Rebecca C. Coll

发表

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

K. Schroder, D. Kastner, I. Vetter, 2015, Nature Medicine.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

B. Kobe, M. Mobli, A. Mansell, 2017, Proceedings of the National Academy of Sciences.

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

L. O’Neill, Rebecca C. Coll, 2013, PLoS ONE.

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

C. Day, K. Schroder, A. Zamoshnikova, 2019, Nature Chemical Biology.

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

L. O’Neill, Rebecca C. Coll, 2011, PloS one.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

A. Sher, W. Leonard, P. Monk, 2016, Science.

NLRP3 and pyroptosis blockers for treating inflammatory diseases.

K. Schroder, P. Pelegrín, Rebecca C. Coll, 2022, Trends in pharmacological sciences.

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Christine E. Becker, S. Kahn, K. H. Mok, 2010, Nature Immunology.

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

Melissa J. Morine, H. Roche, A. Tierney, 2015, Diabetes.

A small molecule inhibitior of the NLRP 3 inflammasome is a potential therapeutic for inflammatory diseases

K. Schroder, D. Kastner, I. Vetter, 2015 .

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.

L. O’Neill, Rebecca C. Coll, P. Board, 2014, Free radical biology & medicine.

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.

J. Cleveland, Sheng Wei, T. Cluzeau, 2016, Blood.

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Jelena S. Bezbradica, Guillermo A. Gomez, Connie M. Ross, 2018, The Journal of experimental medicine.

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

J. Kearney, S. Breit, L. O’Neill, 2017, The Journal of Biological Chemistry.

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

P. Taylor, Simon A. Jones, A. K. Harvey, 2014, Arthritis Research & Therapy.

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

Jelena S. Bezbradica, K. Schroder, Rebecca C. Coll, 2016, Cellular & Molecular Immunology.

Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe

K. Schroder, A. Robertson, Rebecca C. Coll, 2020 .

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway

L. O’Neill, Rebecca C. Coll, P. Board, 2015, Journal of Cell Science.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

A. Sher, W. Leonard, P. Monk, 2016, Science.

Role reversal: adaptive immunity instructs inflammasome activation for anti‐viral defence

Rebecca C. Coll, 2019, The EMBO journal.

Mitochondrial DNA synthesis fuels NLRP3 inflammasome

K. Schroder, Rebecca C. Coll, Caroline L Holley, 2018, Cell Research.

Elevated ferritin is associated with systemic inflammation, inflammasome activation and mortality in Acute Respiratory Distress Syndrome (ARDS)

M. Shankar-Hari, P. Mehta, D. McAuley, 2022, Acute critical care.

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.

M. Haneklaus, L. O’Neill, Rebecca C. Coll, 2013, Current opinion in immunology.

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

Jelena S. Bezbradica, Rebecca C. Coll, J. S. Bezbradica, 2021, Biochemical Society transactions.

NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

Rebecca C. Coll, C. McKee, 2020, Journal of leukocyte biology.

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

L. O’Neill, Rebecca C. Coll, 2010, Journal of Innate Immunity.

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors

K. Schroder, M. Cooper, A. Robertson, 2017, ChemMedChem.

The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

C. Bryant, M. Valvano, Rebecca C. Coll, 2023, bioRxiv.

NLRC3 Restrains Responses to a T.

K. Schroder, Rebecca C. Coll, Caroline L. Holley, 2018, Immunity.

Caging NLRP3 tames inflammasome activity

K. Schroder, Rebecca C. Coll, 2021, Cell.

Sulfonylureas and related compounds and use of the same

K. Schroder, L. O’Neill, A. Robertson, 2016 .

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

M. Febbraio, D. R. Laybutt, G. Lancaster, 2018, Molecular metabolism.

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

K. Schroder, L. O’Neill, Rebecca C. Coll, 2016, Cell Death Discovery.

32 ACTIVATION OF REDOX-SENSITIVE INFLAMMASOMES UNDERLIES THE BIOLOGICAL PHENOTYPE OF MYELODYSPLASTIC SYNDROMES

Sheng Wei, M. Cooper, E. Padron, 2015 .

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

J. Kearney, S. Breit, L. O’Neill, 2017, The Journal of Biological Chemistry.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

A. Sher, W. Leonard, P. Monk, 2016, Science.

Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4+T cells

A. Sher, W. Leonard, P. Monk, 2016 .

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

Connie M. Ross, A. Zamoshnikova, Madhavi P. Maddugoda, 2024, Science Signaling.