R. Kuang

发表

Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032).

W. Groutas, S. Ruan, R. Kuang, 1997, Biochemical and biophysical research communications.

Pharmacology Of SCH900182, A Potent, Selective Inhibitor Of PDE4 For Inhaled Administration

J. Phillips, R. Kuvelkar, R. Kuang, 2010, ATS 2010.

Discovery of oral and inhaled PDE4 inhibitors.

Kung-I Feng, Jianhua Cao, R. Kuang, 2013, Bioorganic & medicinal chemistry letters.

Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase.

W. Groutas, R. Kuang, Dengfeng Dou, 2010, Bioorganic & medicinal chemistry.

Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide.

W. Groutas, R. Kuang, H. Chan, 2000, Bioorganic & medicinal chemistry.

Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners.

O. Prakash, W. Groutas, R. Kuang, 1996, Bioorganic & medicinal chemistry.

Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases.

W. Groutas, S. Ruan, R. Kuang, 1998, Bioorganic & medicinal chemistry letters.

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates.

W. Groutas, S. Ruan, R. Kuang, 2000, Bioorganic & medicinal chemistry.

Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

W. Groutas, S. Ruan, R. Kuang, 1998, Bioorganic & medicinal chemistry.

The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.

J. Hoidal, W. Groutas, R. Kuang, 1995, Bioorganic & medicinal chemistry.

A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

N. Schechter, W. Groutas, S. Ruan, 1999 .

Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.

O. Prakash, W. Groutas, S. Ruan, 1997, Biochemistry.

Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.

Xiaohong Zhu, H. Shue, R. Kuang, 2007, Bioorganic & medicinal chemistry letters.

Solution- and solid-phase synthesis of enantiomerically pure spiro oxindoles

A. McPhail, B. Pramanik, R. Kuang, 2002 .

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

W. Groutas, S. Ruan, R. Kuang, 2001, Bioorganic & medicinal chemistry.

Enantioselective syntheses of carbocyclic ribavirin and its analogs: Linear versus convergent approaches

A. McPhail, B. Pramanik, R. Kuang, 2000 .

The optimization of pyridazinone series of glucan synthase inhibitors.

R. J. Herr, Jianhua Cao, Jinhai Yang, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.

H. Huang, J. Hoidal, W. Groutas, 1995, Bioorganic & medicinal chemistry.

Heterocyclic inhibitors of human leukocyte elastase: 3-Hydroxypyridazopyrimidine, 3-hydroxypyridopyrimidine and 3-hydroxyquinazoline-2,4-1H,3H0dione derivatives

W. Groutas, R. Kuang, J. Epp, 1993 .

Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G.

W. Groutas, R. Kuang, R. Venkataraman, 1994, Biochemical and biophysical research communications.

Discovery of oxazole-based PDE4 inhibitors with picomolar potency.

Jianhua Cao, H. Shue, R. Kuang, 2012, Bioorganic & medicinal chemistry letters.

SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors.

R. J. Herr, Jianhua Cao, Jinhai Yang, 2011, Bioorganic & medicinal chemistry letters.

Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.

R. J. Herr, S. Walker, R. Kuang, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors

R. J. Herr, P. Mann, S. Walker, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.

A. Stamford, R. Hodgson, Yongliang Zhang, 2016, Bioorganic & medicinal chemistry letters.