J. Prot

发表

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.

E. Leclerc, D. A. Ouattara, B. Elena-Herrmann, 2012, Molecular bioSystems.

Microfabricated mammalian organ systems and their integration into models of whole animals and humans.

Mandy B. Esch, Michael L Shuler, James J Hickman, 2013, Lab on a chip.

Piezoelectric bioMEMS cantilever for measurement of muscle contraction and for actuation of mechanosensitive cells

J. Hickman, M. Shuler, Ying I. Wang, 2019, MRS communications.

Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions

F. Bois, E. Leclerc, J. Prot, 2012, BMC Genomics.

The Current Status of Alternatives to Animal Testing and Predictive Toxicology Methods Using Liver Microfluidic Biochips

E. Leclerc, J. Prot, 2012, Annals of Biomedical Engineering.

Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip

Yves Grandvalet, Cécile Legallais, Franck Letourneur, 2011, PloS one.

How multi-organ microdevices can help foster drug development.

Mandy B. Esch, Michael L Shuler, James J Hickman, 2014, Advanced drug delivery reviews.

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.

Michael L Shuler, Jean-Matthieu Prot, Mandy B Esch, 2015, Lab on a chip.

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Cécile Legallais, Eric Leclerc, Régis Baudoin, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.

Laurent Griscom, Cécile Legallais, Florence Razan, 2012, Toxicology and applied pharmacology.

Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.

Cécile Legallais, Eric Leclerc, Vincent Navratil, 2012, Analytical chemistry.

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

Laurent Griscom, Cécile Legallais, Eric Leclerc, 2011 .

Microphysiological systems and low-cost microfluidic platform with analytics

Peter Molnar, Michael L Shuler, James J Hickman, 2013, Stem Cell Research & Therapy.

A phenotypic in vitro model for the main determinants of human whole heart function.

William McLamb, James J. Hickman, Peter Molnar, 2015, Biomaterials.

Improvement of HepG2/C3a cell functions in a microfluidic biochip

Laurent Griscom, Cécile Legallais, Florence Razan, 2011, Biotechnology and bioengineering.

Evaluation of the mass transfers of caffeine and vitamin B12 in chloroacetaldehyde treated renal barrier model using a microfluidic biochip

E. Leclerc, P. Paullier, J. Prot, 2012 .

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

Eric Leclerc, Patrick Paullier, F. Bois, 2014, Biotechnology and bioengineering.

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening.

Cécile Legallais, Eric Leclerc, Jean-Matthieu Prot, 2011, International journal of pharmaceutics.

INTEGRATION OF TRANSCRIPTOMIC , PROTEOMIC AND METABOLOMIC PROFILES IN MICROFLUIDIC BIOARTIFICIAL ORGANS APPLIED TO MECHANISTIC INTERPRETATION OF ACETAMINOPHEN INJURY

L. Griscom, E. Leclerc, B. Elena-Herrmann, 2012 .

The Current Status of Alternatives to Animal Testing and Predictive Toxicology Methods Using Liver Microfluidic Biochips

Eric Leclerc, E. Leclerc, J. Prot, 2011, Annals of Biomedical Engineering.