G. Hitchings

G. Hitchings, G. Elion, H. Nathan, 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Some 2,4,6-Triamino-5-alkyl- and 5-Benzylpyrimidines

G. Hitchings, P. Russell, 1952 .

2,4-Diaminopyrimidines as Antimalarials. III. 5-Aryl Derivatives

G. Hitchings, P. Russell, 1951 .

FOLATE ANTAGONISTS AS ANTIBACTERIAL and ANTIPROTOZOAL AGENTS

G. Hitchings, 1971, Annals of the New York Academy of Sciences.

Effect of Aliphatic Oxime and Isatin Thiosemicarbazones on Vaccinia Infection in the Mouse and in the Rabbit∗

R. L. Thompson, G. Hitchings, P. Russell, 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Effect of heterocyclic and other thiosemicarbazones on vaccinia infection in the mouse.

R. L. Thompson, G. Hitchings, S. Minton, 1953, Journal of immunology.

Ribonucleosides of allopurinol and oxoallopurinol. Isolation from human urine, enzymatic synthesis, and characterization.

G. Hitchings, G. Elion, G H Hitchings, 1967, The Journal of biological chemistry.

XANTHINE AS A PRECURSOR OF NUCLEIC ACID PURINES IN THE MOUSE.

G. Hitchings, G. Elion, R. Pomales, 1965, Biochimica et biophysica acta.

SUMMARY OF INFORMAL DISCUSSION ON THE ROLE OF PURINE ANTAGONISTS.

G. Hitchings, 1963, Cancer research.

Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase

G. Hitchings, G. Elion, R. Rundles, 1963 .

Deamination Studies on Pyrimidine and Condensed Pyrimidine Systems1,2

G. Hitchings, G. Elion, R. Trattner, 1964 .

Studies on condensed pyrimidine systems. XXV. 2,4-diaminopyrido[2,3-d]pyrimidines. Biological data.

R. Ferone, S. Bushby, G. Hitchings, 1968, Journal of medicinal chemistry.

Studies on Condensed Pyrimidine Systems. XIX. A New Synthesis of Pyrido [2,3-d] pyrimidines. The Condensation of 1,3-Diketones and 3-Ketoaldehydes with 4-Aminopyrimidines

R. K. Robins, G. Hitchings, 1958 .

Studies on Condensed Pyrimidine Systems. XI. Some 8-Alkyl-7-pteridones1

G. Hitchings, G. Elion, 1953 .

Studies on Condensed Pyrimidine Systems. XIV. Some Pyrido [3,2-d]pyrimidines

R. K. Robins, G. Hitchings, 1956 .

Studies on Condensed Pyrimidine Systems. XII. Synthesis of Some 4- and 2,4-Substituted Pyrido[2,3-d]pyrimidines

R. K. Robins, G. Hitchings, 1955 .

Studies on Condensed Pyrimidine Systems. VIII (1). The 5,6-Dihydrofuro[2,3-d]Pyrimidine Ring System

G. Hitchings, A. Schrage, 1951 .

Studies on Condensed Pyrimidine Systems. XIII. Some Amino-substituted Derivatives of Guanine and 6-Thioguanine

G. Hitchings, G. Elion, William H. Lange, 1956 .

Studies on Condensed Pyrimidine Systems. X. Some 1,3-Oxazolo(5,4-d)pyrimidines

G. Hitchings, G. Elion, E. A. Falco, 1952 .

Functions of Tetrahydrofolate and the Role of Dihydrofolate Reductase in Cellular Metabolism

G. Hitchings, 1983 .

The Synthesis of Pterorhodin (Rhodopterin)1,1a

G. Hitchings, P. Russell, Robert Purrmann, 1949 .

5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.

B. Roth, S. Bushby, G. Hitchings, 1962, Journal of medicinal and pharmaceutical chemistry.

The Synthesis of Some New Pteridines

G. Hitchings, G. Elion, 1947 .

Studies on Condensed Pyrimidine Systems. XVII. Some Halogenopurines

G. Hitchings, G. Elion, 1956 .

Adenine phosphoribosyltransferase from monkey liver. Specificity and properties.

G. Hitchings, G. Elion, T. Krenitsky, 1969, The Journal of biological chemistry.

Preliminary studies on the effect of 2,6‐diaminopurine on transplanted mouse leukemia

C. P. Rhoads, J. Burchenal, C. Stock, 1949, Cancer.

Antagonists of nucleic acid derivatives as medicinal agents.

G. Hitchings, 1992, Annual Review of Pharmacology and Toxicology.

STUDIES ON CONDENSED PYRIMIDINE SYSTEMS. V. (1) THE PYRIMIDO[4,5-c][1,2,5]THIADIAZOLE RING SYSTEM

G. Hitchings, A. Schrage, 1951 .

A New Condensed Pyrimidine System: Some p-Oxazino [2,3-d] pyrimidines

G. Hitchings, G. Elion, P. Russell, 1949 .

2:4-diaminopyrimidines- a new series of antimalarials.

G. Hitchings, G H HITCHINGS, P B RUSSELL, 1951, British journal of pharmacology and chemotherapy.

Pyrimidopteridines by Oxidative Self-condensation of Aminopyrimidines1,2

G. Hitchings, E. A. Falco, E. Taylor, 1955 .

Kinetics of the reactions of dehydroascorbic acid in the presence of hydrogen sulfide.

S. Levenson, G. Hitchings, H. Rosen, 1951, Archives of biochemistry and biophysics.

Effects of Xanthine Oxidase Inhibitor on Clinical Manifestations and Purine Metabolism in Gout.

G. Hitchings, G. Elion, R. Rundles, 1964 .

Inhibition of Folate Metabolism in Chemotherapy

G. Hitchings, 1983, Handbook of Experimental Pharmacology.

Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.

G. Hitchings, G B ELION, S SINGER, 1954, The Journal of biological chemistry.

Renal clearance of oxipurinol, the chief metabolite of allopurinol.

G. Hitchings, A. Gutman, G. Elion, 1968, The American journal of medicine.

The utilisation of biochemical differences between host and parasite as a basis for chemotherapy. Drugs, parasites and hosts.

G. Hitchings, R. H. Nimmo-Smith, L. Goodwin, 1962 .

Part II. Pyrimethamine. The Use of an Antimetabolite in the Chemotherapy of Malaria and other Infections.

G. Hitchings, 1960 .

THE ESTIMATION OF GUANINE AND XANTHINE

G. Hitchings, 1941 .

212. Some 2 : 6-diamino- and 2-amino-6-hydroxy-derivatives of 5-aryl-4 : 5-dihydropyrimidines. A new synthesis of 4-alkyl-5-arylpyrimidines

G. Hitchings, N. Whittaker, P. Russell, 1956 .

A Biochemical Approach to Chemotherapy

G. Hitchings, 1982, Drug intelligence & clinical pharmacy.

Inhibitor binding analysis of dihydrofolate reductases from various species.

G. Hitchings, J. Burchall, 1965, Molecular pharmacology.

CHAPTER 6 – Purine Analogues

G. Hitchings, G. Elion, 1963 .

EFFECT OF TYROSINASE ON PHENETHYLAMINE DERIVATIVES

G. Hitchings, L. O. Randall, 1944 .

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.

G. Hitchings, G. Elion, A. Kovensky, 1966, Biochemical pharmacology.

The incorporation of exogenous purines into pentose nucleic acid by Lactobacillus casei.

D. Levin, G. Hitchings, G. Elion, 1952, The Journal of biological chemistry.

The limitations of inhibition analysis.

G. Hitchings, G. Elion, H. Vanderwerff, 1948, The Journal of biological chemistry.

5-Arylthiopyrimidines. II. 2- and 4-Alkylamino and 4-Amino Derivatives1

B. Roth, G. Hitchings, 1961 .

Studies on Condensed Pyrimidine Systems. XXI. The Isolation and Synthesis of 6-Mercapto-2,8-purinediol (6-Thiouric Acid)

G. Hitchings, G. Elion, S. Mueller, 1959 .

Inhibition of folate biosynthesis and function as a basis for chemotherapy.

G. Hitchings, J. Burchall, 1965, Advances in enzymology and related areas of molecular biology.

The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria.

R. Ferone, G. Hitchings, R. Wood, 1961, Biochemical pharmacology.

Hematological effects of certain 2,4-diaminopyrimidines, antagonists of folic acid metabolism.

S. Sternberg, L. Hamilton, G. Hitchings, 1954, Blood.

3,5-DIAMINO-AS-TRIAZINES AS INHIBITORS OF LACTIC ACID BACTERIA AND PLASMODIA

H. Werff, G. Hitchings, P. Russell, 1952 .

The Identification of “β-Dihydroxanthopterin” as 2,4-Diamino-6-hydroxy-p-oxazino (2,3-d)pyrimidine

G. Hitchings, G. Elion, 1952 .

SOME ASPECTS OF IMMUNOSUPPRESSION

G. Hitchings, G. Elion, 1966 .

Studies on Condensed Pyrimidine Systems. XV. Some Pyrazolo[3,4-d]pyrimidines

G. Hitchings, E. A. Falco, 1956 .

Studies on Condensed Pyrimidine Systems. XVI. Purines and Thiazolo[5,4-d]pyrimidines from 4-Amino-5-formamido-6-mercaptopyrimidines

G. Hitchings, G. Elion, William H. Lange, 1956 .

Studies on Condensed Pyrimidine Systems. IV.1 Some Thiazolo [5,4-d] pyrimidines

G. Hitchings, E. A. Falco, 1950 .

Antimalarials as Antagonists of Purines and Pteroylglutamic Acid

G. Hitchings, P. Russell, H. Vanderwerff, 1949, Nature.

The Effects of Antagonists on the Multiplication of Vaccinia Virus in Vitro.

R. L. Thompson, G. Hitchings, G. Elion, 1949, Science.

Protection of mice against the vaccinia virus by the administration of phenoxythiouracils.

R. L. Thompson, G. Hitchings, S. Minton, 1951, Journal of immunology.

A Test of Triazolopyrimidines on Mouse Sarcoma 180.∗

C. Stock, G. Hitchings, L. Cavalieri, 1949, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Structure-activity relationships among purines related to 6-mercaptopurine.

C. Stock, G. Hitchings, G. Elion, 1958, Cancer research.

The third Paul Ehrlich lecture basic research as forerunner of new medications

G. Hitchings, 1991, Medicinal research reviews.

THE CHEMISTRY AND BIOCHEMISTRY OF PURINE ANALOGS

G. Hitchings, G. Elion, 1954, Annals of the New York Academy of Sciences.

Selective inhibitors of dihydrofolate reductase

G. Hitchings, 1989, In Vitro Cellular & Developmental Biology.

MICROBIOLOGICAL EFFECTS OF 6‐MERCAPTOPURINE

G. Hitchings, G. Elion, S. Singer, 1954, Annals of the New York Academy of Sciences.

Daraprim as an antagonist of folic and folinic acids.

G. Hitchings, 1952, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Studies on condensed pyrimidine systems. 23. Synthesis of 2,4-diaminopyrido[2,3-d]pyrimidines from beta-keto esters.

G. Hitchings, B. Valenti, P. Stenbuck, 1968, Journal of medicinal chemistry.

STUDIES ON ANALOGS OF PURINES AND PYRIMIDINES

G. Hitchings, G. Elion, E. A. Falco, 1950, Annals of the New York Academy of Sciences.

Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase.

R. Friedman, G. Hitchings, S. Bieber, 1963, Biochimica et biophysica acta.

Observations on the anticancer activity of 6-mercaptopurine.

H. Skipper, G. Hitchings, G. Elion, 1954, Cancer research.

The direct thiation of uracils.

G. Hitchings, G. Elion, 1947, Journal of the American Chemical Society.

The Ultraviolet Absorption Spectra of Thiouracils1

G. Hitchings, G. Elion, W. S. Ide, 1946 .

Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.

G. Hitchings, 1969, Cancer research.

Mechanism of action of 6-azacytosine in bacteria.

E. Bresnick, G. Hitchings, S. Singer, 1960, Biochimica et biophysica acta.

6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.

S. Sternberg, C. Stock, G. Hitchings, 1953, Cancer research.

Effects of purine antagonists on a diaminopurine-resistant strain of Lactobacillus casei.

G. Hitchings, G. Elion, S. Singer, 1953, The Journal of biological chemistry.

The Incorporation of 6-Mercaptopurine-S35 into the Nucleic Acids of Sensitive and Nonsensitive Transplantable Mouse Tumors

G. Hitchings, G. Elion, Daniel S. Martin, 1961 .

Indications for control mechanisms in purine and pyrimidine biosynthesis as revealed by studies with inhibitors.

G. Hitchings, 1974, Advances in enzyme regulation.

Purine and pyrimidine antagonists.

G. Hitchings, 1955, The American journal of clinical nutrition.

1,2,4-Triazine Analogs of the Natural Pyrimidines

G. Hitchings, E. A. Falco, E. Pappas, 1956 .

A study of the uptake and degradation of folic acid, citrovorum factor, aminopterin, and pyrimethamine by bacteria.

G. Hitchings, R. Wood, 1959, The Journal of biological chemistry.

Selective Inhibitors of Dihydrofolate Reductase (Nobel Lecture)

G. Hitchings, 1989 .

Nucleic acids and their derivatives and the development of Rana pipiens. I. Oögenesis.

J. Spence, G. Hitchings, S. Bieber, 1959, Experimental cell research.

A Synthesis of 4-Amino-2-thiopyrimidines

G. Hitchings, G. Elion, E. A. Falco, 1949 .

Condensed Pyrimidine Systems. XX. Purines Related to 6-Mercaptopurine and Thioguanine

G. Hitchings, G. Elion, I. Goodman, 1959 .

The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase.

G. Hitchings, E. A. Falco, 1944, Proceedings of the National Academy of Sciences of the United States of America.

The Synthesis of 6-Thioguanine

G. Hitchings, G. Elion, 1955 .

Synthesis of 8-C14 and of S35-6-Mercaptopurine

G. Hitchings, G. Elion, 1954 .

The effects of 6-mercaptopurine on Lactobacillus casei.

D. Levin, G. Hitchings, G. Elion, 1957, Archives of biochemistry and biophysics.

Thioguanine in Deoxyribonucleic Acid from Tumors of 6-Mercaptopurine-Treated Mice

G. Hitchings, J. Scannell, 1966, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Studies on 2,6‐diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues

G. Hitchings, G. Elion, J. Biesele, 1951 .

Utilization of some purine riboside derivatives by Lactobacillus casei.

D. Levin, G. Hitchings, G. Elion, 1952, The Journal of biological chemistry.

Effects of purine derivatives and analogues on multiplication of the vaccinia virus.

R. L. Thompson, G. Hitchings, G. Elion, 1950, Journal of immunology.

THE EFFECTS OF PYRIMIDINES ON THE GROWTH OF LACTOBACILLUS CASEI.

G. Hitchings, M. B. Sherwood, E. A. Falco, 1945, Science.

The Formation of 6-Hydroxy- and 7-Hydroxypteridines from 4,5-Diaminopyrimidines and α-Ketoacids and Esters

G. Hitchings, G. Elion, P. Russell, 1950 .

Pyrimidine derivatives as antagonists of pteroylglutamic acid.

G. Hitchings, G. Elion, 1948, The Journal of biological chemistry.

Effects of allopurinol in relation to purine biosynthesis.

G. Hitchings, 1966, Annals of the rheumatic diseases.

Symposium on immunosuppressive drugs. Summary and concluding remarks.

G. Hitchings, 1967, Federation proceedings.

Purine metabolism of a diaminopurine-resistant strain of Lactobacillus casei.

D. Levin, G. Hitchings, G. Elion, 1953, The Journal of biological chemistry.

Experimental, clinical, and metabolic studies of thiopurines.

J. Laszlo, G. Hitchings, R. Rundles, 1962, Cancer chemotherapy reports.

The Reaction of Aromatic Nitriles with Guanidine1

G. Hitchings, P. Russell, 1950 .

Pharmacology of allopurinol.

G. Hitchings, 1975, Arthritis and rheumatism.

Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine.

G. Hitchings, G. Elion, E. A. Falco, 1950, The Journal of biological chemistry.

Studies on Condensed Pyrimidine Systems. XVIII. Substances Related to 6-Purinecarboxylic Acid

G. Hitchings, L. Mackay, 1956 .

Studies on Condensed Pyrimidine Systems. VI. Some 2-Aminothiazolo [4,5-d]-pyrimidines1,2

G. Hitchings, A. Maggiolo, 1951 .

A summary of investigations with 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in animals.

G. Hitchings, G. Elion, S. Bieber, 1960, Cancer chemotherapy reports.

The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man.

G. Hitchings, G. Elion, R. Rundles, 1960, Cancer chemotherapy reports.

Properties of purine and pyrimidine analogs.

G. Hitchings, 1991, Advances in enzyme regulation.

Inhibitors of Folate Biosynthesis and Utilization – Evolutionary Changes as a Basis for Chemotherapy

G. Hitchings, 1972 .

The role of metabolites and antimetabolites in the control of folate coenzyme synthesis.

G. Hitchings, J. Burchall, 1968, Advances in enzyme regulation.

The purine metablism of protozoa

G. Hitchings, 1982 .

COMPARATIVE ENZYMOLOGY OF DIHYDROFOLATE REDUCTASES AS A BASIS FOR CHEMOTHERAPY

R. Ferone, G. Hitchings, J. Burchall, 1968 .

Effect of pyrimethamine on folic acid metabolism in Streptococcus faecalis and Escherichia coli.

G. Hitchings, R. Wood, 1959, The Journal of biological chemistry.

Resistance to inhibitors of dihydrofolate reductase in strains of Lactobacillus casei and Proteus vulgaris.

G. Hitchings, G. Elion, S. Singer, 1966, Journal of general microbiology.

The Formation of 1,3,5-Triazines by the Reaction of α-Cyanocarbonyl Compounds with Guanidine

G. Hitchings, James A. Walker, P. Russell, 1952 .

The rat growth factors of the filtrate fraction of liver extracts.

Y. Subbarow, G. Hitchings, 1939 .

Uric Acid

F., N. Ertel, G. Hitchings, 1898, Handbook of Experimental Pharmacology.

The utilization of purine ribotides by Lactobacillus casei.

D. Levin, G. Hitchings, G. Elion, 1953, The Journal of biological chemistry.

2, 4-Diaminopyrimidines as antagonists of folic acid and folinic acid.

J. Burchenal, D. Hutchison, G. Hitchings, 1952, Archives of biochemistry and biophysics.

Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.

R. Ferone, G. Hitchings, J. Burchall, 1969, Molecular pharmacology.

DIVISION OF BIOCHEMISTRY: A BIOCHEMICAL APPROACH TO CHEMOTHERAPY*

G. Hitchings, 1961 .

Effects of growth-inhibitors on amphibian tail blastema.

G. Hitchings, S. Bieber, 1959, Cancer research.

Folate cofactor biosynthesis by Plasmodium berghei. Comparison of folate and dihydrofolate as substrates.

R. Ferone, G. Hitchings, Robert Ferone, 1966, The Journal of protozoology.

A new synthesis of cytosine and 5-methylcytosine.

G. Hitchings, G. Elion, 1949, The Journal of biological chemistry.

Inhibition of Folate Metabolism in Chemotherapy: The Origins and Uses of Co-trimoxazole

G. Hitchings, J. Acar, 2011 .

Studies on Condensed Pyrimidine Systems. VII. Some 8-Arylpurines

G. Hitchings, G. Elion, E. Burgi, 1951 .

Species differences among dihydrofolate reductases as a basis for chemotherapy.

G. Hitchings, 1969, Postgraduate medical journal.

BIOCHEMICAL BACKGROUND OF TRIMETHOPRIM/SULPHAMETHOXAZOLE

G. Hitchings, 1973, The Medical journal of Australia.

Species differences among dihydrofolate reductases.

G. Hitchings, J. Burchall, 1966, Federation proceedings.

SPECIAL MICROBIOLOGICAL SYSTEMS. III. THE USE OF LACTIC ACID BACTERIA FOR THE EVALUATION OF PURINE AND PYRIMIDINE ANTAGONISTS

G. Hitchings, 1958, Annals of the New York Academy of Sciences.

Substrate-inhibitor cooperative interactions with microbial dihydrofolate reductases.

D. Baccanari, G. Hitchings, R. Tansik, 1987, Advances in enzyme regulation.

Studies on 2,6‐diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues

G. Hitchings, G. Elion, J. Biesele, 1951, Cancer.

Folic acid-like activity from xanthopterin.

G. Hitchings, G. Elion, M. B. Sherwood, 1950, Archives of biochemistry.