M. Moroi

发表

Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.

N. Aoki, M. Moroi, 1976, Journal of Biological Chemistry.

Growth and differentiation of a human megakaryoblastic cell line, CMK.

T. Suda, Y. Sakata, N. Komatsu, 1989, Blood.

Two novel, putative mechanisms of action for citalopram-induced platelet inhibition

Aaron A Cook, W. Bergmeier, A. Bonna, 2018, Scientific Reports.

Characterization of a patient with glycoprotein (GP) VI deficiency possessing neither anti‐GPVI autoantibody nor genetic aberration

S. Goto, H. Kojima, T. Nagasawa, 2006, Journal of thrombosis and haemostasis : JTH.

Platelets Interact with Soluble and Insoluble Collagens through Characteristically Different Reactions*

M. Moroi, Stephanie M. Jung, Stephanie M Jung, 1998, The Journal of Biological Chemistry.

Signal-transducing Mechanisms Involved in Activation of the Platelet Collagen Receptor Integrin α2β1 *

M. Moroi, Stephanie M. Jung, Stephanie M Jung, 2000, The Journal of Biological Chemistry.

Involvement of Activated Integrin α2β1 in the Firm Adhesion of Platelets onto a Surface of Immobilized Collagen under Flow Conditions

M. Moroi, S. M. Jung, S. Jung, 2000, Thrombosis and Haemostasis.

The influence of N-linked glycosylation on the function of platelet glycoprotein VI.

M. Moroi, T. Kunicki, K. Furihata, 2005, Blood.

Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion

Toshihiko Hayashi, Y. Imamura, E. Adachi, 2008, Platelets.

A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion.

M. Moroi, M. Okuma, K. Shinmyozu, 1989, The Journal of clinical investigation.

Analysis of platelet adhesion to a collagen-coated surface under flow conditions: the involvement of glycoprotein VI in the platelet adhesion.

M. Díaz-Ricart, Y. Tomiyama, M. Moroi, 1996, Blood.

Cloning and expression of the platelet-specific collagen receptor glycoprotein VI.

M. Moroi, Y. Miura, S. Jung, 2000, Thrombosis research.

Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

O. McCarty, S. Watson, Y. Ozaki, 2006, Blood.

[Platelet receptors for collagen].

M. Moroi, 2000, Seikagaku. The Journal of Japanese Biochemical Society.

Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.

H. Nakauchi, M. Eguchi, N. Komatsu, 1991, Cancer research.

Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice.

B. Nieswandt, M. Moroi, V. Schulte, 2005, Blood.

Relative antithrombotic effect of soluble GPVI dimer versus anti-GPVI antibodies in mice Running title: Antithrombotic effect of soluble GPVI dimer

B. Nieswandt, M. Moroi, V. Schulte, 2004 .

anti-GPVI antibodies in mice Relative antithrombotic effect of soluble GPVI dimer compared with

B. Nieswandt, M. Moroi, V. Schulte, 2013 .

Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI‐dimer—An interaction that may modulate fibrin crosslinking

R. Farndale, M. Moroi, Stephanie M Jung, 2022, Research and practice in thrombosis and haemostasis.

The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin.

S. Watson, O. Berlanga, D. Tulasne, 2002, European journal of biochemistry.

On the interaction of alpha2-plasmin inhibitor and proteases. Evidence for the formation of a covalent crosslinkage and non-covalent weak bondings between the inhibitor and proteases.

N. Aoki, M. Moroi, 1977, Biochimica et biophysica acta.

Mechanism of interaction of bovine trypsin with human α1-antitrypsin

M. Moroi, M. Yamasaki, 1974 .

Establishment of Megakaryoblastic Cell Lines by Coinfection of Abelson Murine Leukemia Virus and Recombinant SV40‐retrovirus

S. Kajigaya, T. Suda, T. Sudo, 1988, Japanese journal of cancer research : Gann.

Laminin stimulates spreading of platelets through integrin α6β1–dependent activation of GPVI

Yukio Ozaki, Zaverio M. Ruggeri, O. McCarty, 2006 .

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation

E. Warburton, A. Bonna, R. Farndale, 2018, Journal of thrombosis and haemostasis : JTH.

Measuring soluble platelet glycoprotein VI in human plasma by ELISA

M. Moroi, M. Al-Tamimi, M. Berndt, 2009, Platelets.

Association of Fyn and Lyn with the Proline-rich Domain of Glycoprotein VI Regulates Intracellular Signaling*

S. Watson, D. Tulasne, O. Inoue, 2002, The Journal of Biological Chemistry.

Analysis of the Interaction of Platelet Collagen Receptor Glycoprotein VI (GPVI) with Collagen

M. Moroi, Tsuyoshi Takahashi, Y. Miura, 2002, The Journal of Biological Chemistry.

Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency

K. Fukutake, M. Moroi, N. Akamatsu, 1995, British journal of haematology.

Compromised ITAM‐based platelet receptor function in a patient with immune thrombocytopenic purpura

M. Moroi, M. Al-Tamimi, M. Berndt, 2008, Journal of thrombosis and haemostasis : JTH.

Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

Y. Sakata, M. Matsuda, N. Aoki, 1978, The Journal of clinical investigation.

Platelet glycoprotein VI: its structure and function.

M. Moroi, Stephanie M Jung, 2004, Thrombosis research.

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood*

S. Watson, T. Nakagaki, D. Bihan, 2012, The Journal of Biological Chemistry.

Gpvi Levels in Platelets: Relationship to Platelet Function at High Shear

S. Watson, Takashi Saito, Y. Senis, 2022 .

Novel approach for formation of platelet-like particles from mouse embryonic stem cells without using feeder cells.

M. Moroi, M. Ohnuma, Stephanie M Jung, 2009, The Kurume medical journal.

Are integrin α2β1, glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow?

T. Kanaji, S. Nomura, M. Moroi, 2010, Platelets.

Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions.

Y. Nakatomi, K. Tomokiyo, Y. Ogata, 2005, Blood.

Analysis of the involvement of the von Willebrand factor-glycoprotein Ib interaction in platelet adhesion to a collagen-coated surface under flow conditions.

M. Díaz-Ricart, S. Nomura, S. Sekiguchi, 1997, Blood.

Glycoprotein (GP) VI dimer as a major collagen‐binding site of native platelets: direct evidence obtained with dimeric GPVI‐specific Fabs

M. Moroi, S. Jung, K. Tsuji, 2009, Journal of thrombosis and haemostasis : JTH.

Dimers of the platelet collagen receptor glycoprotein VI bind specifically to fibrin fibers during clot formation, but not to intact fibrinogen

R. Farndale, M. Moroi, Stephanie M Jung, 2021, Journal of thrombosis and haemostasis : JTH.

Platelet glycoprotein VI.

M. Moroi, Stephanie M Jung, 2008, Advances in experimental medicine and biology.

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI

M. Moroi, M. Berndt, R. Andrews, 2007, Thrombosis and Haemostasis.

The mechanism of loss of glycoprotein in from platelet membrane by freezing and thawing.

Y. Ikeda, S. Sekiguchi, M. Handa, 1994 .

Interaction of Platelets with Collagen

M. Moroi, 1997 .

Molecular basis for Glanzmann's thrombasthenia (GT) in a compound heterozygote with glycoprotein IIb gene: a proposal for the classification of GT based on the biosynthetic pathway of glycoprotein IIb-IIIa complex

N. Aoki, M. Moroi, Koh Yamamoto, 1992 .

Akihiko Kato, N. Aoki, M. Moroi, 1992, Blood.

A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor–glycoprotein Ib and integrin α2β1–collagen interactions make complementary, collagen‐type‐specific contributions to adhesion

M. Moroi, S. M. Jung, S. Jung, 2007, Journal of thrombosis and haemostasis : JTH.

Ligand-binding assays for collagen.

M. Moroi, Stephanie M Jung, 2004, Methods in molecular biology.

Antibody against platelet membrane glycoprotein VI in a patient with systemic lupus erythematosus

M. Moroi, Hoyu Takahashi, 2001, American journal of hematology.

Analyzing the mechanism of Rap1 activation in platelets: Rap1 activation is related to the release reaction mediated through the collagen receptor GPVI.

N. Watanabe, M. Handa, M. Moroi, 2006, Thrombosis research.

Real-time analysis of the interaction of platelets with immobilized thrombospondin under flow conditions.

H. Ikeda, M. Moroi, S. Jung, 2001, Thrombosis research.

Crosslinking of platelet glycoprotein Ib by N-succinimidyl(4-azidophenyldithio)propionate and 3,3'-dithiobis(sulfosuccinimidyl propionate).

M. Moroi, S. Jung, 1983, Biochimica et biophysica acta.

Inhibitory spectrum of alpha 2-plasmin inhibitor.

H. Saito, N. Aoki, M. Moroi, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Platelt Glycoprotein Ib

M. Moroi, 1984 .

Platelet Receptors for Collagen

M. Moroi, S. Jung, Stephanie M Jung, 1997, Thrombosis and Haemostasis.

Weight ‘ y-Chain Variant in a New Congenital Abnormal Fibrinogen

M. Matsuda, M. Moroi, N. Yoshida, 2005 .

Purification of Platelet Glycocalicin and Glycoprotein I by Affinity Techniques

M. Moroi, G. Jamieson, E. Dubay, 1979 .

Polymorphism of platelet glycoprotein Ib in the United States.

E. Plow, M. Moroi, S. M. Jung, 1986, Thrombosis research.

Genetic polymorphism of platelet glycoprotein Ib.

M. Moroi, N. Yoshida, S. M. Jung, 1984, Blood.

Selective staining of human platelet glycoproteins using nitrocellulose transfer of electrophoresed proteins and peroxidase-conjugated lectins.

M. Moroi, S. M. Jung, S. Jung, 1984, Biochimica et biophysica acta.

different molecular weight Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of

N. Aoki, M. Moroi, N. Yoshida, 2005 .

Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of different molecular weight.

N. Aoki, M. Moroi, N. Yoshida, 1988, Blood.

Isolation of platelet glycocalicin by affinity chromatography on thrombin-sepharose.

G. Jamieson, A. Goetze, M. Moroi, 1982, Thrombosis research.

Analysis of the fibrin-polymerizing reaction using sodium dodecylsulfate-agarose gel electrophoresis.

M. Moroi, N. Inoue, M. Yamasaki, 1975, Biochimica et biophysica acta.

Platelet collagen receptor integrin alpha2beta1 activation involves differential participation of ADP-receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change.

M. Moroi, S. M. Jung, S. Jung, 2001, European journal of biochemistry.

Activation of the Platelet Collagen Receptor Integrin α2β1: Its Mechanism and Participation in the Physiological Functions of Platelets

M. Moroi, Masaaki Moroi, Stephanie M. Jung, 2000 .

Activation of the platelet collagen receptor integrin alpha(2)beta(1): its mechanism and participation in the physiological functions of platelets.

M. Moroi, S. M. Jung, S M Jung, 2000, Trends in cardiovascular medicine.

Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin alpha(2)beta(1).

M. Moroi, S. M. Jung, S. Jung, 2000, The Journal of biological chemistry.

Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC.

T. Umata, M. Tsuneoka, M. Moroi, 2008, International journal of oncology.

Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.

N. Watanabe, Y. Terauchi, T. Kadowaki, 2003, Blood.

Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results

W. Ouwehand, K. Downes, K. Rehnstrom, 2022, PloS one.

Characterization of an apparently lower molecular weight gamma-chain variant in fibrinogen Kyoto I. The replacement of gamma-asparagine 308 by lysine which causes accelerated cleavage of fragment D1 by plasmin and the generation of a new plasmin cleavage site.

M. Matsuda, N. Aoki, M. Moroi, 1988, Journal of Biological Chemistry.

An apparently higher molecular weight gamma-chain variant in a new congenital abnormal fibrinogen Tochigi characterized by the replacement of gamma arginine-275 by cysteine.

M. Matsuda, M. Moroi, N. Yoshida, 1988, Blood.

Inhibition of plasminogen binding to fibrin by α2-plasmin inhibitor☆

N. Aoki, M. Moroi, 1977 .

The Behavior of a2-Plasmin Inhibitor in Fibrinolytic States

M. Matsuda, N. Aoki, M. Moroi, 2013 .

A lower molecular weight gamma-chain variant in a congenital abnormal fibrinogen (Kyoto).

M. Matsuda, M. Moroi, N. Yoshida, 1986, Blood.

Plasmic degradation of bovine fibrinogen and non-crosslinked fibrins in solution and in gel form.

M. Moroi, N. Inoue, M. Yamasaki, 1975, Biochimica et biophysica acta.

The behavior of alpha2-plasmin inhibitor in fibrinolytic states.

M. Matsuda, N. Aoki, M. Moroi, 1977, The Journal of clinical investigation.

FIBRINOGENS KYOTO AND TOCHIGI, EACH WITH AN APPARENT ABNORMAL MOL. WT. γ CHAIN, ARE CHARACTERIZED BY REPLACEMENT OF γ ASN-308 BY LYS AND γ ARG-275 BY CYS, RESPECTIVELY

N. Aoki, M. Moroi, N. Yoshida, 1987, Thrombosis and Haemostasis.

Effects of alpha2-plasmin inhibitor on fibrin clot lysis. Its comparison with alpha2-macroglobulin.

N. Aoki, M. Moroi, K. Tachiya, 1978, Thrombosis and haemostasis.

Effects of α2-Plasmin Inhibitor on Fibrin Clot Lysis. Its Comparison with α2-Macroglobulin

N. Aoki, M. Moroi, K. Tachiya, 1978, Thrombosis and Haemostasis.

Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor.

N. Aoki, M. Moroi, 1977, Journal of biochemistry.

Distinction of Serum Inhibitor of Activator-Induced Clot Lysis from α1-Antitrypsin

N. Aoki, M. Moroi, 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

A Defect in Collagen Receptor-Ca2+ Signaling System in Platelets from Cattle with Chediak-Higashi Syndrome

T. Morita, Y. Horii, S. Kawashima, 2002, Thrombosis and Haemostasis.

Platelet adhesion to collagen-coated wells: analysis of this complex process and a comparison with the adhesion to matrigel-coated wells.

M. Moroi, M. Okuma, S. Jung, 1992, Biochimica et biophysica acta.

Integrin-mediated platelet adhesion.

M. Moroi, S. Jung, 1998, Frontiers in bioscience : a journal and virtual library.

Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation.

N. Komatsu, T. Kanaji, K. Izuhara, 2004, Blood.

Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen

T. Kanaji, M. Moroi, T. Okamura, 2012, International Journal of Hematology.

Presence of platelet‐associated anti‐glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency

Y. Kanakura, Y. Tomiyama, M. Moroi, 2009, Journal of thrombosis and haemostasis : JTH.

Activation‐induced changes in platelet surface receptor expression and the contribution of the large‐platelet subpopulation to activation

R. Farndale, M. Moroi, Stephanie M Jung, 2020, Research and practice in thrombosis and haemostasis.

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcγRIIa and induce GPVI ectodomain shedding

M. Moroi, M. Al-Tamimi, M. Berndt, 2009, Platelets.

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

R. W. Farndale, D. M. Owen, D. Owen, 2017, Journal of thrombosis and haemostasis : JTH.

Clustering of GPVI dimers upon adhesion to collagen as a mechanism to regulate GPVI signalling in platelets: GPVI-dimer clustering on collagen

D. Owen, S. Watson, N. Poulter, 2017 .

A mechanism to safeguard platelet adhesion under high‐shear flow: von Willebrand factor‐glycoprotein Ib and integrin α2β1‐collagen interactions make complementary, collagen‐type‐specific contributions to adhesion: reply to a rebuttal

M. Moroi, S. Jung, 2007 .

GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity

F. Casanueva, M. Pardo, A. Sueiro, 2019, Atherosclerosis.

Two novel, putative mechanisms of action for citalopram-induced platelet inhibition

W. Bergmeier, A. Bonna, M. Moroi, 2018, Scientific Reports.

Phorbol ester treatment of two megakaryoblastic cell lines, CMK and UT-7, induces specific protein composition changes with non-coincident time-courses.

N. Komatsu, M. Moroi, T. Sato, 1993, Biochimica et Biophysica Acta.

Analysis of a variant form of platelet glycoprotein (GP) IIb: a second patient with abnormal molecular weight GPIIb.

M. Moroi, S. Jung, H. Koga, 1991, Thrombosis research.

Platelet cytoskeletal protein distributions in two triton-insoluble fractions and how they are affected by stimulants and reagents that modify cytoskeletal protein interactions.

M. Moroi, S. Jung, 1988, Thrombosis research.

GPVI levels in platelets: relationship to platelet function at high shear.

S. Watson, Takashi Saito, Y. Senis, 2003, Blood.

The effect of nocodazole, a microtubule inhibitor, on platelet reactions

M. Moroi, 1983 .

Effect of nocodazole, a new microtubule inhibitor, on platelet aggregation and release.

H. Yamazaki, M. Moroi, T. Tetsuka, 1981, Thrombosis research.