T. Spande

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Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years.

J. Daly, M. A. Donnelly, R. Saporito, 2007, Toxicon : official journal of the International Society on Toxinology.

The enantioselective synthesis of poison-frog alkaloids (−)-203A, (−)-209B, (−)-231C, (−)-233D, and (−)-235B″

J. Daly, T. Spande, N. Toyooka, 2006 .

Chapter One - Alkaloids from Amphibian Skins

J. Daly, T. Spande, H. M. Garraffo, 1999 .

Hydroxyindoles, Indole Alcohols, and Indolethiols

T. Spande, 2008 .

Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics.

J. Sullivan, J. Daly, M. Decker, 2000, Natural product reports.

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog

L. Pannell, J. Daly, H. Yeh, 1992 .

A new subclass of alkaloids from a dendrobatid poison frog: a structure for deoxypumiliotoxin 251H.

J. Daly, H. Yeh, P. Jain, 1995, Journal of Natural Products.

THE ISOLATION AND STRUCTURE OF PUMILIOTOXIN 341A : A NOVEL CYCLIC ETHER FROM THE FROG EPIPEDOBA TES TRICOLOR

J. Daly, P. Jain, T. Spande, 1999 .

Phenolic antioxidants: potent inhibitors of the (Ca2+ + Mg2+‐ATPase of sarcoplasmic reticulum

E. Albuquerque, J. Daly, F. Kauffman, 1986, FEBS letters.

Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.

J. Daly, S. Kadota, Y. Tezuka, 2009, The Journal of organic chemistry.

Alkaloids in Madagascan frogs (Mantella): pumiliotoxins, indolizidines, quinolizidines, and pyrrolizidines.

J. Daly, T. Spande, M. Andriantsiferana, 1993, Journal of natural products.

Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.

J. Daly, T. Spande, H. M. Garraffo, 2005, Journal of natural products.

Alkaloids from bufonid toads (Melanophryniscus): decahydroquinolines, pumiliotoxins and homopumiliotoxins, indolizidines, pyrrolizidines, and quinolizidines.

J. Daly, T. Spande, H. M. Garraffo, 1993, Journal of natural products.

Individual and Geographic Variation of Skin Alkaloids in Three Swamp-Forest Species of Madagascan Poison Frogs (Mantella)

M. Vences, D. Vieites, L. Giddings, 2015, Journal of Chemical Ecology.

Individual and Geographic Variation of Skin Alkaloids in Three Species of Madagascan Poison Frogs (Mantella)

M. Vences, J. Daly, D. Vieites, 2008, Journal of Chemical Ecology.

Ammonia chemical ionization tandem mass spectrometry in structure determination of alkaloids. I. Pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and an azabicyclo[5.3.0]decane.

J. Daly, T. Spande, T. Jones, 1999, Rapid communications in mass spectrometry : RCM.

Epibatidine: A Novel (Chloropyridyl)azabicycloheptane with Potent Analgesic Activity from an Ecuadoran Poison Frog.

L. Pannell, J. Daly, H. Yeh, 1992 .

A review of chemical ecology in poison frogs

M. A. Donnelly, R. Saporito, T. Spande, 2012, Chemoecology.

Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats.

J. Daly, R. Saporito, T. Spande, 2010, Journal of natural products.

Dietary source for skin alkaloids of poison frogs (Dendrobatidae)?

J. Daly, H. Martin Garraffo, T. Spande, 1994, Journal of Chemical Ecology.

Batrachotoxin alkaloids from passerine birds: a second toxic bird genus (Ifrita kowaldi) from New Guinea.

J. Daly, J. Dumbacher, T. Spande, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Homobatrachotoxin in the genus Pitohui: chemical defense in birds?

J. Daly, J. Dumbacher, B. Beehler, 1992, Science.

A concise method for the preparation of deuterium-labeled cortisone: Synthesis of [6,7-2H]cortisone

J. Deschamps, N. Whittaker, Z. Hochberg, 2005, Steroids.

Identification of histrionicotoxins by GC-MS and GC-FTIR: Photo- and chemical-artefacts and revised 13C NMR assignments

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Alkaloids from dendrobatid poison frogs: Further cis-decahydroquinolines and 8-methylindolizidines

J. Daly, T. Spande, H. M. Garraffo, 1991 .

Further Alkaloids Common to Ants and Frogs: Decahydroquinolines and a Quinolizidine

M. Blum, J. Daly, J. Delabie, 1999, Journal of Chemical Ecology.

Arthropod–Frog Connection: Decahydroquinoline and Pyrrolizidine Alkaloids Common to Microsympatric Myrmicine Ants and Dendrobatid Frogs

J. Daly, A. Rand, R. Snelling, 2004, Journal of Chemical Ecology.

Dioicine: A Novel Prenylated Purine Alkaloid from Gymnocladus dioicus

J. Daly, N. F. Whittaker, T. Spande, 2009 .

Histrionicotoxin alkaloids finally detected in an ant.

T. Schultz, T. Jones, T. Spande, 2012, Journal of natural products.

Identification of Histrionicotoxins by GC-MS and GC-FTIR: Photo- and Chemical-Artefacts and Revised 13C NMR Assignments.

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus)

J. Daly, T. Spande, P. Stevenson, 2008, Beilstein journal of organic chemistry.

Individual and Geographic Variation of Skin Alkaloids in Three Swamp-Forest Species of Madagascan Poison Frogs (Mantella)

M. Vences, D. Vieites, L. Giddings, 2015, Journal of Chemical Ecology.

ARTHROPOD ALKALOIDS IN POISON FROGS : A REVIEW OF THE 'DIETARY HYPOTHESIS'

M. A. Donnelly, R. Saporito, T. Spande, 2009 .

Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus).

J. Daly, H. Yeh, J. Faivovich, 2008, Toxicon : official journal of the International Society on Toxinology.

Selective cleavage and modification of peptides and proteins.

B. Witkop, T. Spande, A. Patchornik, 1970, Advances in protein chemistry.

Melyrid beetles (Choresine): a putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds.

J. Daly, J. Dumbacher, T. Spande, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Alkaloids in the Mite Scheloribates laevigatus: Further Alkaloids Common to Oribatid Mites and Poison Frogs

R. Saporito, T. Spande, R. A. Norton, 2011, Journal of Chemical Ecology.

An uptake system for dietary alkaloids in poison frogs (Dendrobatidae).

J. Daly, T. Spande, H. M. Garraffo, 1994, Toxicon : official journal of the International Society on Toxinology.

Contact toxicities of anuran skin alkaloids against the fire ant (Solenopsis invicta)

J. Daly, P. Weldon, R. V. Vander Meer, 2013, Naturwissenschaften.

The structure of gephyrotoxin (GTX) 223AB

J. Daly, D. Hart, T. Spande, 1981, Experientia.

Interaction of gephyrotoxin and indolizidine alkaloids with the nicotinic acetylcholine receptorion channel complex of torpedo electroplax

E. Albuquerque, J. Daly, R. Aronstam, 1986, Neurochemical Research.

Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates

J. Daly, T. Spande, H. M. Garraffo, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 3 Amphibian Alkaloids

J. Daly, T. Spande, H. M. Garraffo, 1993 .

Variability in alkaloid profiles in neotropical poison frogs (Dendrobatidae): genetic versus environmental determinants.

J. Daly, T. Spande, H. M. Garraffo, 1992, Toxicon : official journal of the International Society on Toxinology.

N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide.

H. Schoemaker, J. Daly, F. Rutjes, 2008, Organic letters.

Venom chemistry of the ant Myrmicaria melanogaster from Brunei.

J. Daly, D. Davidson, R. Snelling, 2007, Journal of Natural Products.

Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.

J. Daly, H. Yeh, T. Spande, 2003, Journal of natural products.

Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.

J. Daly, T. Sasaoka, T. Wada, 2007, Bioorganic & medicinal chemistry letters.

Flexible synthetic routes to poison-frog alkaloids of the 5,8-disubstituted indolizidine-class I: synthesis of common lactam chiral building blocks and application to the synthesis of (-)-203A, (-)-205A, and (-)-219F

J. Daly, T. Spande, N. Toyooka, 2007, Beilstein journal of organic chemistry.

Enantioselective syntheses of poison-frog alkaloids : 219F and 221I and an epimer of 193E

J. Daly, T. Spande, N. Toyooka, 2006 .

Alkaloids from dendrobatid frogs: structures of two omega-hydroxy congeners of 3-butyl-5-propylindolizidine and occurrence of 2,5-disubstituted pyrrolidines and a 2,6-disubstituted piperidine.

N. Whittaker, J. Daly, T. Spande, 1986, Journal of natural products.

Enantioselective Synthesis of Poison-Frog Alkaloid 237D and Determination of Absolute Stereochemistry

J. Daly, T. Spande, N. Toyooka, 2005 .

Synthesis of alkaloid 223A and a structural revision.

J. Daly, T. Spande, A. Fukutome, 2002, Organic letters.

A stereospecific synthesis of (+/-)-5,8-disubstituted indolizidines and (+/-)-1,4-disubstituted quinolizidines found in poison frog skins.

J. Daly, A. Rassat, T. Spande, 2000, The Journal of organic chemistry.

The piclavines, antimicrobial indolizidines from the tunicate Clavelina picta

T. Spande, J. Cardellina, M. Raub, 1992 .

Anti‐HIV‐1 limonoid: first isolation from Clausena excavata

J. Daly, T. Spande, C. Yoosook, 2003, Phytotherapy research : PTR.

Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio

J. Daly, T. Spande, N. Toyooka, 2005 .

Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.

J. Daly, T. Spande, N. Kongkathip, 2003, Planta medica.

Epiquinamide: a poison that wasn't from a frog that was.

Shaun R. Patel, J. Daly, T. Spande, 2009, Journal of natural products.

A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.

J. Daly, H. Yeh, P. Stevenson, 2005, Journal of natural products.

Determination of absolute stereochemistry and an alternative synthesis of homopumiliotoxin 223G: identification on chiral GC columns with the natural alkaloid.

J. Daly, T. Spande, C. Kibayashi, 2000, Journal of natural products.

Alkaloid 223A: the first trisubstituted indolizidine from dendrobatid frogs.

J. Daly, P. Jain, T. Spande, 1997, Journal of natural products.

Alkaloids from single skins of the Argentinian toad Melanophryniscus rubriventris (ANURA, BUFONIDAE): An unexpected variability in alkaloid profiles and a profusion of new structures

M. F. Quiroga, M. Vaira, T. Spande, 2012, SpringerPlus.

A common pumiliotoxin from poison frogs exhibits enantioselective toxicity against mosquitoes

J. Daly, P. Weldon, S. Gordon, 2006, Proceedings of the National Academy of Sciences.

Epibatidine: from frog alkaloid to analgesic clinical candidates: a testimonial to "true grit"!

T. Spande, H. M. Garraffo, Michael Williams, 2009 .

Beta-alanyl-L-tyrosine. Chemical synthesis, properties and occurrence in larvae of the fleshfly Sarcophaga bullata Parker.

T. Spande, L. Levenbook, R. Bodnaryk, 1969, The Biochemical journal.

Chemistry of venom alkaloids in someSolenopsis (Diplorhoptrum) species from Puerto Rico

M. Blum, R. Snelling, T. Jones, 1996, Journal of Chemical Ecology.

The Chemistry of Some Dalodesmidean Millipedes from Tasmania (Diplopoda, Polydesmida).

T. Jones, R. Mesibov, R. Saporito, 2017, Journal of natural products.

The Chemistry of Exploding Ants, Camponotus SPP. (Cylindricus COMPLEX)

D. Davidson, R. Snelling, T. Jones, 2004, Journal of Chemical Ecology.

Oribatid mites as a major dietary source for alkaloids in poison frogs

J. Daly, M. A. Donnelly, R. Saporito, 2007, Proceedings of the National Academy of Sciences.

Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source

J. Daly, M. A. Donnelly, T. Spande, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Geographic and Seasonal Variation in Alkaloid-Based Chemical Defenses of Dendrobates pumilio from Bocas del Toro, Panama

J. Daly, M. A. Donnelly, R. Saporito, 2006, Journal of Chemical Ecology.

Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand.

J. Daly, T. Spande, H. M. Garraffo, 2004, Toxicon : official journal of the International Society on Toxinology.

Taxonomic distribution of defensive alkaloids in Nearctic oribatid mites (Acari, Oribatida)

R. Saporito, T. Spande, R. A. Norton, 2015, Experimental and Applied Acarology.

Pyrrolizidine oximes: a novel new class of dendrobatid alkaloids

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.

J. Daly, H. Yeh, T. Spande, 2010, Journal of natural products.

A. A. Madden, M. A. Donnelly, R. Saporito, 2010, Journal of Natural Products.

Evidence for biosynthesis of pseudophrynamine alkaloids by an Australian myobatrachid frog (pseudophryne) and for sequestration of dietary pumiliotoxins.

J. Daly, T. Spande, H. M. Garraffo, 2002, Journal of natural products.

A. A. Madden, M. A. Donnelly, R. Saporito, 2011 .

Structure at 4.5 A resolution of a phosphorylcholine-binding fab.

E. Padlan, D. Davies, S. Rudikoff, 1973, Nature: New biology.

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.

J. Daly, T. Sasaoka, T. Wada, 2007 .

1080, toxic sugars, alkaloids, and a dead cat: The search for a toxicant in Australian Gastrolobium seed

D. Peacock, T. Spande, P. Christensen, 2004 .

A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog (Mantella).

J. Daly, H. Yeh, P. Jain, 1996, Journal of natural products.

Structure of alkaloid 275A, a novel 1-azabicyclo[5.3.0]decane from a dendrobatid frog, Dendrobates lehmanni: synthesis of the tetrahydrodiastereomers.

J. Daly, T. Jones, P. Jain, 2001, Journal of natural products.

Pseudophrynamine A: an unusual prenyl pyrrolo[2,3-b]indole ester from an Australian frog, Pseudophryne coriacea (Myobatrachidae)

L. Pannell, J. Daly, V. Erspamer, 1988 .

Investigation of the TCA cycle and the glyoxylate shunt in Escherichia coli BL21 and JM109 using 13C‐NMR/MS

J. Shiloach, S. Noronha, T. Spande, 2000, Biotechnology and bioengineering.

Alkaloids from dendrobatid poison frogs: Further pumiliotoxins and allopumiliotoxins and a reassignment of the keto function in pumiliotoxin 307F

J. Daly, T. Spande, H. M. Garraffo, 1991 .

Caste-specific tyramides from Myrmicine ants.

J. Daly, R. Snelling, T. Jones, 2010, Journal of natural products.

Alkaloids in Bufonid Toads (Melanophryniscus): Temporal and Geographic Determinants for Two Argentinian Species

R. Gil, J. Daly, M. Vaira, 2007, Journal of Chemical Ecology.

Alkaloids of Anuran Skin: Antimicrobial Function?

J. Daly, T. Jones, T. Spande, 2005, Zeitschrift fur Naturforschung. C, Journal of biosciences.

3-methyl-4-phenylpyrrole from the ants Anochetus kempfi and Anochetus mayri.

R. Snelling, T. Jones, T. Spande, 1999, Journal of natural products.

A review of chemical ecology in poison frogs

M. A. Donnelly, R. Saporito, T. Spande, 2012, Chemoecology.

DISCOVERY OF BATRACHOTOXIN : THE LAUNCH OF THE FROG ALKALOID PROGRAM AT NIH

T. Spande, H. M. Garraffo, 2009 .

Response : Pitohui : How Toxic and to Whom?

J. Daly, B. Beehler, T. Spande, 1993, Science.

Corrigendum to “Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio” [Tetrahedron 61 (2005) 1187]

J. Daly, T. Spande, N. Toyooka, 2005 .

A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F.

H. Yeh, T. Spande, H. Garraffo, 1992, Journal of natural products.