A. C. Storer

发表

The nature of experimental error in enzyme kinetic measurments.

A. Cornish-Bowden, M. Darlison, A. C. Storer, 1975, The Biochemical journal.

Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity.

P. Bonneau, D. Brömme, A. C. Storer, 1994, The Journal of biological chemistry.

Characterization of transient enzyme-substrate bonds by resonance Raman spectroscopy.

P. Carey, A. C. Storer, 1984, Annual review of biophysics and bioengineering.

Identification of Internal Autoproteolytic Cleavage Sites within the Prosegments of Recombinant Procathepsin B and Procathepsin S

A. C. Storer, O. Quraishi, 2001, The Journal of Biological Chemistry.

Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations.

A. Cornish-Bowden, A. C. Storer, 1976, The Biochemical journal.

Mechanistic and structural studies on Rhodococcus ATCC 39484 nitrilase.“

A. Mihoc, D. Stevenson, D. Groleau, 1992, Biotechnology and applied biochemistry.

The kinetics of coupled enzyme reactions. Applications to the assay of glucokinase, with glucose 6-phosphate dehydrogenase as coupling enzyme.

A. Cornish-Bowden, A. C. Storer, 1974, The Biochemical journal.

Nature of papain products resulting from inactivation by a peptidyl O‐acyl hydroxamate

R. Ménard, A. Krantz, A. C. Storer, 1991, FEBS letters.

Detection of covalent enzyme‐substrate complexes of nitrilase by ion‐spray mass spectroscopy

D. Stevenson, A. C. Storer, R. Feng, 1990, FEBS letters.

The active‐site residue Cys‐29 is responsible for the neutral‐pH inactivation and the refolding barrier of human cathepsin B

F. Ni, P. Xu, A. C. Storer, 2000, FEBS letters.

RAT PROCATHEPSIN B

R. Coulombe, M. Cygler, P. Grochulski, 1997 .

Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.

R. Ménard, L. Juliano, A. C. Storer, 1997, Biochemistry.

Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region.

D. Tessier, T. Vernet, D. Y. Thomas, 1990, The Journal of biological chemistry.

Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi.

R. Ménard, J. Scharfstein, A. C. Storer, 1992, Molecular and biochemical parasitology.

Identification of new cysteine protease gene isoforms in Trypanosoma cruzi.

D. Tessier, T. Vernet, J. Scharfstein, 1994, Molecular and biochemical parasitology.

The purification in high yield and characterization of rat hepatic glucokinase.

A. Cornish-Bowden, I. Trayer, A. C. Storer, 1976, The Biochemical journal.

Processing of the Papain Precursor

R. Ménard, D. Tessier, T. Vernet, 1995, The Journal of Biological Chemistry.

The Raman and resonance Raman spectra of some substituted dialkyl dithioesters and their rotational isomers

Y. Ozaki, P. Carey, A. C. Storer, 1982 .

Mechanistic origin of the sigmoidal rate behaviour of rat liver hexokinase D ('glucokinase').

A. Cornish-Bowden, A. C. Storer, 1986, The Biochemical journal.

Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B.

D. Ripoll, M. Abrahamson, P. Lindahl, 1994, Biochemistry.

Vibrational spectra of scissile bonds in enzyme active sites: a resonance Raman study of dithioacylpapains.

Y. Ozaki, P. Carey, A. C. Storer, 1982, Biochemistry.

Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme.

C. Peters, P. Bonneau, T. Vernet, 1993, The Journal of biological chemistry.

Processing of the papain precursor. Purification of the zymogen and characterization of its mechanism of processing.

D. Tessier, T. Vernet, D. Y. Thomas, 1991, The Journal of biological chemistry.

Potent inactivation of cathepsins S and L by peptidyl (acyloxy)methyl ketones.

R. Smith, H. Kirschke, D. Brömme, 1994, Biological chemistry Hoppe-Seyler.

Interdependency of sequence and positional specificities for cysteine proteases of the papain family.

R. Ménard, J. Krupa, A. C. Storer, 1999, Biochemistry.

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.

R. Ménard, T. Vernet, J. Scharfstein, 2001, Molecular and biochemical parasitology.

Modification of S1 subsite specificity in the cysteine protease cathepsin B.

T. Fox, A. C. Storer, J. Mort, 1995, Protein engineering.

Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases.

R. Ménard, J. B. Jones, A. C. Storer, 1995, Journal of medicinal chemistry.

Kinetic evidence for a 'mnemonical' mechanism for rat liver glucokinase.

A. Cornish-Bowden, A. C. Storer, 1977, The Biochemical journal.

A PROTON AND PHOSPHORUS NUCLEAR MAGNETIC RESONANCE STUDY OF TERNARY COMPLEXES OF CYCLIC ADENOSINE 3′-5′-MONOPHOSPHATE, ADENOSINE 5′-TRIPHOSPHATE, AND MANGANESE(2+) ION

G. Hammes, A. C. Storer, S. Fan, 1978 .

A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+.

G. Hammes, A. C. Storer, S. Fan, 1977, Journal of the American Chemical Society.

Resonance Raman spectroscopic and kinetic consequences of a nitrogen ... sulphur enzyme-substrate contact in a series of dithioacylpapains.

P. Tonge, P. Carey, A. C. Storer, 1992, Biophysical journal.

Resonance Raman and electronic absorption spectral studies of some beta-(2-furyl)acryloylglyceraldehyde-3-phosphate dehydrogenases.

P. Carey, A. C. Storer, D. J. Phelps, 1981, Biochemistry.

The occluding loop in cathepsin B defines the pH dependence of inhibition by its propeptide.

M. Cygler, T. Fox, J. Sivaraman, 1999, Biochemistry.

Potent slow-binding inhibition of cathepsin B by its propeptide.

T. Fox, A. C. Storer, J. Mort, 1992, Biochemistry.

Conformational states of N-acylglycine dithioesters in solution: resonance Raman studies of isotopically substituted models for enzyme-substrate complexes.

P. Carey, A. C. Storer, H. Lee, 1983, Biochemistry.

Purification and characterization of a digestive cysteine proteinase from the American lobster (Homarus americanus).

D. Watson, A. C. Storer, M. Laycock, 1989, The Biochemical journal.

Papain in organic solvents: Determination of conditions suitable for biocatalysis and the effect on substrate specificity and inhibition

D. Stevenson, A. C. Storer, 1991, Biotechnology and bioengineering.

Crystal structure of a papain-E-64 complex.

C. P. Huber, P. Carey, K. Varughese, 1989, Biochemistry.

Catalytic mechanism in papain family of cysteine peptidases.

R. Ménard, A. C. Storer, Andrew Cstorer, 1994, Methods in enzymology.

Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions.

A. Cornish-Bowden, A. C. Storer, A Cornish-Bowden, 1976, The Biochemical journal.

The use of resonance Raman spectroscopy to monitor catalytically important bonds during enzymic catalysis. Application to the hydrolysis of methyl thionohippurate by papain.

P. Carey, W. Murphy, A. C. Storer, 1979, The Journal of biological chemistry.

Vibrational spectra and rotational isomerism of simple dialkyl dithioesters and N-acylglycine ethyl dithioesters, thiolesters, and dioxygenesters

Y. Ozaki, P. Carey, A. C. Storer, 1985 .

Comparison of the substrate conformations in the active sites of papain, chymopapain, ficin and bromelain by resonance Raman spectroscopy.

Y. Ozaki, P. Carey, A. C. Storer, 1983, Biochemical and biophysical research communications.

Molecular details of enzyme-substrate transients by resonance Raman spectroscopy

P. Carey, A. C. Storer, 1983 .

Precise structural information for transient enzyme-substrate complexes by a combined X-ray crystallographic-resonance Raman spectroscopic approach.

C. P. Huber, P R Carey, Y. Ozaki, 1982, Biochemistry.

Rotational isomers of ethyl dithioacetate and ethyl thionoacetate: A Raman study

A. L. Verma, Y. Ozaki, P. Carey, 1981 .

Conformational activation of acylpapains and acylcathepsin B's: resonance Raman and kinetic evidence.

P. Carey, A. C. Storer, R. H. Angus, 1986, Biochemistry.

The infrared, Raman, and resonance Raman spectra and normal coordinate analysis of methyl and ethyl dithioacetate

Y. Ozaki, P. Carey, A. C. Storer, 1982 .

Resonance Raman spectroscopic evidence for an intramolecular interaction involving the amide and dithioester groups of N-acyl glycine ethyl dithioesters

Y. Ozaki, P. Carey, A. C. Storer, 1982 .

The structure and dynamics of enzyme-substrate reaction intermediates determined by resonance Raman spectroscopy

P. Carey, A. C. Storer, 1985 .

Relaxed and perturbed substrate conformations in enzyme active sites: evidence from multichannel resonance raman spectra.

P. Carey, A. C. Storer, H. Lee, 1983, Biochemistry.

Directional preference for a catalytically important N•••S contact seen in acyl-thiolproteases

P. Carey, K. Varughese, A. C. Storer, 1984 .

NMR structural studies of human cystatin C dimers and monomers.

K. Gehring, I. Ekiel, S. Labelle, 1997, Journal of molecular biology.

Engineering of papain: selective alteration of substrate specificity by site-directed mutagenesis.

R. Ménard, D. Tessier, T. Vernet, 1991, Biochemistry.

A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain.

R. Ménard, D. Tessier, D. Ripoll, 1990, Biochemistry.

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.

R. Coulombe, M. Cygler, P. Grochulski, 1996, Structure.

Alignment/phylogeny of the papain superfamily of cysteine proteases.

P. Berti, A. C. Storer, P J Berti, 1995, Journal of molecular biology.

The specificity of the S1' subsite of cysteine proteases

R. Ménard, Y. Konishi, D. Brömme, 1993, FEBS letters.

Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites.

P. Berti, C. Faerman, A. C. Storer, 1991, Biochemistry.

Engineering of proteases and protease inhibition.

A. C. Storer, 1991, Current opinion in biotechnology.

Structural and Functional Roles of Asparagine 175 in the Cysteine Protease Papain (*)

R. Ménard, D. Tessier, T. Vernet, 1995, The Journal of Biological Chemistry.

Oxyanion hole interactions in serine and cysteine proteases.

R. Ménard, A. C. Storer, 1992, Biological chemistry Hoppe-Seyler.

Active Site Titration of the Tyrosine Phosphatases SHP-1 and PTP1B Using Aromatic Disulfides

M. Pregel, A. C. Storer, 1997, The Journal of Biological Chemistry.

An NMR‐based identification of peptide fragments mimicking the interactions of the cathepsin B propeptide

W. Vranken, A. C. Storer, N. Goudreau, 1998, FEBS letters.

Modification of the electrostatic environment is tolerated in the oxyanion hole of the cysteine protease papain.

R. Ménard, D. Tessier, T. Vernet, 1995, Biochemistry.

A new method of quantitative affinity chromatography and its application to the study of myosin.

I. Trayer, A. C. Storer, R. Bottomley, 1976, The Biochemical journal.

Affinity purification and elimination of methionine oxidation in recombinant human cystatin C.

P. Berti, I. Ekiel, M. Abrahamson, 1997, Protein expression and purification.

Peptide aldehydes and nitriles as transition state analog inhibitors of cysteine proteases.

R. Ménard, A. C. Storer, E. Dufour, 1995, Biochemistry.

Contribution of the glutamine 19 side chain to transition-state stabilization in the oxyanion hole of papain.

R. Ménard, D. Tessier, T. Vernet, 1991, Biochemistry.

Inhibition of papain by peptide nitriles

A. Krantz, A. Castelhano, A. C. Storer, 1991 .

Engineering nitrile hydratase activity into a cysteine protease by a single mutation.

R. Ménard, A. C. Storer, E. Dufour, 1995, Biochemistry.

A model to explain the pH-dependent specificity of cathepsin B-catalysed hydrolyses.

R. Ménard, A. C. Storer, T. Hirama, 1991, The Biochemical journal.

Chapter 419 – Papain

A. C. Storer, 2013 .

Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B.

R. Ménard, A. C. Storer, P. Lachance, 1993, Journal of medicinal chemistry.

E-64 Analogs as Inhibitors of Cathepsin L and Cathepsin S: Importance of the S2-P2 Interactions for Potency and Selectivity1

P. Bonneau, H. Kirschke, A. C. Storer, 1994 .

E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions.

R. Ménard, A. C. Storer, A C Storer, 1994, The Biochemical journal.

Delineating functionally important regions and residues in the cathepsin B propeptide for inhibitory activity

R. Ménard, A. C. Storer, Céline Plouffe, 1996, FEBS letters.

Temperature-jump study of the interaction of rabbit muscle phosphofructokinase with adenylyl imidodiphosphate and adenosine 5'-triphosphate.

G. Hammes, A. C. Storer, N. Wolfman, 1979, Biochemistry.

An investigation of the biphasic kinetics observed during the hydroxide ion-catalyzed hydrolysis of alkyl dithioesters

A. C. Storer, 1983 .

Importance of hydrogen-bonding interactions involving the side chain of Asp158 in the catalytic mechanism of papain.

R. Ménard, D. Tessier, T. Vernet, 1991, Biochemistry.

Synthesis of amidrazones using an engineered papain nitrile hydratase 1

R. Ménard, A. C. Storer, W. Tam, 1998, FEBS letters.

Inhibition of papain by peptide nitriles : conversion of the nitrile group into other functionalities via the papain : nitrile thioimidate ester adduct

A. C. Storer, P. Lachance, B. Gour-Salin, 1991 .

Inhibition of Papain by Peptide Nitriles: Conversion of the Nitrile Group into Other Functionalities via the Papain Nitrile Thioimidate Ester Adduct.

A. C. Storer, P. Lachance, B. Gour-Salin, 1991 .

Conformational study of N-acyl amino acid esters and thiol esters by FT-IR and x-ray crystallography: evidence for a nitrogen...sulfur interaction in thiol esters

C. P. Huber, P. Carey, A. C. Storer, 1984 .

Structure of enzyme-bound substrates: resonance Raman and kinetic evidence for differential enzyme-substrate contacts in N-(Pentafluoro-benzoyl)glycine dithioacyl and thioacyl papain

P. Carey, A. C. Storer, R. H. Angus, 1989 .

Conformational states of N-acylalanine dithio esters: correlation of resonance Raman spectra with structures.

P. Carey, K. Varughese, A. C. Storer, 1988, Biochemistry.

The structure and resonance Raman spectra – structure correlations for N-benzoyl-DL-alanine ethyl dithioester

P. Carey, K. Varughese, A. C. Storer, 1985 .

The structure and resonance Raman spectra – structure correlations for methyloxycarbonyl-L-phenylalanyl-L-alanine ethyl dithioester

P. Carey, A. C. Storer, R. H. Angus, 1986 .

Identity of acyl group conformations in the active sites of papain and cathepsin B by resonance Raman spectroscopy.

P. Carey, A. C. Storer, R. H. Angus, 1984, The Journal of biological chemistry.

Rate-structure correlation for enzyme-substrate intermediates: Resonance Raman and kinetic studies on some N-benzoylglycine (dithioacyl)papains

Y. Ozaki, P. Carey, A. C. Storer, 1984 .

Comparison of the kinetics and mechanism of the papain-catalyzed hydrolysis of esters and thiono esters.

P. Carey, A. C. Storer, 1985, Biochemistry.

DIRECTIONAL PREFERENCE FOR A CATALYTICALLY IMPORTANT NITROGEN...SULFUR CONTACT SEEN IN ACYL-THIOLPROTEASES

P. Carey, K. Varughese, A. C. Storer, 1985 .

Purification and characterization of an extracellular thiol-containing serine proteinase from Thermomyces lanuginosus.

K. Adeli, A. C. Storer, S. Hasnain, 1992, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Contribution to activity of histidine-aromatic, amide-aromatic, and aromatic-aromatic interactions in the extended catalytic site of cysteine proteinases.

E. Purisima, P. Bonneau, D. Y. Thomas, 1996, Biochemistry.

Markedly different acyl papain structures deacylate at similar rates: resonance Raman spectroscopic and kinetic evidence

R. Ménard, P. Tonge, P. Carey, 1991 .