F. Massé

发表

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

N. Méthot, D. Riendeau, Daigen Xu, 2007, Bioorganic & medicinal chemistry letters.

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.

N. Méthot, D. Riendeau, Daigen Xu, 2009, Bioorganic & medicinal chemistry letters.

Trisubstituted ureas as potent and selective mPGES-1 inhibitors.

N. Méthot, D. Riendeau, Daigen Xu, 2011, Bioorganic & medicinal chemistry letters.

The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.

Christine Brideau, Yves Ducharme, Marc Ouellet, 2010, ACS medicinal chemistry letters.

The identification of potent, selective, and bioavailable cathepsin S inhibitors.

M. Percival, W. Cromlish, J. Gauthier, 2007, Bioorganic & medicinal chemistry letters.

Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside*

M. Prentki, N. Ruderman, A. Saha, 2000, The Journal of Biological Chemistry.

The hemoregulatory peptide N-acetyl-ser-asp-lys-pro impairs angiotensin I-induced contractions in rat aorta.

B. Lévy, E. Ezan, M. Azizi, 1998, European journal of pharmacology.

Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.

M. Prentki, C. Newgard, E. Roche, 2000, The Journal of biological chemistry.

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

J. Falgueyret, R. Oballa, J. Guay, 2010, Bioorganic & medicinal chemistry letters.

Beta-substituted cyclohexanecarboxamide cathepsin K inhibitors: modification of the 1,2-disubstituted aromatic core.

C. Bayly, M. Percival, R. Oballa, 2007, Bioorganic & medicinal chemistry letters.

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

N. Méthot, M. Ndao, F. Massé, 2013, Antimicrobial Agents and Chemotherapy.

Primary amides as selective inhibitors of cathepsin K.

C. Bayly, J. Falgueyret, M. Percival, 2007, Bioorganic & medicinal chemistry letters.

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

J. Falgueyret, J. Palmer, M. Venuti, 2008, Bioorganic & medicinal chemistry letters.

Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools

M. Percival, F. Massé, S. Desmarais, 2009, Biological chemistry.

Identification of a potent and selective non-basic cathepsin K inhibitor.

J. Falgueyret, M. Mcgrath, M. Percival, 2006, Bioorganic & medicinal chemistry letters.

Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors.

R. Oballa, Qingping Wang, F. Massé, 2009, Bioorganic & medicinal chemistry letters.

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

M. Prentki, N. Ruderman, V. Poitout, 2004, Diabetes.

Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.

C. Bayly, J. Falgueyret, M. Percival, 2008, Journal of Medicinal Chemistry.

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell*

M. Prentki, C. Newgard, E. Roche, 2000, The Journal of Biological Chemistry.

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.

J. Falgueyret, M. Percival, R. Young, 2005, Bioorganic & medicinal chemistry letters.

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.

J. Falgueyret, M. Percival, R. Oballa, 2005, Journal of medicinal chemistry.

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

C. Bayly, J. Falgueyret, J. Palmer, 2006, Bioorganic & Medicinal Chemistry Letters.

An Automated Multistep High-Throughput Screening Assay for the Identification of Lead Inhibitors of the Inducible Enzyme mPGES-1

C. Brideau, D. Éthier, J. Guay, 2005, Journal of biomolecular screening.

Application of the Protein Maker as a platform purification system for therapeutic antibody research and development

A. Matte, M. Parat, Cory J. Gerdts, 2016, Computational and Structural Biotechnology Journal.

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease.

Frédéric Massé, N. Méthot, M. Ndao, 2010, Bioorganic & medicinal chemistry letters.

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

J. R. Somoza, C. Bayly, J. Palmer, 2006, Journal of Medicinal Chemistry.

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.

J. Falgueyret, M. Percival, R. Oballa, 2010, Bioorganic & medicinal chemistry letters.