P. Pritchard

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The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.

N. Lawson, D. Brindley, P. Pritchard, 1977, The Biochemical journal.

The effect of chronic diabetes, induced by streptozotocin, on the activities of some enzymes of glycerolipid synthesis in rat liver.

D. Brindley, P. Pritchard, M. Bowley, 1977, The Biochemical journal.

The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol.

S. Pawson, D. Brindley, P. Pritchard, 1979, The Biochemical journal.

125I labelled inulin: a convenient marker for deposition of liposomal contents in vivo.

P. Cullis, P. Pritchard, E. Sommerman, 1984, Biochemical and biophysical research communications.

Differences in Lipoprotein Lipid Concentration and Composition Modify the Plasma Distribution of Cyclosporine

E. Donnachie, K. Wasan, P. Pritchard, 1997, Pharmaceutical Research.

Eur J Clin Pharmacol (2008) 64:651–661 DOI 10.1007/s00228-008-0462-1 CLINICAL TRIAL

M. Trip, J. Kastelein, M. D. de Barse, 2022 .

Expression and characterization of recombinant human 1ecithin:cholesterol acyltransferase

John S. Hill, Xingbo Wang, A. Lacko, 1993 .

Influence of phytostanol phosphoryl ascorbate (FM-VP4) on insulin resistance, hyperglycemia, plasma lipid levels, and gastrointestinal absorption of exogenous cholesterol in Zucker (fa/fa) fatty and lean rats.

R. Pederson, K. Wasan, P. Pritchard, 2003, Journal of pharmaceutical sciences.

Pharmacokinetics, Distribution in Serum Lipoproteins and Tissues, and Renal Toxicities of Amphotericin B and Amphotericin B Lipid Complex in a Hypercholesterolemic Rabbit Model: Single-Dose Studies

K. Wasan, P. Pritchard, M. Ramaswamy, 1998, Antimicrobial Agents and Chemotherapy.

A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity.

A. von Eckardstein, G. Assmann, J. Kastelein, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Effects of high-fat diet and fasting on levels of acyl-coenzyme A binding protein in liver, kidney, and heart of rat.

S. Pande, P. Pritchard, D. Seccombe, 1995, Metabolism: clinical and experimental.

Analysis of familial hypoalphalipoproteinemia syndromes

J. Frohlich, P. Pritchard, 1992, Molecular and Cellular Biochemistry.

The clinical significance of serum high density lipoproteins.

J. Frohlich, P. Pritchard, 1989, Clinical biochemistry.

Familial high‐density‐lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent

J. Kastelein, J. Frohlich, D. Erkelens, 1992, Journal of internal medicine.

A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities.

A. von Eckardstein, G. Assmann, M. Karas, 1991, The Journal of clinical investigation.

Development of novel water-soluble phytostanol analogs: disodium ascorbyl phytostanyl phosphates (FM-VP4): preclinical pharmacology, pharmacokinetics and toxicology.

K. Wasan, P. Pritchard, T. Lukić, 2006, Cardiovascular drug reviews.

Transmission of two novel mutations in a pedigree with familial lecithin:cholesterol acyltransferase deficiency: structure-function relationships and studies in a compound heterozygous proband.

T. Lyons, W. Garvey, R. Klein, 1998, Journal of lipid research.

Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study

J. Ingle, P. Goss, D. Tu, 2012, Breast Cancer Research and Treatment.

Comparison of Cholesterol-Lowering Efficacy and Anti-Atherogenic Properties of Hydrogenated versus Non-Hydrogenated (Phytrol™) Tall Oil-Derived Phytosterols in Apo E-Deficient Mice

M. Moghadasian, P. Pritchard, Min Li, 2003, Cardiovascular Drugs and Therapy.

Cholesterol mobilization and regression of atheroma in cholesterol-fed rabbits induced by large unilamellar vesicles.

M. Hope, S. Klimuk, P. Pritchard, 1998, Biochimica et biophysica acta.

Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties.

C. Nuckolls, A. Dell, H. Morris, 1998, Journal of lipid research.

Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source.

A. Lacko, A. Ayyobi, H. Molhuizen, 2000, Biochimica et biophysica acta.

Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats.

M. Moghadasian, K. Wasan, P. Pritchard, 2001, Journal of pharmaceutical sciences.

Extensive lifestyle management intervention following cardiac rehabilitation: pilot study.

A. Ignaszewski, S. Lear, J. Frohlich, 2001, Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses.

Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.

M. Hayden, J. Frohlich, J. Hill, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Effects of Multidisciplinary Cardiac Rehabilitation Program on Plasma Lipid Profile

A. Ignaszewski, J. Frohlich, J. St-Amand, 1999 .

The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease).

A. Chonn, P. Pritchard, C. Yeung, 1985, Blood.

The role of apoproteins in disorders of lipoprotein metabolism.

J. Frohlich, P. Pritchard, D. Seccombe, 1989, Clinical biochemistry.

Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.

U. Steinbrecher, P. Pritchard, Urs P. Steinbrecher, 1989, Journal of lipid research.

Cholesterol esterification rates in very low density lipoprotein- and low density lipoprotein-depleted plasma. Relation to high density lipoprotein subspecies, sex, hyperlipidemia, and coronary artery disease.

J. Frohlich, M. Dobiášová, D. Sparks, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Lecithin:cholesterol acyltransferase in familial HDL deficiency (Tangier disease).

J. Frohlich, A. Lacko, R. Mcleod, 1988, Biochimica et biophysica acta.

Effects of a novel hydrophilic phytostanol analog on plasma lipid concentrations in gerbils.

K. Wasan, P. Pritchard, K. Peteherych, 2001, Journal of pharmaceutical sciences.

Lp(a) concentration and apo(a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia.

J. Frohlich, J. Hill, P. Pritchard, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Cholesterol esterification rate in plasma depleted of very low and low density lipoproteins is controlled by the proportion of HDL2 and HDL3 subclasses: study in hypertensive and normal middle-aged and septuagenarian men.

J. Frohlich, M. Dobiášová, P. Pritchard, 1992, Journal of lipid research.

Proton magnetic resonance spectroscopy of plasma from patients with dyslipoproteinemia: identification of factors governing methyl and methylene proton line widths.

F. G. Herring, P. S. Phillips, P. Pritchard, 1989, Journal of lipid research.

Plasma lipoprotein abnormalities in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.

J. Frohlich, R. Mcleod, P. Pritchard, 1988, Metabolism: clinical and experimental.

Cholesteryl ester transfer activity in plasma of patients with familial high-density lipoprotein deficiency.

J. Frohlich, D. Sparks, P. Pritchard, 1988, Clinical chemistry.

Hypoalphalipoproteinemia resembling fish eye disease.

M. Hayden, L. Wadsworth, J. Frohlich, 2009, Acta medica Scandinavica.

Cholesteryl ester transfer activity in plasma measured by using solid-phase-bound high-density lipoprotein.

J. Frohlich, P. Cullis, D. Sparks, 1987, Clinical chemistry.

Improved phenotyping of apolipoprotein E: application to population frequency distribution.

J. Hill, P. Pritchard, 1990, Clinical chemistry.

Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers.

A. von Eckardstein, G. Assmann, P. Cullen, 1999, Journal of lipid research.

Influence of phytostanol phosphoryl ascorbate, FM-VP4, on pancreatic lipase activity and cholesterol accumulation within Caco-2 cells.

K. Wasan, P. Pritchard, M. Ramaswamy, 2002, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats.

M. Hayden, J. Brunzell, P. Pritchard, 1990, Clinical and investigative medicine. Medecine clinique et experimentale.

Effect of cyclosporine A on the binding affinity and internalization of low-density lipoproteins in human skin fibroblasts.

E. Donnachie, K. Wasan, P. Pritchard, 2002, Journal of pharmaceutical sciences.

The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L).

E. Perez, J. Ingle, P. Goss, 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

Two novel molecular defects in the LCAT gene are associated with fish eye disease.

J. Kastelein, P. Demacker, A. Stalenhoef, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy.

J. Frohlich, P. Cullis, D. Sparks, 1989, Journal of lipid research.

Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats.

K. Wasan, P. Pritchard, K. Peteherych, 2001, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis.

D. Vance, S. Pelech, D. Brindley, 1983, The Journal of biological chemistry.

Overexpression of acyl-CoA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells

M. Moghadasian, Yingying Yang, P. Pritchard, 2001, Lipids.

Relationship between cholesteryl ester transfer activity and high density lipoprotein composition in hyperlipidemic patients.

J. Frohlich, A. Lacko, D. Sparks, 1989, Atherosclerosis.

Purification of biologically active apolipoproteins by chromatofocussing.

J. Frohlich, A. Lacko, R. Mcleod, 1986, Journal of chromatography.

The influence of size and composition on the cholesterol mobilizing properties of liposomes in vivo.

M. Hope, P. Pritchard, W. Rodrigueza, 1993, Biochimica et biophysica acta.

Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice.

D. Zamfir, M. Moghadasian, K. Wasan, 2003, Metabolism: clinical and experimental.

Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease.

A. von Eckardstein, M. Hayden, H. Wiebusch, 1993, The Journal of clinical investigation.

Detection of protein-free lipoprotein analogues with an apolar lipid core by freeze-etch electron microscopy.

L. Mayer, P. Cullis, K. Wong, 1987, Biochimica et biophysica acta.

Molecular species of phosphatidylcholine in familial lecithin-cholesterol acyltransferase deficiency: effect of enzyme supplementation.

P. Subbaiah, P. Pritchard, 1989, Biochimica et biophysica acta.

Current Controlled Trials in Cardiovascular Medicine A randomized controlled trial of an extensive lifestyle management intervention (ELMI) following cardiac rehabilitation: study design and baseline data

J. Spinelli, W. Linden, A. Ignaszewski, 2002 .

Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency.

J. Frohlich, P. Pritchard, T. Ohta, 1995, Atherosclerosis.

Substrate and positional specificities of human and mouse lecithin-cholesterol acyltransferases. Studies with wild type recombinant and chimeric enzymes expressed in vitro.

J. Senz, M. Liu, P. Subbaiah, 1994, Biochimica et biophysica acta.

Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein.

J. Hill, P. Pritchard, X. Wang, 1993, Journal of lipid research.

Expression and characterization of recombinant human lecithin:cholesterol acyltransferase.

A. Lacko, J. Hill, P. Pritchard, 1993, Journal of lipid research.

Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils.

K. Wasan, P. Pritchard, M. Kwong, 2001, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Prolonged effects of cyclic AMP analogues of phosphatidylcholine biosynthesis in cultured rat hepatocytes.

D. Vance, S. Pelech, P. Pritchard, 1982, Biochimica et biophysica acta.

cAMP analogues inhibit phosphatidylcholine biosynthesis in cultured rat hepatocytes.

D. Vance, S. Pelech, P. Pritchard, 1981, The Journal of biological chemistry.

An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease).

G. Assmann, J. Kastelein, R. Benne, 1996, The Journal of clinical investigation.

Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathway.

P. Chiang, D. Vance, G. Cantoni, 1982, The Journal of biological chemistry.

Effects of disodium ascorbyl phytostanol phosphates (FM-VP4) on cholesterol accumulation within rat intestinal cells

K. Wasan, P. Pritchard, E. Yau, 2003, AAPS PharmSci.

Diethylstilbestrol treatment modulates the enzymatic activities of phosphatidylcholine biosynthesis in rooster liver.

D. Vance, P. Pritchard, H. Paddon, 1981, Biochimica et biophysica acta.

The effects of amphiphilic compounds on phosphatidate metabolism.

D. Brindley, P. Pritchard, M. Bowley, 1978, Advances in experimental medicine and biology.

Effect of cAMP on choline uptake and phosphatidylcholine biosynthesis in cultured chick heart cells.

S. Rabkin, P. Pritchard, P. Sunga, 1988, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Choline metabolism and phosphatidylcholine biosynthesis in cultured rat hepatocytes.

D. Vance, P. Pritchard, 1981, The Biochemical journal.

Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met).

H. Klein, H. Brewer, P. Pritchard, 1992, The Journal of clinical investigation.

Peroxisome Proliferator-Activated Receptor (PPAR)-α: A Pharmacological Target with a Promising Future

D. V. van Raalte, K. Wasan, P. Pritchard, 2004, Pharmaceutical Research.

Stimulation of hepatic phosphatidylcholine biosynthesis in rats fed a high cholesterol and cholate diet correlates with translocation of CTP: phosphocholine cytidylyltransferase from cytosol to microsomes.

D. Vance, P. Pritchard, H. Paddon, 1983, Biochimica et biophysica acta.

The effects of administering N‐(2‐benzoyloxyethyl) norfenfluramine to rats on the hepatic synthesis of glycerolipids

K. A. Lloyd-Davies, D. Brindley, P. Pritchard, 1976, The Journal of pharmacy and pharmacology.

T-->G or T-->A mutation introduced in the branchpoint consensus sequence of intron 4 of lecithin:cholesterol acyltransferase (LCAT) gene: intron retention causing LCAT deficiency.

J. Kuivenhoven, A. Ayyobi, P. Pritchard, 1998, Biochimica et biophysica acta.

Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels.

J. Boer, P. de Knijff, J. Kastelein, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Homozygous Tangier disease and cardiovascular disease.

R. Lees, E. Schaefer, E. Janus, 1994, Atherosclerosis.

Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism.

J. Hill, P. Pritchard, X. Wang, 1993, Biochimica et biophysica acta.

Development and Characterization of Liposomal Disodium Ascorbyl Phytostanyl Phosphates (FM‐VP4)

K. Wasan, P. Pritchard, T. Lukić, 2004, Drug development and industrial pharmacy.

A unique genetic and biochemical presentation of fish-eye disease.

G. Assmann, H. Wiebusch, J. Kastelein, 1995, The Journal of clinical investigation.

"Tall oil"-derived phytosterols reduce atherosclerosis in ApoE-deficient mice.

B. McManus, J. Frohlich, M. Moghadasian, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of the Effects of Mutations in the Putative Branchpoint Sequence of Intron 4 on the Splicing within the Human Lecithin:cholesterol Acyltransferase Gene*

P. Pritchard, Min Li, P. Haydn Pritchard, 2000, The Journal of Biological Chemistry.

Lipid transfer proteins, hypertriglyceridemia, and reduced high-density lipoprotein cholesterol.

J. Frohlich, D. Sparks, P. Pritchard, 1991, American heart journal.

A randomized controlled trial of an extensive lifestyle management intervention (ELMI) following cardiac rehabilitation: study design and baseline data

J. Spinelli, W. Linden, A. Ignaszewski, 2002, Current controlled trials in cardiovascular medicine.

Analogues of cyclic AMP inhibit phosphatidylethanolamine N-methylation by cultured rat hepatocytes.

D. Vance, S. Pelech, P. Pritchard, 1981, Biochimica et biophysica acta.

Separation of liposomes from plasma components using fast protein liquid chromatography.

T. D. Madden, A. Ayyobi, P. Pritchard, 1999, Analytical biochemistry.

A kindred with fish eye disease, corneal opacities, marked high-density lipoprotein deficiency, and statin therapy.

E. Schaefer, J. Frohlich, B. Asztalos, 2014, Journal of clinical lipidology.

Probing the 121-136 domain of lecithin:cholesterol acyltransferase using antibodies.

A. Lacko, A. Ayyobi, J. Hill, 2001, Archives of biochemistry and biophysics.

A first British case of fish-eye disease presenting at age 75 years: a double heterozygote for defined and new mutations affecting LCAT structure and expression.

P. Pritchard, D. Vallance, A. Winder, 1999, Journal of clinical pathology.

Lecithin:cholesterol acyltransferase: role of N-linked glycosylation in enzyme function.

R. Mcleod, J. Hill, P. Pritchard, 1993, The Biochemical journal.

Can the alterations in serum glucocorticoid concentrations explain the effects of ethanol and benfluorex on the synthesis of hepatic triacylglycerols?

D. Brindley, P. Pritchard, P. Haydn Pritchard, 1979, The Journal of pharmacy and pharmacology.

Studies on the ethanol‐induced changes in glycerolipid synthesis in rats and their partial reversal by N‐(2‐benzoyloxyethyl)norfenfluramine (benfluorex)

D. Brindley, P. Pritchard, P. HAYDN PRITCHARD, 1977, The Journal of pharmacy and pharmacology.

Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes.

D. Vance, S. Pelech, D. Brindley, 1983, The Biochemical journal.

Lipid transfer protein I facilitated transfer of cyclosporine from low- to high-density lipoproteins is only partially dependent on its cholesteryl ester transfer activity.

K. Wasan, P. Pritchard, M. Ramaswamy, 1998, Journal of Pharmacology and Experimental Therapeutics.

Cyclosporine Transfer from Low- and High-Density Lipoproteins Is Partially Influenced by Lipid Transfer Protein I Triglyceride Transfer Activity

K. Wasan, P. Pritchard, M. Ramaswamy, 1999, Pharmaceutical Research.

2nd International Symposium on Reverse Cholesterol Transport: report on a meeting.

A. Lacko, P. Pritchard, 1994, Journal of lipid research.

Structural Differences Between Wild-type and Fish Eye Disease Mutant of Lecithin:cholesterol Acyltransferase

Y. Reshetnyak, A. Lacko, P. Pritchard, 2006, Journal of biomolecular structure & dynamics.

Transfer of cholesteryl ester into high density lipoprotein by cholesteryl ester transfer protein: effect of HDL lipid and apoprotein content.

D. Sparks, P. Pritchard, 1989, Journal of lipid research.

Influence of plasma on the osmotic sensitivity of large unilamellar vesicles prepared by extrusion.

P. Cullis, T. D. Madden, B. Mui, 1994, The Journal of biological chemistry.

The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Effects of acute feeding with glucose, fructose, sorbitol, glycerol and ethanol.

D. Brindley, P. Pritchard, R. Sturton, 1978, The Biochemical journal.

THE PLASMA DISTRIBUTION OF BENZOPORPHYRIN DERIVATIVE and THE EFFECTS OF PLASMA LIPOPROTEINS ON ITS BIODISTRIBUTION

A. Richter, B. Allison, J. Levy, 1990, Photochemistry and photobiology.

Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative.

B. Allison, J. Levy, P. Pritchard, 1994, British Journal of Cancer.

Effect of interfacial pressure on the binding and phospholipase A2 activity of recombinant human lecithin-cholesterol acyltransferase.

J. B. Jones, A. Lacko, P. Pritchard, 1995, Biochemical and biophysical research communications.

Role of N-linked glycosylation of lecithin:cholesterol acyltransferase in lipoprotein substrate specificity.

J. Hill, P. Pritchard, K. O, 1995, Biochimica et biophysica acta.

familial high density lipoprotein deficiency (Tangier disease) The degradation of platelet-activating factor in the plasma of a patient with

A. Chonn, P. Pritchard, C. Yeung, 2011 .

Deletion of the propeptide of apolipoprotein A-I impairs exit of nascent apolipoprotein A-I from the endoplasmic reticulum.

R. McLeod, A. Burns, P. Pritchard, 1994, The Biochemical journal.

A mechanism by which fenfluramine and benfluorex could inhibit the synthesis of triacylglycerols [proceedings].

D. Brindley, P. Pritchard, R. Sturton, 1978, British journal of pharmacology.