Susan D. Wong

发表

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

M. Jamei, A. Rostami-Hodjegan, K. Rowland-Yeo, 2016, Drug Metabolism and Disposition.

On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay

J. Halladay, L. Berezhkovskiy, Susan D. Wong, 2013, Journal of Pharmacokinetics and Pharmacodynamics.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

E. Choo, C. Hop, J. Halladay, 2016, Drug Metabolism and Disposition.

A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834

Jeffrey P. Jones, Donald S Kirkpatrick, Jasleen K Sodhi, 2015, Drug Metabolism and Disposition.

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor

John C. Davis, P. Kuebler, J. Lubach, 2011, Drug Metabolism and Disposition.

Metabolic stability screen for drug discovery using cassette analysis and column switching.

J. Halladay, Susan D. Wong, S. Khojasteh-Bakht, 2007, Drug metabolism letters.

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

A. Pottegård, D. Kroetz, F. Nielsen, 2018, British journal of clinical pharmacology.

Comparison of in vitro-in vivo extrapolation of biliary clearance using an empirical scaling factor versus transport-based scaling factors in sandwich-cultured rat hepatocytes.

Xingrong Liu, B. Liederer, Susan D. Wong, 2013, Journal of pharmaceutical sciences.

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Phorbol ester treatment of human myometrial cells suppresses expression of oxytocin receptor through a mechanism that does not involve activator protein-1.

M. Stemerman, Susan D. Wong, B. Mitchell, 2006, American journal of physiology. Endocrinology and metabolism.

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer.

D. Sutherlin, S. Sideris, L. Friedman, 2010, Journal of medicinal chemistry.

Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy?

S. Engelen, S. Davidge, John T. Moore, 2005, American journal of obstetrics and gynecology.

Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways.

E. Johnstone, Susan D. Wong, L. Guilbert, 2006, American journal of physiology. Endocrinology and metabolism.

Transcriptional Regulation of Oxytocin Receptor by Interleukin-1β and Interleukin-6.

Susan D. Wong, B. Mitchell, B. Schmid, 2001, Endocrinology.

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Yuan Chen, J. Mao, C. Hop, 2017, Pharmaceutical Research.

1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9

C. Hop, J. Halladay, S. Mukadam, 2014, Drug Metabolism and Disposition.

Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate

Susan D. Wong, J. Silverman, Xiang-Qing Yu, 2002, Journal of Pharmacology and Experimental Therapeutics.

DRUG METABOLISM Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

A. Pottegård, D. Kroetz, F. Nielsen, 2018 .

Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid

C. Hogarth, N. Isoherranen, Mika Kosaka, 2019, Clinical and translational science.

Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour

M. Taggart, Susan D. Wong, B. Mitchell, 2008, The Journal of physiology.

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.

D. Sutherlin, Leslie B. Lee, F. D. de Sauvage, 2010, Bioorganic & medicinal chemistry letters.

An 'all-inclusive' 96-well cytochrome P450 induction method: measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes.

Susan Grepper, J. Halladay, Susan D. Wong, 2012, Journal of pharmacological and toxicological methods.

Parathyroid Hormone-Related Protein Treatment of Pregnant Rats Delays the Increase in Connexin 43 and Oxytocin Receptor Expression in the Myometrium1

Jennifer A. Mitchell, S. Lye, Susan D. Wong, 2003, Biology of reproduction.

Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor

D. Sampath, P. Dragovich, B. Liederer, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Changes in 17β,20α-hydroxysteroid dehydrogenase activity supporting an increase in the estrogen/progesterone ratio of human fetal membranes at parturition

Susan D. Wong, B. Mitchell, 1993 .

Novel Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor

P. Kuebler, J. Lubach, H. Wong, 2011 .

Intraperitoneal infusion of proinflammatory cytokines does not cause activation of the rat uterus during late gestation.

Susan D. Wong, B. Mitchell, Jana M. Mitchell, 2005, American journal of physiology. Endocrinology and metabolism.

Effects of LPS and IL‐6 on Oxytocin Receptor in Non‐Pregnant and Pregnant Rat Uterus

Susan D. Wong, B. Mitchell, X. Fang, 2000, American journal of reproductive immunology.

Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects

E. Cho, B. Liederer, R. Sane, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability.

J. Vederas, Susan D. Wong, B. Mitchell, 2005, The Journal of organic chemistry.

Synthesis of biologically active dicarba analogues of the peptide hormone oxytocin using ring-closing metathesis.

J. Vederas, Susan D. Wong, B. Mitchell, 2003, Organic letters.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo

G. Dresser, D. Bailey, Susan D. Wong, 2002, Clinical pharmacology and therapeutics.

Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors

Zhengyin Yan, Albert P. Li, Susan D. Wong, 2020, Pharmacology research & perspectives.

Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole.

Susan D. Wong, V. Wacher, H. Wong, 2002, Journal of pharmaceutical sciences.

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.

D. Sutherlin, S. Sideris, Irina S. Chuckowree, 2010, Bioorganic & medicinal chemistry letters.

Determination of In Vitro Cytochrome P450 Induction Potential Using Cryopreserved Human Hepatocytes

Susan D. Wong, 2021, Methods in Pharmacology and Toxicology.

GDC-0449-a potent inhibitor of the hedgehog pathway.

K. Kotkow, L. Rubin, D. Sutherlin, 2009, Bioorganic & medicinal chemistry letters.

Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.

Liling Liu, J. Ly, Susan D. Wong, 2021, Drug metabolism and disposition: the biological fate of chemicals.

Utility of pooled cryopreserved human enterocytes as an in vitro model for assessing intestinal clearance and drug–drug interactions

Zhengyin Yan, Susan D. Wong, Suzanne Tay, 2018 .

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Sarah J. Robinson, J. Ly, Susan D. Wong, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study

Yuan Chen, L. Chinn, K. Nagapudi, 2020, Clinical pharmacology and therapeutics.

Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes

Zhengyin Yan, Susan D. Wong, Donglu Zhang, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human

Leslie B. Lee, D. Sampath, E. Plise, 2012, Drug Metabolism and Disposition.

Filling a nick in NIK: extending the half-life of a NIK inhibitor through structure-based drug design.

Matthew L Landry, P. McEwan, Adam Johnson, 2023, Bioorganic & medicinal chemistry letters.

Minimal effect of ketoconazole on cyclosporine (SangCyATM) oral absorption and first‐pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption

Susan D. Wong, V. Wacher, H. Wong, 2002, Biopharmaceutics & drug disposition.

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human

E. Plise, L. Salphati, J. Halladay, 2011 .

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human.

E. Plise, L. Salphati, J. Halladay, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

High-Throughput, 384-Well, LC-MS/MS CYP Inhibition Assay Using Automation, Cassette-Analysis Technique, and Streamlined Data Analysi.

J. Halladay, Susan D. Wong, S. C. Khojasteh, 2011, Drug metabolism letters.

An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.

Shaofei Ji, E. Plise, Uchenna A. Anene, 2022, Analytical chemistry.

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.

J. Driscoll, C. Hop, Shuguang Ma, 2016, Drug metabolism letters.

C ] Cobimetinib , a MEK Inhibitor , in Humans

Isabelle, E. Choo, C. Hop, 2015 .

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Yuan Chen, J. Mao, C. Hop, 2017, Pharmaceutical Research.

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

K. Kotkow, L. Rubin, D. Sutherlin, 2010 .

Synthesis and Biological Evaluation of Antagonist Analogs of the Peptide Hormone Oxytocin

J. Vederas, Susan D. Wong, B. Mitchell, 2006 .

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Sarah J. Robinson, J. Ly, Susan D. Wong, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1).

S. Girish, L. Salphati, J. Halladay, 2011 .

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.

Zhengyin Yan, Albert P. Li, Mika Kosaka, 2017, Drug metabolism letters.

In Vitro Reaction Phenotyping of Cytochrome P450 Enzymes

Zhengyin Yan, Susan D. Wong, 2021, Methods in Pharmacology and Toxicology.