J. Thon

发表

Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

Kwang-Soo Kim, Shijiang Lu, R. Lanza, 2014, Stem cell reports.

D. Weitz, L. Mazutis, A. Ehrlicher, 2014, Blood.

Scale-up of platelet production from human pluripotent stem cells for developing targeted therapies: advances & challenges

J. Thon, S. Karlsson, 2017 .

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

J. Hartwig, N. Mohandas, X. An, 2011, Blood.

PLATELETS AND THROMBOPOIESIS Platelet bioreactor-ona-chip

D. Weitz, L. Mazutis, A. Ehrlicher, 2014 .

A Secreted Tyrosine Kinase Acts in the Extracellular Environment

C. Worby, J. Dixon, J. Asara, 2014, Cell.

Does size matter in platelet production?

J. Italiano, J. Thon, 2012, Blood.

Cytoskeletal mechanics of proplatelet maturation and platelet release

J. Hartwig, A. Ehrlicher, J. Italiano, 2010, The Journal of cell biology.

Lysyl oxidase is associated with increased thrombosis and platelet reactivity.

M. Koupenova, P. Toselli, K. Ravid, 2016, Blood.

Platelets: production, morphology and ultrastructure.

J. Italiano, J. Thon, Jonathan N Thon, 2012, Handbook of experimental pharmacology.

Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors.

C. Ghevaert, A. Evans, Moyra Lawrence, 2021, Blood advances.

A signaling pathway contributing to platelet storage lesion development: targeting PI3‐kinase–dependent Rap1 activation slows storage‐induced platelet deterioration

D. Devine, J. Kast, J. Thon, 2009, Transfusion.

Translation of glycoprotein IIIa in stored blood platelets

D. Devine, J. Thon, D. Devine, 2007, Transfusion.

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4.

V. Mootha, B. Paw, S. Dimauro, 2013, American journal of human genetics.

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.

P. Deloukas, W. Ouwehand, A. Rendon, 2012, Blood.

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation

J. Italiano, J. Thon, K. Machlus, 2014, British journal of haematology.

Visualization and manipulation of the platelet and megakaryocyte cytoskeleton.

J. Italiano, J. Thon, Jonathan N Thon, 2012, Methods in molecular biology.

membrane systems and is essential for proplatelet and platelet formation The spectrin-based membrane skeleton stabilizes mouse megakaryocyte

J. Hartwig, N. Mohandas, J. Italiano, 2011 .

Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets.

R. Flaumenhaft, L. Noetzli, J. Italiano, 2019, Blood advances.

Megakaryocytes compensate for Kit insufficiency in murine arthritis

Y. Iwakura, J. Ware, P. Nigrovic, 2017, The Journal of clinical investigation.

Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.

N. Watkins, I. Macaulay, A. Rendon, 2013, Blood.

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

E. Hahm, Shijiang Lu, R. Lanza, 2011, Cell Research.

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production.

J. Italiano, J. Thon, J. Tibbitts, 2012, Blood.

Platelet bioreactor-on-a-chip.

D. Weitz, L. Mazutis, Stephen Wu, 2014, Blood.

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates

S. Henry, H. Gaus, J. Italiano, 2021, Haematologica.

Application of proteomics to the study of protein translation in stored platelet units

J. Thon, Jonathan N Thon, 2008 .

T granules in human platelets function in TLR9 organization and signaling

R. Flaumenhaft, T. Fuchs, A. Weyrich, 2012, The Journal of cell biology.

Platelet storage lesion: a new understanding from a proteomic perspective.

D. Devine, J. Thon, P. Schubert, 2008, Transfusion medicine reviews.

Platelet bioreactor: accelerated evolution of design and manufacture

L. Beaulieu, J. Thon, B. Dykstra, 2017, Platelets.

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.

S. Halene, Elenoe C Smith, J. Italiano, 2012, Blood.

PLATELET FORMATION

Joseph E Italiano, J. Italiano, J. Thon, 2010 .

Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition.

S. Sykes, M. Vitale, P. Mirandola, 2013, Blood.

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

L. Mazutis, J. Hartwig, A. Ehrlicher, 2015, Blood.

Road blocks in making platelets for transfusion

J. Italiano, J. Thon, S. Karlsson, 2015, Journal of thrombosis and haemostasis : JTH.

SDF-1 directs megakaryocyte relocation.

J. Thon, Jonathan N Thon, 2014, Blood.

The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.

L. Donahue, R. Bronson, K. Johnson, 2010, Blood.

Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches

D. Devine, J. Kast, J. Thon, 2008, Transfusion.

Microtubule and cortical forces determine platelet size during vascular platelet production

A. Mogilner, J. Hartwig, J. Italiano, 2012, Nature Communications.

The Functional Role of TLR9 in Human Platelets

R. Flaumenhaft, A. Weyrich, J. Rowley, 2011 .

A Secreted Tyrosine Kinase Acts in the Extracellular Environment

C. Worby, J. Dixon, J. Asara, 2014, Cell.

Scientific Category: Platelets and Thrombopoiesis Article title: Microtubule sliding drives proplatelet elongation and is dependent on

Stephen Wu, A. Ehrlicher, J. Italiano, 2017 .

Explorer A GWAS sequence variant for platelet volume marks an alternative DNM 3 promoter in megakaryocytes near a MEIS 1 binding site

P. Deloukas, W. Ouwehand, A. Rendon, 2017 .

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

L. Mazutis, J. Hartwig, A. Ehrlicher, 2015, Blood.

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

B. Paw, S. Alper, N. Lawson, 2015, Haematologica.

Homozygous knockout of the piezo 1 gene in the zebrafish is not associated with anemia

B. Paw, S. Alper, N. Lawson, 2015 .

Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

Shijiang Lu, R. Lanza, Hongguang Huo, 2014, Stem cell reports.