P. N. Lowe

发表

Residues in Cdc42 that specify binding to individual CRIB effector proteins.

E. Laue, H. Mott, D. Owen, 2000, Biochemistry.

Effect of detergent on "promiscuous" inhibitors.

C. Chung, P. N. Lowe, A. Ryan, 2003, Journal of medicinal chemistry.

Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non‐covalent electrospray ionization mass spectrometry

S. W. Bligh, P. N. Lowe, T. Haley, 2003, Journal of molecular recognition : JMR.

Bromopyruvate as an active-site-directed inhibitor of the pyruvate dehydrogenase multienzyme complex from Escherichia coli.

R. Perham, P. N. Lowe, 1984, Biochemistry.

Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli.

P. N. Lowe, S. Rhodes, 1988, The Biochemical journal.

Regulation of Ras signal transduction in normal and transformed cells.

R. Skinner, P. N. Lowe, 1994, Cellular signalling.

Wild-type and mutant forms of the pyruvate dehydrogenase multienzyme complex from Bacillus subtilis.

R. Perham, P. N. Lowe, J. A. Hodgson, 1983, The Biochemical journal.

Stereoisomers of tetrahydrothiamin pyrophosphate, potent inhibitors of the pyruvate dehydrogenase multienzyme complex from Escherichia coli.

R. Perham, F. Leeper, P. N. Lowe, 1983, Biochemistry.

The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride.

J. Eccleston, P. N. Lowe, Debbie L Graham, 1999, Biochemistry.

Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.

M. Webb, A. Nixon, P. N. Lowe, 1995, Biochemistry.

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras.

M. Webb, R. Skinner, P. N. Lowe, 1993, The Journal of biological chemistry.

Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins.

D. Stammers, A. L. Brown, R. Skinner, 1991, The Journal of biological chemistry.

Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system.

A. Hall, R. Skinner, P. N. Lowe, 1989, The Journal of biological chemistry.

Aminotransferase activities in Trichomonas vaginalis.

P. N. Lowe, A. Rowe, 1986, Molecular and biochemical parasitology.

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

H. Mott, D. Owen, S. McLaughlin, 2013, Biochemistry.

Mechanism of Inhibition by Arachidonic Acid of the Catalytic Activity of Ras GTPase-activating Proteins (*)

J. Eccleston, R. Skinner, P. N. Lowe, 1996, The Journal of Biological Chemistry.

Dual role of a single multienzyme complex in the oxidative decarboxylation of pyruvate and branched-chain 2-oxo acids in Bacillus subtilis.

R. Perham, P. N. Lowe, J. A. Hodgson, 1983, The Biochemical journal.

Purification and characterization of pyruvate: ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis.

P. Leadlay, P. N. Lowe, K. Williams, 1987, The Biochemical journal.

Application of β-Galactosidase Enzyme Complementation Technology as a High Throughput Screening Format for Antagonists of the Epidermal Growth Factor Receptor

S. Rees, M. Palmer, P. N. Lowe, 2001 .

Use of the insect/baculovirus expression system to produce lipid-modified ras proteins for electrospray mass spectrometric studies

D. Cooper, A. Magee, A. Aitken, 1990 .

Isolation and properties of the branched-chain 2-keto acid and pyruvate dehydrogenase multienzyme complex from Bacillus subtilis.

R. Perham, P. N. Lowe, 1988, Methods in enzymology.

MgATP-induced inhibition of the enzymic activity of chloroform-released ox-heart mitochondrial ATPase.

H. Baum, P. N. Lowe, P. Linnett, 1979, Biochemical and biophysical research communications.

Direct measurement of the binding of RAS to neurofibromin using a scintillation proximity assay.

R. Skinner, P. N. Lowe, J. Rowedder, 1994, Analytical biochemistry.

Cysteine-200 of human inducible nitric oxide synthase is essential for dimerization of haem domains and for binding of haem, nitroarginine and tetrahydrobiopterin.

I. Charles, W. Alderton, P. N. Lowe, 1997, The Biochemical journal.

Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.

I. Charles, D. Stammers, S. Moncada, 1996, The Biochemical journal.

Expression of polyisoprenylated Ras proteins in the insect/baculovirus system.

D. Cooper, R. Skinner, P. N. Lowe, 1992, Biochemical Society transactions.

Evidence for the Presence of Three Distinct Binding Sites for the Thioflavin T Class of Alzheimer's Disease PET Imaging Agents on β-Amyloid Peptide Fibrils*

A. Gee, A. Lockhart, Liang Ye, 2005, Journal of Biological Chemistry.

Preparation and chemical properties of periodate-oxidized adenosine triphosphate and some related compounds [proceedings].

H. Baum, P. N. Lowe, R. Beechey, 1979, Biochemical Society transactions.

Interactions between periodate-oxidized adenosine triphosphate and the mitochondrial adenosine triphosphatase [proceedings].

H. Baum, P. N. Lowe, R. Beechey, 1979, Biochemical Society transactions.

The Ha-ras protein, p21, is modified by a derivative of mevalonate and methyl-esterified when expressed in the insect/baculovirus system.

P. N. Lowe, M. Page, M. Sydenham, 1990, Oncogene.

Solution dynamics of p21ras proteins bound with fluorescent nucleotides: a time-resolved fluorescence study.

J. Eccleston, T. Hazlett, D. Jameson, 1993, Biochemistry.

Measurement of protein-ligand complex formation.

C. Vaughan, T. Daviter, P. N. Lowe, 2013, Methods in molecular biology.

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.

B. Gusterson, T. Kamalati, P. J. Mitchell, 1994, Oncogene.

The IQGAP1-Rac1 and IQGAP1-Cdc42 Interactions

H. Mott, D. Owen, D. Sacks, 2008, Journal of Biological Chemistry.

Structure of Cdc42 bound to the GTPase binding domain of PAK

E. Laue, D. Nietlispach, H. Mott, 2000, Nature Structural Biology.

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

E. Laue, L. Lim, D. Nietlispach, 1999, Nature.

Probing the active sites of aspartate: 2-oxoglutarate aminotransferases from Trichomonas vaginalis and pig heart cytoplasm using substrate analogues.

P. N. Lowe, A. Rowe, 1987, Comparative biochemistry and physiology. B, Comparative biochemistry.

Characterization of ras Proteins Produced at High Levels in the Baculovirus Expression System

A. Hall, R. Skinner, P. N. Lowe, 1989 .

MgF(3)(-) as a transition state analog of phosphoryl transfer.

S. Smerdon, K. Rittinger, S. Gamblin, 2002, Chemistry & biology.

The Importance of Two Conserved Arginine Residues for Catalysis by the Ras GTPase-activating Protein, Neurofibromin*

J. Eccleston, P. N. Lowe, J F Eccleston, 1998, The Journal of Biological Chemistry.

Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras.

J. Eccleston, R. Skinner, P. N. Lowe, 1993, The Journal of biological chemistry.

Equilibrium and Kinetic Measurements Reveal Rapidly Reversible Binding of Ras to Raf (*)

S. Neidle, R. Skinner, P. N. Lowe, 1996, The Journal of Biological Chemistry.

Characterization of Normal and Mutant Human Kirsten- ras (4B) p21 and of the Catalytic Domain of GAP

R. Skinner, P. N. Lowe, S. Bradley, 1991 .

Specificity determinants on Cdc42 for binding its effector protein ACK.

E. Laue, H. Mott, D. Owen, 2005, Biochemistry.

Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1)*

T. Blundell, P. Parker, D. Nietlispach, 2003, Journal of Biological Chemistry.

Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.

W. Alderton, P. N. Lowe, A. Boyhan, 1998, The Biochemical journal.

Characterization of recombinant human Kirsten-ras (4B) p21 produced at high levels in Escherichia coli and insect baculovirus expression systems.

H. Paterson, R. Skinner, P. N. Lowe, 1991, The Journal of biological chemistry.

Cloning and expression of a rat neuronal nitric oxide synthase coding sequence in a baculovirus/insect cell system.

I. Charles, S. Moncada, R. Gill, 1993, Biochemical and biophysical research communications.

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase.

H. Mott, S. W. Bligh, P. N. Lowe, 2004, Assay and drug development technologies.

A method to measure the interaction of Rac/Cdc42 with their binding partners using fluorescence resonance energy transfer between mutants of green fluorescent protein.

P. N. Lowe, P. Chalk, Debbie L Graham, 2001, Analytical biochemistry.

MgATP-induced inhibition of the adenosine triphosphatase activity of submitochondrial particles.

P. N. Lowe, R. Beechey, 1981, The Biochemical journal.

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

H. Mott, D. Owen, S. McLaughlin, 2011, Biochemistry.

Aspartate:2-oxoglutarate aminotransferase from Trichomonas vaginalis: comparison with pig heart cytoplasmic enzyme.

P. N. Lowe, A. Rowe, 1986, Comparative biochemistry and physiology. B, Comparative biochemistry.

The kinetic mechanism of the GAP-activated GTPase of p21 ras.

J. Eccleston, P. N. Lowe, K. J. Moore, 1992, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Involvement of the endogenous inhibitor protein in the MgATP-induced inhibition of soluble mitochondrial adenosine triphosphatase activity.

P. N. Lowe, R. Beechey, 1981, The Biochemical journal.

Delineation of the Cdc42/Rac-binding domain of p21-activated kinase.

D. Owen, P. N. Lowe, P. Chalk, 1998, Biochemistry.

Fluorescence approaches to the study of the p21ras GTPase mechanism.

J. Eccleston, M. Webb, P. N. Lowe, 1991, Biochemical Society transactions.

Modulation of amino acid and 2-oxo acid pools in Trichomonas vaginalis by aspartate aminotransferase inhibitors.

P. N. Lowe, A. Rowe, 1986, Molecular and biochemical parasitology.

Scintillation proximity assay to measure nitroarginine and tetrahydrobiopterin binding to heme domain of neuronal nitric oxide synthase.

W. Alderton, P. N. Lowe, 1999, Methods in enzymology.

Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak

E. Laue, D. Nietlispach, H. Mott, 2000 .

Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins.

C. Chung, J. Eccleston, P. N. Lowe, 1999, Biochemistry.

Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction.

H. Mott, D. Owen, P. N. Lowe, 2007, Biochemistry.