A. Scilimati

M. de Candia, N. Denora, V. Laquintana, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers

M. Bellis, F. Corbo, M. Sinicropi, 2007 .

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

N. Colabufo, R. Jockers, M. Perrone, 2008, Bioorganic & medicinal chemistry.

Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.

C. Fortuna, A. Boccarelli, M. Coluccia, 2017, European journal of medicinal chemistry.

Effects of Oral Supplementation with Myo-Inositol and D-Chiro-Inositol on Ovarian Functions in Female Long-Term Survivors of Lymphoma: Results from a Prospective Case–Control Analysis

A. Sapino, E. Cicinelli, V. Chiantera, 2022, Journal of personalized medicine.

Myogenic effect of SP-1f and SP-1h two novel β3-adrenoceptor (β3-AR) agonists in human colonic circular smooth muscle.

M. Perrone, M. Maselli, A. Scilimati, 2014, European journal of pharmacology.

Microfluidic pervaporation of ethanol from radiopharmaceutical formulations

M. G. Manera, R. Rella, S. Ferorelli, 2019, Chemical Engineering and Processing - Process Intensification.

Carbon-carbon bond formation by means of substitution and addition reactions involving the polymer-supported carbanion from methyl nitroacetate

F. Naso, A. Scilimati, V. Fiandanese, 1984 .

Olive Mill Wastewater Fermented with Microbial Pools as a New Potential Functional Beverage

F. Romeo, C. Randazzo, M. Perrone, 2023, Molecules.

Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.

C. Fortuna, P. Sathler, A. Boccarelli, 2019, European journal of medicinal chemistry.

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

G. Nicolardi, A. Cianciulli, R. Calvello, 2017, Front. Neurol..

Selective COX-1 inhibition: A therapeutic target to be reconsidered.

M. Perrone, A. Scilimati, M G Perrone, 2010, Current medicinal chemistry.

Optically active sulfoxides by enantiospecific reactions of bromovinyl aryl sulfoxides with grignard reagents

F. Naso, A. Scilimati, V. Fiandanese, 1992 .

Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalysts for ketone reductions

M. Perrone, A. Scilimati, F. Perna, 2011 .

Decomposition of arylazides by thf/-butyllithium-II-isolation of 1-aryl-4,5-dihydro-5-hydroxy-1h-1,2,3-triazoles

A. Scilimati, L. Nunno, 1986 .

Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines

A. Scilimati, P. Vitale, 2017 .

Chemical and chemoenzymatic routes to 1-(benzothiazol-2-ylsulfanyl)-3-chloropropan-2-ol, a precursor of drugs with potential β-blocker activity

M. Sinicropi, C. Franchini, A. Scilimati, 2000 .

A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists.

M. Perrone, A. Scilimati, P. Tortorella, 2006, Bioorganic & medicinal chemistry.

The Reaction of Arylaldehydes with Hexamethylphosphorous Triamide and the Use of the Resulting Products for the Synthesis of Enamines and Deoxybenzoins

F. Babudri, F. Naso, A. Scilimati, 1991 .

Diarylheterocycle Core Ring Features Effect in Selective COX‐1 Inhibition

E. Novellino, A. Lavecchia, A. Altomare, 2012, ChemMedChem.

Isoxazole‐Based‐Scaffold Inhibitors Targeting Cyclooxygenases (COXs)

A. Lavecchia, M. Perrone, S. Ferorelli, 2016, ChemMedChem.

Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles

G. Agrimi, A. Scilimati, F. Perna, 2017 .

Baker's yeast-induced asymmetric reduction of α-ketosulfides: synthesis of optically active 1-(benzothiazol-2-ylsulfanyl)-2-alkanols, 2-alkanols, and thiiranes

M. Sinicropi, C. Franchini, A. Nacci, 1999 .

Chelation-controlled chemo-, regio- and enantio-selective synthesis of homoallylic alcohols

A. Nacci, A. Scilimati, V. Calō, 1994 .

Regiocontrol by anchimeric co-ordination in the reactions of organocopper reagents with allylic substrates bearing two leaving groups. Synthesis of optically active homoallylic alcohols

A. Scilimati, V. Calō, C. D. Nitti, 1992 .

Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones

M. Perrone, A. Scilimati, F. Perna, 2013 .

Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl 5

A. Scilimati, P. Vitale, L. Nunno, 2013 .

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.

C. Fortuna, M. Perrone, A. Scilimati, 2015, European journal of medicinal chemistry.

Palladium-catalysed synthesis of α-diallylated ketosulphides of benzothiazole and their transformation into diallyl thiiranes and trienes

A. Nacci, A. Scilimati, V. Calō, 1995 .

A chemoenzymatic synthesis of (+)-castanospermine

C. Sih, A. Scilimati, R. Mortezaei, 1990 .

A novel injectable formulation of 6-fluoro-l-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson's disease.

A. Trapani, G. Trapani, D. Mandracchia, 2017, International journal of pharmaceutics.

Stereospecific synthesis and absolute configuration of mexiletine

F. Corbo, G. Lentini, C. Franchini, 1994 .

Macrocyclic lactones via biocatalysis in non-aqueous media

C. Sih, A. Scilimati, G. Fülling, 1988 .

Stereoselective Prostereogenic 3-Oxo Ester Reduction Mediated by a Novel Yeast Alcohol Dehydrogenase Derived from Kluyveromyces marxianus CBS 6556

C. Syldatk, M. Perrone, A. Scilimati, 2007 .

Kluyveromyces marxianus CBS 6556 Growing Cells as a New Biocatalyst in the Asymmetric Reduction of Substituted Acetophenones.

M. Perrone, A. Scilimati, F. Perna, 2013 .

Three-dimensional structure of human cyclooxygenase (hCOX)-1

G. Cingolani, R. Caliandro, B. D. Belviso, 2021, Scientific Reports.

Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective.

M. Perrone, S. Ferorelli, A. Scilimati, 2020, Current medicinal chemistry.

A chemoenzymic route to (-)-pyrenophorin

C. Sih, A. Scilimati, Zhi-wei Guo, 1989 .

Selective reduction of aldehydes to the corresponding primary alcohols by lithium enolate of acetaldehyde

A. Scilimati, L. Nunno, 1988 .

Regioselective synthesis and side-chain metallation and elaboration of 3-aryl-5-alkylisoxazoles

A. Scilimati, P. Vitale, L. Nunno, 2002 .

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.

A. De Luca, F. Corbo, M. M. Cavalluzzi, 2003, Journal of medicinal chemistry.

A new synthesis of β-phenylaminothioesters and β-lactams via base-induced ring-opening of 2-phenyl-3-aryl-5-phenyl-thioisoxazolidines☆

A. Scilimati, L. Nunno, 1993 .

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

A. Cianciulli, R. Calvello, M. Panaro, 2015, Pharmacology.

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.

A. Cianciulli, R. Calvello, M. Panaro, 2012, Pharmacological research.

Translational Theragnostic of Ovarian Cancer: Where do we stand?

A. De Grassi, M. Perrone, S. Ferorelli, 2019, Current medicinal chemistry.

Upregulation of β3-Adrenergic Receptor mRNA in Human Colon Cancer: A Preliminary Study

M. Perrone, A. Scilimati, V. Tutino, 2008, Oncology.

β3-Adrenoceptor ligand development history through patent review

M. Perrone, A. Scilimati, 2011, Expert opinion on therapeutic patents.

SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism

A. Cianciulli, M. Mazzone, A. Menga, 2017, The FEBS journal.

COX‐1 Inhibitors: Beyond Structure Toward Therapy

M. Perrone, A. Scilimati, P. Vitale, 2016, Medicinal research reviews.

Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats

J. Kaplanski, A. Zlotnik, M. Perrone, 2020, Neuroscience Letters.

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).

R. Armen, C. Fortuna, G. Cingolani, 2017, European journal of medicinal chemistry.

Single-dose extended-toxicity preclinical study on novel radiotracer formulations for use in the diagnosis of neuroendocrine tumor and neurodegenerative disorders

N. Denora, V. Laquintana, A. Scilimati, 2019 .

Biocatalytic resolution of (±)-hydroxyalkanoic esters. A strategy for enhancing the enantiomeric specificity of lipase-catalyzed ester hydrolysis

C. Sih, A. Scilimati, T. Ngooi, 1988 .

Biocatalytic Resolution of (.+‐.)‐Hydroxyalkanoic Esters. A Strategy for Enhancing the Enantiomeric Specificity of Lipase‐Catalyzed Ester Hydrolysis.

C. Sih, A. Scilimati, T. Ngooi, 1989 .

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

A. De Luca, F. Corbo, G. Lentini, 2000, Journal of medicinal chemistry.

Candida cylindracea Lipase‐Mediated Kinetic Resolution of α‐ Substituted α‐Aryloxyacetic Acid Methyl Esters.

M. Sinicropi, C. Franchini, S. Ferorelli, 2010 .

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

L. Marnett, M. Perrone, H. Manning, 2014, European journal of medicinal chemistry.

5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity

A. Scilimati, P. Vitale, L. Nunno, 2005 .

Reaction of 3-phenylisoxazole with alkyllithiums

A. Scilimati, P. Vitale, L. Nunno, 2005 .

Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal.

S. Tacconelli, A. Scilimati, P. Patrignani, 2004, Journal of medicinal chemistry.

5‐Hydroxy‐3‐phenyl‐5‐vinyl‐2‐isoxazoline (III) and 3‐Phenyl‐5‐vinylisoxazole (V): Synthesis and Reactivity.

A. Scilimati, P. Vitale, L. Nunno, 2006 .

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

E. Sotelo, A. Ligresti, F. Leonetti, 2023, International journal of molecular sciences.

Current and emerging applications of fluorine in medicinal chemistry

M. Perrone, A. Scilimati, P. Vitale, 2015 .

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents.

A. De Luca, F. Corbo, M. Sinicropi, 2008, European journal of medicinal chemistry.

[18F]F-DOPA synthesis by poly(dimethylsiloxane)-based platforms: thermal aging protocol to reduce chemicals-induced damage

M. G. Manera, C. Malitesta, R. Rella, 2018 .

Zoledronic Acid as a Novel Dual Blocker of KIR6.1/2-SUR2 Subunits of ATP-Sensitive K+ Channels: Role in the Adverse Drug Reactions

M. Perrone, A. Scilimati, C. Pierri, 2021, Pharmaceutics.

m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity

R. J. Doerksen, J. Menéndez, M. Perrone, 2023, Molecules.

Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection.

L. Marnett, C. Fortuna, M. Perrone, 2019, European journal of medicinal chemistry.

Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts.

G. Agrimi, A. Scilimati, F. Perna, 2016, Organic & biomolecular chemistry.

Update on SAR Studies Toward New COX-1 Selective Inhibitors.

M. Perrone, A. Scilimati, P. Vitale, 2015, Current medicinal chemistry.

Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent KATP Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome

C. Nichols, M. Perrone, A. Scilimati, 2023, Cells.

Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.

A. Lavecchia, M. Perrone, S. Tacconelli, 2013, Journal of medicinal chemistry.

Diarylheterocycle Core Ring Features Effect in Selective COX‐1 Inhibition

E. Novellino, A. Lavecchia, A. Altomare, 2012, ChemMedChem.

β3-Adrenoceptor ligand development history through patent review

M. Perrone, A. Scilimati, 2011, Expert opinion on therapeutic patents.

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents.

A. De Luca, F. Corbo, M. Sinicropi, 2008, European journal of medicinal chemistry.

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use‐dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo

A. De Luca, H. Jockusch, F. Corbo, 2001, British journal of pharmacology.

Pediatric Diffuse Midline Glioma H3K27-Altered: From Developmental Origins to Therapeutic Challenges

S. Ferorelli, A. Scilimati, Morena Miciaccia, 2024, Cancers.