C. Léon

发表

Desensitization of the Platelet Aggregation Response to ADP: Differential Down-regulation of the P2Y1 and P2cyc Receptors

J. Cazenave, C. Gachet, A. Baurand, 2000, Thrombosis and Haemostasis.

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

R. Tiedt, R. Skoda, M. Freund, 2007, Blood.

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

C. Gachet, A. Eckly, C. Léon, 2014, Blood.

Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP‐sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia

I. Forsythe, C. Gachet, R. Evans, 2004, British journal of pharmacology.

The P 2 Y 1 Receptor Is Necessary for Adenosine 5 8-Diphosphate – Induced Platelet Aggregation

J. Cazenave, C. Gachet, P. Vigne, 1998 .

Calmodulin interacts with the platelet ADP receptor P2Y1.

C. Gachet, C. Léon, M. Berndt, 2006, The Biochemical journal.

Decreased Thrombotic Tendency in Mouse Models of the Bernard-Soulier Syndrome

T. David, M. Freund, C. Gachet, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Differential Involvement of the P 2 Y 1 and P 2 Y 12 Receptors in Platelet Procoagulant Activity

M. Freund, J. Cazenave, C. Gachet, 2003 .

Differential Involvement of the P2Y1 and P2Y12 Receptors in Platelet Procoagulant Activity

M. Freund, J. Cazenave, C. Gachet, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

B. Ludewig, Mélanie Chypre, H. Yagita, 2016, PloS one.

The P2Y12 receptor induces platelet aggregation through weak activation of the αIIbβ3 integrin – a phosphoinositide 3‐kinase‐dependent mechanism

B. Nieswandt, J. Cazenave, C. Gachet, 2001 .

Activation of ADP Receptors and Platelet Function

P. Ohlmann, J. Cazenave, C. Gachet, 1997, Thrombosis and Haemostasis.

Cdc42‐dependent F‐actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

B. Payrastre, C. Gachet, S. Severin, 2016, Journal of thrombosis and haemostasis : JTH.

Transgenic Animals in Primary Hemostasis and Thrombosis

C. Gachet, C. Léon, B. Hechler, 2004 .

The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice

A. Farret, M. Freund, J. Cazenave, 2005, Purinergic Signalling.

The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells

J. Cazenave, C. Gachet, C. Vial, 1997, FEBS letters.

Major Contribution of the P2Y1 Receptor in Purinergic Regulation of TNF&agr;-Induced Vascular Inflammation

M. Freund, J. Cazenave, C. Gachet, 2011, Circulation.

Platelet ADP receptors contribute to the initiation of intravascular coagulation.

B. Engelmann, C. Gachet, M. Spannagl, 2004, Blood.

Inhibition of localized thrombosis in P2Y1‐deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist

M. Freund, J. Cazenave, C. Gachet, 2003, Journal of thrombosis and haemostasis : JTH.

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

S. Watson, J. Monypenny, T. Holyoake, 2013, Blood.

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

M. Freund, C. Gachet, A. Eckly, 2019, Blood advances.

P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.

C. Daniel, K. Amann, M. Freund, 2007, Journal of the American Society of Nephrology : JASN.

The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.

J. Cazenave, C. Gachet, P. Vigne, 1998, Blood.

Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties?

J. Galzi, J. Cazenave, C. Gachet, 2005, Molecular Pharmacology.

The platelet P2 receptors in arterial thrombosis.

C. Gachet, C. Léon, B. Hechler, 2006, Blood cells, molecules & diseases.

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

M. Freund, J. Cazenave, C. Gachet, 2009, Blood.

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria

T. Gudermann, K. Lauber, M. Sixt, 2017, Cell.

Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.

J. Bourguignon, M. Freund, J. Cazenave, 2001, European journal of pharmacology.

Purinergic receptors on blood platelets.

J. Cazenave, C. Gachet, P. Ohlmann, 1996, Platelets.

Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.

J. Cazenave, C. Gachet, C. Vial, 1996, Gene.

Contribution of P2Y1 receptors to ADP signalling in mouse spinal cord cultures

I. Forsythe, C. Gachet, R. Evans, 2008, Neuroscience Letters.

The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.

B. Nieswandt, J. Cazenave, C. Gachet, 2001, FEBS letters.

Key Role of the P2Y1 Receptor in Tissue Factor–Induced Thrombin-Dependent Acute Thromboembolism: Studies in P2Y1-Knockout Mice and Mice Treated With a P2Y1 Antagonist

M. Freund, J. Cazenave, C. Gachet, 2001 .

Broader expression of the mouse platelet factor 4‐cre transgene beyond the megakaryocyte lineage

C. Gachet, J. Freund, A. Eckly, 2015, Journal of thrombosis and haemostasis : JTH.

Presence of P2X1 Purinoceptors in Human Platelets and Megakaryoblastic Cell Lines

J. Cazenave, C. Gachet, C. Vial, 1997, Thrombosis and Haemostasis.

with megakaryocyte-restricted MYH9 inactivation Abnormal megakaryocyte morphology and proplatelet formation in mice

M. Freund, J. Cazenave, A. Eckly, 2013 .

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice.

J P Cazenave, M Freund, A. Dierich, 1999, The Journal of clinical investigation.

receptor signaling megakaryocyte represents a fully functional model of platelet P2 megakaryocyte cation influx currents by ADP: evidence that the primary Interplay between P2Y1, P2Y12, and P2X1 receptors in the activation of

C. Gachet, R. Evans, G. Tolhurst, 2013 .

Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling.

C. Gachet, R. Evans, G. Tolhurst, 2005, Blood.

Direct Voltage Control of Signaling via P2Y1 and Other Gαq-coupled Receptors*

C. Gachet, R. Evans, C. Vial, 2005, Journal of Biological Chemistry.

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors.

J. Cazenave, C. Gachet, A. Eckly, 2012, Experimental cell research.

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function

K. Ravid, C. Gachet, C. Léon, 2018, American journal of hematology.

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

C. Gachet, A. Eckly, C. Léon, 2016, Blood.

Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids

H. de la Salle, C. Gachet, D. Michel, 2020, Journal of thrombosis and haemostasis : JTH.

The P2Y1 Receptor Is Normal in a Patient Presenting a Severe Deficiency of ADP-induced Platelet Aggregation

P. Ohlmann, J. Cazenave, C. Gachet, 1999, Thrombosis and Haemostasis.

The contribution of mouse models to the understanding of constitutional thrombocytopenia

C. Gachet, C. Léon, F. Lanza, 2016, Haematologica.

Contribution of mouse models in constitutional thrombocytopenia

C. Gachet, C. Léon, F. Lanza, 2015 .

Podocyte-Specific Deletion of Myh9 Encoding Nonmuscle Myosin Heavy Chain 2A Predisposes Mice to Glomerulopathy

L. Holzman, C. Gachet, Jidong Zhang, 2011, Molecular and Cellular Biology.

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.

F. Dombrowski, A. Greinacher, C. Gachet, 2012, Blood.

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice

J. Cazenave, C. Gachet, A. Eckly, 2010, Journal of thrombosis and haemostasis : JTH.

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

D. Bluteau, W. Vainchenker, N. Debili, 2012, Nature Communications.

Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

C. Hunter, D. Discher, F. Rehfeldt, 2014, Cell stem cell.

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.

W. Geerts, C. Gachet, A. Eckly, 2014, Blood.

Blood platelet formation at a glance

A. Eckly, C. Léon, F. Lanza, 2020, Journal of Cell Science.

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome

M. Freund, J. Cazenave, C. Gachet, 2009, Haematologica.

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

C. Gachet, A. Eckly, C. Léon, 2020, Haematologica.

Cell Stem Cell Myosin-II Regulates Adult Hematopoiesis

C. Hunter, D. Discher, F. Rehfeldt, 2013 .

Possible Involvement of P2Y2 Metabotropic Receptors in ATP-Induced Transient Receptor Potential Vanilloid Receptor 1-Mediated Thermal Hypersensitivity

T. Fukuoka, K. Noguchi, M. Tominaga, 2003, The Journal of Neuroscience.

Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.

M. Freund, J. Cazenave, C. Gachet, 2001, Circulation.

ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor.

C. Gachet, P. Vigne, C. Léon, 1998, Molecular pharmacology.

Characterization of megakaryocyte development in the native bone marrow environment.

J. Cazenave, C. Gachet, A. Eckly, 2012, Methods in molecular biology.

Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation.

C. Gachet, C. Léon, F. Pertuy, 2018, Methods in molecular biology.

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

C. Gachet, F. Ataullakhanov, M. Panteleev, 2019, Arteriosclerosis, thrombosis, and vascular biology.

β-Arrestin-2 Interaction and Internalization of the Human P2Y1 Receptor Are Dependent on C-Terminal Phosphorylation Sites

K. Lorenz, M. Lohse, C. Gachet, 2009, Molecular Pharmacology.

Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix

H. de la Salle, B. Payrastre, S. Courtneidge, 2022, Scientific Reports.

CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring

J. Cazenave, C. Gachet, C. Léon, 2009, Journal of thrombosis and haemostasis : JTH.

Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors.

C. Gachet, R. Evans, C. Vial, 2005, The Journal of biological chemistry.