R. Khalil

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Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins.

J. Raffetto, X. Qiao, Vera V. Koledova, 2008, Journal of vascular surgery.

Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.

S. Kourembanas, S. A. Mitsialis, Sally H Vitali, 2012, American journal of physiology. Lung cellular and molecular physiology.

Comparative Risks and Predictors of Preeclamptic Pregnancy in the Eastern, Western and Developing World.

Ning Zhang, R. Khalil, Haifeng Yang, 2020, Biochemical pharmacology.

Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders.

R. Khalil, Yin Xia, 2016, American journal of physiology. Heart and circulatory physiology.

Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy.

Wei Li, R. Khalil, O. Reslan, 2015, American journal of physiology. Heart and circulatory physiology.

Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction.

J. Granger, B. Alexander, R. Khalil, 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Elastase Promotes Aortic Dilation by Inhibiting Ca2+ Influx into Vascular Smooth Muscle

R. Khalil, J. Orshal, D. Chew, 2004, Journal of cardiovascular pharmacology.

Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction.

R. Khalil, M. Conte, D. Chew, 2004, Journal of vascular surgery.

Elastase-Induced Suppression of Endothelin-Mediated Ca2+ Entry Mechanisms of Vascular Contraction

R. Khalil, J. Orshal, D. Chew, 2003, Hypertension.

Vascular Contraction Entry Mechanisms of 2 + Elastase-Induced Suppression of Endothelin-Mediated Ca

R. Khalil, J. Orshal, W. Chew, 2003 .

Gender, sex hormones, and vascular tone.

R. Khalil, J. Orshal, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

CD146+Mesenchymal stem cells treatment improves vascularization, muscle contraction and VEGF expression, and reduces apoptosis in rat ischemic hind limb.

R. Khalil, Haifeng Yang, Jing Tan, 2021, Biochemical pharmacology.

Sex hormones as potential modulators of vascular function in hypertension.

R. Khalil, 2005, Hypertension.

Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease.

R. Khalil, V. B. Gencel, M. M. Benjamin, 2012, Mini reviews in medicinal chemistry.

Sex steroids and vascular responses in hypertension and aging.

X. Qiao, R. Khalil, K. R. McConnell, 2008, Gender medicine.

Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease.

R. Khalil, M. Mazzuca, 2012, Biochemical pharmacology.

Role of Endothelin B Receptors in Enhancing Endothelium-Dependent Nitric Oxide–Mediated Vascular Relaxation During High Salt Diet

J. Granger, R. Khalil, J. B. Giardina, 2001, Hypertension.

Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease.

R. Khalil, Graciliano R A do Nascimento, Yaskara V R Barros, 2009, Current hypertension reviews.

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.

R. Khalil, Dania A Shah, 2015, Biochemical pharmacology.

Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.

R. Khalil, 2013, Biochemical pharmacology.

Vascular effects of estrogenic menopausal hormone therapy.

R. Khalil, O. Reslan, 2012, Reviews on recent clinical trials.

Sex hormones, vascular function and the outcome of hormone replacement therapy in cardiovascular disease.

R. Khalil, 2007, Future cardiology.

Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease

Vera V. Koledova, R. Khalil, 2007, Expert review of cardiovascular therapy.

EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone.

Wei Li, R. Khalil, Yiping Dang, 2013, Biochemical pharmacology.

MiR‐126a‐5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS‐4 expression

Shuang Pan, R. Khalil, Biao Wang, 2020, Journal of cellular and molecular medicine.

Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia.

R. Khalil, O. Reslan, 2010, Cardiovascular & hematological agents in medicinal chemistry.

Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

R. Khalil, Arda Kucukguven, 2013, Current drug targets.

Mechanisms of Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins.

J. Raffetto, R. Khalil, 2021, Vessel plus.

Biochemical and Biological Attributes of Matrix Metalloproteinases.

N. Cui, R. Khalil, Min Hu, 2017, Progress in molecular biology and translational science.

Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease.

J. Raffetto, R. Khalil, Yunfei Chen, 2017, Progress in molecular biology and translational science.

Rolling Role of ADAMs in Endothelial Cell Permeability : Cadherin Shedding and Leukocyte

R. Khalil, Bharathy Ponnuchamy, 2008 .

Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling.

R. Khalil, Bharathy Ponnuchamy, 2008, Circulation research.

Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population.

J. Xiong, Xin Jia, Wei Guo, 2017, Atherosclerosis.

Ca2+, calmodulin, and cyclins in vascular smooth muscle cell cycle.

Vera V. Koledova, R. Khalil, 2006, Circulation research.

Physiologic Increases in Extracellular Sodium Salt Enhance Coronary Vasoconstriction and Ca2+ Entry

R. Khalil, D. Coleman, 2002, Journal of cardiovascular pharmacology.

Antagonistic effects of 17 beta-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction.

R. Khalil, J. K. Crews, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK‐1 channel

Yunxia Cao, R. Khalil, Zhaolian Wei, 2018, Biochemical pharmacology.

Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus

Yunxia Cao, R. Khalil, Bing Shen, 2017, Oncotarget.

Decreased Endothelium-Dependent NO-cGMP Vascular Relaxation and Hypertension in Growth-Restricted Rats on a High-Salt Diet

B. Alexander, R. Khalil, J. A. Payne, 2004, Hypertension.

Reduced Endothelial Vascular Relaxation in Growth-Restricted Offspring of Pregnant Rats With Reduced Uterine Perfusion

B. Alexander, R. Khalil, J. A. Payne, 2003, Hypertension.

Enhanced endothelin receptor type B‐mediated vasodilation and underlying [Ca2+]i in mesenteric microvessels of pregnant rats

R. Khalil, M. Mazzuca, Yiping Dang, 2013, British journal of pharmacology.

Mechanism of Calcium Activation in Vascular Smooth Muscle

R. Khalil, N. Lodge, C. van Breemen, 1987, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

R. Khalil, J. Reckelhoff, J. A. Payne, 2004, Hypertension.

Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.

J. Raffetto, R. Khalil, Reagan L. Ross, 2007, Journal of vascular surgery.

Decreased Uterine Vascularization and Uterine Arterial Expansive Remodeling with Reduced Matrix Metalloproteinase-2 and -9 in Hypertensive Pregnancy.

N. Cui, R. Khalil, Chen Lin, 2019, American journal of physiology. Heart and circulatory physiology.

Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway.

J. Raffetto, R. Khalil, P. Mattana, 2019, Biochemical pharmacology.

Circulating and Vascular Bioactive Factors during Hypertension in Pregnancy.

R. Khalil, Alain F Tanbe, Alain F. Tanbe, 2010, Current bioactive compounds.

Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy.

R. Khalil, S. J. Sheppard, 2010, Cardiovascular & hematological disorders drug targets.

Pathophysiology of pregnancy-induced hypertension.

J. Granger, B. Alexander, R. Khalil, 2001, American journal of hypertension.

Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

H. Hudalla, Jun Li, S. Kourembanas, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Sex hormones and vascular protection in pulmonary arterial hypertension.

R. Khalil, H. Christou, 2010, Journal of cardiovascular pharmacology.

Mechanisms of Pulmonary Vascular Dysfunction in Pulmonary Hypertension and Implications for Novel Therapies.

R. Khalil, H. Christou, 2022, American journal of physiology. Heart and circulatory physiology.

Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats

Sally H Vitali, R. Khalil, H. Christou, 2010, Journal of Pharmacology and Experimental Therapeutics.

The vascular endothelin system in hypertension--recent patents and discoveries.

R. Khalil, Meri M Hynynen, 2006, Recent patents on cardiovascular drug discovery.

Gender-specific reduction in contractility and [Ca(2+)](i) in vascular smooth muscle cells of female rat.

R. Khalil, J. G. Murphy, Jason G. Murphy, 2000, American journal of physiology. Cell physiology.

Sulodexide Improves Contraction and Decreases Matrix Metalloproteinase-2 and -9 in Veins under Prolonged Stretch.

J. Raffetto, R. Khalil, P. Mattana, 2019, Journal of cardiovascular pharmacology.

MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides.

J. Raffetto, R. Khalil, Yaskara V R Barros, 2010, The Journal of surgical research.

Mechanisms of varicose vein formation: valve dysfunction and wall dilation

J. Raffetto, R. Khalil, 2008, Phlebology.

Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy.

N. Cui, R. Khalil, Zongli Ren, 2018, American journal of physiology. Heart and circulatory physiology.

Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle.

C. Lajoie, K. Morgan, R. Khalil, 1992, The American journal of physiology.

Vascular and cellular calcium in normal and hypertensive pregnancy.

R. Khalil, Z. Adamová, S. Ozkan, 2009, Current clinical pharmacology.

Vascular Mechanisms and Molecular Targets in Hypertensive Pregnancy and Preeclampsia.

Hongmei Qu, R. Khalil, 2020, American journal of physiology. Heart and circulatory physiology.

Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy.

R. Khalil, J. S. Possomato‐Vieira, Zongli Ren, 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

Downregulation of Microvascular Endothelial Type B Endothelin Receptor Is a Central Vascular Mechanism in Hypertensive Pregnancy

Wei Li, R. Khalil, O. Reslan, 2014, Hypertension.

Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins.

J. Raffetto, X. Qiao, R. Khalil, 2010, Journal of vascular surgery.

R. Khalil, Yin Xia, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment

J. Raffetto, F. Mannello, D. Ligi, 2020, Journal of clinical medicine.

Decreased homodimerization and increased TIMP‐1 complexation of uteroplacental and uterine arterial matrix metalloproteinase‐9 during hypertension‐in‐pregnancy

R. Khalil, Juanjuan Chen, Zongli Ren, 2017, Biochemical pharmacology.

Endothelium-dependent nitric oxide and hyperpolarization-mediated venous relaxation pathways in rat inferior vena cava.

J. Raffetto, R. Khalil, O. Reslan, 2012, Journal of vascular surgery.

Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α.

N. Cui, Wei Li, R. Khalil, 2017, American journal of physiology. Heart and circulatory physiology.

Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat.

J. Granger, R. Khalil, J. K. Crews, 2000, Hypertension.

Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy

R. Khalil, Sajjadh M. J. Ali, 2015, Expert opinion on therapeutic targets.

Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats.

Vera V. Koledova, R. Khalil, Anthony E. Falone, 2009, American journal of physiology. Heart and circulatory physiology.

Role of ADAM and ADAMTS Disintegrin and Metalloproteinases in Normal Pregnancy and Preeclampsia.

Hongmei Qu, R. Khalil, 2022, Biochemical pharmacology.

Reduced Endothelial NO-cGMP–Mediated Vascular Relaxation and Hypertension in IL-6–Infused Pregnant Rats

R. Khalil, J. Orshal, 2004, Hypertension.

Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.

R. Khalil, J. Orshal, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

Experimental Benefits of Sex Hormones on Vascular Function and the Outcome of Hormone Therapy in Cardiovascular Disease

R. Khalil, Reagan L. Ross, M. R. Serock, 2008, Current cardiology reviews.

PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation.

K. Morgan, R. Khalil, 1993, The American journal of physiology.

Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy.

Wei Li, R. Khalil, M. Mazzuca, 2014, Biochemical pharmacology.

TNFα Blockade Reverses Vascular and Uteroplacental Matrix Metalloproteinases Imbalance and Collagen Accumulation in Hypertensive Pregnant Rats.

N. Cui, R. Khalil, Zongli Ren, 2021, Biochemical pharmacology.

Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors.

R. Khalil, Juanjuan Chen, Zongli Ren, 2017, Methods in molecular biology.

Gender‐Specific Inhibition of Ca2+ Entry Mechanisms of Arterial Vasoconstriction by Sex Hormones

R. Khalil, J. K. Crews, 1999, Clinical and experimental pharmacology & physiology.

Angiogenic imbalance and diminished matrix metalloproteinase‐2 and ‐9 underlie regional decreases in uteroplacental vascularization and feto‐placental growth in hypertensive pregnancy

N. Cui, R. Khalil, J. S. Possomato‐Vieira, 2017, Biochemical pharmacology.

Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension.

R. Khalil, 2011, Current molecular pharmacology.

TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats.

J. Granger, R. Khalil, K. Cockrell, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

Microsoft Word-15948392-file00

G. Adler, R. Khalil, O. Reslan, 2013 .

Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR.

R. Khalil, J. Reckelhoff, J. A. Payne, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Role of Oxidative Stress in Age-Related Reduction of NO-cGMP Mediated Vascular Relaxation in SHR Rats

R. Khalil, J. Reckelhoff, J. A. Payne, 2003 .

degeneration in oxygen-induced retinopathy Role of thromboxane in retinal microvascular

E. Chew, F. Holz, S. Chemtob, 2015 .

Estrogen Receptor Subtypes Mediate Distinct Microvascular Dilation and Reduction in [Ca2+]i in Mesenteric Microvessels of Female Rat

Wei Li, R. Khalil, M. Mazzuca, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause.

R. Khalil, Amanda K Wells, M. R. Serock, 2008, Recent patents on cardiovascular drug discovery.

Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.

Justin R. Davis, J. Granger, B. Alexander, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

Chronic Reductions in Uteroplacental Perfusion Pressure in Pregnant Animals as a Model to Study Preeclampsia

J. Granger, B. Alexander, R. Khalil, 2001 .

Testosterone and coronary vascular tone: Implications in coronary artery disease

R. Khalil, F. L. Wynne, 2003, Journal of endocrinological investigation.

Superficial Sarcoplasmic Reticulum Regulates Activated and Steady-State Cytosolic Ca2+ Concentrations in Vascular Smooth Muscle

M. Cannell, R. Khalil, O. Thastrup, 1991 .

Gender-Specific Reduction in Contraction is Associated with Increased Estrogen Receptor Expression in Single Vascular Smooth Muscle Cells of Female Rat

R. Khalil, O. Reslan, Anthony E. Falone, 2010, Cellular Physiology and Biochemistry.

Gender differences in Ca(2+) entry mechanisms of vasoconstriction in Wistar-Kyoto and spontaneously hypertensive rats.

R. Khalil, J. G. Murphy, J. K. Crews, 1999, Hypertension.

Neurovascular mechanisms of hypertension in pregnancy.

R. Khalil, A. Stennett, 2006, Current neurovascular research.

Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?

R. Khalil, C. van Breemen, C. Breemen, 1988, The Journal of pharmacology and experimental therapeutics.

Low-Salt Diet Enhances Vascular Reactivity and Ca2+ Entry in Pregnant Rats With Normal and Reduced Uterine Perfusion Pressure

J. Granger, R. Khalil, K. Cockrell, 2002, Hypertension.

Preserved Oxytocin-Induced Myometrium Contraction and Sensitivity to Progesterone Inhibition following Rat Uterus Thermal Insult. Impact on Fertility.

R. Khalil, Zongzhi Yin, Dan Li, 2022, Biochemical pharmacology.

Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins.

J. Raffetto, R. Khalil, 2011, Journal of vascular surgery.

Increased Ca2+-Dependent Intrinsic Tone and Arterial Stiffness in Mesenteric Microvessels of Hypertensive Pregnant Rats.

R. Khalil, M. Mazzuca, Kadir Buyukcelebi, 2022, Biochemical pharmacology.

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

R. Khalil, Batoule H. Majed, 2012, Pharmacological Reviews.

Matrix metalloproteinases in venous tissue remodeling and varicose vein formation.

J. Raffetto, R. Khalil, 2008, Current vascular pharmacology.

Chapter 24 – Enzyme Translocations during Smooth Muscle Activation

R. Khalil, 1996 .

Isoform-specific protein kinase C activity at variable Ca2+ entry during coronary artery contraction by vasoactive eicosanoids.

R. Khalil, C. A. Kanashiro, 1998, Canadian journal of physiology and pharmacology.

Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.

R. Khalil, M. M. Benjamin, 2012, Experientia supplementum.

SIGNAL TRANSDUCTION BY PROTEIN KINASE C IN MAMMALIAN CELLS

R. Khalil, C. A. Kanashiro, 1998, Clinical and experimental pharmacology & physiology.

Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease.

R. Khalil, Zhongwei Liu, 2018, Biochemical pharmacology.

Regulation of Vascular Smooth Muscle Function

R. Khalil, 2014 .

Endothelin-1 Promotes Ca2+ Antagonist-Insensitive Coronary Smooth Muscle Contraction Via Activation of &egr;-Protein Kinase C

R. Khalil, L. L. Mcnair, Daisy A. Salamanca, 2004, Hypertension.

Intracellular free calcium concentration / force relationship in rabbit inferior vena cava activated by norepinephrine and high K+

R. Khalil, C. Breemen, 1990, Pflügers Archiv.

Ca2+ antagonist-insensitive coronary smooth muscle contraction involves activation of ϵ-protein kinase C-dependent pathway

R. Khalil, Andrea Dallas, 2003 .

Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure.

J. Granger, R. Khalil, J. N. Herrington, 2003, American journal of physiology. Heart and circulatory physiology.

Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells.

C. L. Wang, K. Morgan, R. Khalil, 1995, Circulation research.

In situ determination of [Ca2+]i threshold for translocation of the alpha-protein kinase C isoform.

C. Lajoie, K. Morgan, R. Khalil, 1994, The American journal of physiology.

Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models.

J. Granger, R. Khalil, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

Agonist‐Induced Vascular Tone

J. Nishimura, R. Khalil, C. van Breemen, 1989, Hypertension.

Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease.

R. Khalil, Xi Wang, 2018, Advances in pharmacology.

Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.

R. Khalil, H. C. Ringvold, Raouf A. Khalil, 2017, Advances in pharmacology.

Pathophysiology of Preeclampsia: Linking Placental Ischemia/Hypoxia with Microvascular Dysfunction

J. Granger, B. Alexander, R. Khalil, 2002, Microcirculation.

ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease.

R. Khalil, Hai-kun Yang, 2022, Advances in pharmacology.

Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.

J. Raffetto, G. Adler, Y. Shi, 2011, American journal of physiology. Heart and circulatory physiology.

Inflammatory cytokines in vascular dysfunction and vascular disease.

R. Khalil, Alexander H Sprague, 2009, Biochemical pharmacology.

A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease.

R. Khalil, S. Zhong, 2019, Biochemical pharmacology.

Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease

R. Khalil, Elisabeth MacColl, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava.

A. Davies, J. Raffetto, R. Khalil, 2010, Journal of vascular surgery.

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.

J. Raffetto, R. Khalil, 2008, Biochemical pharmacology.

Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.

Jie Liu, R. Khalil, 2017, Progress in molecular biology and translational science.

Subtype-specific Estrogen Receptor-mediated Vasodilator Activity in the Cephalic, Thoracic, and Abdominal Vasculature of Female Rat

R. Khalil, O. Reslan, Zongzhi Yin, 2013, Journal of cardiovascular pharmacology.

Adaptive Regulation of Endothelin Receptor Type‐A and Type‐B in Vascular Smooth Muscle Cells during Pregnancy in Rats

R. Khalil, M. Mazzuca, Minghui Ou, 2014, Journal of cellular physiology.

Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction.

J. Granger, B. Alexander, R. Khalil, 2001, Hypertension.

Gender differences in the regulation of vascular tone

R. Khalil, Janell Thompson, 2003, Clinical and experimental pharmacology & physiology.

Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins.

J. Raffetto, R. Khalil, Virak Mam, 2010, Journal of vascular surgery.

invited review Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models

J. Granger, R. Khalil, 2002 .

Stimulated mechanisms of Ca2+entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats.

J. Granger, R. Khalil, J. Novak, 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

Stimulated mechanisms of Ca 2 1 entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats

J. Granger, R. Khalil, J. Novak, 1999 .

Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats.

J. Granger, R. Khalil, S. Kassab, 1998, Hypertension.

Endothelin-1–Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca2+]i Sensitization Pathways

R. Khalil, Ashley E. Cain, D. M. Tanner, 2002 .

Brief Imaging of Protein Kinase C Distribution and Translocation in Living Vascular Smooth Muscle Cells

K. Morgan, R. Khalil, 2005 .

Phenylephrine‐induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret.

K. Morgan, R. Khalil, 1992, The Journal of physiology.

Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells.

K. Morgan, R. Khalil, 1991, Circulation research.

R. Khalil, C. A. Kanashiro, 2001, American journal of physiology. Cell physiology.

Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats.

R. Khalil, Wensheng Chen, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension.

R. Khalil, Daisy A. Salamanca, 2005, Biochemical pharmacology.

Ca2+ antagonist-insensitive coronary smooth muscle contraction involves activation of epsilon-protein kinase C-dependent pathway.

R. Khalil, Andrea Dallas, 2003, American journal of physiology. Cell physiology.

[Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS.

J. Granger, R. Khalil, J. G. Murphy, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

Cellular mediators of renal vascular dysfunction in hypertension.

R. Khalil, Bharathy Ponnuchamy, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.

R. Khalil, J. S. Possomato‐Vieira, 2016, Advances in pharmacology.

Hypertension and Vascular Dysfunction

R. Khalil, 2013 .

Dietary salt and hypertension: new molecular targets add more spice.

R. Khalil, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia

R. Khalil, Wei Gao, Wentao Yu, 2018, Microcirculation.

Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.

Raouf A Khalil, R. Khalil, Juanjuan Chen, 2017, Progress in molecular biology and translational science.

Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.

R. Khalil, O. Reslan, Zongzhi Yin, 2012, American journal of physiology. Endocrinology and metabolism.

Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization.

G. Adler, R. Bafford, I. Jaffe, 2011, American journal of physiology. Heart and circulatory physiology.

Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells.

K. Kent, K. Morgan, R. Khalil, 1996, The American journal of physiology.

[Ca]i Signaling of Vasoconstriction in Mesenteric Microvessels of Normal and Reduced Uterine Perfusion Pregnant Rats

R. Khalil, 2008 .

Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels.

R. Khalil, Dia A Smiley, Dia A. Smiley, 2009, Current medicinal chemistry.

Reduced Uterine Perfusion Pressure Entry in Pregnant Rats With 2 + Low-Salt Diet Enhances Vascular Reactivity and Ca

J. Granger, R. Khalil, K. Cockrell, 2002 .

Pathophysiology of essential hypertension: role of the pump, the vessel, and the kidney.

Raouf A Khalil, R. Khalil, Ashley E Cain, 2002, Seminars in nephrology.

Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease.

R. Khalil, E. Roach, K. G. Beauregard, 2010, Current drug metabolism.

Sex difference in cardiovascular risk: role of pulse pressure amplification.

B. Pannier, M. Safar, F. Thomas, 2012, Journal of the American College of Cardiology.

Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone.

R. Khalil, J. G. Murphy, Jason G. Murphy, 1999, The Journal of pharmacology and experimental therapeutics.

Potential approaches to enhance the effects of estrogen on senescent blood vessels and postmenopausal cardiovascular disease.

R. Khalil, 2010, Cardiovascular & hematological agents in medicinal chemistry.

MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm.

R. Khalil, Weicheng Wang, Yongqi Li, 2020, Life sciences.

Sex hormones and the vascular smooth muscle

R. Khalil, J. Orshal, 2004 .

α- and ϵ-Protein Kinase C Activity during Smooth Muscle Cell Apoptosis in Response to γ-Radiation

R. Khalil, M. Oshiro, A. T. Ferreira, 2007, Journal of Pharmacology and Experimental Therapeutics.

Gender Differences in Vascular Smooth Muscle Reactivity to Increases in Extracellular Sodium Salt

R. Khalil, Gachavis M Green, Laura A. Barron, 2002, Hypertension.

Sodium Salt Gender Differences in Vascular Smooth Muscle Reactivity to Increases in Extracellular

R. Khalil, Gachavis M Green, Laura A. Barron, 2002 .

Gender Differences in Ca2+ Entry Mechanisms of Vasoconstriction in Wistar-Kyoto and Spontaneously Hypertensive Rats

R. Khalil, J. K. Crews, Jason G Murphy, 1999 .

more spice Dietary salt and hypertension: new molecular targets add

R. Khalil, 2016 .

Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice.

G. Adler, R. Khalil, J. Romero, 2010, American journal of physiology. Heart and circulatory physiology.

Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice.

J. Raffetto, G. Adler, R. Khalil, 2008, American journal of physiology. Heart and circulatory physiology.

High-Salt Diet Enhances Vascular Reactivity in Pregnant Rats With Normal and Reduced Uterine Perfusion Pressure

J. Granger, R. Khalil, J. B. Giardina, 2001, Hypertension.

Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide–High Angiotensin II–Induced Cardiovascular Injury

G. Adler, R. Khalil, O. Reslan, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Dissociation of Hyperglycemia from Altered Vascular Contraction and Relaxation Mechanisms in Caveolin-1 Null Mice

G. Adler, R. Khalil, O. Reslan, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Faculty of 1000 evaluation for Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility.

Raouf Khalil, R. Khalil, 2010 .

Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava.

E. Holmes, P. Vorkas, J. Li, 2016, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways.

R. Khalil, Ashley E. Cain, D. M. Tanner, 2002, Hypertension.

Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults

Xiping Xu, Wei Guo, Xin Jia, 2017, Scientific Reports.

Protein Kinase C Inhibitors as Modulators of Vascular Function and Their Application in Vascular Disease

R. Khalil, Raouf A. Khalil, 2013, Pharmaceuticals.

Oxidized-LDL Enhances Coronary Vasoconstriction by Increasing the Activity of Protein Kinase C Isoforms α and ε

R. Khalil, J. B. Giardina, D. J. Tanner, 2001 .

Endothelin-Induced Increases in Ca2+ Entry Mechanisms of Vascular Contraction Are Enhanced During High-Salt Diet

J. Granger, R. Khalil, M. Sedeek, 2003, Hypertension.

Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase.

R. D. Manning, R. Khalil, A. Gannon, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.