K. Broadley

发表

Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M3) receptors.

E. J. Thomas, B. Bradshaw, P. Evans, 2008, Organic & biomolecular chemistry.

Muscling in on salbutamol

K. Broadley, P. J. Spencer, 1993, The Lancet.

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation

P. Taylor, E. Kidd, S. Farrow, 2017, Cellular immunology.

Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors.

E. Kidd, K. Broadley, J. H. Clark, 2006, Autonomic & autacoid pharmacology.

Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine

E. Kidd, K. Broadley, W. Ford, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

The vascular effects of trace amines and amphetamines.

K. Broadley, 2010, Pharmacology & therapeutics.

Effects of dietary amines on the gut and its vasculature

E. Kidd, K. Broadley, W. Ford, 2008, British Journal of Nutrition.

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity

Stephen R. Clark, M. Wise, P. Taylor, 2011, Thorax.

Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea.

B. Kariuki, E. Kidd, C. Simons, 2011, Journal of ethnopharmacology.

Activation of β-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction

E. Kidd, Peter E. Penson, K. Broadley, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of Endogenous Adenosine and Adenosine Receptor Agonists on Hypoxia-Induced Myocardial Stunning in Guinea-Pig Atria and Papillary Muscles

K. Broadley, L. Yates, N. M. Gardner, 2004, Journal of cardiovascular pharmacology.

A physiological basis for subclassifying beta‐adrenoceptors examined by chemical sympathectomy of guinea‐pigs.

K. Broadley, P. Grassby, R. Chess-Williams, 1986, The Journal of physiology.

The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.

D. Ward, D. Riccardi, R. Fenton, 2016, American journal of physiology. Cell physiology.

Comparative effects of inhaled budesonide and the NO-donating budesonide derivative, NCX 1020, against leukocyte influx and airway hyperreactivity following lipopolysaccharide challenge.

K. Broadley, B. Nevin, 2004, Pulmonary pharmacology & therapeutics.

TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs.

E. Kidd, L. Paquet, N. Ferrari, 2010, European journal of pharmacology.

Contractile responses to adenosine, R‐PIA and ovalbumen in passively sensitized guinea‐pig isolated airways

K. Broadley, T. J. Martin, Kenneth J Broadley, 2002, British journal of pharmacology.

Effects of adenosine receptor agonists on guinea‐pig isolated working hearts and the role of endothelium and NO

H. Maddock, K. Broadley, N. Khandoudi, 2002, The Journal of pharmacy and pharmacology.

Khat: pharmacological and medical aspects and its social use in Yemen

A. Al‐Motarreb, K. Broadley, K. Baker, 2002, Phytotherapy research : PTR.

Evidence from agonist and antagonist studies to suggest that the β1‐adrenoceptors subserving the positive inotropic and chronotropic responses of the heart do not belong to two separate subgroups

K. Broadley, K. Broadley, P. Lumley, 1977, The Journal of pharmacy and pharmacology.

Beta-adrenoceptor sensitivity of brown and white adipocytes after chronic pretreatment of rats with reserpine.

K. Broadley, J. Arch, P. Grassby, 1987, Biochemical pharmacology.

The coronary vasodilator mediator released by hypoxia and isoprenaline is not affected by cyclo-oxygenase inhibition.

A. Rothaul, K. Broadley, 1986, Prostaglandins.

Analysis of the inotropic: chronotropic selectivity of dobutamine and dopamine in anaethetised dogs and guinea-pig isolated atria.

K. Broadley, G. P. Levy, P. Lumley, 1977, Cardiovascular research.

Adenosine receptor subtypes in airways responses of sensitized guinea-pigs to inhaled ovalbumin.

K. Broadley, N. Smith, Nicola Smith, 2010, Pulmonary pharmacology & therapeutics.

β-Adrenoceptor ligand binding and supersensitivity to isoprenaline of ventricular muscle after chronic reserpine pretreatment

K. Broadley, M. Hawthorn, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differences between the Vasorelaxant Activity of Adenosine‐receptor Agonists on Guinea‐pig Isolated Aorta Precontracted with Noradrenaline or Phenylephrine

R. Buckingham, H. Maddock, K. Broadley, 1999, The Journal of pharmacy and pharmacology.

Effects of adenosine receptor agonists on induction of contractions to phenylephrine of guinea-pig aorta mediated via intra- or extracellular calcium.

K. Broadley, W. Ford, 1999, General pharmacology.

Functional classification of P1-purinoceptors in guinea-pig left and right atria: anomalous characteristics of antagonism by cyclopentyltheophyline

K. Broadley, W. Ford, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

Actions and interactions of adenosine, theophylline and enprofylline on the guinea-pig spirally cut trachea.

K. Broadley, N. Darmani, 1986, European journal of pharmacology.

Hypothermia‐induced supersensitivity to adenosine for responses mediated via A1receptors but not A2‐receptors

D. Paton, K. Broadley, S. Broome, 1985, British journal of pharmacology.

The roles of alpha- and beta-adrenoceptor stimulation in myocardial ischaemia.

Peter E. Penson, K. Broadley, 2004, Autonomic & autacoid pharmacology.

Evidence from use of neuronal uptake inhibition that β1‐adrenoceptors, but not β2‐adrenoceptors, are innervated

K. Broadley, M. Hawthorn, 1982 .

Beta-adrenoceptor responses of the airways: for better or worse?

K. Broadley, 2006, European journal of pharmacology.

Effect of vagotomy on airway hyperreactivity to endogenously released neurotransmitters at 18-24 h after inhaled antigen.

K. Broadley, A. Johnson, 1998, European journal of pharmacology.

Effects of inhibitors of phosphodiesterase, on antigen‐induced bronchial hyperreactivity in conscious sensitized guinea‐pigs and airway leukocyte infiltration

H. Danahay, K. Broadley, 1997, British journal of pharmacology.

Adenosine‐induced bronchoconstriction of isolated lung and trachea from sensitized guinea‐pigs

K. Broadley, J. R. Thorne, Julian R. Thorne, 1992, British journal of pharmacology.

Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease.

K. Broadley, N. Smith, T. Toward, 2004, American journal of respiratory and critical care medicine.

Early and late phase bronchoconstrictions in conscious sensitized guinea-pigs after macro- and microshock inhalation of allergen and associated airway accumulation of leukocytes.

K. Broadley, C. A. Lewis, A. Johnson, 1996, International journal of immunopharmacology.

Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs.

E. Kidd, J. Bugert, K. Broadley, 2013, Clinical science.

Temporal relationships between leukocytes, IL-5 and IL-8 in guinea pig lungs, plasma cortisol and airway function after antigen challenge

H. Danahay, K. Broadley, A. Nials, 1999, Inflammation Research.

A simple, rapid, and sensitive scintillation proximity assay for the determination of levels of guinea-pig interleukin-5 in bronchoalveolar lavage samples.

H. Danahay, K. Broadley, A. Nials, 1997, Journal of pharmacological and toxicological methods.

BJP Effects of LPS in a guinea pig model of asthma

E. Kidd, K. Broadley, A. Nials, 2019 .

LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma

E. Kidd, K. Broadley, A. Nials, 2015, British journal of pharmacology.

Establishing the phenotype in novel acute and chronic murine models of allergic asthma.

E. Kidd, K. Broadley, W. Ford, 2008, International immunopharmacology.

Bradykinin-Induced Lung Inflammation and Bronchoconstriction: Role in Parainfluenze-3 Virus-Induced Inflammation and Airway Hyperreactivity

E. Kidd, J. Bugert, K. Broadley, 2010, Journal of Pharmacology and Experimental Therapeutics.

Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs.

K. Broadley, J. R. Thorne, 1994, American journal of respiratory and critical care medicine.

Adjustment of sensitisation and challenge protocols restores functional and in ﬂ ammatory responses to ovalbumin in guinea-pigs and Methods

E. Kidd, K. Broadley, A. Nials, 2022 .

Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs

E. Kidd, K. Broadley, A. Nials, 2015, Journal of pharmacological and toxicological methods.

A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.

Richard Graham Knowles, E. Kidd, K. Broadley, 2012, Pulmonary pharmacology & therapeutics.

Cardiac alpha- and beta-adrenoceptor sensitivity and binding characteristics after chronic reserpine pretreatment

R. Chess-Williams, D. Sheridan, K. Broadley, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

Cardiac post-junctional alpha 1- and beta-adrenoceptors: effects of chronic chemical sympathectomy with 6-hydroxydopamine.

D. Sheridan, K. Broadley, R. Chess-Williams, 1987, Journal of receptor research.

CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms The vascular Ca -sensing receptor regulates blood vessel tone and blood pressure

D. Ward, D. Riccardi, R. Fenton, 2015 .

111In–Labelled Leukocyte Migration to the Lungs of Ovalbumin–Sensitized Guinea–Pigs after Aerosol Challenge with Ovalbumin Monitored by Gamma Scintigraphy

K. Broadley, S. Warren, C. A. Lewis, 1999, International Archives of Allergy and Immunology.

Adenosine receptor subtypes in the airways responses to 5′‐adenosine monophosphate inhalation of sensitized guinea‐pigs

K. Broadley, N. Smith, Nicola Smith, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Effects of nebulised magnesium sulphate on inflammation and function of the guinea‐pig airway

E. Kidd, C. Powell, K. Broadley, 2017, European journal of pharmacology.

Differential blockade of guinea-pig atrial rate and force responses to (--)-noradrenaline by practolol - an uptake phenomenon.

K. Broadley, P. Lumley, 1975, European journal of pharmacology.

Review Muscarinic Receptor Agonists and Antagonists

K. Broadley, D. Kelly, 2001 .

Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma.

K. Broadley, N. Smith, 2007, International immunopharmacology.

Inhaled calcilytics: effects on airway inflammation and remodeling

E. Kidd, Y. Prakash, D. Riccardi, 2016 .

Airway Reactivity to Inhaled Spasmogens 18–24 h after Antigen‐challenge in Sensitized Anaesthetized Guinea‐pigs

K. Broadley, A. Johnson, 1997, The Journal of pharmacy and pharmacology.

Airway hyper‐ or hyporeactivity to inhaled spasmogens 24 h after ovalbumin challenge of sensitized guinea‐pigs

K. Broadley, C. A. Lewis, Kenneth J. Broadley, 1995, British journal of pharmacology.

Route of Administration Affects Corticosteroid Sensitivity of a Combined Ovalbumin and Lipopolysaccharide Model of Asthma Exacerbation in Guinea Pigs

E. Kidd, K. Broadley, A. Nials, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Adenylyl and guanylyl cyclase and PDE activities toward cAMP and cGMP in isolated lungs during LPS-induced airway reactivity changes [Abstract]

K. Broadley, T. Toward, 2002 .

A3 receptors mediate rapid inflammatory cell influx into the lungs of sensitized guinea‐pigs

K. Broadley, L. Spruntulis, L. M. Spruntulis, 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitized guinea-pig lungs and trachea.

H. Danahay, K. Broadley, J. R. Thorne, 1996, European journal of pharmacology.

Responses mediated via beta-1 adrenoceptors but not beta-2 adrenoceptors exhibit supersensitivity after chronic reserpine pretreatment.

K. Broadley, P. Grassby, 1986, The Journal of pharmacology and experimental therapeutics.

Influence of spasmogen inhalation by guinea pigs upon subsequent demonstration of ovalbumin-induced hyperreactivity in isolated airways tissues.

K. Broadley, C. A. Lewis, C. Lewis, 1995, Journal of pharmacological and toxicological methods.

Development of a method for monitoring the migration of 111In-labeled eosinophils and neutrophils to the lungs of anaesthetized guinea pigs by gamma scintigraphy and bronchoalveolar lavage.

K. Broadley, S. Farr, C. A. Lewis, 1996, Journal of immunological methods.

Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma.

E. Kidd, K. Broadley, W. Ford, 2010, Pulmonary pharmacology & therapeutics.

EFFECTS OF LOW-LEVEL OZONE EXPOSURE ON REACTIVITY AND CONDUCTANCE IN GUINEA PIG AIRWAYS

K. Broadley, C. A. Lewis, Johnson Alexia, 1998 .

Review of mechanisms involved in the apparent differential desensitization of beta1- and beta2-adrenoceptor-mediated functional responses.

K. Broadley, 1999, Journal of autonomic pharmacology.

Characterization of β‐adrenoceptors mediating relaxation of the guinea‐pig ileum

K. Broadley, P. Grassby, 1984 .

Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A(2A) receptors.

H. Maddock, K. Broadley, N. Khandoudi, 2001, Journal of autonomic pharmacology.

Respiratory syncytial virus infections: characteristics and treatment

K. Broadley, Sharon M. Chidgey, 2005, The Journal of pharmacy and pharmacology.

Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines.

E. Kidd, K. Broadley, W. Ford, 2013, European journal of pharmacology.

Resistance of beta 2-adrenoceptor-mediated responses of lung strips to desensitization by long-term agonist exposure--comparison with atrial beta 1-adrenoceptor-mediated responses.

K. Broadley, M. Herepath, 1992, European journal of pharmacology.

Comparison of adenosine receptor agonists with other vasodilators on noradrenaline-, potassium- and phorbol ester-contracted rabbit aorta.

K. Broadley, R. Urquhart, 1991, European journal of pharmacology.

In vivo demonstration of alpha-adrenoceptor-mediated positive inotropy in pithed rats: evidence that noradrenaline does not stimulate myocardial alpha-adrenoceptors.

A. Roach, K. Broadley, K. Williamson, 1999, Journal of autonomic pharmacology.

Do both adrenaline and noradrenaline stimulate cardiac α‐adrenoceptors to induce positive inotropy of rat atria?

K. Broadley, K. Williamson, 1989, British journal of pharmacology.

Catecholamine-induced vasodilator metabolite release from guinea-pig hearts is not due to increased myocardial activity

A. Rothaul, K. Broadley, 1981, Pflügers Archiv.

Non‐adrenergic vasoconstriction and vasodilatation of guinea‐pig aorta by &bgr;‐phenylethylamine and amphetamine – Role of nitric oxide determined with L‐NAME and NO scavengers

K. Broadley, H. Broadley, 2018, European journal of pharmacology.

Vasoconstriction of porcine left anterior descending coronary artery by ecstasy and cathinone is not an indirect sympathomimetic effect.

K. Broadley, A. A. Herbert, K. E. Baker, 2007, Vascular pharmacology.

The contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses.

K. Broadley, C. Duncan, 1977, General pharmacology.

Dietary trace amine‐dependent vasoconstriction in porcine coronary artery

E. Kidd, K. Broadley, A. A. Herbert, 2008, British journal of pharmacology.

Examination of cardiac alpha-adrenoceptors from pharmacological responses and radioligand binding. Comparison of rat and guinea pig tissues.

K. Broadley, R. Chess-Williams, 1987, Journal of pharmacological methods.

The effects of temperature on responses of the isolated perfused heart of the guinea pig to catecholamines: a separation of the rate and force responses.

K. Broadley, 1972, European Journal of Pharmacology.

The effect of salbutamol on early and late asthmatic responses, bronchial hyperreactivity and airway leukocyte infiltration in guinea‐pigs

K. Broadley, L. Spruntulis, 1998 .

Towards a Thermodynamic Definition of Efficacy in Partial Agonism: I Concentration-Response Theory for Explicit Agonist and Antagonist Complexes

R. Davies, K. Broadley, S. Sykes, 2010 .

Affinities of full agonists for cardiac β-adrenoceptors calculated by use of in vitro desensitization

K. Broadley, M. Herepath, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Distortion and energetics in the agonist conformation bound phenoxypropanolamine agents in the β1‐adrenoceptor

A. Wilkinson, R. Davies, K. Broadley, 1994 .

Determination of agonist affinity for cardiac beta-adrenoceptors during reserpine-induced supersensitivity.

K. Broadley, R. G. Williams, 1983, European journal of pharmacology.

Influences, decisions and serendipity: an autobiography.

K. Broadley, 2009, Autonomic & autacoid pharmacology.

Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M1) receptor agonists: a novel M1 allosteric modulator.

E. J. Thomas, E. Burnell, R. Davies, 2016, Organic & biomolecular chemistry.

Muscarinic Receptor Agonists and Antagonists

K. Broadley, D. Kelly, 2001, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry.

The synthesis of a series of adenosine A3 receptor agonists.

E. J. Thomas, E. Burnell, Alan T. L. Lee, 2016, Organic & biomolecular chemistry.

Effects of noradnamine (5-aminomethyl-2,3,7,8-tetrahydroxydibenzo-[a,e[cycloheptatriene) on the blood pressure of the anaesthetized cat and rat.

K. Broadley, D. Roberts, 1967, British journal of pharmacology and chemotherapy.

Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation.

J. Birchall, M. Gumbleton, Y. Özsoy, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Stepwise phosphorylation mechanisms and signal transmission within a ligand–receptor–Gαβγ-protein-complex

A. Wilkinson, H. Timmerman, R. Davies, 1998 .

The Langendorff heart preparation—Reappraisal of its role as a research and teaching model for coronary vasoactive drugs

K. Broadley, Kenneth J. Broadley, 1979 .

Synthesis of antagonists of muscarinic (M3) receptors

E. J. Thomas, Peter E. Penson, Alan T. L. Lee, 2011 .

Ex Vivo Examination of β‐Adrenoceptor Characteristics After Propranolol Withdrawal

K. Broadley, R. Chess-Williams, 1984, Journal of cardiovascular pharmacology.

Analysis of the atypical characteristics of adenosine receptors mediating negative inotropic and chronotropic responses of guinea‐pig isolated atria and papillary muscles

K. Broadley, N. M. Gardner, 1999, British journal of pharmacology.

Inhibition of field stimulation‐induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN‐A‐343 for M1 receptors

R. Davies, K. Broadley, Helen E. Scholes, 2001, The Journal of pharmacy and pharmacology.

Coronary and aortic vasoconstriction by cathinone, the active constituent of khat.

A. Al‐Motarreb, K. Broadley, 2003, Autonomic & autacoid pharmacology.

Vasopressors for cardiopulmonary resuscitation. Does pharmacological evidence support clinical practice?

Peter E. Penson, K. Broadley, W. Ford, 2007, Pharmacology & therapeutics.

P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia.

H. Maddock, K. Broadley, 1996, Journal of autonomic pharmacology.

Effects of hypoxia on the vasodilator activity of nifedipine and evidence of secondary pharmacological properties.

Peter E. Penson, K. Broadley, 2006, European journal of pharmacology.

Drugs modulating adenosine receptors as potential therapeutic agents for cardiovascular diseases

K. Broadley, 2000 .

Alpha- and beta-adrenoceptor-mediated responses of the guinea-pig ileum and the effects of neuronal uptake inhibition

K. Broadley, P. Grassby, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Comparison of the uptake and O-methylation of isoprenaline by cardiac and respiratory tissues of guinea-pigs.

D. Paton, K. Broadley, 1990, Pharmacological research.

The influence of temperature upon reserpine-induced supersensitivity of guinea-pig isolated atria to isoprenaline and salbutamol

K. Broadley, C. Duncan, 1977, Naunyn-Schmiedeberg's Archives of Pharmacology.

The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity.

K. Broadley, P. Grassby, R. Chess-Williams, 1985, Journal of autonomic pharmacology.

Temperature dependence of beta 1-adrenoceptor-mediated responses examined by use of partial agonists.

K. Broadley, R. Chess-Williams, 1985, European journal of pharmacology.

A fundamental temperature-dependent difference between beta-adrenoceptor agonists and antagonists.

R. Chess-Williams, K. Broadley, R. Chess-Williams, 1984, Life sciences.

Temperature‐induced changes in dissociation constants (KA) of agonists at cardiac β‐adrenoceptors determined by use of the irreversible antagonist Ro 03–7894

K. Broadley, Russell G. Williams, 1983, British journal of pharmacology.

Responses mediated via β1, but not β2-andrenoceptors, exhibit hypothermia-induced supersensitivity

K. Broadley, Russell G. Williams, 1982 .

THE USE OF AN IRREVERSIBLE β-ADRENORECEPTOR ANTAGONIST TO EXAMINE RESERPINE- AND HYPOTHERMIA-INDUCED SUPERSENSITIVITY OF GUINEA-PIG ATRIA

K. Broadley, C. Nicholson, 1980 .

Measurements of oxygen tension in perfusates from guinea pig isolated hearts and the demonstration of coronary vasodilator material.

A. Rothaul, K. Broadley, 1982, Journal of pharmacological methods.

Adenosine is not the sole vasodilator released on exposure of isolated guinea-pig hearts to histamine and isoprenaline.

K. Broadley, A. N. Wilson, Andrew N. A. Wilson, 1994, General pharmacology.

Uptake and metabolism of histamine in guinea-pig isolated atria and their relationship to the pharmacological responses

K. Broadley, I. R. Smith, D. Owen, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The effect of phosphodiesterase inhibitors on guinea-pig cardiac responses to histamine and isoprenaline

K. Broadley, C. Wilson, 1980, Agents and Actions.

A positive inotropic response of guinea pig isolated atria to histamine not mediated via H1 or H2 receptors.

K. Broadley, C. Wilson, 1980, Canadian journal of physiology and pharmacology.

The ligand-receptor-G-protein ternary complex as a GTP-synthase. steady-state proton pumping and dose-response relationships for beta -adrenoceptors.

H. Timmerman, R. Davies, K. Broadley, 2000, Journal of theoretical biology.

Partial agonists at guinea-pig atrial β-adrenoceptors display relaxation responses in the guinea-pig ileum independent of β-adrenoceptor stimulation☆

K. Broadley, P. Grassby, 1987 .

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

H. Kita, E. Kidd, M. Thompson, 2015, Science Translational Medicine.

Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed

K. Broadley, W. Ford, M. Anwar, 2013, Vascular pharmacology.

Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma

B. Kariuki, E. Kidd, D. Riccardi, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma

B. Kariuki, E. Kidd, D. Riccardi, 2020 .

Airway function, oedema, cell infiltration and nitric oxide generation in conscious ozone‐exposed guinea‐pigs: effects of dexamethasone and rolipram

K. Broadley, T. Toward, 2002, British journal of pharmacology.

Protection from myocardial stunning by ischaemia and hypoxia with the adenosine A3 receptor agonist, IB-MECA.

H. Maddock, K. Broadley, N. Khandoudi, 2003, European journal of pharmacology.

Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone

K. Broadley, T. Toward, 2002, Journal of Pharmacology and Experimental Therapeutics.

Nitric oxide in respiratory diseases.

K. Broadley, B. Nevin, 2002, Pharmacology & therapeutics.

Resistance to antagonism of atrial P(1) purinoceptor responses in the presence of K(+) channel blockade.

K. Broadley, N. M. Gardner, 1999, European journal of pharmacology.

Does endogenous adenosine have a role in the cardiac responses to isoprenaline and in the rapid fade of the inotropic response of perfused heart?

K. Broadley, A. N. Wilson, 1994, Canadian journal of physiology and pharmacology.

The effects of P1- and muscarinic-receptor agonists upon cAMP-dependent and independent inotropic responses of guinea-pig cardiac preparations.

K. Broadley, R. Urquhart, 1992, General pharmacology.

Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.

R. Davies, K. Broadley, S. Sykes, 2010, Biochemical pharmacology.

Modulation of vascular responses of guinea-pig aorta by non-endothelial nitric oxide: A minor role for the endothelium.

K. Broadley, H. Broadley, 2019, Vascular pharmacology.

Whether phenylephrine exerts inotropic effects through alpha- or beta-adrenoceptors depends upon the relative receptor populations.

K. Broadley, R. Chess-Williams, K. Williamson, 1990, Fundamental & Clinical Pharmacology.

Irreversible β-adrenoceptor blockade of atrial rate and tension responses

K. Broadley, C. Nicholson, 1978 .

Atypical antagonism of D1-receptor-mediated vasodilator response in the perfused kidney by SCH23390.

K. Broadley, S. Martin, 1995, Pharmacological research.

Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine

R. Chess-Williams, D. Sheridan, K. Broadley, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

DISSOCIATION CONSTANTS OF ISOPRENALINE AND ORCIPRENALINE AND THEIR RELATIVE EFFICACIES ON GUINEA‐PIG ISOLATED ATRIA DETERMINED BY USE OF AN IRREVERSIBLE β‐ADRENOCEPTOR ANTAGONIST

K. Broadley, C. Nicholson, 1981, British journal of pharmacology.

Effects of chronic intravenous infusions of dopexamine and isoprenaline to rats on D1‐, β1‐ and β2‐receptor‐mediated responses

K. Broadley, S. Martin, 1994 .

Dissociation constants (KA) and relative efficacies of sympathomimetic amines in isolated atria during hypothermia-induced supersensitivity.

J. McNeill, K. Broadley, 1983, Canadian Journal of Physiology and Pharmacology.

Reserpine-induced supersensitivity occurs for beta-adrenoceptor-mediated responses of heart and trachea but not of the uterus and lung.

K. Broadley, M. Hawthorn, 1984, European journal of pharmacology.

Arrhythmias and α1-adrenoceptor binding characteristics of the guinea -pig perfused heart during ischaemia and reperfusion

R. Chess-Williams, D. Sheridan, K. Broadley, 1990 .

Further characterization of the guinea pig left atrial tension response to histamine by use of selective agonists

K. Broadley, C. Wilson, 1981, Agents and Actions.

86Rubidium efflux and negative inotropy induced by P1- and muscarinic-receptor agonists in guinea-pig left atria. Effects of potassium channel blockers.

A. Rothaul, K. Broadley, R. Urquhart, 1991, Biochemical Pharmacology.

Analysis of the direct and indirect effects of adenosine on atrial and ventricular cardiac muscle.

K. Broadley, A. N. Wilson, 1989, Canadian Journal of Physiology and Pharmacology.

Interactions of Tyr377 in a ligand-activation model of signal transmission through β1-adrenoceptor α-helices

R. Davies, K. Broadley, D. Timms, 1992 .

Early and late bronchoconstrictions, airway hyper‐reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram

K. Broadley, T. Toward, 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Relationships between cardiac hyperactivity, oxygen tension, and release of vasodilator material in coronary autoregulation of guinea-pig hearts.

A. Rothaul, K. Broadley, 1986, Canadian journal of physiology and pharmacology.

Effects of K+‐channel blockers on A1‐adenosine receptor‐mediated negative inotropy and chronotropy of guinea‐pig isolated left and right atria

K. Broadley, W. Ford, Kenneth J. Broadley, 1999, Fundamental & clinical pharmacology.

Pulmonary edema measured by MRI correlates with late-phase response to allergen challenge

E. Kidd, K. Broadley, A. Nials, 2015, Experimental lung research.

Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone.

K. Broadley, T. Toward, 2001, The Journal of pharmacology and experimental therapeutics.

Airway reactivity, inflammatory cell influx and nitric oxide in guinea‐pig airways after lipopolysaccharide inhalation

K. Broadley, T. Toward, 2000, British journal of pharmacology.

Trace amine-induced vasoconstriction of human mammary artery and saphenous vein.

K. Broadley, D. Mehta, 2023, Vascular pharmacology.

Mediators of adenosine- and ovalbumen-induced bronchoconstriction of sensitized guinea-pig isolated airways.

K. Broadley, T. J. Martin, 2002, European journal of pharmacology.

Blockade by 4‐Aminopyridine of the Muscarinic‐receptor‐mediated Responses of Guinea‐pig Atria and Trachea

K. Broadley, R. Urquhart, KENNETH J. BROADLEY, 1991, The Journal of pharmacy and pharmacology.

A comparison of the responses to histamine of left and right atria and papillary muscles of guinea-pig hearts.

K. Broadley, C. Wilson, 1981, General pharmacology.

The effect of chemical structure on chromatographic multiple spot formation by sympathomimetic amines in the presence of hydrochloric acid

K. Broadley, D. Roberts, 1966, The Journal of pharmacy and pharmacology.

Studies on the nature of some chromatographic multispots from adrenaline.

K. Broadley, D. Roberts, 1967, Journal of chromatography.

Inhibition of catechol-O-methyl transferase by some acid degradation products of adrenaline and noradrenaline.

K. Broadley, D. Roberts, E. T. Abbs, 1967, Biochemical pharmacology.

Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future research.

A. Al‐Motarreb, K. Broadley, M. Al-Habori, 2010, Journal of ethnopharmacology.

Evidence from lack of decentralization-induced supersensitivity that beta 2-adrenoceptors of the cat nictitating membrane are non-innervated.

K. Broadley, 1990, Acta physiologica Scandinavica.

Airway hyperresponsiveness in anaesthetised guinea-pigs 18-24 hours after antigen inhalation does not occur with all intravenously administered spasmogens.

K. Broadley, A. Johnson, 1999, Pharmacology & toxicology.

LPS exacerbates functional and inﬂammatory responses to ovalbumin and decreases sensitivity to inhaled ﬂuticasone propionate in a guinea pig model of asthma

K. Broadley, W. Ford, A. P. Lowe, 2023 .

BJP Effects of LPS in a guinea pig model of asthma

E. Kidd, K. Broadley, A. Nials, 2017 .

BJP Effects of LPS in a guinea pig model of asthma

Cardiff, E. Kidd, K. Broadley, 2016 .

Effects of dietary amines on the gut and its vasculature

E. Kidd, K. Broadley, W. Ford, 2008, British Journal of Nutrition.

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation

P. Taylor, E. Kidd, S. Farrow, 2017, Cellular immunology.

An analysis of the coronary vascular responses to catecholamines, using a modified Langendorff heart preparation

K. Broadley, K. Broadley, 1970, British journal of pharmacology.

Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs.

E. Kidd, J. Bugert, K. Broadley, 2013, Clinical science.

Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation.

J. Birchall, M. Gumbleton, Y. Özsoy, 2012, Journal of controlled release : official journal of the Controlled Release Society.

THE RELEASE OF A CORONARY VASODILATOR METABOLITE FROM THE GUINEA‐PIG ISOLATED PERFUSED HEART STIMULATED BY CATECHOLAMINES, HISTAMINE AND ELECTRICAL PACING AND BY EXPOSURE TO ANOXIA

K. Broadley, K. Broadley, K.J. BROADLEY, 1976, British journal of pharmacology.

The influence of antidepressant drugs on akinesia produced in mice by intracisternally administered noradrenaline, dopamine and noradnamine

K. Broadley, D. Roberts, 1967, Experientia.

A comparative study of the effects of temperature upon the rate and force responses to isoprenaline of isolated atria of several species

K. Broadley, 1975 .

Ligand-activated trans-membrane proton transfer in beta 1-adrenergic and m2-muscarinic receptors.

D Timms, A. Wilkinson, R. Davies, 1994, Receptors & channels.

Examination of the bronchoconstrictor response of guinea-pig isolated lung to beta-phenylethylamine.

K. Broadley, M. Hawthorn, C. J. Gibbon, 1985, General pharmacology.