J. Sadler

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Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans.

D. Tollefsen, J. Sheehan, J. Sadler, 1994, The Journal of biological chemistry.

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

A. Tulinsky, J. Sadler, A Tulinsky, 1994, The Journal of biological chemistry.

von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1

B. Yawn, T. Ortel, R. Montgomery, 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms.

J. Sadler, S. Lentz, M. Tsiang, 1991, Blood.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami

C. Denis, R. Marschalek, R. Montgomery, 2016, Journal of thrombosis and haemostasis : JTH.

Induction of specific storage organelles by von Willebrand factor propolypeptide

T. Mayadas, D. Wagner, J. Sadler, 1991, Cell.

Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor.

P. Reitsma, J. Eikenboom, G. Castaman, 1996, Blood.

Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins.

J. Eikenboom, J. Sadler, E. Tuley, 2001, Blood.

Biochemistry and genetics of von Willebrand factor.

F. Cohen, S. Prusiner, D. Carling, 1998, Annual review of biochemistry.

Phylogenetic and Functional Analysis of Histidine Residues Essential for pH-dependent Multimerization of von Willebrand Factor*♦

J. Sadler, Ren-huai Huang, Luke Dang, 2011, The Journal of Biological Chemistry.

Multi‐step binding of ADAMTS‐13 to von Willebrand factor

J. Sadler, K. Vanhoorelbeke, H. Feys, 2009, Journal of thrombosis and haemostasis : JTH.

A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.

D. Fremont, R. Schaub, J. Sadler, 2009, Structure.

von Willebrand factor assembly and secretion

J. Sadler, 2009, Journal of thrombosis and haemostasis : JTH.

Assembly of Weibel–Palade body-like tubules from N-terminal domains of von Willebrand factor

E. Egelman, Xiong Yu, Robyn Roth, 2008, Proceedings of the National Academy of Sciences of the United States of America.

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

H. Saito, T. Naoe, Koji Yamamoto, 2008, International journal of hematology.

Zinc and Calcium Ions Cooperatively Modulate ADAMTS13 Activity*

K. Kokame, J. Sadler, P. Anderson, 2006, Journal of Biological Chemistry.

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

J. Sadler, E. Tuley, P. Anderson, 2006, Proceedings of the National Academy of Sciences.

Binding of ADAMTS13 to von Willebrand Factor*

J. Sadler, P. Anderson, E. Majerus, 2005, Journal of Biological Chemistry.

ADAMTS13: von Willebrand factor-cleaving protease

J. Sadler, D. Chung, 2004 .

SYNTHETIC RGD-CONTAINING PEPTIDES OF VON WILLEBRAND FACTOR INHIBIT PLATELET ADHESION TO COLLAGEN

É. Fressinaud, D. Meyer, J. Sadler, 1987, Thrombosis and Haemostasis.

Disulfide bonds required to assemble functional von Willebrand factor multimers.

R. Thoma, J. Sadler, D. Crimmins, 1994, The Journal of biological chemistry.

cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.

R. Ye, J. Sadler, T. Wun, 1987, The Journal of biological chemistry.

Human tissue factor: cDNA sequence and chromosome localization of the gene.

J. Miletich, R. Flandermeyer, G. Broze, 1987, Biochemistry.

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

J. Sadler, S. Lentz, Evan, 1991, The Journal of clinical investigation.

Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.

R. Hill, J. Paulson, J. Sadler, 1981, Advances in enzymology and related areas of molecular biology.

Affinity chromatography of glycosyltransferases.

R. Hill, J. Sadler, T. A. Beyer, 1981, Journal of chromatography.

Thrombomodulin Structure and Function

J. Sadler, Howard Hughes, 1997, Thrombosis and Haemostasis.

von Willebrand factor: two sides of a coin

J. Sadler, 2005, Journal of thrombosis and haemostasis : JTH.

Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.

R. Hill, J. Sadler, T. A. Beyer, 1980, The Journal of biological chemistry.

Slippery criteria for von Willebrand disease type 1

J. Sadler, 2004, Journal of thrombosis and haemostasis : JTH.

Von Willebrand disease type 1: a diagnosis in search of a disease.

J. Sadler, J. E. Sadler, 2003, Blood.

von Willebrand factor.

J. Sadler, 2002, The Journal of biological chemistry.

Allosteric activation of ADAMTS13 by von Willebrand factor

N. Tolia, Robyn Roth, J. Heuser, 2014, Proceedings of the National Academy of Sciences.

Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequences.

R. Hill, J. Paulson, J. Sadler, 1979, The Journal of biological chemistry.

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.

R. Huber, W. Bode, P. Fuentes-Prior, 2002, Biochemistry.

Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13*

J. Sadler, Xinglong Zheng, K. Nishio, 2003, Journal of Biological Chemistry.

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow.

A. Bernardo, José A López, J. Sadler, 2005, Blood.

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.

J. Sadler, P. Anderson, Wei-qiang Gao, 2008, Blood.

Apical Sorting of Bovine Enteropeptidase Does Not Involve Detergent-resistant Association with Sphingolipid-Cholesterol Rafts*

J. Sadler, X. Zheng, Xinglong Zheng, 1999, The Journal of Biological Chemistry.

Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland.

R. Hill, J. Paulson, J. Sadler, 1979, The Journal of biological chemistry.

A Covalent Oxidoreductase Intermediate in Propeptide-dependent von Willebrand Factor Multimerization*

J. Sadler, A. R. Purvis, J. E. Sadler, 2004, Journal of Biological Chemistry.

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding

R. Schaub, J. Sadler, D. Fremont, 2009 .

Low von Willebrand factor: sometimes a risk factor and sometimes a disease.

J. Sadler, J. Sadler, 2009, Hematology. American Society of Hematology. Education Program.

von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

D. Mancuso, I. Rabinowitz, J. Sadler, 1992, Proceedings of the National Academy of Sciences of the United States of America.

von Willebrand factor.

J. Sadler, 1991, The Journal of biological chemistry.

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

A. Federici, P. Mannucci, J. Sadler, 1987, The Journal of clinical investigation.

Acquired von Willebrand Syndrome: Data from an International Registry

P. V. van Genderen, H. Mohri, P. Bucciarelli, 2000, Thrombosis and Haemostasis.

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

F. Rodeghiero, J. Sadler, 2005, Journal of thrombosis and haemostasis : JTH.

Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.

P. Mannucci, P. Mannucci, D. Mancuso, 1991, The Journal of clinical investigation.

Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic acid with pure sialyltransferases.

R. Hill, J. Paulson, J. Sadler, 1979, The Journal of biological chemistry.

Structure and localization of the thrombin receptor gene on mouse Chromosome 13

N. Copeland, D. Gilbert, N. Jenkins, 1996, Mammalian Genome.

Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.

S. Korsmeyer, R. Ye, G. Silverman, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

J. Sadler, S. Lentz, M. Tsiang, 1990, Biochemistry.

dominant mutations of oligomeric proteins retention and degradation of heterodimers: a possible general mechanism for Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular

J. Eikenboom, J. Sadler, E. Tuley, 2013 .

Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin.

M. L. Le Beau, R. Lebo, R. Ye, 1989, The Journal of biological chemistry.

[41] Purification of mammalian glycosyltransferases

R. Hill, J. Paulson, J. Sadler, 1982 .

Molecular Biology of von Willebrand Factor

D. Mancuso, J. Sadler, A. Randi, 1991, Annals of the New York Academy of Sciences.

Platelet Glycoprotein Ibα Binds to Thrombin Anion-binding Exosite II Inducing Allosteric Changes in the Activity of Thrombin*

A. Vindigni, M. Wardell, Chester Q. Li, 2001, The Journal of Biological Chemistry.

The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.

P. Majerus, J. Sadler, W. Dittman, 1988, The Journal of biological chemistry.

Evolution of human von Willebrand factor: cDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II.

J. Miletich, G. Broze, J. Sadler, 1987, Biochemical and biophysical research communications.

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation.

Jian Zhu, G. Gupta, J. Sadler, 2019, Blood.

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

K. Titani, E. Davie, J. Harlan, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor.

J. Sadler, E. M. Scarpati, 1989, The Journal of biological chemistry.

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner.

Jing Huang, J. Sadler, S. Haberichter, 2012, Blood.

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways.

Jing Huang, J. Sadler, Fang Liu, 2011, Blood.

Pathogenesis of thrombotic microangiopathies.

J. Sadler, X. Zheng, 2008, Annual review of pathology.

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice.

D. Motto, D. Bundle, Jing Huang, 2010, Blood.

Adjuvant low-dose rituximab and plasma exchange for acquired TTP.

J. Zwicker, J. Sadler, J. Muia, 2019, Blood.

The role of sialic acid in the expression of human MN blood group antigens.

R. Hill, J. Paulson, J. Sadler, 1979, The Journal of biological chemistry.

cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen.

H. Donis-Keller, R. Veile, J. Sadler, 1995, Biochemistry.

Thrombotic thrombocytopenic purpura: a moving target.

J. Sadler, J. Sadler, 2006, Hematology. American Society of Hematology. Education Program.

A new name in thrombosis, ADAMTS13

J. Sadler, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Platelets: thrombotic thrombocytopenic purpura.

J. George, B. Lämmle, J. Sadler, 2002, Hematology. American Society of Hematology. Education Program.

Report on the workshop: Von Willebrand factor and thrombotic thrombocytopenic purpura

J. Moake, P. Mannucci, J. Sadler, 2001, American journal of hematology.

Ligand specificity of human thrombomodulin. Equilibrium binding of human thrombin, meizothrombin, and factor Xa to recombinant thrombomodulin.

J. Sadler, S. Lentz, M. Tsiang, 1992, The Journal of biological chemistry.

Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum.

J. Sadler, S. Lentz, Steven R. Lentz, 1993, Blood.

Commentary: a new classification for von Willebrand disease.

H. Gralnick, J. Sadler, Harvey R. Gralnick, 1994, Blood.

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

K. Friedman, J. Sadler, S. Haberichter, 2013, Journal of thrombosis and haemostasis : JTH.

Von Willebrand factor , ADAMTS 13 , and thrombotic thrombocytopenic purpura

J. Sadler, 2008 .

Remission of Chronic Thrombotic Thrombocytopenic Purpura after Treatment with Cyclophosphamide and Rituximab

L. Goodnough, J. Sadler, A. Pallera, 2003, Annals of Internal Medicine.

Pathophysiology of thrombotic thrombocytopenic purpura.

J. Sadler, J. Evan Sadler, J. E. Sadler, 2017, Blood.

Integrin (cid:1) v (cid:2) 3 on human endothelial cells binds von Willebrand factor strings under ﬂuid shear stress

Robyn Roth, J. Heuser, Jing Huang, 2009 .

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

L. Goodnough, R. Kaufman, J. Sadler, 2004, Blood.

Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma.

J. Sadler, K. Vanhoorelbeke, H. Feys, 2007, Haematologica.

Molecular Mechanism and Classification of von Willebrand Disease

T. Matsushita, J. Sadler, E. Tuley, 1995, Thrombosis and Haemostasis.

ADAMTS13 and TTP

J. Sadler, Xinglong Zheng, E. Majerus, 2002, Current opinion in hematology.

Thrombotic thrombocytopenic purpura

J. Sadler, 2015 .

Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development.

J. Sadler, Xinglong Zheng, D. Rubin, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development.

J. Sadler, X. Zheng, D. Rubin, 1998, The American journal of physiology.

R268A, inhibits thrombosis in a model of acute carotid artery injury A recombinant murine meizothrombin precursor, prothrombin R157A/

K. Shim, J. Sadler, L. Westfield, 2013 .

A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury.

K. Shim, J. Sadler, L. Westfield, 2004, Blood.

Atypical HUS may become a diagnosis of inclusion.

J. Sadler, 2015, Blood.

Accelerated clearance alone explains ultra‐large multimers in von Willebrand disease Vicenza

I. Deák, T. Masszi, A. Gézsi, 2010, Journal of thrombosis and haemostasis : JTH.

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Luke T. Dang, J. Gross, R. Townsend, 2007, Proceedings of the National Academy of Sciences.

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13

T. Springer, H. Deckmyn, S. D. De Meyer, 2015, Journal of thrombosis and haemostasis : JTH.

The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor.

C. Mazurier, C. Gaucher, S. Jorieux, 1992, Blood.

What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.

J. Sadler, 2015, Hematology. American Society of Hematology. Education Program.

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C*

K. Kokame, J. Sadler, Xinglong Zheng, 1998, The Journal of Biological Chemistry.

Structure-function relationships of the thrombin-thrombomodulin interaction.

J. Sheehan, J. Sadler, S. Lentz, 1993, Haemostasis.

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.

J. Sadler, S. Lentz, M. Tsiang, 1992, The Journal of biological chemistry.

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

P. Mannucci, J. Eikenboom, R. Montgomery, 2006, Journal of thrombosis and haemostasis : JTH.

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.

L. Deaven, P. Majerus, R. Ye, 1987, Biochemistry.

Structure of the gene for human von Willebrand factor.

J M Sorace, D. Mancuso, J. Sadler, 1989, The Journal of biological chemistry.

Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction.

M. L. Le Beau, D. Mancuso, J. Sadler, 1991, Biochemistry.

Medicine: K is for koagulation

J. Sadler, 2004, Nature.

A Revised Classification of von Willebrand Disease

J. Sadler, J E Sadler, E. Sadler, 1994, Thrombosis and Haemostasis.

Impact, Diagnosis and Treatment of von Willebrand Disease

P. Mannucci, D. Ginsburg, F. Rodeghiero, 2000, Thrombosis and Haemostasis.

Expression of von Willebrand factor "Normandy": an autosomal mutation that mimics hemophilia A.

C. Mazurier, C. Gaucher, S. Jorieux, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Amino acid sequence of human von Willebrand factor.

R. D. Wade, K. Fujikawa, K. Titani, 1986, Biochemistry.

Family studies and prenatal diagnosis in severe von Willebrand disease by polymerase chain reaction amplification of a variable number tandem repeat region of the von Willebrand factor gene.

A. Bloom, I. Peake, D. Bowen, 1990, Blood.

Appendix II: A revised classification of Von Willebrand disease *

J. Sadler, J E Sadler, 1997, Haemophilia : the official journal of the World Federation of Hemophilia.

Clinical and laboratory diagnosis of von Willebrand disease: A synopsis of the 2008 NHLBI/NIH guidelines

B. Yawn, T. Ortel, R. Montgomery, 2009, American journal of hematology.

Characterization of Partial Gene Deletions in Type III von Willebrand Disease with Alloantibody Inhibitors

P. Mannucci, D. Mancuso, J. Evan Sadler, 1994, Thrombosis and Haemostasis.

Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual.

D. Mancuso, I. Peake, G. Standen, 1990, Blood.

New concepts in von Willebrand disease.

J. Sadler, J Evan Sadler, 2005, Annual review of medicine.

A Standard Nomenclature for von Willebrand Factor Gene Mutations and Polymorphisms

J. Eikenboom, D. Ginsburg, F. Rodeghiero, 2001, Thrombosis and Haemostasis.

Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.

I. Rabinowitz, K. Shindler, J. Sadler, 1993, The Journal of biological chemistry.

Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method

P. Mannucci, G. Castaman, P. Mannucci, 1993 .

Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin.

C. Mazurier, S. Jorieux, J. Sadler, 1992, The Journal of biological chemistry.

Characterization of Three Mutations Causing von Willebrand Disease Type IIA in Five Unrelated Families

Pille Harrison, I. Rabinowitz, B. Brenner, 1992, Thrombosis and Haemostasis.

cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms.

K. Titani, J. Sadler, B. B. Shelton-Inloes, 1986, Biochemistry.

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

M. Gross, G. Bowman, Hao Zhang, 2016, Nature Structural &Molecular Biology.

Crystal Structure of von Willebrand Factor A1 Domain Complexed with Snake Venom, Bitiscetin

H. Mizuno, T. Morita, J. Sadler, 2003, Journal of Biological Chemistry.

Activation of recombinant proenteropeptidase by duodenase

J. Sadler, T. S. Zamolodchikova, D. Lu, 2000, FEBS letters.

Bovine Proenteropeptidase Is Activated by Trypsin, and the Specificity of Enteropeptidase Depends on the Heavy Chain*

J. Sadler, X. Zheng, Xinglong Zheng, 1997, The Journal of Biological Chemistry.

Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands.

R. Hill, J. Paulson, J. Sadler, 1979, The Journal of biological chemistry.

Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.

R. Hill, J. Sadler, J. Rearick, 1979, The Journal of biological chemistry.

GLYCOSYL TRANSFERASES IN OLIGOSACCHARIDE BIOSYNTHESIS AND THEIR USE IN STRUCTURE - FUNCTION ANALYSIS OF GLYCOPROTEINS

R. Hill, J. Paulson, J. Sadler, 1980 .

Purification and Characterization of Two Sialyltransferase Activities from Porcine Submaxillary Glands

R. Hill, J. Paulson, J. Sadler, 1979 .

Isolation and characterization of glycosyl transferases.

R. Hill, J. Paulson, J. Sadler, 1977, Upsala journal of medical sciences.

Type 2M von Willebrand Disease: F606I and I662F Mutations in the Glycoprotein Ib Binding Domain Selectively Impair Ristocetin- but not Botrocetin-Mediated Binding of von Willebrand Factor to Platelets

J. Ponder, J. Scott, R. Montgomery, 1998 .

Identification of Amino Acid Residues Essential for von Willebrand Factor Binding to Platelet Glycoprotein Ib.

T. Matsushita, J. Sadler, 1995, The Journal of Biological Chemistry.

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor*

J. Sadler, E. Tuley, I. Bodó, 2000, The Journal of Biological Chemistry.

Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura*

K. Fujikawa, J. Sadler, T. Takayama, 2001, The Journal of Biological Chemistry.

Effect of Type IIB von Willebrand Disease Mutation Arg(545)Cys on Platelet Glycoprotein Ib Binding – Studies with Recombinant von Willebrand Factor

Pille Harrison, J. Sadler, N. Kornbrot, 1993, Thrombosis and Haemostasis.

Interaction of von Willebrand factor domain A1 with platelet glycoprotein Ibalpha-(1-289). Slow intrinsic binding kinetics mediate rapid platelet adhesion.

M. Wardell, J. Sadler, H. Wang, 2000, The Journal of biological chemistry.

Localization of von Willebrand Factor-binding Sites for Platelet Glycoprotein Ib and Botrocetin by Charged-to-Alanine Scanning Mutagenesis*

T. Matsushita, D. Meyer, J. Sadler, 2000, The Journal of Biological Chemistry.

Functional architecture of Weibel-Palade bodies.

J. Voorberg, J. Valentijn, K. Valentijn, 2011, Blood.

Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress.

K. Shim, J. Sadler, E. Tuley, 2008, Blood.

Pathogenesis of thrombotic microangiopathies.

J. Sadler, X. Zheng, 2008, Annual review of pathology.

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.

J. Sadler, 2008, Blood.

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress.

Robyn Roth, J. Heuser, Jing Huang, 2009, Blood.

Regional localization of the human thrombomodulin gene to 20p12-cen.

R. Espinosa, M. L. Le Beau, J. Sadler, 1989, Genomics.

Regulation of human tissue factor expression by mRNA turnover.

T. Miyata, J. Sadler, T Miyata, 1993, The Journal of biological chemistry.

under fluid shear stress

Robyn Roth, J. Heuser, Jing Huang, 2013 .

Recent advances in thrombotic thrombocytopenic purpura.

J. Moake, J. George, T. Miyata, 2004, Hematology. American Society of Hematology. Education Program.

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

J. Sadler, X. Zheng, K. Nishio, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.

J. Sadler, Y. Kitamoto, D. McCourt, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Enteropeptidase, a type II transmembrane serine protease.

J. Sadler, Y. Kitamoto, X. Zheng, 2009, Frontiers in bioscience.

Scientific Report of the Registry on Acquired von Willebrand Syndrome : Recommendations for Diagnosis and Management

H. Mohri, P. Bucciarelli, J. Rand, 2000 .

Aortic stenosis, von Willebrand factor, and bleeding.

J. Sadler, J. Sadler, 2003, The New England journal of medicine.

Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease.

M. Halks-Miller, J. Morser, J. Sadler, 1998, The Journal of clinical investigation.

Molecular mapping of the heparin-binding exosite of thrombin.

J. Sheehan, J. Sadler, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Activation-induced exposure of the thrombin anion-binding exosite. Interactions of recombinant mutant prothrombins with thrombomodulin and a thrombin exosite-specific antibody.

M. Aiach, V. Picard, J. Sadler, 1994, The Journal of biological chemistry.

Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite.

J. Sadler, M. Tsiang, Qingyu Wu, 1992, The Journal of biological chemistry.

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

J. Sheehan, J. Sadler, S. Lentz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Refractory immune hemolytic anemia with a high thermal amplitude, low affinity IgG anti-Pra cold autoantibody.

C. Eby, H. Chaplin, J. Sadler, 1992, Autoimmunity.

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity*

J. Sadler, Xinglong Zheng, E. Tuley, 2003, Journal of Biological Chemistry.

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

M. Wardell, Chester Q. Li, J. Sadler, 2000, The Journal of Biological Chemistry.

Redeeming ristocetin.

J. Sadler, 2010, Blood.

Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen.

E. Davie, D. Malinowski, J. Sadler, 1984, Biochemistry.

Mammalian protein secretion without signal peptide removal. Biosynthesis of plasminogen activator inhibitor-2 in U-937 cells.

R. Ye, J. Sadler, R D Ye, 1988, The Journal of biological chemistry.

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.

G Waksman, G. Waksman, K. Fütterer, 1999, Journal of molecular biology.

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice.

K. Shim, J. Sadler, Xinglong Zheng, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Contact--How Platelets Touch von Willebrand Factor

J. Sadler, 2002, Science.

Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond

H. Saito, T. Matsushita, T. Kojima, 2003 .

von Willebrand's factor and von Willebrand's disease.

T. Matsushita, J. Sadler, Z. Dong, 1994, Current opinion in hematology.

fluid shear stress Platelet-VWF complexes are preferred substrates of ADAMTS13 under

K. Shim, J. Sadler, E. Tuley, 2013 .

shear stress Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid

K. Shim, J. Sadler, E. Tuley, 2013 .

fluid shear stress Platelet-VWF complexes are preferred substrates of ADAMTS 13 under

K. Shim, J. Sadler, E. Tuley, 2007 .

New variant of von Willebrand disease type II with markedly increased levels of von Willebrand factor antigen and dominant mode of inheritance: von Willebrand disease type IIC Miami.

I. Rabinowitz, F. Civantos, J. Sadler, 1993, Blood.

A Database of Polymorphisms in the von Willebrand Factor Gene and Pseudogene

D. Ginsburg, J. Sadler, 1993, Thrombosis and Haemostasis.

Identification and mapping of RFLPs for human tissue factor (HTF) to chromosome 1p.

Y. Nakamura, M. Leppert, P. O'Connell, 1987, Nucleic acids research.

Synthetic RGDS-Containing Peptides of von Willebrand Factor Inhibit Platelet Adhesion to Collagen

É. Fressinaud, D. Meyer, J. Sadler, 1990, Thrombosis and Haemostasis.

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency.

A. Holzinger, P. Mayerhofer, A. Roscher, 2002, American journal of human genetics.

Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa.

T. Miyata, T. Miki, S. Iwanaga, 1992, The Journal of biological chemistry.

Race, Rituximab, and Relapse in TTP.

Gustaaf G. de Ridder, K. McCrae, Shruti Chaturvedi, 2022, Blood.

THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR

J. Sadler, 1991, Thrombosis and Haemostasis.

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor.

T. Naoe, H. Saito, T. Matsushita, 2006, Biochemical and biophysical research communications.

Crystal structure of the human α‐thrombin–haemadin complex: an exosite II‐binding inhibitor

R. Huber, W. Bode, P. Fuentes-Prior, 2000, The EMBO journal.

Mucin-like Domain of Enteropeptidase Directs Apical Targeting in Madin-Darby Canine Kidney Cells*

J. Sadler, Xinglong Zheng, 2002, The Journal of Biological Chemistry.

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis.

P. Schlesinger, S. Wickline, J. Myerson, 2013, Molecular pharmaceutics.

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project.

P. Yarnold, C. Buffie, T. Ortel, 2007, Journal of the American College of Cardiology.

Crystal structure of von Willebrand Factor A1 domain complexed with snake venom bitiscetin

H. Mizuno, T. Morita, J. Sadler, 2003 .

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.

I. Mathews, J. Sadler, J E Sadler, 1994, Biochemistry.

Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method.

P. Mannucci, G. Castaman, J. Sadler, 1993, Blood.

Single Particle Tracking of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type-1 Repeats) Molecules on Endothelial von Willebrand Factor Strings*

J. Hofkens, H. Uji‐i, Susana Rocha, 2014, The Journal of Biological Chemistry.

Interesting variations on how a disease is defined: comparisons of von Willebrand disease and Glanzmann thrombasthenia. Reply to a rebuttal

J. Sadler, 2007 .

VWD data worth 10 000 words

J. Sadler, 2007 .

Response: Diagnosing VWD type 1: when is it useful and when illogical?

J. Sadler, 2007 .

Purification of mammalian glycosyltransferases.

R. Hill, J. Paulson, J. Sadler, 1982, Methods in enzymology.

Unfolding the A2 domain of von Willebrand factor with the optical trap.

J. Shao, J. Sadler, L. Westfield, 2010, Biophysical journal.

The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding

P. D. de Groot, D. Bihan, R. Farndale, 2016, Thrombosis and Haemostasis.

The functions of the A 1 A 2 A 3 domains in von Willebrand factor include multimerin 1 binding SHORTENED TITLE ( 50 Characters ) : VWF A 1 A 2 A 3 domains support MMRN 1 binding

Dominique, R. Farndale, J. Sadler, 2016 .

Weibel-Palade bodies.

J. Sadler, 2011, Clinical advances in hematology & oncology : H&O.

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering.

N. Tolia, Jian Zhu, G. Gupta, 2019, Blood.

Chapter 586 – Enteropeptidase

J. Sadler, 2013 .

A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains

N. Tolia, Jian Zhu, J. Sadler, 2014 .

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.

A. Tulinsky, J. Sadler, R. Krishnan, 2000, Acta crystallographica. Section D, Biological crystallography.

Willebrand factor by abolishing binding to factor VIII. Studies with recombinant von The mutation Arg (53)----Trp causes von Willebrand disease Normandy

C. Mazurier, C. Gaucher, S. Jorieux, 2011 .

Binding of ADAMTS13 to Von Willebrand Factor Under Static Conditions and Under Fluid Shear Stress

J. Sadler, H. Feys, P. Anderson, 2008 .

Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation.

A. Levinson, M. Shuman, R. Cohen, 1989, The Journal of biological chemistry.

Recombinant DNA Methods in Hemophilia A: Carrier Detection and Prenatal Diagnosis*

J. Sadler, 1990, Seminars in thrombosis and hemostasis.

Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases*

Jian Zhu, J. Sadler, E. Tuley, 2012, The Journal of Biological Chemistry.

Analysis of Arg834Gln and Val902Glu type 2A von Willebrand disease mutations: studies with recombinant von Willebrand factor and correlation with patient characteristics.

P. Mannucci, J. Sadler, A. Lattuada, 1996, Blood.

Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity.

D. Tollefsen, J. Sheehan, J. Sadler, 1993, The Journal of biological chemistry.

Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets.

J. Ponder, R. Montgomery, J. Gill, 1998, Blood.

Cloning of cDNA and genomic DNA for human von Willebrand factor.

K. Titani, J. Sadler, J. Sorace, 1986, Cold Spring Harbor symposia on quantitative biology.

Abstract 306: The Atherogenic Metalloprotease ADAMTS7 Secretion Requires Propeptide and Substrate Screening Suggests Broad Specificity

Jian Zhu, J. Sadler, L. Westfield, 2019 .

Very Low Frequency of “Normandy Type” Mutations among Type 1 von Willebrand Disease Families

P. Mannucci, J. Sadler, N. Kornbrot, 1995, Thrombosis and Haemostasis.

Should all adult patients with diarrhoea-associated HUS receive plasma exchange?

J. George, P. Tarr, W. Chandler, 2012, The Lancet.

Assembly of Weibel–Palade body-like tubules from N-terminal domains of von Willebrand factor

E. Egelman, Xiong Yu, Robyn Roth, 2008, Proceedings of the National Academy of Sciences.

von Willebrand factor assembly and secretion

J. Sadler, 2009, Journal of thrombosis and haemostasis : JTH.

von Willebrand Factor

J. Sadler, 2002 .