J. Stassen

发表

Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies*

A. Gils, P. Declerck, A. Bijnens, 2000, The Journal of Biological Chemistry.

The Distal Hinge of the Reactive Site Loop and Its Proximity

A. Gils, P. Declerck, A. Bijnens, 2001, The Journal of Biological Chemistry.

Release of experimental retinal vein occlusions by direct intraluminal injection of ocriplasmin

Marc D de Smet, Thijs C M Meenink, Maarten J Beelen, 2016, British Journal of Ophthalmology.

Robotic Assisted Cannulation of Occluded Retinal Veins

Marc D de Smet, Thijs C M Meenink, Maarten J Beelen, 2016, PloS one.

Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.

H. Nar, M. Bauer, J. Stassen, 2001, Structure.

The role of different VEGF isoforms in scar formation after glaucoma filtration surgery.

L. Moons, M. Dewerchin, S. Van de Veire, 2010, Experimental eye research.

Different therapy options protecting microvasculature after experimental cerebral ischaemia and reperfusion

D. Burggraf, G. Hamann, J. Stassen, 2010, Thrombosis and Haemostasis.

Comparative Immunogenicit and Thrombolytic Properties Toward Arterial and Venous Thrombi of Streptokinase and Recombinant Staphylokinase in Baboons

D. Collen, J. Stassen, F. de Cock, 1993, Circulation.

Emerging treatments for thrombocytopenia: increasing platelet production.

C. Van Geet, K. Freson, D. Collen, 2008, Drug discovery today.

Monoclonal antibody TB-403: a first-in-human, Phase I, double-blind, dose escalation study directed against placental growth factor in healthy male subjects.

R. Riisbro, J. Stassen, S. Pakola, 2011, Clinical therapeutics.

Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats

J. Stassen, U. Ries, W. Wienen, 2007, Thrombosis and Haemostasis.

Effects of BIIB513 on ischemia-induced arrhythmias and myocardial infarction in anesthetized rats

J. Stassen, Dongmei Wu, H. Doods, 2000, Basic Research in Cardiology.

Inhibition of Human Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Sabiporide, a New Specific NHE-1 Inhibitor

J. Stassen, Dongmei Wu, H. Doods, 2006, Journal of cardiovascular pharmacology.

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

J. Stassen, U. Ries, W. Wienen, 2007, Thrombosis and Haemostasis.

Placental growth factor supports neuroendocrine tumor growth and predicts disease prognosis in patients.

B. Wiedenmann, K. Detjen, M. Pavel, 2013, Endocrine-related cancer.

A phase I, dose-escalation study of TB-403, a monoclonal antibody directed against PlGF, in patients with advanced solid tumours

D. Nielsen, U. Lassen, J. Stassen, 2012, British Journal of Cancer.

Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis

J. Stassen, U. Ries, W. Wienen, 2007, Journal of thrombosis and haemostasis : JTH.

Inhibition of Rho-Associated Kinase Prevents Pathological Wound Healing and Neovascularization After Corneal Trauma

L. Moons, I. Stalmans, J. Stassen, 2015, Cornea.

Adenovirus-Mediated Transfer of Tissue-Type Plasminogen Activator Augments Thrombolysis in Tissue-Type Plasminogen Activator–Deficient and Plasminogen Activator Inhibitor-1–Overexpressing Mice

P. Carmeliet, R. S. Meidell, R. Gerard, 1997 .

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models

P. Carmeliet, S. Coulon, F. Heindryckx, 2013, Hepatology.

Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice

P. Carmeliet, R. Bataller, S. Coulon, 2011, Hepatology.

Differential Vitreous Dye Diffusion Following Microplasmin or Plasmin Pre-Treatment

M. D. de Smet, J. Stassen, Ashraf M. Gad Elkareem, 2010, Current eye research.

THROMBOLYSIS Synergism of thrombolytic agents in vivo

M. Verstraete, D. Collen, J. Stassen, 2005 .

Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor

F. Heindryckx, A. Geerts, I. Colle, 2012, Molecular and Cellular Biochemistry.

Comparative Fibrinolytic Properties of Staphylokinase and Streptokinase in Animal Models of Venous Thrombosis

K. Okada, O. Matsuo, D. Collen, 1991, Thrombosis and Haemostasis.

Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. Interference of tissue-derived components.

J. Paramo, M. Colucci, D. Collen, 1986, The Journal of clinical investigation.

Influence oftheFast-acting Inhibitor ofPlasminogen Activator on InVivo Thrombolysis InducedbyTissue-Type Plasminogen Activator inRabbits Interference ofTissue-derived Components

J. Paramo, M. Colucci, J. Stassen, 1986 .

Small Animal Thrombosis Models for the Evaluation of Thrombolytic Agents

L. Kieckens, D. Collen, J. Stassen, 1991, Circulation.

Characterization of a Stabilized Form of Microplasmin for the Induction of Posterior Vitreous Detachment

M. Vanhove, B. Willekens, M. D. de Smet, 2010, Current eye research.

Differential Inhibition with Antifibrinolytic Agents of Staphylokinase and Streptokinase Induced Clot Lysis

D. Collen, J. Stassen, H. Lijnen, 1995, Thrombosis and Haemostasis.

Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents.

H. Nar, G. Mihm, J. Stassen, 2003, Bioorganic & medicinal chemistry letters.

Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives.

H. Nar, E. Haaksma, J. Stassen, 2003, Bioorganic & Medicinal Chemistry Letters.

Structure-based design of novel potent nonpeptide thrombin inhibitors.

H. Nar, J. Stassen, Herbert Nar, 2002, Journal of medicinal chemistry.

Neutralization of alpha(2)-antiplasmin by microplasmin: a randomized, double-blind, placebo-controlled, ascending-dose study in healthy male volunteers.

P. Verhamme, J. Stassen, H. Lijnen, 2009, Clinical therapeutics.

Tolerability and pharmacokinetics of TB-402 in healthy male volunteers.

P. Verhamme, K. Peerlinck, J. Saint-Remy, 2010, Clinical therapeutics.

Heterocyclic Thrombin Inhibitors. Part 1. Design and Synthesis of Amidino-Phenoxy Quinoline Derivatives.

H. Nar, E. Haaksma, J. Stassen, 2003 .

Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension.

P. Carmeliet, D. Laukens, A. Geerts, 2009, Gastroenterology.

Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor 1*

J. Ambati, M. Presta, R. Albuquerque, 2008, Journal of Biological Chemistry.

Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

M. Giacca, P. Carmeliet, L. Moons, 2007, Cell.

Synergistic Antithrombotic Properties of G4120, a RGD-Containing Synthetic Peptide, and Argatroban, a Synthetic Thrombin Inhibitor, in a Hamster Femoral Vein Platelet-Rich Thrombosis Model

E. Lesaffre, H. Gold, D. Collen, 1992, Thrombosis and Haemostasis.

Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.

D. Leysen, S. Boland, J. Stassen, 2015, Journal of medicinal chemistry.

Increased expression of placental growth factor in high-grade endometrial carcinoma

I. Vergote, F. Amant, L. Coenegrachts, 2012, Oncology reports.

Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions.

P. Carmeliet, L. Moons, D. Collen, 2010, Cardiovascular research.

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.

A. Gils, H. Nar, P. Declerck, 2000, Journal of molecular biology.

Elucidation of the paratope of scFv-8H9D4, a PAI-1 neutralizing antibody derivative

A. Gils, P. Declerck, J. Stassen, 2003, Thrombosis and Haemostasis.

Antagonism of vWF Inhibits both Injury Induced Arterial and Venous Thrombosis in the Hamster

J. Vermylen, M. Hoylaerts, H. Yamamoto, 1998, Thrombosis and Haemostasis.

Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation.

P. Carmeliet, R. Bouillon, G. Carmeliet, 2010, Cancer research.

Thrombolytic Profiles of Clot-Targeted Plasminogen Activators

T. Tollenaere, M. Dewerchin, H. Lijnen, 2005 .

Thrombolytic Profiles of Clot‐Targeted Plasminogen Activators Parameters Determining Potency and Initial and Maximal Rates

M. Dewerchin, H. Lijnen, P. Gaffney, 1993, Circulation.

Elucidation of the Binding Regions of PAI-1 Neutralizing Antibodies Using Chimeric Variants of Human and Rat PAI-1

A. Gils, P. Declerck, I. Knockaert, 2001, Thrombosis and Haemostasis.

Comparative Thrombolytic Properties of Tissue-Type Plasminogen Activator and of a Plasminogen Activator Inhibitor-1 -Resistant Glycosylation Variant, in a Combined Arterial and Venous Thrombosis Model in the Dog

B. Keyt, H. Gold, T. Roskams, 1994, Thrombosis and Haemostasis.

Comparative Effects of Enoxaparin and Heparin on Arterial and Venous Clot Lysis with Alteplase in Dogs

D. Collen, J. Stassen, I. Vanlinthout, 1993, Thrombosis and Haemostasis.

Characterisation of a Novel Series of Aprotinin-Derived Anticoagulants

J. Vermylen, J. Sixma, A. Lambeir, 1995, Thrombosis and Haemostasis.

Antithrombotic Effects and Bleeding Time Prolongation with Synthetic Platelet GPIIb/llla Inhibitors in Animal Models of Platelet-Mediated Thrombosis

T. Yasuda, S. Bunting, D. Collen, 1994, Thrombosis and Haemostasis.

Enhancement of Clot Lysis In Vitro and In Vivo with a Bispecific Monoclonal Antibody Directed against Human Fibrin and against Urokinase-Type Plasminogen Activator

A. Kakinuma, D. Collen, J. Stassen, 1991, Thrombosis and Haemostasis.

Thrombolytic efficacy of recombinant human microplasmin in a canine model of copper coil-induced coronary artery thrombosis

P. Verhamme, F. Werf, J. Stassen, 2010, Journal of Thrombosis and Thrombolysis.

Pharmacokinetics of ocriplasmin in vitreous.

M. Vanhove, M. D. de Smet, J. Van Calster, 2012, Investigative ophthalmology & visual science.

A Technique to Investigate Mural Thrombus Formation in Small Arteries and Veins: I. Comparative Morphometric and Histological Analysis

J. Vermylen, M. Hoylaerts, J. Stassen, 1997, Annals of plastic surgery.

Characterization and Comparative Evaluation of a Novel PAI-1 Inhibitor

A. Gils, H. Nar, P. Declerck, 2002, Thrombosis and Haemostasis.

Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma.

C. Dooms, P. Carmeliet, P. Hellings, 2012, American journal of respiratory cell and molecular biology.

Importance of N-Terminal Residues in Plasminogen Activator Inhibitor 1 on its Antibody Induced Latency Transition

P. Declerck, Yan Zhou, J. Stassen, 2002, Thrombosis and Haemostasis.

Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains.

Karen Vanhoorelbeke, J. Desmet, H. Deckmyn, 2006, Molecular immunology.

On the lmmunogenicity of Recombinant Staphylokinase

F., D. Collen, J. Stassen, 2018 .

Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model

P. Carmeliet, S. Coulon, F. Heindryckx, 2012, European journal of gastroenterology & hepatology.

Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor

F. Heindryckx, A. Geerts, I. Colle, 2012, Molecular and Cellular Biochemistry.

The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.

P. Carmeliet, S. Coulon, F. Heindryckx, 2013, Journal of hepatology.

Inhibition of placental growth factor improves surgical outcome of glaucoma surgery

L. Moons, I. Stalmans, J. Stassen, 2013, Journal of cellular and molecular medicine.

Elucidation of the paratope of scFv-8H9D4, a PAI-1 neutralizing antibody derivative

A. Gils, P. Declerck, J. Stassen, 2003, Thrombosis and Haemostasis.

Oxidized low density lipoproteins in patients with transplant-associated coronary artery disease.

D. Collen, P. Holvoet, J. Van Cleemput, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Vascular wound healing and neointima formation induced by perivascular electric injury in mice.

P. Carmeliet, J. J. van den Oord, L. Moons, 1997, The American journal of pathology.

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

P. Carmeliet, J. J. van den Oord, R. Mulligan, 1993, The Journal of clinical investigation.

A Historical Review of Hemostasis, Thrombosis, and Antithrombotic Therapy

J. Stassen, J. Stassen, Å. Nyström, 1997, Annals of plastic surgery.