N. Schechter

发表

Antichymotrypsin interaction with chymotrypsin. Partitioning of the complex.

E. Rescorla, B. Cooperman, E. Stavridi, 1993, The Journal of biological chemistry.

Distortion of the active site of chymotrypsin complexed with a serpin.

L. Mayne, M. Plotnick, H. Rubin, 1996, Biochemistry.

Mast Cell Chymase Modifies Cell-Matrix Interactions and Inhibits Mitogen-Induced Proliferation of Human Airway Smooth Muscle Cells1

J. Rosenbloom, E. Puré, R. Panettieri, 2002, The Journal of Immunology.

Highly efficient inhibition of human chymase by alpha(2)-macroglobulin.

N. Schechter, M. Walter, R. Sutton, 1999, Archives of biochemistry and biophysics.

Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.

J. Travis, N. Schechter, C. Reilly, 1982, The Journal of biological chemistry.

Enzymatic and Molecular Characteristics of the Efficiency and Specificity of Exfoliative Toxin Cleavage of Desmoglein 1*

Y. Hanakawa, M. Amagai, N. Schechter, 2004, Journal of Biological Chemistry.

Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin.

Y. Hanakawa, T. Selwood, N. Schechter, 2003, The Journal of investigative dermatology.

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome.

Y. Hanakawa, M. Amagai, M. Sugai, 2002, The Journal of clinical investigation.

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2*

J. Hoxie, A. Cumashi, L. Brass, 1997, The Journal of Biological Chemistry.

Identification and Partial Characterization

D. Proud, N. Schechter, B. Wintroub, 1986 .

The FASEB Journal • Research Communication Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

Henry Lin, A. Hovnanian, R. Gallo, 2022 .

Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell.

L. Schwartz, N. Schechter, B. Wintroub, 1990, Journal of immunology.

Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase*

G. Silverman, N. Schechter, P. Pemberton, 1997, The Journal of Biological Chemistry.

Use of gel chromatography for the determination of the Stokes radii of proteins in the presence and absence of detergents. A reexamination.

C. Tanford, Y. Nozaki, J. Reynolds, 1976, Biochemistry.

Cleavage of Type I Procollagen by Human Mast Cell Chymase Initiates Collagen Fibril Formation and Generates a Unique Carboxyl-terminal Propeptide*

R. Diegelmann, L. Schwartz, M. Graham, 1997, The Journal of Biological Chemistry.

The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.

S. Shapiro, N. Schechter, T. Takayama, 2001, Biochemistry.

Specificity Profiling of Seven Human Tissue Kallikreins Reveals Individual Subsite Preferences*

C. Craik, W. Bode, V. Magdolen, 2006, Journal of Biological Chemistry.

Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.

S. Lessin, H. Rubin, Z. M. Wang, 1994, Journal of immunology.

Structural changes associated with the spontaneous inactivation of the serine proteinase human tryptase.

T. Selwood, D. McCaslin, N. Schechter, 1995, Biochemistry.

Two types of human mast cells that have distinct neutral protease compositions.

L. Schwartz, N. Schechter, S. Craig, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)

Y. Hanakawa, G. Clayman, E. Choi, 2005, Biological chemistry.

Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase.

R. Fetter, D. Slavin, G. Lazarus, 1988, Archives of biochemistry and biophysics.

Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.

N. Schechter, I. Harvima, R. Harvima, 1988, Biochimica et biophysica acta.

Inhibition of human mast cell chymase by secretory leukocyte proteinase inhibitor: enhancement of the interaction by heparin.

M. Plotnick, N. Schechter, M. Walter, 1996, Archives of biochemistry and biophysics.

Early cellular events in evolving cutaneous delayed hypersensitivity in humans.

L. Walsh, G. Murphy, N. Schechter, 1991, The American journal of pathology.

Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody

N. Schechter, D. Siegel, J. Seykora, 2013, The Journal of investigative dermatology.

Effects of topical corticosteroids on human dermis

R. Lavker, G. Lazarus, N. Schechter, 1986, The British journal of dermatology.

Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.

M. Carr, B. Undem, N. Schechter, 2000, American journal of respiratory and critical care medicine.

A human lung mast cell chymotrypsin-like enzyme. Identification and partial characterization.

D. Proud, N. Schechter, B. Wintroub, 1986, The Journal of clinical investigation.

Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells.

L. Schwartz, M. Castells, N. Schechter, 1987, Journal of immunology.

Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes

J. Fraki, R. Briggaman, G. Lazarus, 1984, The Journal of experimental medicine.

Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I.

G. Lazarus, N. Schechter, J. Geesin, 1983, The Journal of biological chemistry.

Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors.

B. Cooperman, H. Rubin, G. Lazarus, 1989, The Journal of biological chemistry.

Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex.

M. Plotnick, H. Rubin, Z. M. Wang, 1997, Biochemistry.

Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties.

B. Cooperman, H. Rubin, Z. M. Wang, 1993, The Journal of biological chemistry.

Ultrastructural analysis of human T and TC mast cells identified by immunoelectron microscopy.

L. Schwartz, N. Schechter, S. Craig, 1988, Laboratory investigation; a journal of technical methods and pathology.

Serine proteinases in human cutaneous mastocytosis

G. Lazarus, N. Schechter, J. Fräki, 2004, Archives of Dermatological Research.

Recombinant Expression of Human Mast Cell Proteases Chymase and Tryptase

T. Selwood, H. Rubin, N. Schechter, 1998, Biological chemistry.

Human skin tryptase: kinetic characterization of its spontaneous inactivation.

D. McCaslin, N. Schechter, G. Eng, 1993, Biochemistry.

Urticaria pigmentosum: nature's experiment in mast cell biology.

R. Lavker, G. Murphy, C. Guzzo, 1991, Journal of dermatological science.

Production of active recombinant human chymase from a construct containing the enterokinase cleavage site of trypsinogen in place of the native propeptide sequence.

H. Rubin, Z. M. Wang, N. Schechter, 1995, Biological chemistry Hoppe-Seyler.

Identification of a chymotrypsin-like proteinase in human mast cells.

R. Lavker, D. Proud, D. Slavin, 1986, Journal of immunology.

Demonstration of tryptase in bovine cutaneous and tumor mast cells.

M. Welle, N. Schechter, I. Harvima, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Chymase cleavage of stem cell factor yields a bioactive, soluble product.

R. Halaban, D. Williams, Y. Ma, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts

R. Lavker, P. Jensen, L. Brass, 1998, Journal of cellular physiology.

IL‐6 attenuates apoptosis, while neither IL‐6 nor IL‐10 affect the numbers or protease phenotype of fetal liver‐derived human mast cells

L. Schwartz, N. Schechter, N. Kambe, 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Ultrastructural analysis of maturing human T and TC mast cells in situ.

L. Schwartz, N. Schechter, S. Craig, 1989, Laboratory investigation; a journal of technical methods and pathology.

Treatment of urticaria pigmentosa with corticosteroids.

R. Lavker, G. Lazarus, N. Schechter, 1985, Archives of dermatology.

Cutaneous mast cell depletion results from topical corticosteroid usage.

R. Lavker, N. Schechter, 1985, Journal of immunology.

Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans.

R. Iozzo, G. Lazarus, N. Schechter, 1987, The Journal of biological chemistry.

The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.

D. Brömme, G. Silverman, N. Schechter, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

N. Schechter, W. Groutas, S. Ruan, 1999 .

Conversion of alpha 1-antichymotrypsin into a human neutrophil elastase inhibitor: demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities.

B. Cooperman, M. Plotnick, H. Rubin, 1994, Biochemistry.

Measurement of the kinetic parameters mediating protease-serpin inhibition.

M. Plotnick, N. Schechter, 2004, Methods.

Mast cell chymase is a possible mediator of neurogenic bladder fibrosis

P. Howard, U. Kucich, N. Schechter, 2004, Neurourology and urodynamics.

Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones.

M. Gütschow, N. Schechter, U. Neumann, 2001, Bioorganic & medicinal chemistry.

Structural basis of the zinc inhibition of human tissue kallikrein 5.

R. Huber, W. Bode, V. Magdolen, 2007, Journal of molecular biology.

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

J. Winkler, H. Rubin, N. Schechter, 2010, The Journal of Biological Chemistry.

Serine proteinases are regionally segregated within mast cell granules.

D. Whitaker‐Menezes, G. Murphy, N. Schechter, 1995, Laboratory investigation; a journal of technical methods and pathology.

A comparative study of histone acetylation, histone deacetylation, and ribonucleic acid synthesis in avian reticulocytes and erythrocytes.

N. Schechter, L. A. Sanders, K. McCarty, 1973, Biochemistry.

Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.

T. Tanaka, J. Harper, G. Lazarus, 1985, Biochemistry.

Erythrocyte spectrin. Purification in deoxycholate and preliminary characterization.

C. Tanford, J. Reynolds, N. Schechter, 1976, Biochemistry.

Adenovirus coded deoxyribonucleic acid binding protein. Isolation, physical properties, and effects of proteolytic digestion.

C. Anderson, N. Schechter, W. Davies, 1980, Biochemistry.

Fish intermediate filament proteins in structure, evolution, and function.

J. Markl, N. Schechter, 1998, Sub-cellular biochemistry.

The Effects of Reactive Site Location on the Inhibitory Properties of the Serpin α1-Antichymotrypsin*

M. Plotnick, H. Rubin, N. Schechter, 2002, The Journal of Biological Chemistry.

Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies.

C. Kepley, L. Schwartz, N. Schechter, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function.

C. Elson, L. Schwartz, N. Schechter, 1987, Journal of immunology.

Soybean Bowman-Birk protease inhibitor is a highly effective inhibitor of human mast cell chymase.

H. Rubin, N. Schechter, X. Wan, 1997, Archives of biochemistry and biophysics.

UV suppression of mast cell-mediated wealing in human skin.

R. Gollhausen, N. Schechter, K. Kaidbey, 1985, Photo-dermatology.

Chapter 18 – Structure and Function of Human Chymase

S. Strobl, N. Schechter, P. Pereira, 2000 .

Plasminogen activator inhibitor type 2: an intracellular keratinocyte differentiation product that is incorporated into the cornified envelope.

P. Jensen, N. Schechter, Y. Ando, 1995, Experimental cell research.

Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

N. Schechter, W. Groutas, P. Huang, 1999, Bioorganic & medicinal chemistry letters.

Potent Bivalent Inhibition of Human Tryptase-? by a Synthetic Inhibitor

T. Selwood, N. Schechter, K. Elrod, 2003 .

The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.

R. Huber, W. Bode, S. Strobl, 1999, Journal of molecular biology.

Aggressive topical corticosteroid therapy: a novel approach to mast-cell-dependent cutaneous disorders.

R. Lavker, C. Guzzo, G. Lazarus, 1987, Dermatologica.

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7

Manfred Schmitt, C. Craik, W. Bode, 2008, Biological chemistry.

Chymotryptic specificity determinants in the 1.0 Å structure of the zinc-inhibited human tissue kallikrein 7

R. Huber, W. Bode, V. Magdolen, 2007, Proceedings of the National Academy of Sciences.

The Role of the Novel Exopolyphosphatase MT0516 in Mycobacterium tuberculosis Drug Tolerance and Persistence

P. Karakousis, N. Morrison, H. Rubin, 2011, PloS one.

X-ray Structures of Free and Leupeptin-complexed Human αI-Tryptase Mutants: Indication for an α→β-Tryptase Transition

R. Huber, W. Bode, T. Selwood, 2006 .

Studies of RNA polymerase in mature avian erythrocytes.

N. Schechter, 1973, Biochimica et biophysica acta.

The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.

T. Selwood, D. McCaslin, N. Schechter, 2005, Biochemistry.

Diverse Effects of pH on the Inhibition of Human Chymase by Serpins*

T. Selwood, M. Plotnick, H. Rubin, 1997, The Journal of Biological Chemistry.

Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin.

B. Cooperman, D. Christianson, H. Rubin, 1992, Journal of molecular biology.

Mycobacterium tuberculosis Type II NADH-Menaquinone Oxidoreductase Catalyzes Electron Transfer through a Two-Site Ping-Pong Mechanism and Has Two Quinone-Binding Sites

H. Rubin, N. Schechter, T. Yano, 2014, Biochemistry.

Mast cell enzymes alter the connective tissue phenotype of bladder wall fibroblasts and smooth muscle cells.

P. Howard, U. Kucich, N. Schechter, 2001, Urology.

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

R. Black, T. Kupper, H. Mizutani, 1991, The Journal of experimental medicine.

Spontaneous inactivation of human tryptase involves conformational changes consistent with conversion of the active site to a zymogen-like structure.

T. Selwood, D. McCaslin, N. Schechter, 1998, Biochemistry.

Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket.

T. Selwood, D. McCaslin, N. Schechter, 2002, Biochemistry.

Evidence for diversity of substrate specificity among members of the chymase family of serine proteases

T. Selwood, N. Schechter, Zhe-mei Wang, 2002, FEBS letters.

Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.

T. Selwood, N. Schechter, K. Elrod, 2003, Biological chemistry.