annals of oncology : official journal of the European Society for Medical Oncology.

Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines

D. Strumberg, S. Seeber, A. Harstrick, 1996, Anti-cancer drugs.

Role of Chemotherapy Against Micrometastatic Cancer

S. Seeber, W. Eberhardt, A. Harstrick, 2004, Cancer and Metastasis Reviews.

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.

Armando Santoro, David Khayat, David Cunningham, 2004, The New England journal of medicine.

Capecitabine and irinotecan as first-line chemotherapy in patients with metastatic colorectal cancer: results of an extended phase I study.

S. Frings, U. Vanhoefer, Y. Rustum, 2003, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase I study of a weekly 1 h infusion of paclitaxel in patients with unresectable hepatocellular carcinoma.

D. Strumberg, S. Seeber, W. Eberhardt, 1998, European journal of cancer.

Paclitaxel in combination with weekly 24-hour infusional 5-fluorouracil plus leucovorin in the second-line treatment of metastatic breast cancer: results of a phase II study.

D. Strumberg, S. Seeber, W. Eberhardt, 1998, Annals of oncology : official journal of the European Society for Medical Oncology.

Fluorouracil-based combinations in the treatment of metastatic breast cancer.

S. Seeber, A. Harstrick, H. Wilke, 1998, Oncology.

Phase I/II study with a weekly 24-hour infusion of 5-fluorouracil plus high-dose folinic acid (HD-FU/FA) in intensively pretreated patients with metastatic breast cancer.

U. Vanhoefer, S. Seeber, R. Becher, 1996, Annals of oncology : official journal of the European Society for Medical Oncology.

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation.

M. Krause, M. Baumann, H. Thames, 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

New Drugs in Colorectal Cancer: A Review of Antitumor Activity and Cross-Resistance Patterns of Topoisomerase I Inhibitors, Thymidylate Synthetase Inhibitors, and Oxaliplatin

U. Vanhoefer, S. Seeber, A. Harstrick, 1998, Oncology Research and Treatment.

Modulation of fluoropyrimidines: role of dose and schedule of leucovorin administration.

Y. Rustum, A. Harstrick, Z. Zhang, 1992, Seminars in oncology.

Clinical phase I dose escalation and pharmacokinetic study of high-dose chemotherapy with treosulfan and autologous peripheral blood stem cell transplantation in patients with advanced malignancies.

A. Schindler, S. Seeber, R. Hilger, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Dose Escalation and Pharmacokinetic Study of High-Dose Chemotherapy with Treosulfan and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Advanced Malignancies 1

A. Schindler, S. Seeber, R. Hilger, 2000 .

Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin® protein MP0250: a preclinical study

D. Ribatti, U. Fiedler, A. Vacca, 2018, Oncotarget.

Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients.

B. Hill, J. Hansson, K. Scanlon, 1994, European journal of cancer.

Paclitaxel and UFT plus oral calcium folinate in pretreated metastatic breast cancer.

S. Seeber, C. Oberhoff, A. Harstrick, 1999, Oncology.

Cardiotoxicity of 5‐fluorouracil in combination with folinic acid in patients with gastrointestinal cancer

W. Hiddemann, C. Bokemeyer, A. Mügge, 1993, Cancer.

Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N- nitrosourea associated with inhibition of multidrug resistance protein (MRP) function.

M. Yin, U. Vanhoefer, Y. Rustum, 1997, Biochemical pharmacology.

Phase I/II study of capecitabine and vinorelbine in pretreated patients with metastatic breast cancer.

S. Loibl, G. von Minckwitz, U. Vanhoefer, 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

Weekly infusional 5-fluorouracil plus/minus other drugs for the treatment of advanced gastric cancer.

C. Köhne, S. Seeber, H. Schmoll, 1996, The Journal of infusional chemotherapy.

Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials.

H. Schmoll, Y. Rustum, A. Harstrick, 1992, Seminars in oncology.

No synergistic activity of epirubicin and interferon-α2b in the treatment of hepatocellular carcinoma

C. Bokemeyer, H. Schmoll, A. Harstrick, 1995, Cancer Chemotherapy and Pharmacology.

Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. Results of a phase II study.

W. Hiddemann, B. Dörken, C. Bokemeyer, 1997, European journal of cancer.

Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma.

W. Hiddemann, C. Köhne, D. Strumberg, 1997, Annals of oncology : official journal of the European Society for Medical Oncology.

Extended phase I study of capecitabine and weekly irinotecan as first-line chemotherapy in metastatic colorectal cancer

S. Frings, U. Vanhoefer, Y. Rustum, 2001 .

Cisplatin, etoposide, ifosfamide, vincristine and bleomycin combination chemotherapy for far advanced testicular carcinoma.

W. Siegert, F. Natt, L. Bergmann, 1991, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase II study of paclitaxel in patients with relapsed or cisplatin-refractory testicular cancer.

C. Bokemeyer, L. Weissbach, J. Beyer, 1996, Annals of oncology : official journal of the European Society for Medical Oncology.

Gemcitabine in patients with relapsed or cisplatin-refractory testicular cancer.

C. Bokemeyer, L. Kanz, N. Niederle, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The use of dose-intensified chemotherapy in the treatment of metastatic nonseminomatous testicular germ cell tumors. German Testicular Cancer Study Group.

H. Gerhartz, C. Bokemeyer, L. Kanz, 1998, Seminars in oncology.

Differential formation and enhanced removal of specific cisplatin-DNA adducts in two cisplatin-selected resistant human testicular teratoma sublines.

B. Hill, H. Schmoll, A. Harstrick, 1994, Anti-cancer drugs.

Paclitaxel plus ifosfamide in advanced ovarian cancer: results of a phase I study.

D. Strumberg, S. Seeber, A. Harstrick, 1998, Anti-cancer drugs.

Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines

C. Bokemeyer, H. Schmoll, A. Harstrick, 2004, Cancer Chemotherapy and Pharmacology.

Titanocendichloride activity in cisplatin and doxorubicin-resistant human ovarian carcinoma cell lines.

Y. Rustum, H. Schmoll, A. Harstrick, 1993, European journal of cancer.

Single‐agent carboplatinum for advanced seminoma a phase II study

C. Bokemeyer, R. Souchon, W. Berdel, 1993, Cancer.

Bilateral testicular tumours: prevalence and clinical implications.

C. Bokemeyer, P. Schöffski, H. Schmoll, 1993, European journal of cancer.

Single-Agent Carboplatinum for Advanced Seminoma

C. Bokemeyer, W. Berdel, K. Dieckmann, 1993 .

A randomized trial of cisplatin, etoposide and bleomycin (PEB) versus carboplatin, etoposide and bleomycin (CEB) for patients with 'good-risk' metastatic non-seminomatous germ cell tumors.

C. Bokemeyer, L. Weissbach, P. Schöffski, 1996, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase II study of continuous 120 h infusion of mitomycin C as salvage chemotherapy in patients with progressive or rapidly recurrent colorectal cancer.

C. Bokemeyer, L. Kanz, S. Seeber, 1998, Anti-cancer drugs.

Mechanisms of resistance to fluoropyrimidines.

Y. Rustum, A. Harstrick, Z. Zhang, 1992, Seminars in oncology.

249 Preoperative chemotherapy and concurrent chemoradiotherapy based on hyperfractionated accelerated radiation followed by surgery in locally advanced (LAD) inoperable NSCLC stages IIIA and IIIB — The value of PCI

V. Budach, S. Seeber, M. Stuschke, 1997 .

Thrombopoietin serum levels at the start of mobilization, collection, and transfusion of autologous peripheral blood stem cells

S. Seeber, T. Moritz, M. Flasshove, 1999, Journal of clinical apheresis.

Modulation of cytotoxic drug activity by dipyridamole.

H. Schmoll, A. Harstrick, H. Wilke, 1990, Cancer treatment reviews.

Weekly high-dose 5-fluorouracil and folinic acid as salvage treatment in advanced gastric cancer.

U. Vanhoefer, S. Seeber, M. Stahl, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

High-dose chemotherapy with autologous stem cell transplantation in patients with oligometastatic breast cancer

U. Vanhoefer, S. Seeber, M. Scheulen, 2004, Bone Marrow Transplantation.

Cisplatin/etoposide/ifosfamide stepwise dose escalation with concomitant granulocyte/macrophage-colony-stimulating factor for patients with far-advanced testicular carcinoma

W. Siegert, C. Bokemeyer, H. Schmoll, 2005, Journal of Cancer Research and Clinical Oncology.

Activity of cytostatic drugs in two heterotransplanted human testicular cancer cell lines with different sensitivity to standard agents.

H. Schmoll, A. Harstrick, H. Wilke, 1990, European journal of cancer.

Comparative antitumour activity of cisplatin and two new cisplatin-analogues JM8 and JM9 in human testicular carcinoma xenografts.

H. Schmoll, A. Harstrick, J. Casper, 1987, International Journal of Andrology.

Modulation of cytostatic drugs by nifedipine in two heterotransplanted human testicular‐cancer cell lines differing in their sensitivity to standard agents

H. Schmoll, A. Harstrick, H. Poliwoda, 1994, International journal of cancer.

Phase I study of docetaxel in combination with gemcitabine as first line chemotherapy (CT) in patients with metastatic non-small cell lung cancer (NSCLC)

U. Gatzemeier, M. Reck, W. Eberhardt, 1999 .

Preclinical and clinical study results of the combination of paclitaxel and 5-fluorouracil/folinic acid in the treatment of metastatic breast cancer.

S. Seeber, A. Harstrick, H. Wilke, 1996, Seminars in oncology.

Effect of 4-Hydroperoxyifosfamide on the Cellular Glutathione Pathway

U. Vanhoefer, S. Seeber, A. Harstrick, 1998, Oncology Research and Treatment.

Phase I clinical and pharmacokinetic study of titanocene dichloride in adults with advanced solid tumors.

E. Thiel, O. Gründel, H. Schmoll, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Down-regulation of topoisomerase II by camptothecin does not prevent additive activity of the topoisomerase II inhibitor etoposide in vitro

M. Stahl, A. Harstrick, S. Kasimir-Bauer, 1997, Anti-cancer drugs.

Detection of germ-cell tumor cells in the peripheral blood by nested reverse transcription-polymerase chain reaction for alpha-fetoprotein-messenger RNA and beta human chorionic gonadotropin-messenger RNA.

Mengji Lu, A. Bex, M. Roggendorf, 2000, Cancer research.

Cisplatin, etoposide, and ifosfamide salvage therapy for refractory or relapsing germ cell carcinoma.

C. Bokemeyer, H. Schmoll, M. Stahl, 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

First-line high-dose chemotherapy compared with standard-dose PEB/VIP chemotherapy in patients with advanced germ cell tumors: A multivariate and matched-pair analysis.

C. Meisner, C. Bokemeyer, L. Kanz, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Detection of chromosomal DNA gains and losses in testicular germ cell tumors by comparative genomic hybridization

D. Weghuis, A. V. van Kessel, S. Seeber, 1996, Genes, chromosomes & cancer.

Comparative activity of four anthracyclines against heterotransplanted germ cell tumor lines

H. Schmoll, A. Harstrick, H. Wilke, 2004, Investigational New Drugs.

Transcription-Polymerase Chain Reaction for a-Fetoprotein-Messenger RNA and b Human Chorionic Gonadotropin-Messenger RNA 1

Mengji Lu, A. Bex, M. Roggendorf, 2000 .

Clinical pharmacokinetics of intravenous treosulfan in patients with advanced solid tumors

S. Seeber, R. Hilger, M. Scheulen, 1998, Cancer Chemotherapy and Pharmacology.

First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors

A. Harris, M. Stumpp, U. Fiedler, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumors.

C. Bokemeyer, L. Kanz, P. Biron, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Etoposide, folinic acid, and 5-fluorouracil in carboplatin-pretreated patients with advanced gastric cancer

S. Seeber, H. Schmoll, M. Stahl, 2004, Cancer Chemotherapy and Pharmacology.

Etoposide, Leukovorin and 5-Fluorouracil (ELF) in Advanced Gastric Carcinoma – Final Results of a Phase-II Study in Elderly Patients or Patients with Cardiac Risk

H. Schmoll, M. Stahl, A. Harstrick, 1991 .

Preoperative chemotherapy followed by concurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: mature results of a phase II trial.

V. Budach, H. Sack, S. Seeber, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Irinotecan in the treatment of colorectal cancer: clinical overview.

U. Vanhoefer, Y. Rustum, S. Seeber, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Comparison of an immunoperoxidase "sandwich" staining method and western blot detection of P-glycoprotein in human cell lines and sarcomas.

Y. Rustum, M. Arredondo, H. Slocum, 1992, The American journal of pathology.

A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours.

W. Siegert, C. Bokemeyer, W. Berdel, 1993, European journal of cancer.

Comparison of the antitumor activity of cisplatin, carboplatin, and iproplatin against established human testicular cancer cell lines in vivo and in vitro

H. Schmoll, A. Harstrick, H. Wilke, 1989, Cancer.

Side-effects of GM-CSF treatment in advanced testicular cancer.

C. Bokemeyer, H. Schmoll, A. Harstrick, 1993, European journal of cancer.

Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

R. Pieters, K. Sikora, W. Siegert, 1991, Journal of Cancer Research and Clinical Oncology.

Comparative antitumor efficacy of docetaxel and paclitaxel in nude mice bearing human tumor xenografts that overexpress the multidrug resistance protein (MRP)

S Seeber, U. Vanhoefer, Y. Rustum, 1997, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase II study of single-agent etoposide in patients with metastatic squamous-cell carcinoma of the esophagus

C. Bokemeyer, H. Schmoll, M. Stahl, 2004, Cancer Chemotherapy and Pharmacology.

Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.

M. Yin, U. Vanhoefer, Y. Rustum, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A Phase I Dose Escalation Trial of Intravenous Treosulfan in Refractory Cancer

D. Strumberg, S. Seeber, M. Scheulen, 1996 .

360 Phase I/II study with paclitaxel in combination with weekly high dose 5-FU/Folinic acid in the treatment of metastatic breast cancer

D. Strumberg, S. Seeber, R. Becher, 1995 .

The use of carboplatin in malignant germ cell tumours.

C. Bokemeyer, H. Schmoll, A. Harstrick, 1994, European journal of cancer.

Phase I/II study with paclitaxel in combination with weekly high-dose 5-fluorouracil/folinic acid in the treatment of metastatic breast cancer: an interim analysis.

D. Strumberg, S. Seeber, R. Becher, 1995, Seminars in Oncology.

Epirubicin/dacarbazine rapidly alternated with ifosfamide in the treatment of metastatic soft tissue sarcomas.

C. Bokemeyer, P. Schöffski, H. Schmoll, 1992, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck.

J. Baselga, P. Gascón, R. Hitt, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Antitumor-activity and toxicity of continuous-infusion versus bolus administration of bleomycin in 2 heterotransplanted human testicular cancer cell-lines.

C. Bokemeyer, E. Ludwig, H. Schmoll, 1995, Oncology reports.

Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC.

M. Krause, M. Baumann, N. Pimentel, 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Comparison between short or long exposure to 5-fluorouracil in human gastric and colon cancer cell lines: biochemical mechanism of resistance.

J. Formento, G. Milano, U. Vanhoefer, 1998, Anti-cancer drugs.

New systemic frontline treatment for metastatic colorectal carcinoma

U. Vanhoefer, A. Braun, A. Harstrick, 2004, Cancer.

Cellular determinants of resistance to indolocarbazole analogue 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13(beta-D-glucopyranosyl)- 5H-indolo[2,3-alpha]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), a novel potent topoisomerase I inhibitor, in multidrug-resistant human tumor cells.

W. Voigt, M. Yin, U. Vanhoefer, 1997, Oncology research.

Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

J. Bourhis, C. Borel, A. Schueler, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The anti-tumour activity of ifosfamide on heterotransplanted testicular cancer cell lines remains unaltered by the uroprotector mesna.

C. Bokemeyer, E. Ludwig, H. Schmoll, 1994, British Journal of Cancer.

5-Fluorouracil, folinic acid, etoposide and cisplatin chemotherapy for locally advanced or metastatic carcinoma of the oesophagus.

M. Stahl, A. Harstrick, H. Wilke, 1994, European journal of cancer.

First-Line High-Dose Chemotherapy for ’Poor Risk’ Metastatic Non-Seminomatous Testicular Germ Cell Tumors

B. Kempf, H. Gerhartz, C. Bokemeyer, 1998, Oncology Research and Treatment.

Infusional 5-FU, folinic acid, paclitaxel, and cisplatin for metastatic breast cancer.

S. Seeber, C. Müller, M. Korn, 1997, Oncology.

Abstract CT003: Innate cell engager (ICE®) AFM13 combined with preactivated and expanded cord blood (CB)-derived NK cells for patients with refractory/relapsed CD30+ lymphoma

R. Başar, K. Rezvani, E. Shpall, 2022, Cancer Research.

Phase II trial of continuous oral trofosfamide in patients with advanced colorectal cancer refractory to 5-fluorouracil.

D. Strumberg, S. Seeber, W. Eberhardt, 1997, Anti-cancer drugs.

Treatment of patients with cisplatin‐refractory testicular germ‐cell cancer

C. Bokemeyer, L. Kanz, C. Kollmannsberger, 1999 .

Treatment of patients with cisplatin-refractory testicular germ-cell cancer. German Testicular Cancer Study Group (GTCSG).

C. Bokemeyer, L. Kanz, C. Kollmannsberger, 1999, International journal of cancer.

Cytotoxicity of phenol to musculoskeletal tumours

U. Quint, A. Harstrick, R. T. Müller, 1996 .

Innate Cell Engager AFM13 Combined with Preactivated and Expanded Cord Blood-Derived NK Cells for Patients with Double Refractory CD30+ Lymphoma

R. Başar, E. Shpall, Y. Nieto, 2022, Blood.

Abstract B25: First-in-human Phase I study to evaluate MP0250, a DARPin blocking HGF and VEGF, in patients with advanced solid tumors

M. Stumpp, M. Middleton, R. Baird, 2015 .

Short report: High dose epirubicin in refractory or relapsed non-seminomatous testicular cancer: A phase II study

C. Bokemeyer, H. Schmoll, M. Stahl, 1990 .

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.

E. Van Cutsem, A. Santoro, D. Khayat, 2004, The New England journal of medicine.

The anti-tumour activity of ifosfamide on heterotransplanted testicular cancer cell lines remains unaltered by the uroprotector mesna.

E. Ludwig, H. Schmoll, A. Harstrick, 1994, British Journal of Cancer.

Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines

U. Vanhoefer, Y. Rustum, S. Seeber, 1999, British Journal of Cancer.

Ifosfamide-based drug combinations: preclinical evaluation of drug interactions and translation into the clinic.

U. Vanhoefer, S. Seeber, N. Schleucher, 2000, Seminars in oncology.