P. Lettéron

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Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo.

D. Pessayre, B. Fromenty, A. Berson, 1996, Gastroenterology.

Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation.

D. Pessayre, G. Feldmann, M. Robin, 1997, The American journal of physiology.

Inhibition of microsomal triglyceride transfer protein: Another mechanism for drug‐induced steatosis in mice

D. Pessayre, B. Fromenty, A. Sutton, 2003, Hepatology.

Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II.

D. Pessayre, B. Fromenty, A. Berson, 1990, The Journal of pharmacology and experimental therapeutics.

Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model

C. Beaumont, C. Ged, T. Lefèbvre, 2017, Haematologica.

Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction.

D. Pessayre, B. Fromenty, G. Feldmann, 1996, Gastroenterology.

Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation.

C. Beaumont, S. Lasocki, Z. Karim, 2010, Blood.

Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents

B. Viollet, A. Bado, P. Lettéron, 2009, PloS one.

Central role of mitochondria in drug-induced liver injury

D. Pessayre, B. Fromenty, R. Moreau, 2012, Drug metabolism reviews.

Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice.

D. Pessayre, B. Fromenty, C. Degott, 1996, Journal of hepatology.

Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.

C. Beaumont, A. Bado, Z. Karim, 2011, Gastroenterology.

Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice

C. Beaumont, J. Deybach, L. Gouya, 2013, Mammalian Genome.

Effects of Zidovudine, Stavudine and β-Aminoisobutyric Acid on Lipid Homeostasis in Mice: Possible Role in Human Fat Wasting

D. Pessayre, B. Fromenty, J. Bastin, 2004, Antiviral therapy.

Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene.

C. Beaumont, J. Deybach, L. Gouya, 2007, Gastroenterology.

Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis.

D. Thabut, E. Ogier-Denis, J. Devière, 2011, Journal of hepatology.

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

V. Paradis, J. Wan, R. Moreau, 2018, Nature Communications.

NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation

R. Moreau, P. Lettéron, P. Rautou, 2017, Gut.

Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy

D. Pessayre, B. Fromenty, G. Feldmann, 1993, Hepatology.

Mechanism for isaxonine hepatitis. I. Metabolic activation by mouse and human cytochrome P-450.

G. Danan, D. Pessayre, J. Belghiti, 1984, The Journal of pharmacology and experimental therapeutics.

Hepatotoxicity of germander in mice.

D. Pessayre, C. Degott, P. Dansette, 1994, Gastroenterology.

Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450.

D. Pessayre, J. Belghiti, P. Maurel, 1990, Biochemical pharmacology.

Inhibitory effects of nilutamide, a new androgen receptor antagonist, on mouse and human liver cytochrome P-450.

D. Pessayre, A. Berson, P. Lettéron, 1989, Biochemical pharmacology.

Methoxsalen decreases the metabolic activation and prevents the hepatotoxicity and nephrotoxicity of chloroform in mice.

G. Labbe, D. Pessayre, C. Degott, 1987, Toxicology and applied pharmacology.

The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.

G. Labbe, D. Pessayre, C. Degott, 1987, Biochemical pharmacology.

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives.

D. Pessayre, J. Belghiti, P. Lettéron, 1987, Biochemical pharmacology.

Formation of an inactive cytochrome P-450Fe(II)-metabolite complex after administration of amiodarone in rats, mice and hamsters.

D. Pessayre, P. Lettéron, V. Descatoire, 1986, Biochemical pharmacology.

Regulation of renal cytochrome P-450. Effects of two-thirds hepatectomy, cholestasis, biliary cirrhosis and post-necrotic cirrhosis on hepatic and renal microsomal enzymes.

D. Pessayre, C. Degott, C. Funck-Brentano, 1985, Biochemical pharmacology.

Protective effect of 16,16-dimethyl prostaglandin E2 on the hepatotoxicity of bromobenzene in mice.

D. Pessayre, C. Degott, C. Funck-Brentano, 1984, Biochemical pharmacology.

Effect of stavudine on mitochondrial genome and fatty acid oxidation in lean and obese mice.

D. Pessayre, B. Fromenty, C. Degott, 2001, The Journal of pharmacology and experimental therapeutics.

Genetic predisposition to drug hepatotoxicity: Role in hepatitis caused by amineptine, a tricyclic antidepressant

D. Pessayre, A. Berson, P. Dansette, 1989, Hepatology.

Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.

G. Labbe, D. Pessayre, B. Fromenty, 1990, Biochemical pharmacology.

An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice.

D. Pessayre, B. Fromenty, G. Feldmann, 1999, Gastroenterology.

Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats.

D. Pessayre, P. Lettéron, V. Descatoire, 1986, The Journal of pharmacology and experimental therapeutics.

Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.

V. Paradis, R. Moreau, D. Valla, 2012, Gastroenterology.

β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency

B. Fromenty, K. Begriche, J. Massart, 2008, Obesity.

Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence

E. Denamur, O. Clermont, M. Nicolas-Chanoine, 2020, Infection and Immunity.

Efficacy and toxicity of intravenous iron in a mouse model of critical care anemia*

E. Denamur, C. Beaumont, S. Lasocki, 2012, Critical care medicine.

NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions

A. Tlili, A. Pelletier, P. Lettéron, 2018, Mucosal Immunology.

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

J. Wan, H. Guillou, B. Cravatt, 2018, Gut.

Remodeling of the Residual Gastric Mucosa after Roux-En-Y Gastric Bypass or Vertical Sleeve Gastrectomy in Diet-Induced Obese Rats

M. le Gall, A. Bado, A. Couvelard, 2015, PloS one.

Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments

D. Pessayre, B. Fromenty, G. Peytavin, 2003, Antimicrobial Agents and Chemotherapy.

Treatments Five Single-and Three Dual-NRTI Inhibitors ( NRTIs ) in Mice Receiving One of Nucleoside Reverse Transcriptase Mitochondrial and Metabolic Effects of

D. Pessayre, B. Fromenty, G. Peytavin, 2003 .

High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.

D. Pessayre, B. Fromenty, G. Feldmann, 2007, Journal of hepatology.

Fluid therapy directly interferes with immunoassay for cardiac troponin I

J. Marty, P. Lettéron, F. Lagneau, 1999, Intensive Care Medicine.

Prolonged, but not acute, glutathione depletion promotes Fas‐mediated mitochondrial permeability transition and apoptosis in mice

D. Pessayre, G. Feldmann, A. Moreau, 2001, Hepatology.

Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation.

D. Pessayre, G. Feldmann, A. Berson, 2008, Toxicology and applied pharmacology.

Effects of methoxsalen on the metabolism of acetaminophen in humans.

G. Labbe, D. Pessayre, J. Belghiti, 1987, Biochemical pharmacology.

Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice

C. Beaumont, J. Deybach, L. Gouya, 2013, Mammalian Genome.

Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.

D. Pessayre, B. Fromenty, A. Berson, 1994, The Journal of pharmacology and experimental therapeutics.

Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver

D. Pessayre, B. Fromenty, G. Feldmann, 2007, Journal of Pharmacology and Experimental Therapeutics.

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

G. Labbe, D. Pessayre, P. Lettéron, 1989, The Journal of pharmacology and experimental therapeutics.

Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic

G. Labbe, D. Pessayre, C. Degott, 1988, Hepatology.

Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival.

D. Pessayre, B. Fromenty, A. Berson, 1993, Biochemical pharmacology.

Cytochrome P450–generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes

D. Pessayre, G. Feldmann, M. Robin, 2000, Hepatology.

Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats

M. Gougerot-Pocidalo, P. Lettéron, J. El-Benna, 2009, PloS one.

Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man

D. Pessayre, P. Lettéron, V. Descatoire, 1989, Hepatology.

Hepatic Mitochondrial DNA Depletion after an Alcohol Binge in Mice: Probable Role of Peroxynitrite and Modulation by Manganese Superoxide Dismutase

D. Pessayre, B. Fromenty, R. Moreau, 2010, Journal of Pharmacology and Experimental Therapeutics.

Chronic Ethanol Consumption Lessens the Gain of Body Weight, Liver Triglycerides, and Diabetes in Obese ob/ob Mice

B. Fromenty, A. Fautrel, M. Robin, 2009, Journal of Pharmacology and Experimental Therapeutics.

Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice.

D. Pessayre, B. Fromenty, C. Degott, 2002, Gastroenterology.

Inactivation of cytochrome P-450 by the drug methoxsalen.

D. Pessayre, H. Fouin-Fortunet, P. Lettéron, 1986, The Journal of pharmacology and experimental therapeutics.

Comparison of erythrocyte transketolase activity with thiamine and thiamine phosphate ester levels in chronic alcoholic patients.

P. Lettéron, P. Beyne, E. Delacoux, 1995, Clinica chimica acta; international journal of clinical chemistry.

Genetically determined oxidation polymorphism and drug hepatotoxicity. Study of 51 patients.

F. Iglicki, A. Berson, H. Fouin-Fortunet, 1989, Journal of hepatology.

Inhibition of mitochondrial beta-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug.

G. Labbe, D. Pessayre, C. Degott, 1987, The Journal of pharmacology and experimental therapeutics.

High Doses of Stavudine Induce Fat Wasting and Mild Liver Damage without Impairing Mitochondrial Respiration in Mice

D. Pessayre, B. Fromenty, G. Feldmann, 2006, Antiviral therapy.

Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model.

D. Pessayre, F. Carnot, C. Bréchot, 2003, Journal of hepatology.

Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation.

D. Pessayre, A. Sutton, G. Feldmann, 2001, Journal of hepatology.

Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids.

G. Labbe, D. Pessayre, B. Fromenty, 1990, The Journal of pharmacology and experimental therapeutics.

Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.

D. Pessayre, B. Fromenty, A. Bado, 2008, American journal of physiology. Endocrinology and metabolism.

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

J. Mallet, J. Launay, R. Jockers, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

R. Moreau, D. Valla, A. Groyer, 2013, Journal of hepatology.

NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions

A. Tlili, A. Pelletier, P. Lettéron, 2018, Mucosal Immunology.

Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease.

D. Pessayre, B. Fromenty, C. Degott, 1997, Gastroenterology.

Lipopolysaccharide-induced mitochondrial DNA depletion.

D. Pessayre, R. Moreau, P. Nahon, 2011, Antioxidants & redox signaling.

Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice.

G. Labbe, D. Pessayre, B. Fromenty, 1990, The Journal of pharmacology and experimental therapeutics.

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

E. Denamur, M. Sari, C. Beaumont, 2016, Journal of the American Society of Nephrology : JASN.

In Vivo Assessment of Lipid Peroxidation in Experimental Edematous and Necrotizing Rat Pancreatitis

D. Pessayre, C. Rozé, F. Paye, 1997, Pancreas.

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral‐related steatosis

D. Pessayre, Y. Chrétien, A. Sabile, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria

S. Sandberg, Aurora Martínez, K. Toska, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver

V. Paradis, S. Sandberg, J. Scoazec, 2018, Journal of internal medicine.

Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population.

D. Pessayre, A. Berson, Y. Horsmans, 1991, British journal of clinical pharmacology.

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.

C. Epstein, D. Pessayre, B. Fromenty, 2009, Toxicology and applied pharmacology.

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.

D. Pessayre, B. Fromenty, C. Moreau, 1998, Gastroenterology.

Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia

C. Beaumont, S. Lasocki, P. Montravers, 2008, Critical care medicine.

Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy.

P. Beaune, G. Labbe, D. Pessayre, 1999, Biochemical pharmacology.

Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model.

C. Beaumont, G. Berdeaux, J. Deybach, 2011, Gastroenterology.

Success of Escherichia coli O25b:H4 ST131 clade C associated with a decrease in virulence

E. Denamur, O. Clermont, M. Nicolas-Chanoine, 2019, bioRxiv.

Effect of liver disease on dextromethorphan oxidation capacity and phenotype: a study in 107 patients.

D. Pessayre, P. Lettéron, G. Amouyal, 1989, British journal of clinical pharmacology.

Polymorphism of dextromethorphan oxidation in a French population.

G. Labbe, D. Pessayre, A. Berson, 1987, British journal of clinical pharmacology.

Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice.

G. Labbe, D. Pessayre, B. Fromenty, 1991, Biochemical pharmacology.

Nilutamide inhibits mephenytoin 4-hydroxylation in untreated male rats and in human liver microsomes.

D. Pessayre, Y. Horsmans, P. Lettéron, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

V. Paradis, J. Wan, R. Moreau, 2018, Nature Communications.

Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.

G. Labbe, D. Pessayre, B. Fromenty, 1989, Biochemical pharmacology.

Alcohol increases tumor necrosis factor α and decreases nuclear factor‐κb to activate hepatic apoptosis in genetically obese mice

V. Paradis, D. Pessayre, B. Fromenty, 2005 .

Resistin-Like Molecule-β Inhibits SGLT-1 Activity and Enhances GLUT2-Dependent Jejunal Glucose Transport

P. Lettéron, R. Ducroc, J. Marie, 2009, Diabetes.

Metabolic activation of the tricyclic antidepressant amineptine--I. Cytochrome P-450-mediated in vitro covalent binding.

D. Pessayre, P. Lettéron, V. Descatoire, 1987, Biochemical pharmacology.

Metabolic activation of the tricyclic antidepressant amineptine--II. Protective role of glutathione against in vitro and in vivo covalent binding.

D. Pessayre, C. Degott, P. Lettéron, 1987, Biochemical pharmacology.

Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers.

D. Pessayre, B. Fromenty, C. Degott, 1993, Gut.

Suicide inactivation of cytochrome P-450 by methoxsalen. Evidence for the covalent binding of a reactive intermediate to the protein moiety.

P. Beaune, G. Labbe, D. Pessayre, 1989, The Journal of pharmacology and experimental therapeutics.

Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice.

G. Labbe, D. Pessayre, C. Degott, 1988, The Journal of pharmacology and experimental therapeutics.

Effects of pregnancy on the toxicity and metabolism of acetaminophen in mice.

D. Pessayre, C. Degott, P. Lettéron, 1986, The Journal of pharmacology and experimental therapeutics.

Metabolic activation of the antidepressant tianeptine. II. In vivo covalent binding and toxicological studies at sublethal doses.

G. Labbe, D. Pessayre, C. Degott, 1989, Biochemical Pharmacology.

Metabolic activation of the antidepressant tianeptine. I. Cytochrome P-450-mediated in vitro covalent binding.

G. Labbe, D. Pessayre, P. Maurel, 1989, Biochemical pharmacology.

Hepatic Proliferation and Angiogenesis Markers Are Increased after Portal Deprivation in Rats: A Study of Molecular, Histological and Radiological Changes

V. Paradis, B. V. Van Beers, V. Vilgrain, 2015, PloS one.

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis

B. Fromenty, A. Bado, A. Fautrel, 2012, British journal of pharmacology.

Central role of mitochondria in drug-induced liver injury

D. Pessayre, B. Fromenty, R. Moreau, 2012, Drug metabolism reviews.

β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency

B. Fromenty, J. Massart, P. Lettéron, 2008, Obesity.

Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.

C. Beaumont, A. Bado, Z. Karim, 2011, Gastroenterology.

Hepcidin regulates intrarenal iron handling at the distal nephron.

C. Beaumont, L. Gouya, H. Puy, 2013, Kidney international.

Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation.

C. Beaumont, S. Lasocki, Z. Karim, 2010, Blood.

Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice.

V. Paradis, D. Pessayre, B. Fromenty, 2005, Hepatology.