A. Clark

发表

Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.

H. Elsohly, L. Walker, Zhizhen Zhang, 2002, Planta medica.

Nonoxynol-9: differential antibacterial activity and enhancement of bacterial adherence to vaginal epithelial cells.

T. Hooton, W. Stamm, A. Clark, 1991, The Journal of infectious diseases.

Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments

A. Clark, J. Mcchesney, C. D. Huford, 1981, Antimicrobial Agents and Chemotherapy.

Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template.

Xing-Cong Li, Shabana I. Khan, M. Jacob, 2011, ACS medicinal chemistry letters.

Synthesis and the Biological Evaluation of the Structural Units of Drummondin C

A. Clark, J. Mcchesney, H. Jayasuriya, 1991, Pharmaceutical Research.

Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp.

D. Ferreira, Xing-Cong Li, M. Jacob, 2009, Journal of natural products.

Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi.

A. Clark, C. D. Hufford, E. Li, 1995, Journal of natural products.

Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.

A. Clark, C. Turner, H. N. Eisohly, 1982, Journal of pharmaceutical sciences.

Antimicrobial activity of essential oils of Brazilian plants

J. W. Alencar, A. Craveiro, A. Clark, 1990 .

Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema

L. Walker, S. Takamatsu, A. Clark, 2003, Phytotherapy research : PTR.

Rapid method for the determination of apomorphine in plasma using high-performance liquid chromatography.

A. Clark, A. E. Klein, D. Humphrey, 1979, Journal of chromatography.

The use of microorganisms for the study of drug metabolism

A. Clark, J. Mcchesney, C. D. Hufford, 1985, Medicinal research reviews.

A Potent Plant-Derived Antifungal Acetylenic Acid Mediates Its Activity by Interfering with Fatty Acid Homeostasis

M. Lorenz, Xing-Cong Li, Tao Xu, 2012, Antimicrobial Agents and Chemotherapy.

Site-specific variation in the root chemistry

Andrew W. Douglas, M. Slattery, A. Clark, 2004 .

Probing the N-5 region of the indoloquinoline alkaloid, cryptolepine for anticryptococcal activity.

A. Nimrod, A. Clark, P. Fan, 1999, Bioorganic & medicinal chemistry.

Potent In Vitro Antifungal Activities of Naturally Occurring Acetylenic Acids

H. Elsohly, Xing-Cong Li, Shabana I. Khan, 2008, Antimicrobial Agents and Chemotherapy.

Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.

H. Elsohly, Xing-Cong Li, L. Walker, 2003, Journal of natural products.

Use of a urine enzyme immunoassay as a diagnostic tool for Chlamydia trachomatis urethritis in men

M. Pettinger, J. Schwebke, W. Stamm, 1991, Journal of clinical microbiology.

Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani.

Xing-Cong Li, I. Khan, D. Newman, 2013, Research and reports in medicinal chemistry.

Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani

Xing-Cong Li, I. Khan, D. Newman, 2012 .

The Need for New Antifungal Drugs

A. Clark, 1992 .

Indolopyridoquinazoline alkaloid from Leptothyrsa sprucei.

H. Elsohly, L. Walker, A. Clark, 2001, Phytochemistry.

Antifungal Activity of Eupolauridine and Its Action on DNA Topoisomerases

L. Walker, Shabana I. Khan, A. Nimrod, 2002, Antimicrobial Agents and Chemotherapy.

Discovery of Antifungal Agents from Natural Sources: Virulence Factor Targets

L. Walker, A. Clark, 1999 .

Discovery and Development of Novel Prototype Antibiotics for Opportunistic Infections Related to Acquired Immunodeficiency Syndrome

A. Clark, C. D. Hufford, 1994 .

Diagnosis of Chlamydia trachomatis endocervical infections by a commercial polymerase chain reaction assay

W. Stamm, A. Clark, A. Clark, 1993, Journal of clinical microbiology.

Synthesis and antifungal activities of miltefosine analogs.

J. Heitman, Xuewen Pan, Xing-Cong Li, 2013, Bioorganic & medicinal chemistry letters.

Natural and synthetic substances related to human health (IUPAC Technical Report)

J. Topliss, E. Ernst, J. Rimoldi, 2002 .

Use of microorganisms for the study of drug metabolism: An update

A. Clark, C. D. Hufford, 1991, Medicinal research reviews.

Microbial transformation of sampangine.

K. Orabi, A. Clark, C. D. Hufford, 1999, Journal of natural products.

Metabolism of imipramine by microorganisms.

A. Clark, C. D. Hufford, J. K. Baker, 1981, Journal of pharmaceutical sciences.

Antimicrobial Diterpenes of Croton sonderianus. II. ent-Beyer-15-en-18-oic Acid

A. Clark, J. Mcchesney, E. Silveira, 1991, Pharmaceutical Research.

NMR assignments of ellagic acid derivatives

H. Elsohly, Xing-Cong Li, A. Clark, 1999 .

Microbial models of mammalian metabolism of xenobiotics: An updated review.

E. Abourashed, A. Clark, C. D. Hufford, 1999, Current medicinal chemistry.

Microbial transformations of the sesquiterpene lactone costunolide

A. Clark, C. D. Hufford, 1980 .

Apoptosis Induced by the Alkaloid Sampangine in HL‐60 Leukemia Cells

C. Bailly, J. Kluza, A. Clark, 2003, Annals of the New York Academy of Sciences.

Demethylation of imipramine by enteric bacteria.

R. Clinton, A. Clark, C. D. Hufford, 1983, Journal of pharmaceutical sciences.

Study of the metabolic conversion of imipramine and desipramine to N-nitrosodesipramine by bacteria using a nitrogen-selective GC analysis.

A. Clark, C. D. Hufford, J. K. Baker, 1982, Journal of pharmaceutical sciences.

Microbial transformations and 13C-NMR analysis of colchicine.

C. C. Collins, A. Clark, C. D. Hufford, 1979, Journal of pharmaceutical sciences.

Antimicrobial activity of phenolic constituents of Magnolia grandiflora L.

A. Clark, F. El-Feraly, W. Li, 1981, Journal of pharmaceutical sciences.

A new dammarane-type triterpene glycoside from Polyscias fulva.

L. Walker, I. Khan, N. Toyang, 2001, Journal of natural products.

Hydroxylations of biphenyl by fungi.

A. Clark, P. Davis, R. Smith, 1980, The Journal of applied bacteriology.

Metabolism of phencyclidine by microorganisms.

A. Clark, C. D. Hufford, J. K. Baker, 1981, Journal of pharmaceutical sciences.

Synthesis and antimicrobial activity of 6,7-annulated pyrido[2,3-d]pyrimidines.

A. Clark, I. Donkor, N. Zhu, 1995, Journal of pharmaceutical sciences.

Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins.

A. Clark, D. Rotella, C. D. Hufford, 1995, Journal of natural products.

Antifungal cyclopentenediones from Piper coruscans.

H. Elsohly, D. Ferreira, Xing-Cong Li, 2004, Journal of the American Chemical Society.

Dihydrochalcones from Piper longicaudatum.

H. Elsohly, L. Walker, A. Nimrod, 2001, Planta medica.

Substituted indoloquinolines as new antifungal agents.

A. Clark, P. Fan, S. Ablordeppey, 2002, Bioorganic & medicinal chemistry.

Antimicrobial activity of juglone

A. Clark, C. D. Hufford, T. Jurgens, 1990 .

In Vitro Antimicrobial Activity of Benzoquinolinediones

A. Clark, Cheng-Yu Ma, C.-h. Ho, 1984, Pharmaceutical Research.

Anticandidal activity of eupolauridine and onychine, alkaloids from Cleistopholis patens.

A. Clark, C. D. Hufford, B. Oguntimein, 1987, Journal of natural products.

Chapter 2 Antifungal Alkaloids

A. Clark, C. D. Hufford, 1992 .

Synthesis and Antifungal Activity Evaluation of Phloeodictine Analogues.

Xing-Cong Li, Shabana I. Khan, M. Jacob, 2021, Journal of natural products.

GC-MS Analysis of the 8-Aminoquinoline Antimalarial [NPC1161] and its Carboxy Metabolite in Plasma and Red Blood Cells of Primates

L. Walker, Shabana I. Khan, M. Elsohly, 2006 .

The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.

Shabana I. Khan, A. Clark, J. Secrist, 2016, Bioorganic & medicinal chemistry.

3-Methoxysampangine, a novel antifungal copyrine alkaloid from Cleistopholis patens

A. Clark, C. D. Hufford, B. Oguntimein, 1990, Antimicrobial Agents and Chemotherapy.

Synthesis of asperphenamate, a novel fungal metabolite

A. Clark, C. D. Hufford, 1978 .

New antimicrobial filicinic acid derivatives from Hypericum drummondii.

A. Clark, J. Mcchesney, H. Jayasuriya, 1991, Journal of natural products.

Site-specific variation in the root chemistry and antifungal activity of Caltha leptosepala and Trollius laxus (Ranunculaceae)

Andrew W. Douglas, M. Slattery, A. Clark, 2004 .

The metabolism of muzigadial by microorganisms.

A. Clark, C. D. Hufford, T. Jurgens, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Antimicrobial properties of Honduran medicinal plants.

O. Ibrahimi, A. Clark, A. Okunade, 1998, Journal of ethnopharmacology.

Antifungal activity of Trillium grandiflorum constituents.

A. Clark, C. D. Hufford, S. Liu, 1988, Journal of natural products.

Antimicrobial diterpenes of Croton sonderianus, 1. Hardwickic and 3,4-secotrachylobanoic acids.

A. Clark, J. Mcchesney, E. Silveira, 1991, Journal of natural products.

Natural Products as a Resource for New Drugs

A. Clark, 1996, Pharmaceutical Research.

Antimicrobial Properties of the Constituents of Piper aduncum

A. Clark, A. Okunade, C. D. Hufford, 1997 .

Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.

K. E. El Sayed, A. Mayer, A. Clark, 2000, Journal of natural products.

Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Xuewen Pan, Xing-Cong Li, I. Khan, 2017, The Journal of Biological Chemistry.

Antimicrobial properties of heartwood, bark/sapwood and leaves of Juniperus species

A. Clark, J. Mcchesney, R. P. Adams, 1990 .

Resolution and absolute configuration of naturally occurring auronols.

H. Elsohly, A. Clark, D. Ferreira, 2001, Journal of natural products.

Sesquiterpene lactones from Peucephyllum schottii

R. Rogers, A. Clark, A. Okunade, 1993 .

Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues.

D. Ferreira, Xing-Cong Li, Shabana I. Khan, 2006, Journal of medicinal chemistry.

In Vivo Efficacy of Antifungal Oxoaporphine Alkaloids in Experimental Disseminated Candidiasis

A. Clark, C. D. Hufford, M. Ashfaq, 1987, Pharmaceutical Research.

High-performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite.

A. Clark, J. Mcchesney, C. D. Hufford, 1982, Journal of chromatography.

ent-Kaurane glycosides from Tricalysia okelensis.

Xing-Cong Li, Zongsuo Liang, M. Jacob, 2010, Chemical & pharmaceutical bulletin.

The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis

Bharathi Avula, Tao Xu, Melissa R. Jacob, 2011, Antimicrobial Agents and Chemotherapy.

New indole alkaloids from the bark of Nauclea orientalis.

H. Elsohly, L. Walker, M. Jacob, 2001, Journal of natural products.

7-Caffeoylsedoheptulose from Nyssa sylvatica.

H. Elsohly, A. Clark, X. C. Li, 2000, Phytochemistry.

Antimicrobial compounds from Petalostemum purpureum.

R. Rogers, A. Clark, A. Okunade, 1993, Journal of natural products.

Role of Heme in the Antifungal Activity of the Azaoxoaporphine Alkaloid Sampangine

Tao Xu, Melissa R. Jacob, Alice M. Clark, 2007, Eukaryotic Cell.

Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces cerevisiae*

J. Cleary, L. Walker, K. Barker, 2003, Journal of Biological Chemistry.

Azaanthraquinone: an antimicrobial alkaloid from Mitracarpus scaber.

A. Clark, A. Okunade, C. D. Hufford, 1999, Planta medica.

Diagnosis of Chlamydia trachomatis urethritis in men by polymerase chain reaction assay of first-catch urine

M. Loeffelholz, W. Stamm, A. Clark, 1993, Journal of clinical microbiology.

Phenolic glycosides from Potalia amara.

H. Elsohly, Xing-Cong Li, L. Walker, 2005, Planta medica.

N-demethylation of lergotrile by Streptomyces platensis

A. Clark, P. Davis, R. Smith, 1979, Applied and environmental microbiology.

Antifungal chalcones from Maclura tinctoria.

H. Elsohly, L. Walker, A. Nimrod, 2001, Planta medica.

Microbial transformation of benzosampangine.

K. Orabi, A. Clark, C. D. Hufford, 2000, Journal of natural products.

Microbial metabolism of bornaprine, 3-(diethylamino)propyl 2-phenylbicyclo[2.2.1]heptane-2-carboxylate.

A. Clark, C. D. Hufford, J. K. Baker, 1986, Journal of pharmaceutical sciences.

Two metabolites from Aspergillus flavipes.

L. Robertson, A. Clark, C. D. Hufford, 1977, Lloydia.

Two auronols from Pseudolarix amabilis.

H. Elsohly, A. Nimrod, A. Clark, 1999, Journal of natural products.

Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway

R. J. Doerksen, D. E. Levin, Xuewen Pan, 2020, mSphere.

FLAVONOL GLYCOSIDES FROM THE NATIVE AMERICAN PLANT GAURA LONGIFLORA.

Xing-Cong Li, Zongsuo Liang, M. Jacob, 2009, Heterocycles.

Capisterones A and B, which enhance fluconazole activity in Saccharomyces cerevisiae, from the marine green alga Penicillus capitatus.

D. Ferreira, Xing-Cong Li, Shabana I. Khan, 2006, Journal of natural products.

Exploring the Molecular Basis of Antifungal Synergies Using Genome-Wide Approaches

Xing-Cong Li, Tao Xu, M. Jacob, 2012, Front. Microbio..

Sampangine Inhibits Heme Biosynthesis in both Yeast and Human

Xuewen Pan, Kaifu Chen, Wei Li, 2011, Eukaryotic Cell.

Genipatriol, a new cycloartane triterpene from Genipa spruceana.

L. Walker, C. F. Hossain, D. Nagle, 2003, Journal of natural products.

Antifungal activity of (-)-epigallocatechin gallate from Coccoloba dugandiana.

H. Elsohly, A. Nimrod, A. Clark, 1999, Planta medica.

Synthesis and antifungal activity of natural product-based 6-alkyl-2,3,4,5-tetrahydropyridines.

Xing-Cong Li, I. Khan, Shabana I. Khan, 2011, Journal of Natural Products.

Excretion, distribution, and metabolism of primaquine in rats.

A. Clark, J. K. Baker, J. McChesney, 1984, Journal of pharmaceutical sciences.

Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.

L. Walker, S. Takamatsu, A. Clark, 2001, Journal of natural products.

Oxoaporphine Alkaloids: Conversion of Lysicamine into Liriodendronine and its 2‐O‐Methyl Ether, and Antifungal Activity

C. George, J. Flippen-Anderson, A. Brossi, 1991, Archiv der Pharmazie.

Antimicrobial properties of alkaloids from Xanthorhiza simplicissima.

A. Clark, A. Okunade, C. D. Hufford, 1994, Journal of pharmaceutical sciences.

Effects of doxycycline and antiinflammatory agents on experimentally induced chlamydial upper genital tract infection in female macaques.

J. Hughes, W. Stamm, N. Bohannon, 1997, The Journal of infectious diseases.

Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate.

L. Walker, C. F. Hossain, D. Nagle, 2003, Journal of natural products.

Puupehanol, a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp.

D. Ferreira, Xing-Cong Li, Zongsuo Liang, 2009, Bioorganic & medicinal chemistry letters.

Phenolic compounds from Miconia myriantha inhibiting Candida aspartic proteases.

H. Elsohly, L. Walker, A. Nimrod, 2001, Journal of natural products.

New antimycobacterial saponin from Colubrina retusa.

H. Elsohly, A. Nimrod, A. Clark, 1999, Journal of natural products.

A primate model for chancroid.

N. Kiviat, W. Stamm, A. Clark, 1994, The Journal of infectious diseases.

Fungal Metabolism of 4-Methylprimaquine

A. Clark, C. D. Hufford, J. McChesney, 1986, Pharmaceutical Research.

Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.

H. Elsohly, L. Walker, Zhizhen Zhang, 2002, Journal of natural products.

New sesquiterpenoids from the root of Guatteria multivenia.

H. Elsohly, L. Walker, Zhizhen Zhang, 2002, Journal of natural products.

3-Dimethylallylindole: an antibacterial and antifungal metabolite from Monodora tenuifolia.

A. Clark, A O Adeoye, B O Oguntimein, 1986, Journal of natural products.

Natural and synthetic substances related to human health

J. Topliss, E. Ernst, J. Rimoldi, 2002 .

Bioactivity screenings of plants selected on the basis of folkloric use or presence of lignans in a family

A. Clark, J. Peterson, M. Richardson, 1992 .

Interfering with Fatty Acid Homeostasis Acetylenic Acid Mediates Its Activity by A Potent Plant-Derived Antifungal

M. Lorenz, Xing-Cong Li, Tao Xu, 2012 .

Production of a novel dimeric metabolite of primaquine by Streptomyces rimosus

A. Clark, C. D. Hufford, R. Puri, 1984, Applied and Environmental Microbiology.

Microbial transformation of primaquine by Candida tropicalis

R. Gupta, A. Clark, C. D. Hufford, 1984, Applied and environmental microbiology.

The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian Metabolism

A. Clark, T. M. Jürgens, 1990, Pharmaceutical Research.

Novel sulfur-containing microbial metabolite of primaquine

A. Clark, C. D. Hufford, J. K. Baker, 1986, Antimicrobial Agents and Chemotherapy.

High performance liquid chromatographic separation of the enantiomers and diastereomers of primaquine and its metabolites

A. Clark, C. D. Hufford, J. K. Baker, 1986 .

Microbial N-acetylation of Primaquine by Two Streptomyces Species: Time Course Studies and Hplc Analyses

A. Clark, C. D. Hufford, S. Evans, 1982 .

Microbial metabolism studies on the major microbial and mammalian metabolite of primaquine.

A. Clark, C. D. Hufford, J. K. Baker, 1983, Journal of pharmaceutical sciences.

LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia.

Xing-Cong Li, L. Walker, Shabana I. Khan, 2015, Journal of natural products.

Chemical composition and antimicrobial activity of essential oils of Jasonia candicans and J. montana.

A. Clark, M. A. Abd El-Kawy, F. Soliman, 1993, Planta medica.

Mechanism of hydroxylation of biphenyl by Cunninghamella echinulata.

A. Clark, P. Davis, R. Smith, 1981, The Biochemical journal.

A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosides.

H. Elsohly, L. Walker, A. Nimrod, 2001, Journal of natural products.

The Path Forward: The Future of Graduate Education in the Pharmaceutical Sciences: The Report of the 2010-2011 Research and Graduate Affairs Committee

R. Brueggemeier, A. Clark, L. Maine, 2011, American Journal of Pharmaceutical Education.

The Path Forward: The Future of Graduate Education in the Pharmaceutical Sciences

Lucinda L. Maine, Alice M. Clark, Bernard A. Sorofman, 2010 .

Anti-Cryptococcal and Nitric Oxide Synthase Inhibitory Imidazole Alkaloids from the Calcareous Sponge Leucetta cf chagosensis

M. Hamann, J. Rimoldi, M. Kelly, 2000 .

Antifungal jujubogenin saponins from Colubrina retusa.

H. Elsohly, Xing-Cong Li, A. Nimrod, 1999, Journal of natural products.

The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis

I. Khan, L. Walker, M. Hamann, 2011, Antimicrobial Agents and Chemotherapy.

Synthesis and antifungal activity of natural product-based 6-alkyl-2,3,4,5-tetrahydropyridines.

Xing-Cong Li, I. Khan, Shabana I. Khan, 2011, Journal of natural products.

Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines.

R. Rogers, A. Clark, C. D. Hufford, 1992, Journal of medicinal chemistry.