P. Späth

发表

Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function.

E. Couture-Tosi, M. López-Trascasa, E. Verpy, 1995, The Journal of clinical investigation.

HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus

P. Schneider, H. Peter, J. Frey, 2004, Rheumatology International.

Current IgG Products and Future Perspectives

P. Späth, 2018 .

Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass.

J. E. Doran, P. Späth, W. Harringer, 1994, The Journal of thoracic and cardiovascular surgery.

Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations

P. Späth, S. von Gunten, C. Schneider, 2017, Archivum Immunologiae et Therapiae Experimentalis.

Properties of SDS-polyacrylamide gels highly cross-linked with N,N'-diallyltartardiamide and the rapid isolation of macromolecules from the gel matrix.

P. Späth, H. Koblet, 1979, Analytical biochemistry.

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

P. Keith, J. Bernstein, R. Schellenberg, 2010, Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.

Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations.

W. Dietrich, P. Späth, J. Richter, 1997, The Journal of thoracic and cardiovascular surgery.

Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?

P. Itin, S. Moll, P. Späth, 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Monomeric Complement-Activating IgG

C. Hess, J. Tissot, P. Späth, 1999 .

Paraproteins Monomeric Complement-Activating IgG

C. Hess, J. Tissot, P. Späth, 1999 .

Monomeric complement-activating IgG paraproteins.

C. Hess, J. Tissot, P. Späth, 1999, Journal of immunology.

Essentials of the Production of Safe and Efficacious State-of-the-Art Polyclonal IgG Concentrates

P. Späth, 2017, Antibody Therapy.

Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

A. Tordai, L. Truedsson, M. López-Trascasa, 2004, Journal of Allergy and Clinical Immunology.

Intravenously applied IgG stimulates complement attenuation in a complement-dependent autoimmune disease at the amplifying C3 convertase level.

H. Lutz, R. Trüeb, R. Burger, 2004, Blood.

IVIG – mechanisms of action

H. Simon, P. Späth, 2003, Allergy.

High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn-IgG complexes.

H. Lutz, P. Späth, P. Stammler, 1996, Blood.

IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy

N. Yuki, P. Späth, T. Nakajima, 2010, Journal of Neurology, Neurosurgery & Psychiatry.

UvA-DARE ( Digital Academic Repository ) 6 th International Immunoglobulin Symposium : Poster presentations

Winkelmann, A. Durandy, S. Kaveri, 2010 .

Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.

William H. Yang, P. Keith, R. Schellenberg, 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Icatibant, the bradykinin B2 receptor antagonist with target to the interconnected kinin systems

C. Drouet, P. Späth, Ludovic Martin, 2012, Expert opinion on pharmacotherapy.

Immunoglobulin-mediated shifting of immune complexes to increased complement-dependent solubility and immunoadherence.

P. Späth, U. Nydegger, M. Spycher, 1984, Molecular immunology.

Measurement by Flow Cytometry of Intracellular Free Ca2+ Concentration and Complement Receptor Expression in Activated Neutrophils and Monocytes

D. Fearon, P. Späth, M. Spycher, 1989 .

Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations.

H. Simon, P. Späth, S. von Gunten, 2003, The Journal of allergy and clinical immunology.

Acquired angioedema and anti-C1-inhibitor autoantibody.

B. Wüthrich, J. Alsenz, P. Späth, 1989, Archives of internal medicine.

Two parallel routes of the complement‐mediated antibody‐dependent enhancement of HIV‐1 infection

N. Thielens, G. Arlaud, Z. Prohászka, 1997, AIDS.

Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass.

J. E. Doran, S. Necek, P. Späth, 1991, The Journal of thoracic and cardiovascular surgery.

Naturally occurring antibodies/autoantibodies in polyclonal immunoglobulin concentrates.

H. Lutz, P. Späth, 2012, Advances in experimental medicine and biology.

Combined complete C5 and partial C4 deficiency in humans: clinical consequences and complement-mediated functions in vitro.

A. Gianella-Borradori, P. Schneider, L. Borradori, 1990, Clinical immunology and immunopathology.

Purified Fibronectin Administration to Patients with Severe Abdominal Infections: A Controlled Clinical Trial

J. E. Doran, P. Späth, J. Morgenthaler, 1985, Annals of surgery.

A glance on recent progresses in diagnosis and treatment of primary immunodeficiencies/ Progrese recente în diagnosticul şi tratamentul imunodeficienţelor primare

P. Späth, 2014 .

Immunoglobulin g for the treatment of chronic pain: report of an expert workshop.

Stefano Tamburin, G. Zanette, G. Sobue, 2014, Pain medicine.

On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events

T. Kuijpers, P. Späth, I. Quinti, 2015, Front. Immunol..

Molecular basis of hereditary factor I deficiency

M. Walport, T. Vyse, P. Späth, 1998 .

Cardiovascular Effects of Ketanserin in the Treatment of Hypertension During Coronary Artery Bypass Surgery

E. Göb, P. Späth, J. Richter, 1986, Journal of cardiovascular pharmacology.

The influence of rapid potassium administration on hemodynamics and endogenous catecholamine production during extracorporeal circulation.

P. Späth, J. Richter, A. Barankay, 1989, Journal of cardiothoracic anesthesia.

C5 deficiency and meningitis in a Swiss family.

A. Gianella-Borradori, L. Borradori, P. Späth, 1988, Archives of internal medicine.

Hereditary angioedema (HAE) in children and adolescents—a consensus on therapeutic strategies

D. Meyer‐Olson, V. Wahn, W. Aberer, 2012, European Journal of Pediatrics.

Autoimmune C1 inhibitor deficiency: report of eight patients.

M. Cicardi, P. Späth, M. Cugno, 1993, The American journal of medicine.

[Angioedema due to acquired complement-C1-inhibitor deficiency in a female patient with non-Hodgkin lymphoma and autoimmune hemolytic anemia].

G. Martinelli, P. Späth, F. Cavalli, 1991, Schweizerische medizinische Wochenschrift.

Biocompatibility studies on a clinically well-tolerated extracorporeal system

P. Späth, H. Borberg, A. Gaczkowski, 1987 .

Inhibitors of complement activation and complement breakdown products

P. Späth, 1987 .

High doses of antigen-nonspecific IgG do not inhibit pemphigus acantholysis in skin organ cultures

U. Wiesmann, P. Späth, U. Nydegger, 2004, Archives of Dermatological Research.

Efficacy, tolerability, safety and pharmacokinetics of a nanofiltered intravenous immunoglobulin: studies in patients with immune thrombocytopenic purpura and primary immunodeficiencies

P. Williams, H. Wolf, W. Egner, 2003, Vox sanguinis.

Will Immunoglobulin Therapy of Autoimmune Blistering Skin Diseases Survive the New Financial Management of Inpatients?

P. Späth, T. Hunziker, 2011, Dermatology.

Structure and Function of Immunoglobulins

P. Späth, 1999 .

Virus safety of intravenous immunoglobulin

C. Kempf, P. Späth, M. Stucki, 2005, Clinical reviews in allergy & immunology.

Is Dosing of Therapeutic Immunoglobulins Optimal? A Review of a Three-Decade Long Debate in Europe

W. Sewell, T. Kuijpers, M. Eibl, 2014, Front. Immunol..

High‐Dose Intravenous Immunoglobulins in HIV‐1‐Infected Adults with AIDS‐Related Complex and Walter‐Reed 5

B. Salzberger, T. Mertens, U. Schaad, 1990, Vox sanguinis.

Characterization of various immunoglobulin preparations for intravenous application. II. Complement activation and binding to staphylococcus protein A.

P. Späth, U. Nydegger, F. Skvaril, 1982, Vox sanguinis.

S. Kaveri, V. Deneys, M. Toungouz, 2011, Acta clinica Belgica.

Recurrent meningitis in a patient with congenital deficiency of the C9 component of complement. First case of C9 deficiency in Europe.

M. Zoppi, P. Späth, U E Nydegger, 1990, Archives of internal medicine.

Quantification of C1-inhibitor functional activities by immunodiffusion assay in plasma of patients with hereditary angioedema--evidence of a functionally critical level of C1-inhibitor concentration.

B. Wüthrich, P. Späth, R. Bütler, 1984, Complement.

Hereditary angioedema and oral contraception.

M. Rybojad, P. Morel, L. Borradori, 1990, Dermatologica.

Hereditary angioedema in children and adolescents – A consensus update on therapeutic strategies for German‐speaking countries

R. Krüger, V. Wahn, W. Aberer, 2020, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Malignancy masquerading as food hypersensitivity

B. Wüthrich, P. Späth, A. Fontana, 2001, Allergy. European Journal of Allergy and Clinical Immunology.

[Hereditary angioedema. A clinical and immunologic contribution based on our 8 clinical cases under long-term treatment with androgens].

B. Wüthrich, P. Späth, H. Zimmermann, 1983, Schweizerische medizinische Wochenschrift.

Circulating immune complexes in patients with psoriasis: Do they exist?

P. Späth, Thomas Hunziker, Agnes Kolmár, 1992, Experimental dermatology.

Recurrent angioedema associated with hypogonadism or anti-androgen therapy.

R. Lehner, W. Pichler, P. Späth, 1989, Annals of allergy.

C1 inhibitor functional activities in hereditary angioedema plasma of patients under therapy with attenuated androgens.

B. Wüthrich, P. Späth, R. Bütler, 1984, Dermatologica.

[Clinical facets of hereditary angioedema among Swiss patients].

P. Späth, W. Wuillemin, U. Steiner, 2010, Praxis.

Colorectal intussusception: an unusual gastrointestinal complication of hereditary angioedema.

J. Saltzman, P. Späth, E. Frei, 1996, International archives of allergy and immunology.

Angioedema. A review on the acquired, allergic or non-allergic, and the hereditary forms.

B. Wüthrich, P. Späth, 1990, Recenti progressi in medicina.

[Hereditary or acquired angioedema caused by functional deficiency of C1 inhibitor--a still unfamiliar disease picture].

B. Wüthrich, P. Späth, J. Devay, 1999, Schweizerische medizinische Wochenschrift.

[Hereditary angioedema. A rare cause of acute abdominal pain with ascites].

B. Wüthrich, P. Späth, G. Melcher, 1998, Deutsche medizinische Wochenschrift.

Hereditary complement factor I deficiency.

M. Walport, T. Vyse, K. Davies, 1994, QJM : monthly journal of the Association of Physicians.

6th International Immunoglobulin Symposium: Poster presentations

E Fernandez-Cruz, S V Kaveri, H-H Peter, 2009, Clinical and experimental immunology.

Central venous catheterization in infants and children with congenital heart diseases: Experiences with 500 consecutive catheter placements

P. Späth, J. Richter, A. Barankay, 1992, Pediatric Cardiology.

Dysfunctional C8β Chain in Patients with C8 Deficiency

P. Späth, J. Tschopp, J. Schifferli, 1986 .

Clinical manifestations in humans of combined C7 and C4 deficiency associated with low levels of C2, C8, and C9.

P. Späth, P. Straub, B. Uring-Lambert, 1991, Complement and inflammation.

Functionally active complement proteins C6 and C7 detected in C6‐ and C7‐deficient individuals

O. Götze, B. Morgan, R. Würzner, 1991, Clinical and experimental immunology.

Human properdin deficiency has a heterogeneous genetic background.

M. Uhlén, J. Westberg, L. Truedsson, 1997, Immunopharmacology.

Genetic basis of human complement C8 beta deficiency.

P. Schneider, Francesco Saverio Tedesco, C. Rittner, 1993, Journal of immunology.

Polyclonal IgM and IgA block in vitro complement deposition mediated by anti-ganglioside antibodies in autoimmune neuropathies.

N. Yuki, Y. Yamaguchi, M. Sudo, 2016, International immunopharmacology.

Humoral immune response to pneumococcal antigen 23-F in an asplenic patient with recurrent fulminant pneumococcaemia.

W. Zimmerli, P. Späth, A. Schaffner, 1991, The Journal of infection.

Historical Aspects of Polyclonal IgG Preparations

V. Wahn, P. Späth, 2017, Antibody Therapy.

A C3 convertase assay for nephritic factor functional activity.

H. Lutz, M. Schlumberger, S. Sadallah, 2001, Journal of immunological methods.

Anti-inflammatory effect of intravenous immunoglobulin mediated through modulation of complement activation

H. Lutz, P. Späth, 2005, Clinical reviews in allergy & immunology.

Postexposure prophylaxis with intravenous immunoglobulin G prevents infants from getting measles

H. von Bernuth, A. Mankertz, S. Santibanez, 2017, Acta paediatrica.

Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement.

S. Thiel, M. Daha, N. Thielens, 2003, Molecular immunology.

Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study

H. Przuntek, M. Sailer, C. Heesen, 2007, Multiple sclerosis.

Human serum induced opsonization of immunoglobulin G-coated polystyrene microspheres with complement components C3 and C4 as measured by flow cytometry.

P. Späth, M. Spycher-Burger, M. Spycher, 1991, Journal of immunological methods.

Clinical Properties of a Novel Liquid Intravenous Immunoglobulin: Studies in Patients with Immune Thrombocytopenic Purpura and Primary Immunodeficiencies

C. Farber, P. Späth, M. Borte, 2004, Transfusion Medicine and Hemotherapy.

In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons.

P. Späth, M. Kirschfink, B. Schmidt, 1995, Immunology letters.

Different IVIG Glycoforms Affect In Vitro Inhibition of Anti-Ganglioside Antibody-Mediated Complement Deposition

N. Yuki, Y. Yamaguchi, M. Sudo, 2014, PloS one.

[Interdisciplinary AWMF guideline for the treatment of primary antibody deficiencies].

H. Sitter, T. Welte, V. Wahn, 2012, Klinische Padiatrie.

Complement and humoral immune parameters in bone marrow transplant recipients: effects of intravenous immunoglobulin administration.

A. Gratwohl, A. Tichelli, P. Bachmann, 1989, Transplantation Proceedings.

Chronic immune thrombocytopenic purpura — Immunological analyses of a patient pre- and post-HIV seroconversion

P. Späth, U. Bühlmann, P. Imbach, 1989, Blut.

Linkage analysis in properdin deficiency families: refined location in proximal Xp

C. Wadelius, A. Sjöholm, M. Sundvall, 1992, Clinical genetics.

[Hereditary angioedema in the German-speaking region].

B. Wüthrich, R. Bauer, K. Bork, 1998, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

Solubilization of immune precipitates by complement in the absence of properdin or factor D

P. Späth, M. Pascual, J. Schifferli, 1988, FEBS letters.

Total intravenous anaesthesia for CABG-operations the value of real-time electroencephalographic monitoring

P. Späth, J. Richter, A. Barankay, 1994 .

Total intravenous anesthesia for infants and children undergoing correction of tetralogy of Fallot: sufentanil versus sufentanil-flunitrazepam technique.

P. Späth, J. Richter, A. Barankay, 1992, Journal of cardiothoracic and vascular anesthesia.

The human complement C9 gene: identification of two mutations causing deficiency and revision of the gene structure.

C Rittner, P M Schneider, P. Schneider, 1997, Journal of immunology.

[Angioedema caused by enalapril (Reniten)].

B. Wüthrich, H. Jungbluth, P. Späth, 1989, Schweizerische medizinische Wochenschrift.

ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY REVIEW Open Access

P. Keith, J. Bernstein, R. Schellenberg, 2022 .

Complement Levels and Circulating Immune Complexes in a Controlled, Longitudinal, Multicentre Study on Effects of Intravenous Immunoglobulin in Adults with AIDS‐Related Complex/Walter‐Reed 5 1

P. Späth, G. Mauff, M. Braun, 1990, Vox sanguinis.

Effects of aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass

S. Necek, P. Späth, P. Brücke, 1990 .